Bisoprolol analogues in tablets without side effects

Bisoprolol is a 2nd generation beta-blocker. It is actively used in the monotherapy of hypertension and the treatment of heart failure. This drug is also used in complex therapy when taken simultaneously with ACE inhibitors, angiotensin antagonists and calcium antagonists.

It is also often prescribed with specific drugs from the cardiological group. Available in tablet form. But this particular drug is not always suitable, there is a particular intolerance to its main component, and it is a substance of the same name, so you have to select analogues.

Bisoprolol is prescribed to patients who have been diagnosed with:

• IHD;
• myocardial infarction;
• chronic form of heart failure;
• glaucoma;
• tachyarrhythmia.

According to reviews from specialists who have been monitoring the health of patients taking Bisoprolol for many years, the drug quickly and easily reduces blood pressure. But it has a bad effect on your heart rate during exercise.

Bisoprolol is an inexpensive but effective drug in tablets that has the following actions:

• significantly reduces cardiac output and heart rate;
• suppresses the secretion of renin, due to which a decrease in blood pressure occurs;
• causes a decrease in peripheral resistance of blood vessels and expansion of their walls, which allows to further reduce pressure;
• eye pressure also has a positive effect, normalizing it without reducing visual acuity;
• provokes contraction of the smooth muscles of internal organs.

Bisoprolol analogues in tablets without side effects are needed for those who, after starting to take the medication, experience undesirable symptoms, manifested in the form of such conditions:

• digestive disorders;
• reducing blood pressure levels;
• insomnia;
• fatigue;
• depressive disorders;
• headache;
• memory and vision impairment;
• exacerbation of asthma.

As for contraindications, Bisoprolol is contraindicated for use if the patient has:

• special intolerance to the active component or additional ones;
• acute heart failure or chronic decompensation;
• cardiogenic shock;
• sick sinus syndrome;
• sinoarterial blockade;
• bradycardia;
• chronic decrease in blood pressure;
• severe course of bronchial asthma;
• metabolic acidosis.

A specialist should select an analogue, even if it has no contraindications or undesirable manifestations. Self-medication can lead to serious complications.

Analogues in composition

Bisoprolol analogues in tablets with identical main components have the same indications for use, and they also have similar contraindications and side effects. The difference may be the list of additional components. Almost all beta-blockers cannot be taken by women during pregnancy and breastfeeding, and they are also not suitable for use by children under the age of 18.

Bidop

This drug belongs to the selective beta-adrenergic receptor blockers, suppresses the synthesis of renin, reducing its concentration in the blood. It is thanks to this feature that the medicine easily reduces the heart rate, and in case of angina pectoris it helps to reduce the myocardial oxygen demand.

Analogues of Bisoprolol in tablets include Bidop, which contains a substance called bisoprolol as an active component, but the auxiliary components are different. It also has identical indications for use with Bisoprolol. But the contraindications for use are radically different.

For example, Bidop is not prescribed to patients with the following problems:

• allergies to components from the composition;
• cardiogenic shock;
• pheochromocytoma;
• atrioventricular block;
• weak sinus node;
• hypotension;
• during anesthesia or the first day after it.

As for undesirable manifestations, Bidop exhibits them in very rare cases. The price of Bidop is almost several times higher than that of Bisoprolol.

Bisogamma

This is another analogue of Bisoprolol, available in tablet form. The drug was launched on the market by a German pharmaceutical company. The active component in it is the substance Bisoprolol.

Both drugs have completely similar indications for use, contraindications and undesirable effects. But even despite the almost identical similarity, the drug should be prescribed only by a specialist who will not only collect the patient’s medical history, but will also conduct a number of necessary studies that will help not only prescribe an effective drug, but also correctly calculate the dosage.

Both drugs from the same group differ only in price; for Bisogamma it is slightly higher.

Concor

Analogues of Bisoprolol in tablets include Concor, which has an identical active substance in its composition. Concor is a German-made drug that is especially popular due to its undeniable advantages:

• high efficiency;
• exact formula of the established composition;
• minimum side effects.

Comparing the 2 drugs, it can be noted that they both have the same effect on the body:

• quickly reduce blood pressure;
• reduce heart rate;
• expand the lumen of blood vessels;
• relieve pain during angina attacks;
• normalize the circulation of impulses in the atria.

Comparing the 2 drugs, we can say that they are interchangeable. They have no differences in indications for use, contraindications, or undesirable manifestations. Their only difference is the price. Concor's is ½ higher.

Bisomore

This is another effective and affordable analogue of Bisoprolol, produced by an Indian pharmaceutical company. Comparing the two drugs, we can say for sure that their main differences are price and name. They are both available in tablet form and contain bisoprolol as an active ingredient.

Indications, contraindications, and adverse events for both drugs are almost identical. The 2 drugs also have some differences in additional components, which is why they can act as substitutes for patients with arterial hypertension and other heart problems if some component of the composition is not suitable for some reason.

Biprolol

This is another drug from the group of highly selective beta blockers. It also contains the active component bisporolol, which has the ability to reduce the concentration of renin in the body, thereby reducing blood pressure levels. Taking Biprolol tablets helps reduce the speed of blood flow in the heart, thereby increasing the moment of diastole. Both drugs are prescribed for hypertension, angina pectoris and complex therapy with other cardiac drugs.

Biprolol - an analogue of Bisoprolol in tablets

Both drugs have completely identical side effects and contraindications. As for the price, it is also not much different.

Cordinorm

This is another analogue of Bisoprolol, which is available in tablet form and contains one active substance - bisoprolol. Their main differences are the manufacturing company (Bisoprolol is produced by a Russian concern, and Cordinorm by a German one), the price of the analogue is slightly higher and the additional components are different.

And so, comparing 2 drugs, we can say for sure that they can replace each other if for some reason there are contraindications to use or the patient is particularly sensitive to one of the substances.

Coronal

This drug, available in tablet form, is actively used for heart disease. It belongs to the group of selective beta-adrenergic blockers. Already after taking one tablet, a decrease in a substance such as renin is observed, and due to a decrease in its amount, the heart rate also decreases. Thanks to this action, the oxygen demand of cardiomyocytes decreases.

Comparing Coronal and Bisoprolol, we can say for sure that the drugs have almost no differences. The main differences are the name and the manufacturing company. Indications, contraindications, active ingredient are identical. Even the price of both drugs is almost the same.

Contraindications

The use of Bisoprolol is contraindicated in:

• hypersensitivity to the components of the drug;
• hypersensitivity to other β-blockers;
• acute heart failure (AHF);
• CHF in the stage of decompensation (if the patient requires inotropic therapy);
• shock (including cardiogenic shock);
• syndrome of weakness (dysfunction) of the sinus node;
• pulmonary edema;
• sinoatrial blockade;
• bradycardia (extremely low heart rate, in which the heart rate does not exceed 60 beats per minute);
• 2nd and 3rd degree AV block without pacemaker;
• severe form of arterial hypotension , in which the systolic blood pressure does not exceed 100 mm Hg. Art.);
• severe bronchial asthma
• noted in the history of COPD ;
• pheochromocytoma (in cases where the patient is not simultaneously prescribed α-blockers);
• poorly controlled diabetes mellitus ;
• metabolic acidosis;
• peripheral circulatory disorders in late stages (for example, with Raynaud's syndrome );
• refractory hypokalemia , hypercalcemia or hyponatremia ;
• hypolactasia;
• lactase deficiency;
• glucose-galactose malabsorption syndrome.

Due to the fact that there is not enough data on the safety and effectiveness of the drug for patients under 18 years of age, Bisoprolol is not used in pediatrics.

In addition, the drug is not prescribed to patients who are undergoing treatment with MAO inhibitors (with the exception of cases when the patient is prescribed B-type monoamine oxidase inhibitors).

Analogues in action

Despite the fact that a substance such as bisoprolol effectively and quickly reduces the level of renin in the blood, due to which blood pressure is easily and without consequences, there is still a category of patients who cannot tolerate it. They have an allergic reaction to this component. In such cases, analogues are selected for the patient for a similar effect, but with a different active component.

Metoprolol

Bisoprolol can easily replace a drug such as Metoprolol. It contains a substance of the same name. And the drug also belongs to the group of beta-blockers and has antianginal, antihypertensive and antiarrhythmic effects on the body. The drug is available in tablets and is an ideal analogue in action. This analogue has a huge list of indications for use.

These include:

• thyrotoxicosis;
• migraine;
• hypertension;
• angina pectoris;
• acute form of myocardial infarction.

The two drugs have another difference - the price, for the analogue it is much higher, and the drug is excreted only by the liver, while Bisoprolol is excreted by the liver and kidneys.

Sotahexal

The analogue of Bisoprolol in Sotahexal tablets has identical indications for use. It is also available in tablet form, but contains sotalol hydrochloride as an active ingredient. Both drugs have an antiarrhythmic effect on the human body.

Prescribed to patients to eliminate problems:

• tachycardia;
• atrial fibrillation;
• ventricular extrasystole.

As for the differences between the 2 drugs, Bisoprolol is prescribed in a lower dosage, and this feature allows it to be used even in people with a lot of concomitant pathologies. And the price of Bisoprolol is several times lower than Sotahexal.

Nebivolol

Bisoprolol and its analog Nebivolol are 2 drugs available in tablet form. They both belong to the group of selective beta-blockers, but there is a difference - these are the active components. In Nebivolol it is a substance of the same name.

Comparing both drugs, it is worth saying that they have identical effects on the body:

• antiarrhythmic;
• hypotensive;
• antianginal.

Nebivolol is considered an effective analogue of Bisoprolol, but has a different substance, therefore it almost does not cause any unwanted effects and is suitable for people who have a particular intolerance to the components of Bisoprolol.

As for the price, Nebivolol will cost slightly more than its analogue.

Egilok

The effectiveness of this analogue of Bisoprolol is no different. Both drugs have identical ability to have the maximum possible effect on the body. But experts say that Egilk’s therapeutic effect is more pronounced, so each patient should select the dosage individually. The speed of therapy with the analogue is much higher. But the number of contraindications and undesirable manifestations of the drugs is almost identical.

As for the differences, one of them is the active substance. In Egilok it is metoprolol. And one more difference is the price; for the analogue it is much lower.

Betalok

This is another tablet analogue of Bisoprolol, which belongs to the same pharmaceutical group. But the manufacturer included another active substance in Betalok - metoprolol. But doctors more often prescribe Bisoprolol to patients with chronic pathologies affecting the heart and blood vessels, as well as complicated blood pressure, where the numbers are greatly inflated and other drugs cannot cope with their normalization.

Despite the fact that both drugs have the same indicators for use, as well as contraindications and undesirable manifestations, only a specialist should prescribe them. The doctor necessarily relies on laboratory tests and other methods of diagnosis.

As for comparing the cost of 2 drugs, Betalok’s is significantly higher.

Analapril

This is another analogue that can, if necessary, act as a substitute for Bisporolol tablets. Both drugs are very similar in terms of indications for use, contraindications and undesirable effects. But they also have distinctive features - this is the active component, in Analapril it is the substance propranolol. And also the second difference is that the price of the analogue is much higher, although the effect of taking it is also better than that of Bisoprolol.

The analogue has proven to be highly effective and can be used if the patient should be transferred to more serious therapy for hypertension.

Vasocardin

This is another analogue of Bisoprolol, which is also included in the same group as beta-adrenergic receptor blockers. It is also available in tablet form, but the active component in it is a substance with a different name - metoprolol.

This substance also has the ability to reduce the level of renin in the blood and thereby normalize blood pressure. Both drugs have identical indications, contraindications and undesirable manifestations. Another difference between the drugs is the price. With Vazocardin it is slightly higher.

To make it clear how different the price of Bisporolol and its analogues is, you can study the table, which will indicate the name of the drug, the dose of the active component and the price.

Bisoprolol is an effective and inexpensive drug that helps normalize blood pressure in a short time after taking it and supports the heart well under heavy loads. But some patients still have a special sensitivity to its active component or additional ones, so it is necessary to select an analogue.

A specialist must prescribe another drug with a similar effect. He will also prescribe an examination and, based on its results, will select one of the best drugs to replace Bisoprolol in tablet form, with the same active ingredient or another.

Bisoprolol tablets, instructions for use (Method and dosage)

The dosage of the drug is selected individually. The tablets are taken in the morning, before meals, without chewing. The course of treatment begins by prescribing the patient 5 mg, which is taken once. For patients whose blood pressure is slightly elevated, the starting dose is 2.5 mg per day.

In cases where this is necessary, the dose is doubled. The dosage regimen remains the same.

The highest daily dose is 20 mg. For patients with renal dysfunction , which is characterized by a decrease in creatinine clearance (CC) below 20 ml per minute, the highest dose should be half that (10 mg per day).

Exceeding the prescribed average daily dose is allowed in extreme cases. The drug is usually used for a long time.

Elderly patients do not need dose adjustment.

The instructions for use of Bisoprolol-Ratiopharm are identical to the instructions for use of Bisoprolol-Lugal and the instructions for use of Bisoprolol-Teva. Bisoprolol-Prana and other bisoprolol preparations are taken according to the same regimen.

Overdose

An overdose of the drug is accompanied by the following symptoms:

• severe bradycardia ;
• ventricular extrasystole;
• AV block;
• arrhythmia;
• a pronounced decrease in blood pressure;
• CHF;
• cyanosis (blueness) of the fingers or palms;
• difficulty breathing;
• dizzy;
• bronchospasm;
• syncope;
• convulsions.

Treatment involves performing a gastric lavage procedure, taking adsorbent medications and prescribing symptomatic therapy:

• of Atropine or epinephrine into a vein for AV block (in some patients, a temporary pacemaker is installed to solve the problem);
• injection of Lidocaine for ventricular extrasystole (class IA drugs should not be used);
• moving the patient to the Trendelenburg position when blood pressure decreases;
• intravenous administration of plasma-substituting solutions (if there are no signs of incipient pulmonary edema epinephrine , Dobutamine or Dopamine to maintain chrono- and inotropic effects and stop a pronounced decrease in blood pressure );
• prescription of cardiac glycosides, diuretics, as well as Glucagon for heart failure;
• intravenous administration of Diazepam for seizures;
• inhaled administration of β-adrenergic stimulants for bronchospasm .

Bisoprolol price, where to buy

The price of Bisoprolol depends on which pharmaceutical company produced the drug.

The drug Bisoprolol 2.5 mg 30 pcs. can be bought for 80 rubles in Russian pharmacies, Bisoprolol 5 mg 30 pcs. - for a price of about 100 rubles, Bisoprolol 10 mg 50 pcs. - at a price of about 300 rubles. Price Bisoprolol-Teva 5 mg 30 pcs. - about 160 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Bisoprolol-Teva tablets p/o captivity.
  10 mg 30 pcs LLC R-Pharm Novoselki 222 rub. order
• Bisoprolol-Prana tablets p.p.o. 2.5 mg 30 pcs. Pranapharm LLC

  81 RUR order

• Bisoprolol-Vertek film-coated tablets 2.5 mg 60 pcsVertex AO

  RUB 161 order

• Bisoprolol tablets p.p.o. 2.5 mg 30 pcs. Rapharma JSC

  106 rub. order

• Bisoprolol tablets p.p.o. 10 mg 50 pcs. Ozone LLC/Ozone Pharm LLC

  RUB 229 order

Pharmacy Dialogue

• Bisoprolol-Teva tablets 10 mg No. 50 Teva LLC

  RUB 264 order

• Bisoprolol (tab.p.pl/vol. 5 mg No. 30) Uniquem Laboratories

  104 rub. order

• Bisoprolol (tablet p/o 10 mg No. 30)Biocom

  135 rub. order

• Bisoprolol (tablet p/o 5 mg No. 30)Biocom

  88 rub. order

• Bisoprolol Velpharm (tab.p.pl.vol.5mg No. 50) Velpharm LLC

  RUB 218 order

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Pharmacy24

• Bisoprolol-Teva 10 mg N50 tablets Merkle GmbH, Nimechchina
  64 UAH. order
• Bisoprolol KPKA 10 mg N30 tablets KRKA, d.d., Novo Mesto, Slovenia/TAD Pharma GmbH, Nimeččina

  22 UAH order

• Bisoprolol-KV 10 mg N30 tablets PAT "Kiev Vitamin Plant", Kiev, Ukraine

  22 UAH order

• Bisoprolol-Teva 10 mg No. 30 tablets Merkle GmbH, Nimechchina

  39 UAH order

• Bisoprolol KPKA 5 mg No. 30 tablets KRKA, d.d., Novo Mesto, Slovenia/TAD Pharma GmbH, Nimeččina

  20 UAH order

PaniPharmacy

• Bisoprolol tablets Bisoprolol-KV tablets 5 mg N30 Ukraine, Kiev Vitamin Plant PJSC

  13 UAH order

• BISOPROLOL tablets Bisoprolol Sandoz film-coated tablets 5 mg No. 30 Germany, Salutas Pharma

  28 UAH order

• BISOPROLOL tablets Bisoprolol tablets 5 mg No. 20 Ukraine, Astrapharm LLC

  13 UAH order

• BISOPROLOL tablets Bisoprolol tablets 5 mg No. 50 Germany, Merckle

  59 UAH order

• BISOPROLOL tablets Bisoprolol Sandoz film-coated tablets 10 mg No. 90 Germany, Salutas Pharma

  76 UAH order

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Interaction

Combinations of Bisoprolol with Floctafenine and Sultopride .

It is not recommended to combine:

• with calcium antagonists;
• with antihypertensive drugs that are characterized by a central mechanism of action;
• with MAO inhibitors (except for MAO-B inhibitors).

The drug is prescribed with caution with:

• antiarrhythmic drugs of class I and III;
• calcium antagonists, which belong to the group of dihydropyridine ;
• anticholinesterase drugs;
• Local β-blockers;
• insulin preparations and oral antidiabetic agents;
• cardiac glycosides (digitalis preparations);
• anesthetics;
• non-steroidal anti-inflammatory drugs;
• ergotamine derivatives ;
• β-sympathomimetics;
• sympathomimetics, which are characterized by the ability to activate α- and β-adrenergic receptors;
• antihypertensive drugs that increase the risk of hypotension (for example, tricyclic antidepressants, phenothiazines or barbiturates);
• Baclofen and Amifostine ;
• parasympathomimetics.

Allowed combinations:

• mefloquine;
• corticosteroid drugs.

special instructions

The drug should be prescribed with caution:

• patients diagnosed with psoriasis , as well as patients whose family history contains indications of this disease;
• with diabetes mellitus in the stage of decompensation;
• patients who are predisposed to allergic reactions;
• patients whose work requires a high speed of psychomotor reactions or potentially threatens health and/or life (as a rule, the reaction speed may decrease in the initial stages of treatment, when changing the drug, as well as when Bisoprolol interacts with alcohol).

For patients diagnosed with pheochromocytoma , the drug is prescribed only after completing a course of treatment with α-blockers.

Sudden withdrawal of the drug is unacceptable; the course of its use is completed gradually, gradually reducing the prescribed dose (it is considered optimal to reduce it by halving the dose daily).

Reviews of Bisoprolol

Most often, the topic of drug withdrawal is discussed on relevant forums. Reviews about Bisoprolol left by patients and doctors are mainly related to withdrawal syndrome , which occurs against the background of an abrupt cessation of treatment with this drug.

Particular manifestations of it are increased heart rate and attacks of arterial hypertension . Some patients note that during treatment with the drug their vision decreased significantly.

However, since Bisoprolol is prescribed for a long period of time (for some patients even for life), visual impairment and medication intake may be unrelated phenomena.

Taking Bisoprolol may be accompanied by side effects. Some patients practically do not notice them in themselves, while in others, if you believe the reviews, they are quite pronounced.

In connection with all of the above, neither treatment nor discontinuation of the use of this drug should be an independent decision of the patient. In each specific case, the treatment regimen and dosage regimen are determined solely by the doctor who is caring for the patient.

Indications and restrictions for use

Bisoprolol is prescribed for the following diseases:

• – hypertension;
• – rapid heartbeat (tachycardia);
• – chronic heart failure;
• – angina pectoris (for prevention purposes);
• – myocardial infarction.

Which is better, Gaviscon or Maalox?

The drug stabilizes the functioning of membranes, reduces the level of retin in the blood plasma, and reduces the need for oxygen absorption by the myocardium.

Main restrictions on admission:

• – asthma and other diseases of the lungs and bronchi;
• – children under 18 years of age;
• – personal intolerance to the components of the drug;
• – hypotension;
• – psoriasis and other dermatological pathologies;
• – metabolic acidosis;
• – heart rhythm disturbances;
• – left ventricular failure;
• – acute decompensation with the development of chronic heart failure.

The medicine is excreted through the kidneys . In this regard, special care should be taken when taking patients with the following diseases:

• - diabetes;
• – liver and kidney diseases;
• – myasthenia gravis;
• – acute depressive state.

During pregnancy

Bisoprolol is not recommended for the treatment of pregnant and lactating women. However, in situations where the benefits to the mother potentially outweigh the likely risks to the developing fetus, the drug may still be prescribed.

In exceptional cases, when the medicine is used during pregnancy , it should be discontinued no later than 72 hours before the expected date of birth. Otherwise, there is a high probability of developing hypoglycemia , arterial hypotension , bradycardia , and respiratory depression in the newborn child.

When withdrawal is not possible, constant monitoring of the baby's condition is necessary during the first 72 hours after birth.

If it is necessary to prescribe Bisoprolol to a nursing woman, it is necessary to resolve the issue of stopping lactation .

Our recommendations

• When choosing a medication with the active substance bisoprolol, it is better to choose Concor. Medicines produced in Europe are no less effective.
• When purchasing Russian drugs, the huge advantage is the price. However, there can be the same quality underneath the low price.
• The choice of analogue must be approached with all responsibility. Otherwise, the situation may only get worse. A properly selected analogue can completely replace Bisoprolol.

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