Problems with potency and erections often arise not due to the presence of a serious disease, but as a result of various disorders. One of the causes of disorders is considered to be insufficient blood supply to the pelvic organs. Cells do not receive enough oxygen and nutrients, as a result of which potency deteriorates and the duration of sexual intercourse decreases. For persistent erection and long-lasting sex, doctors recommend using Heparin ointment.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
When applied to the skin, the ointment prevents the formation of blood clots and has an anti-inflammatory and local anesthetic effect.
Heparin , which is gradually released from the ointment, reduces the inflammatory process and has an antithrombotic effect ; benzyl nicotinate (benzyl ester of nicotinic acid) dilates superficial vessels, thereby promoting the absorption of heparin ; Benzocaine relieves pain.
Pharmacokinetics
Heparin from the skin surface in small quantities. Up to 95% of the substance is in a state bound to plasma proteins, the volume of distribution (Vd) is 0.06 l/kg.
It does not penetrate the placental barrier or into breast milk.
Metabolized in the liver. T1/2 of heparin - on average, 1.5 hours. The substance is excreted by the kidneys.
Local application of Heparin ointment does not lead to changes in blood .
Benzyl nicotinate penetrates all layers of the skin, but practically does not enter the systemic circulation. Benzocaine is almost not absorbed when applied externally.
Properties of the drug
The complex effect of the drug is determined by the active substances included in its composition. After contact with the skin, each component exhibits its effect.
Heparin-based products destroy blood clots and prevent the formation of new ones
Nicotinic acid benzyl ester promotes vasodilation, thanks to which the main component is absorbed faster. And sodium heparin, after entering the bloodstream, stimulates antithrombin III (a protein that regulates blood clotting). As a result, the activity of thrombin (an enzyme that provokes blood clotting) decreases, platelets lose their ability to stick together and create blood clots. In addition, thanks to heparin, the blood produces fibrin (the basis for blood clots) more slowly.
Thanks to the properties described above, products containing heparin destroy formed blood clots in the lumen of the vessel and prevent their appearance. These are not all the advantages of medications based on sodium heparin. The creams perfectly resolve hematomas and eliminate the inflammatory process in the damaged area.
Benzocaine is a local anesthetic that reduces the intensity of pain.
After treatment, the product containing heparin penetrates all layers of the skin, but is almost not absorbed into the bloodstream. That is, the concentration of the active component in the blood is quite low.
Heparin ointment is used for varicose veins, thrombophlebitis, hemorrhoids, mastitis
Side effects
With prolonged use, local reactions may develop in the form of decreased sensitivity in the treated area, skin hyperemia, hypersensitivity reactions ( skin rash , itching ).
When using topical forms of heparin , the risk of developing type II HIT (with a sharp drop in platelet (Tr) to <50% of the initial value, a decrease in the number of Thr <100,000 × 109/l, with venous/arterial thrombosis or embolism) cannot be excluded.
For this reason, when using the drug, the level of Tr in the blood should be additionally monitored in patients with a history of thromboembolism
In patients without pre-existing hypersensitivity to heparin, with parenteral administration of heparin , a decrease in Tp levels is usually observed 6-14 days after the start of treatment. In case of hypersensitivity to heparin, HIT may develop within a few hours.
Side effects
Topical
(local application) forms of heparin do not change systemic blood parameters. However, long-term use of the drug may cause skin reactions:
- redness on the skin;
- itching;
- rash.
Even with a slight manifestation of an allergy, treatment with the drug should be stopped immediately.
Heparin ointment, instructions for use (Method and dosage)
Instructions for use of Heparin ointment for phlebitis and thrombophlebitis
For post-infusion/post-injection phlebitis , as well as for the treatment of thrombophlebitis of the superficial veins, the ointment 2-3 times a day is applied in a thin layer to the affected area and gently rubbed into the skin. To treat an area with a diameter of 3-5 cm, 0.5-1 g of the drug is enough. Treatment usually lasts from 3 to 7 days.
Heparin ointment for hemorrhoids
In case of exacerbation of chronic hemorrhoids, the ointment is applied directly to the inflamed hemorrhoids on a linen or calico pad, which is then fixed with a bandage.
Reviews indicate that another way of using the drug is no less effective - in the form of tampons: the tampon is soaked in ointment and then inserted into the anus.
to use Heparin ointment for hemorrhoids daily 2 or 3 times a day until the inflammation disappears. Treatment lasts no more than 10 days.
Hemorrhoids are a fairly common occurrence during pregnancy , but it should be remembered that pregnant women are allowed to use any medications only with the approval of a doctor.
Heparin ointment for varicose veins
For varicose veins , the drug is especially effective in the early stages of the disease, when spider veins and dilated veins are just beginning to appear: the product reduces pain, relieves the feeling of heaviness, redness, itching and swelling, accelerates the resorption of already formed blood clots and prevents the formation of new ones, and normalizes microcirculation.
The medicine should be applied to the area of altered blood vessels daily 3 times a day for 2 weeks.
Contraindications for use in varicose veins ( varicose veins ) are the presence of open ulcers or any other damage to the skin, as well as known intolerance to any drug from the group of local anesthetics.
Heparin ointment for bruises
Heparin is considered one of the most effective remedies for bruises. Having an anticoagulant effect , it accelerates the resorption of blood clots formed under the skin and improves the condition of capillaries.
The benzyl ester of nicotinic acid contained in Heparin ointment has a vasodilating effect, thereby improving the absorption of heparin . The local anesthetic benzocaine helps relieve pain.
Method of using ointment for bruises: the course of treatment heparin -containing agents ranges from 5 to 15 days. The ointment is applied to the site of the injury/bruise 2-3 times a day and gently rubbed into the skin.
Almost all the reviews that can be read on forums about Heparin ointment are positive: the product copes with subcutaneous hematomas in 2-4 days.
Why is Heparin ointment used in cosmetology?
Many pharmaceutical products are quite successfully used to eliminate certain cosmetic defects. Since the main indications for the use of Heparin ointment are VVR, hemorrhoids , mastitis , bruises, the question naturally arises, why can the drug be used in cosmetology?
For the face, ointment is used as a remedy:
- from wrinkles;
- for acne;
- from bags under the eyes.
One of the signs that a person has impaired blood flow is swelling . And they are especially noticeable under the eyes, since the skin in this place is very thin and delicate. Swelling is often accompanied by darkening of the skin.
To get rid of this problem, you should apply Heparin ointment under the eyes once a day: with your fingertips, lightly patting the skin, and not too close to the mucous membrane.
Important! For the face, the drug is used only after testing for allergies to it. To check the tolerability of the product, apply it to the inside of the wrist or elbow and observe the reaction.
The ointment relieves inflammation well and reduces pain in the affected area. Due to these properties, it is sometimes used as a remedy for acne. For this purpose, the drug is applied to the face in a thin layer 3 times a day until the inflammation completely goes away.
In the same way, the drug is used to treat rosacea .
As a remedy for wrinkles, Heparin ointment is used 2 times a day. Apply it with light massage movements without stretching the skin (especially around the eyes). The anti-aging properties of heparin are most likely due to its absorbent and anti-edematous properties.
Reviews about the use of the facial product allow us to conclude that it is impossible to radically solve the problem of wrinkles that have already appeared with the help of the drug. However, it is able to prevent the emergence of new ones and stop the development of existing ones.
Composition and action
Heparin ointment
is a complex product for external use. Available in tubes of 10, 25 or 50 g. Produced by several domestic and Belarusian pharmaceutical factories. It contains three active ingredients:
Component | Quantity | Action |
Heparin sodium | 100 IU/g | anticoagulant |
Benzocaine | 40 mg/g | local anesthetic |
Benzyl nicotinate | 0.8 mg/g | local vasodilator |
As the name suggests, the main “actor” of the drug is heparin. This substance is an anticoagulant, it increases blood fluidity and dissolves blood clots. In cardiological practice, heparin is used for myocardial infarction and embolism.
As part of the ointment, it acts in a similar way on superficial hematomas, helps with varicose veins and thrombophlebitis, reduces hemorrhoids and reduces their swelling.
Benzocaine acts as an anesthetic for bruises, varicose veins and hemorrhoids. Benzyl nicotinate performs a transport function - it promotes maximum absorption of active substances, providing a local vasodilator effect. The composition contains glycerin, petroleum jelly and peach oil as a fatty base.
Interaction
The anticoagulant effect of heparin is enhanced by the simultaneous use of the drug with antiplatelet agents , anticoagulants and NSAIDs.
The use of the drug with thyrotoxin , ergot alkaloids , antihistamines , tetracycline and nicotine reduce the effect of heparin .
Heparin should not be administered topically in combination with NSAIDs, H1-histamine receptor blockers, or tetracyclines.
Heparin ointment 25g No. 1
Name
Heparin, ointment for external use.
Description
The ointment is white with a yellowish tint.
Main active ingredient
Sodium heparin + benzocaine + benzyl nicotinate.
Release form
Ointment.
pharmachologic effect
Heparin ointment, when applied to the skin, has an anti-inflammatory effect, prevents the formation of blood clots and has a local anesthetic effect.
Indications for use
Thrombophlebitis of superficial veins, post-injection and post-infusion phlebitis, inflammation of external hemorrhoids.
Directions for use and doses
Thrombophlebitis of superficial veins, post-injection and post-infusion phlebitis. Apply a thin layer of ointment (0.5-1 g per area with a diameter of 3-5 cm) to the affected area and carefully rub the ointment into the skin. Inflammation of external hemorrhoids. The ointment is applied to a calico or linen pad, which is applied directly to the hemorrhoids and secured with a bandage. For the same purpose, you can use a tampon soaked in heparin ointment, which is inserted into the anus. For children, the drug is applied in a thin layer to the affected area of the skin and rubbed in with light movements. A single dose for children depends on the area of the lesion and can be 0.5 - 3 cm of a column of ointment. The ointment is used 2-3 times a day every day until the inflammation disappears, no more than 10 days.
Use during pregnancy and lactation
The safety of the drug during pregnancy and lactation has not been established. Heparin does not cross the placental barrier and is not excreted in breast milk. There is no information about the passage of other components of the drug into breast milk. Heparin ointment is used during pregnancy and lactation (breastfeeding) only if the expected benefit to the mother outweighs the potential risk to the fetus or child.
Precautionary measures
With prolonged use of heparin ointment over large areas and simultaneous use of oral medications that affect the blood coagulation system and/or hematopoiesis, clotting time and prothrombin time should be monitored. If a long course of treatment is necessary and for large areas of damage in pregnant women and women over the age of 65, similar monitoring is recommended. It should not be applied to open wounds in the presence of purulent processes. The use of ointment is not recommended for deep venous thrombosis. Patients with a history of thromboembolic complications should be prescribed the drug Heparin, ointment for external use, with caution, due to the possibility of its systemic action. For the purpose of differential diagnosis of heparin-induced thrombocytopenia type II, it is recommended to determine the number of platelets in the blood. Methyl parahydroxybenzoate and propyl parahydroxybenzoate may cause delayed allergic reactions.
Interaction with other drugs
The anticoagulant effect of heparin is enhanced by the simultaneous use of anticoagulants, antiplatelet agents and non-steroidal anti-inflammatory drugs. Ergot alkaloids, thyroxine, tetracycline, antihistamines and nicotine reduce the effect of heparin. The ointment is not prescribed topically simultaneously with nonsteroidal anti-inflammatory drugs (NSAIDs), tetracyclines, and H1-histamine receptor blockers.
Contraindications
Hypersensitivity to the components of the drug; violation of the integrity of the skin of the affected area (open infected wounds, ulcerative-necrotic processes in particular); children's age up to one year. Hypocoagulation, thrombocytopenia. The presence or history of heparin-induced thrombocytopenia type II.
Compound
For one tube: active substance: heparin (in the form of sodium heparin) - 2500 IU; benzocaine (anesthetic) - 1000.0 mg, benzylnicotinate - 20.0 mg; excipients: glycerin, emulsifier No. 1, soft paraffin, white, stearic acid, sunflower oil, methyl parahydroxybenzoate, propyl parahydroxybenzoate, purified water.
Overdose
To date, the phenomena of overdose when using heparin ointment have not been described. With prolonged use on large surfaces, hemorrhagic complications are possible. Treatment: drug withdrawal. If necessary, use the heparin antagonist protamine sulfate (1% solution).
Side effect
With prolonged use of the drug, local reactions are possible in the form of skin hyperemia, decreased sensitivity at the site of application, allergic reactions (skin rash, itching). Risk of developing heparin-induced, antibody-mediated thrombocytopenia type II (with a decrease in platelet count
Storage conditions
At a temperature not higher than 25 °C. Keep out of the reach of children.
Buy Heparin ointment 25g No. 1 in the pharmacy
Price for Heparin ointment 25g No. 1
Instructions for use for Heparin ointment 25g No. 1
special instructions
If long-term treatment is necessary, as well as in the case of using the drug to treat large areas of the body and simultaneous ingestion of drugs that affect hematopoiesis and/or coagulation system, it is necessary to monitor PTI and clotting time.
Similar monitoring is required if long-term use is necessary and for large areas of damage in women over 65 years of age and in pregnant women.
The drug is not intended for treating open wounds. Also, you should not apply it to the skin in the presence of purulent processes.
Not recommended for use in cases of DVT ( deep vein thrombosis ).
Due to the possibility of systemic action of heparin, patients with a history of thromboembolic complications
Methyl and propyl parahydroxybenzoate may cause delayed hypersensitivity reactions.
Does not adversely affect the ability to operate machinery and drive vehicles.
Application specifics
Using Heparin ointment is not difficult; a little product is applied to the area where the damaged veins are located and distributed evenly. The ointment is rubbed in gently, without pressure.
Heparin ointment or gel is applied to the damaged area and gently rubbed in
On average, the drug is used twice or three times a day. The therapeutic course ranges from 3 days to 1 week. If necessary, the doctor will extend the treatment to 2-3 weeks, this applies to those cases when a person eliminates large hematomas.
Regardless of the problem, you should consult a doctor before using the medicine.
Specifics of using ointment or gel for different pathologies:
- For external hemorrhoids, soak a piece of tissue with ointment, apply it to the thrombosed nodes and fix it. To eliminate inflammation and pain in the anal canal, use a tampon, which is also soaked in heparin ointment, and then inserted rectally.
- As mentioned earlier, heparin products are used to eliminate vascular networks and treat thrombophlebitis. In this case, the gel or ointment is applied with extreme caution so as not to aggravate the course of the disease.
- If there is a bruise, it is not recommended to rub the ointment into the affected area immediately after the injury, otherwise hemorrhage will occur. Doctors advise treating the damaged area on the second day, to enhance the therapeutic effect, apply a bandage or gauze over the ointment.
Heparin ointment has long been successfully used in cosmetology to eliminate wrinkles, pimples and bags under the eyes. To eliminate bags under the eyes, a little ointment is carefully applied to the skin with your fingertips once every 24 hours. For acne, apply a thin ball of product to a cleansed face three times a day until the inflammation disappears. The same method is used to treat rosacea.
Thanks to its absorbent and anti-edematous properties, the product is used to combat small wrinkles. To do this, the ointment is applied to the skin, all movements should be light. Use the drug to smooth out wrinkles twice a day.
Analogs
Level 4 ATC code matches:
Girudoproct
Heparoid Zentiva
Heparin
Gepatrombin G
Lyoton
Trombless
Venolife
Hepatrombin
Analogs of Heparin ointment with a similar mechanism of action: Venolife , Venitan Forte , Hepatrombin , Geparoid Zentiva , Trombless , Contractubex , Lyoton 1000 , Venabos , Heparin , Venabos , Trombless Plus .
Which is better: Lyoton or Heparin ointment?
The drug Lyoton 1000 , like its analogue, contains sodium heparin as an active substance, but in a much higher concentration - 1000 IU/g.
Lyoton is produced in the form of a gel, therefore, it penetrates the skin better and faster than products produced in the form of an ointment.
Another difference between the drugs is that Heparin ointment, in addition to heparin, also contains components that enhance its effect - benzyl nicotinate and benzocaine .
Which is better: Troxevasin or Heparin ointment?
Troxevasin is a capillary stabilizing agent. Its active substance is a mixture of bioflavonoids , which contains at least 95% troxerutin ( troxerutin in 1 gram of ointment is 20 mg).
The action of the drug is aimed at reducing swelling, pain, improving trophism and eliminating various kinds of pathological disorders caused by venous insufficiency.
Both drugs are good, but their effects are somewhat different. Troxerutin has venotonic, angioprotective, anti-edematous and anti-inflammatory effects. Heparin is a local anesthetic and anticoagulant.
It is believed that Troxevasin is more effective when it is necessary to relieve swelling, and its analogue is more effective when it is necessary to accelerate the resorption of the hematoma.
Price and analogues
The cost of Heparin ointment ranges from 24 to 86 rubles, depending on the manufacturer and the capacity of the tube. Heparin is included in some treatments for varicose veins. They have similar indications for use:
Analogue | Active substance | Price |
Gel Lyoton 1000 | Heparin sodium | 270-1000 rubles depending on volume (30, 50, 100 g) |
Gel Troxevasin Neo |
| From 200 to 270 rubles |
Wessel due F | Sulodexide | 2700 |
The drug is stored for 3 years at a temperature not exceeding 20°C. You can buy it at a pharmacy without a prescription.
Reviews of Heparin ointment
Heparin ointment is an inexpensive and very effective remedy. It is used for hemorrhoids , bruises , and varicose veins . You can also find good reviews about Heparin ointment for the face: in cosmetology, the drug is most often used to eliminate bruises and bags under the eyes.
Reviews about Heparin Ointment for Wrinkles are more controversial: some say that the drug is very effective in the fight to preserve youthful skin, while others claim that they have not noticed any serious improvements.
But reviews of Heparin ointment for hemorrhoids are extremely positive - the drug works great when it comes to such a delicate problem, and if indicated, it can be used even during pregnancy.
varicose veins has proven itself no less well : patients say that spider veins on the legs noticeably decrease (and sometimes completely disappear) after just 1-2 weeks of regular use.
Purpose of the drug
As the instructions say, the use of ointment is permissible in the following cases:
- Varicose veins of the lower extremities. Heparin-based drugs are most often used to treat varicose veins in the legs. It's no secret that varicose veins occur as a result of impaired blood flow and valve failure. At the early stage of the disease, swelling and redness of the affected area occur. A little later, spider veins appear on the lower extremities. It is at this stage of the disease that it is recommended to use heparin ointment; the product quickly eliminates the inflammatory process and normalizes blood circulation. The drug is recommended to be used for 14 days.
- Thrombophlebitis. This pathology is characterized by inflammation of the internal venous wall with the formation of a blood clot that closes the lumen of the vessel. Heparin ointment or gel is also actively used to eliminate the symptoms of thrombophlebitis. The active ingredients stop inflammation, accelerate the destruction of blood clots, and prevent their re-formation. However, the damaged area must be treated with extreme caution, since strong rubbing increases the likelihood of a blood clot breaking off.
- The use of products containing heparin is permissible for periphlebitis (inflammation of the tissues surrounding the vein), as well as for inflammation of the venous wall after an injection or injection of solutions that irritate the vessel.
- Heparin ointment is used to treat hemorrhoids. This disease occurs due to blockage of the veins of the rectum, and therefore for effective therapy it is necessary to eliminate its cause (that is, a blood clot in the lumen of the vessel). With the help of heparin ointment, the inflammatory process and pain quickly disappear. In addition, the drug eliminates formed blood clots and prevents the formation of new clots.
- Heparin-based gel or ointment can heal trophic ulcers (an open wound on the skin or mucous membrane that does not heal for a long time). The drug dilates blood vessels, reduces blood viscosity, so that it circulates faster, saturates the damaged area with useful substances and oxygen. As a result, wound healing accelerates. However, it is forbidden to apply ointment and gel to the defect itself, as the likelihood of hemorrhage increases.
- Inflammation of the mammary gland during breastfeeding. The drug with sodium heparin is sometimes used as part of complex therapy. For lactation mastitis, the anti-inflammatory properties of the drug are incredibly useful.
In addition, heparin-based products are used for lymphangitis (inflammation of the lymphatic vessels), elephantiasis (elephantiasis of the legs), hematomas, and edema.
How much does Heparin ointment cost?
The price of Heparin ointment in Russia is from 63 to 92 rubles: you can buy a manufactured drug for 64 rubles, and the cost of an ointment for external use produced by is 85 rubles.
The price of Heparin ointment in Ukraine is from 46 to 60 UAH. At the same time, the price in Kharkov is practically no different from the price in Kyiv or, for example, Odessa pharmacies.
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