Muskomed is a branded Turkish muscle relaxant drug, the advantage of which is the absence of a curare-like effect. When treated with the drug, the development of paralysis and dysfunction of the cardiovascular and respiratory systems does not occur in the patient. The composition of the medication includes thiocolchicoside, which is a semi-synthetic sulfide derivative of colchicoside, a substance of natural origin that is classified as a glycoside.
The active substance selectively acts on glycine receptors, which are characterized by sensitivity to gamma-aminobutyric acid - GABA and strychnine and has a muscle relaxant effect by activating the central mechanisms of action of the brain and spinal cord, which regulate the tone of skeletal muscles. As a result, membranes in neurons are stabilized, the transmission of nerve impulses is blocked and spasms are reduced.
Pharmacological properties
Pharmacodynamics.
Muscomed contains the active substance thiocolchicoside, a semi-synthetic muscle relaxant, which is obtained from the natural glycoside colchicoside. exhibits selective affinity for GABA and glycine receptors, which determines the action of the drug at various levels of the nervous system, both for local spasms and for spasms of central origin. Muskomed does not have a curare-like effect, does not cause paralysis and does not affect the cardiovascular and respiratory systems.
Pharmacokinetics. When administered intramuscularly, thiocolchicoside is rapidly distributed in the blood, Cmax in blood plasma is reached in 15–45 minutes. After one intramuscular injection at a dose of 4 mg of thiocolchicoside, Cmax in blood plasma is 61 ng/ml.
Protein binding (mainly albumin) is 13%. The average apparent volume of distribution is 76 L after one IM injection at a dose of 4 mg.
T½ is 2.5–5 hours. Approximately 20% of the dose is excreted in the urine in the form of unchanged metabolites, 75–81% is excreted in the feces.
MUSKOMED CREAM 0.25% 30 GR
Instructions
Trade name of the drug: Muscomed
Active ingredients: Thiocolchicoside*
Pharmacotherapeutic group: Centrally acting muscle relaxants., Centrally acting muscle relaxants.
Release form:
cream 30 g in an aluminum tube. 1 aluminum tube with instructions for use in a cardboard box.
Dosage form:
Cream for external use 0.25%, 30 g (tubes)
Compound:
1 g of cream contains: Active substance: thiocolchicoside – 2.5 mg. Excipients: polysorbate 80, hydrogenated lanolin, cetyl alcohol, cetyl ether wax, stearic acid, methyl parahydroxybenzoate, ethyl parahydroxybenzoate, sodium alginate, sodium lauryl sulfate, linden essence, purified water.
Pharmacological properties:
Muskomed contains thiocolchicoside as an active substance, a semi-synthetic muscle relaxant obtained from the natural glycoside colchicoside. The selectivity of the central muscle relaxant effect of thiocolchicoside as an agonist of GABA and glycinergic receptors has been proven, which determines the effect of the drug at various levels of the nervous system, both with spasms of a local nature and with spasms of central origin. Moderately reduces or eliminates muscle spasms caused by effects from the central nervous system. In case of spastic muscle hypertension, it reduces the passive resistance of muscles to tension or reduces painful involuntary muscle spasms. Muscomed does not have a neuromuscular blocking property, does not have a curare-like effect, does not cause paralysis and does not affect the cardiovascular and respiratory systems. Muscomed has a muscle relaxant, anti-inflammatory and analgesic effect in rheumatoid pain of skeletal muscles and painful reflex muscle spasm syndrome of various origins. Does not suppress tonic impulses, which provide the muscle strength necessary for movement and maintaining posture and posture.
Pharmacokinetics:
When applied topically, it practically does not penetrate into the systemic circulation. About 70% of the active substance is localized at the site of application of the drug. Protein binding (mainly albumin) is 13%. Thiocolchicoside and its metabolites are excreted primarily in feces.
Indications for use:
• — degenerative diseases and static pathologies of the spine: dorsalgia and lumbodynia; • — vertebrogenic spasm of the cervical muscles (transient torticollis); • — neurological disorders accompanied by spasticity: cervicobrachial neuralgia, sciatica or sciatic pain (sciatic neuralgia); • — sports injuries and other traumatic disorders; • — postoperative pain syndrome; • — a period of physical rehabilitation to eliminate muscle contracture; • - symptomatic treatment of painful muscle spasms.
Mode of application:
Muscomed cream is used externally. In adults and children over 15 years of age, Muscomed cream is used 2-3 times a day under the supervision of a physician. A strip of cream is applied to the skin and lightly rubbed. The amount of the drug used depends on the size of the painful area. After applying the drug, hands must be washed. The duration of treatment depends on the indications and effectiveness of therapy.
Side effects:
With prolonged use, hypersensitivity reactions may develop (contact dermatitis, rash, urticaria, bronchial asthma, angioedema).
Contraindications:
- hypersensitivity to the components of the drug; — violation of the integrity of the skin; - muscle hypotonia; - mild paralysis; - pregnancy; - lactation period; - children under 15 years of age.
Drug interactions:
There are no data on drug interactions. However, caution is recommended when used concomitantly with other muscle relaxants. When used simultaneously with drugs that depress the central nervous system, including alcohol, antihypertensive drugs, and curare-like drugs, increased muscle relaxation and depression of the central nervous system and the development of hypotension are possible. When used simultaneously with anticoagulants, the risk of bleeding increases.
Special instructions:
If hypersensitivity reactions develop, treatment with the drug should be discontinued. Muscomed cream should be applied only to intact skin, avoiding contact with open wounds. After application, do not apply an occlusive dressing. The drug should not come into contact with the eyes and mucous membranes. Influence on the ability to drive a car and other mechanisms. During the treatment period, care must be taken when driving vehicles and performing other potentially hazardous activities that require increased concentration and speed of psychomotor reactions. Use during pregnancy and breastfeeding. Muskomed is contraindicated during pregnancy and lactation. Application in pediatrics. The drug is contraindicated in children under 15 years of age. The drug should be stored out of the reach of children and not used after the expiration date.
Overdose:
Symptoms: possible increased side effects. Treatment: symptomatic and supportive therapy.
Storage conditions:
Store at a temperature not exceeding 25°C.
Shelf life: 3 years.
Conditions of release: Dispensed by prescription.
Manufacturer:
World Medicine Ilac San. ve Tic. AS, Türkiye made by: Zentiva Saglik Urunleri Sanayi ve Ticaret AS, Türkiye
special instructions
The drug should be used with caution in cases of impaired renal or liver function. The drug should be used with caution in patients with epilepsy or risk of seizures.
Use during pregnancy or breastfeeding. The drug is contraindicated during pregnancy and breastfeeding.
Children. The drug is contraindicated in children under 16 years of age.
The ability to influence reaction speed when driving vehicles or working with other mechanisms. During the treatment period, care must be taken when driving vehicles and engaging in other potentially unsafe activities that require increased concentration and speed of psychomotor reactions.
Contraindications for use
The medication is not prescribed for:
- hypersensitivity in patients to the active and excipients of the drug,
- pregnancy, since the instructions for the medicine do not contain information about conducting studies in patients,
- breastfeeding, due to the passage of a muscle relaxant into breast milk,
- flaccid paralysis,
- muscle hypotonia.
The medicine is contraindicated:
- teenagers under 16 years old,
- young women of childbearing age who do not use contraceptives.
Note!
Description of the drug Muskomed solution d/in. 4mg/2ml amp. 2ml No. 6 on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
Muskomed, indications for use
Injections and capsules are used in additional therapy for patients who suffer from muscle contractures.
The medicine is used for short-term relief of spasms in acute pathologies of the spine. The cream is prescribed topically for the treatment of painful muscle spasms due to:
- transverse sacral radiculitis,
- brachial neuralgia and spastic torticollis in acute cases,
- pain that occurs after injuries and operations.
Muscomed for back pain is used to relieve painful spasms in degenerative-dystrophic lesions in the vertebral discs and joints. Pain disturbs the patient at rest, at night and in the morning when the patient wakes up. The introduction of the drug reduces the prescription of NSAIDs. The medicine accumulates in the body and acts for 3-4 days after completion of the course of treatment. Muskomed for neuralgia is injected according to the standard scheme and additionally damaged areas of the body are lubricated with cream two to three times a day by massaging into the skin. Doctors often prescribe Muscomed in tablets for patients, while pharmacists and pharmacists take care of the buyer’s health and dispense the drug in capsules.
Dosage regimen: Muscomed injections for adults and adolescents 16 years of age are injected slowly into the muscle, one ampoule - 4.0 mg of the drug twice a day. The drug is injected in a short course, which lasts three to five days. Then doctors recommend continuing therapy with the oral dosage form, which is prescribed according to the following scheme: Adults and 16-year-old children drink one four or eight mg capsule twice a day after meals. Do not exceed the maximum daily dose, which is eight to sixteen milligrams of the medication. The course of treatment is five to seven days.
Interaction with other drugs and other types of interactions
There are no data on drug interactions. However, caution is recommended when used concomitantly with other muscle relaxants.
When used simultaneously with drugs that depress the central nervous system (CNS), including alcohol, antihypertensive drugs, and curare-like drugs, increased muscle relaxation and CNS depression and the development of hypotension are possible.
When used simultaneously with anticoagulants, the risk of bleeding increases.
Popular questions about Muskomed
What does Muskomed help with?
The medicine is prescribed for short-term pain relief in patients who suffer from muscle contractures, which lead to limited mobility of tissue in the muscles.
How to replace Muskomed?
Imported analogs of the drug based on the active substance - Tionex and Tiyoside - are sold in pharmacies of the retail pharmaceutical network 9-1-1.
How to give Muscomed injections?
Muskomed injections are injected into adults and adolescents from 16 years of age slowly into the muscle - one ampoule twice a day. Doctors recommend not to exceed the course of treatment, which is three to five days.
How quickly does Muskomed work?
Reduction of pain in patients and relief of well-being occurs: thirty to forty minutes after the injection, one to two hours after the capsule enters the body.
Features of application
The medication is prescribed carefully:
- car drivers, due to drowsiness when the medication enters the body,
- for epilepsy, since after taking the medicine the patient increases the risk of developing an epileptic attack and convulsions,
- with impaired liver and kidney function. The drug cannot be combined with alcoholic beverages and drugs that:
- belong to the group of muscle relaxants,
- inhibit the functions of the central nervous system,
- used to lower blood pressure,
- have a curare-like effect due to increased muscle relaxation, depression of the nervous system and the risk of developing hypotension.
The drug is not prescribed together with anticoagulants, as the risk of bleeding increases.
