Instructions for use MARVELON® (MARVELON)

Marvelon

Contraceptive pills based on ethinyl estradiol and desogestrel. It acts to suppress ovulation, change the structure of the endometrium and increase the viscosity of cervical mucus. It is difficult for sperm to pass through the cervix, and the fertilized cell cannot attach to the endometrium.

In addition to the contraceptive effect, Marvelon has a beneficial effect on menorrhagia (painful, excessively heavy menstruation), affects the condition of the skin and reduces the appearance of acne vulgaris, when taken regularly, it normalizes the menstrual cycle and helps prevent the development of a number of gynecological diseases, including cancer.

Contraindications to taking Marvelon are:

• liver failure;
• congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes);
• liver tumors, liver diseases;
• thromboembolism;
• cerebrovascular accidents, including stroke;
• cardiac ischemia;
• high blood pressure;
• atherosclerosis;
• decompensated heart defects, myocarditis;
• diabetes;
• retinopathy, angiopathy, sickle cell anemia;
• breast and endometrial cancer;
• endometrial hyperplasia, endometriosis;
• breast fibroadenoma,
• disorders of fat metabolism;
• jaundice or itching during a former pregnancy;
• otosclerosis worsening during pregnancy.

Marvelon should not be taken during pregnancy. It is not recommended for women over 35 who smoke.

Although the drug belongs to a new generation of contraceptives and has minimal side effects, they are nevertheless present and can manifest themselves, especially in the first months of use. Side effects may include:

• headache, nausea, vomiting;
• soreness and engorgement of the mammary glands;
• weight gain;
• fluid retention in the body, swelling;
• change in libido;
• mood swings, irritability, depression;
• skin rash;
• conjunctivitis, discomfort when wearing contact lenses;
• visual or hearing impairment;
• thrombophlebitis, thromboembolism;
• cholestatic jaundice;
• increased blood pressure;
• intermenstrual bleeding;
• changes in vaginal secretion, up to the development of vaginal candidiasis.

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Reception scheme

Marvelon is taken one tablet per day, preferably at the same time. The first day of admission is the first day of the menstrual cycle. The duration of administration is 21 days, until the tablets in the package run out. Next, a break is taken for seven days, during which menstrual-like bleeding occurs. After the break, you begin taking pills from the next package. This means that the first tablet from each package is taken on the same day of the week.

It is allowed to start taking it on the second to fourth day of the menstrual cycle, but no later than the fifth day. In this case, you need to additionally use barrier methods of contraception for two weeks.

If more than 5 days have passed since the start of menstruation, then taking the pills should be postponed and wait until the next menstruation.

After a natural birth or cesarean section, you must wait until your first spontaneous menstruation. After a miscarriage or induced abortion, Marvelon should be taken immediately or wait until the first menstruation.

If you forget to take your pill

It must be remembered that the continuous maximum contraceptive effect of Marvelon is maintained only if the tablets are taken systematically. The delay in taking the drug should not exceed 12 hours. If for some reason you did not take the pill on time and the duration of the delay exceeds 13 hours, then the next day at the usual time you should take 2 tablets of the drug, and at the same time use additional barrier contraceptives for the next 14 days or until the next day. menses.

It is important to know!

Before starting to take Marvelon and then every six months, it is recommended to undergo a general medical and gynecological examination, which includes:

• gynecological examination,
• examination of the condition of the mammary glands,
• liver function test,
• control of blood pressure and cholesterol concentration in the blood,
• Analysis of urine.

Due to the fact that the contraceptive effect of the drug does not fully manifest itself immediately, but only by the 14th day from the start of administration, it is recommended to additionally use barrier methods of contraception during these 14 days.

If you have suffered acute viral hepatitis, then you need to wait until your liver function normalizes (usually this happens no earlier than six months later).

In case of intestinal disorders and vomiting, the contraceptive effect may be reduced, so additional barrier methods of protection must be used.

Marvelon is not recommended for smoking women over 35 years of age.

Women who have chloasma should avoid exposure to the sun while taking Marvelon.

If you take a number of medications, the contraceptive effect of Marvelon may be reduced. Be sure to notify your doctor about the contraceptive you are taking if he has prescribed you: rifampicin, isoniazid, ampicillin, neomycin, penicillins, tetracycline, chloramphenicol, griseofulvin, barbiturates, carbamazepine, activated charcoal and laxatives.

Pharmacological effects

Marvelon is a drug that is part of a group of hormonal contraceptive medications intended for oral administration.

The drug has a pronounced contraceptive effect on the body and prevents the onset of unwanted pregnancy due to its constituent ethinyl estradiol, used as an estrogen, and desogestrel, used as a progestin.

According to reviews, Marvelon is suitable for most women after 35 years.

Along with the main effect, it has a number of other positive effects on the body:

1. Reduces the severity of bleeding during menstruation.
2. Regulates the menstrual cycle, helps reduce menstrual pain.
3. Helps reduce the risk of the occurrence and development of diseases such as fibrous cystosis.
4. Significantly reduces the risk of anemia due to iron deficiency.
5. Reduces the likelihood of tumors.
6. Prevents the development of cysts.
7. Stops the development of inflammation in the pelvis.
8. Reduces the likelihood of ectopic pregnancy.

Reviews of Marvelon contraceptives will be presented below.

The main components of the drug suppress ovulation and stimulate the production of cervical mucus.

Desogestrel, which is a progestogenic substance, inhibits the secretion of follicle-stimulating and luteinizing hormones by gonadotropic cells in the pituitary gland. As a result, the normal maturation of the follicle is interrupted and the onset of ovulation is blocked.

According to reviews from women over 40 years of age, Marvelon is well tolerated.

In addition, desogestrel is capable of:

1. Influence the composition of the mucus filling the cervical canal by thickening it. As a result, cervical mucus becomes difficult for sperm to pass through.
2. Reduce the concentration of estradiol to the level characteristic of the early follicular phase.
3. Do not affect the metabolism of lipids and carbohydrates.
4. Do not affect hemostasis.
5. Significantly reduce blood loss during menstruation. In women suffering from menorrhagia, blood loss is normalized and approaches the physiological norm.
6. Improve the condition of the skin if acne is present.
7. Prevent some gynecological diseases, including those of a tumor nature.
8. Normalize the menstrual cycle.

Reviews from women about Marvelon confirm that periods become less abundant and almost painless.

Ethinyl estradiol is a synthetically produced hormonal agent of a number of estrogens. Its pharmacological action is similar to that of the sex hormone estradiol.

When taking ethinyl estradiol, the following changes occur in the body:

1. Endometrial tissue increases due to the activation of cell division.
2. Female secondary sexual characteristics develop (if they are underdeveloped).
3. The uterus is developing.
4. Blood cholesterol levels are reduced.
5. Glucose processing processes are normalized.
6. Insulin sensitivity increases.
7. The level of beta lipoproteins in the blood increases.

Ethinyl estradiol in high doses reduces and in small doses increases the activity of follicle-stimulating hormone secretion.

When taken orally, desogestrel is absorbed from the stomach and intestines as completely and quickly as possible. In this case, transformation occurs into etonogestrel.

The bioavailability range of desogestrel is 62-81%. When taking the drug daily, the concentration of the substance in the blood increases three times.

Desogestrel is excreted and the metabolites formed after its transformation are excreted in the urine.

The substance etonogestrel is capable of binding to globulin by 50-70%, with albumin. Only 2-4% of etonogestrel remains free.

Ethinyl estradiol increases the concentration of globulin, which is responsible for binding sex hormones, threefold.

The bioavailability of ethinyl estradiol after its transformation in the body and absorption in the stomach and intestines reaches 60%.

Indications for use

The main indication for prescribing a hormonal drug is to prevent unwanted pregnancy.

According to reviews from women over 40, Marvelon does an excellent job with this.

Overdose

Ethinyl estradiol and desogestrel are low-toxic substances, and therefore the likelihood of side effects that threaten health is extremely low.

If several tablets were taken at the same time, nausea and vomiting, and mild bleeding from the vagina may occur.

The drug has no antidotes. If an overdose occurs, symptomatic treatment should be provided.

We will also consider reviews from doctors about Marvelon.

Negative Impacts

According to reviews of Marvelon, in some cases, when taking it, women notice the manifestation of side effects, expressed in disruption of the functioning of individual organs or their systems.

The following negative effects may occur on the part of the reproductive system:

1. Amenorrhea.
2. Impaired secretion of cervical mucus.
3. Swelling and hardening of the mammary glands.
4. Bloody discharge from the genital tract observed between menstruation.

From the gastrointestinal tract, nausea and vomiting may occur.

From the central nervous system, migraines, headaches, dizziness, and mood lability may occur.

Sometimes, when taking Marvelon, according to reviews from women after 35 years, fluctuations in body weight, fluid retention and, as a result, mild swelling occur. The occurrence of chloasma, skin rashes, and nodose (nodular) erythrema cannot be ruled out. Complete or partial intolerance to contact lenses is possible, and the risk of blood vessel blockage by a blood clot increases.

Reviews from women about Marvelon confirm this.

Advantages and disadvantages

What are the pros and cons of this tool? Let's look at the pros first. His level of contraception is very high. The contraceptive effect begins immediately with the first pill.

Most women do not have to worry about their health while taking Marvelon. This does not cause any difficulties. You can stop drinking this remedy at any time. This drug has a beneficial effect on some body functions. It even treats some forms of infertility. Menstruation becomes painless, shorter, and the cycle length becomes constant.

The downside is the possibility of developing individual intolerance and side effects. The risk of blood clots also increases.

We reviewed doctors' reviews of Marvelon, the pros and cons of the drug, as well as instructions for use.

Interaction with other substances

The contraceptive effect of the drug is suppressed by substances such as: carbamazepine, rifampicin, griseofulvin, hydantoin derivatives, topiramate, isoniazid, barbiturates, oxcarbazepine, felbamate, primidone.

Along with a decrease in the effect of contraception, heavy vaginal bleeding may occur.

The effect of Marvelon is also inhibited when taken simultaneously with penicillin and tetracycline antibiotics, activated carbon, laxatives, chloramphenicol, and neomycin.

Marvelon, in turn, inhibits the effect of drugs such as oral coagulants, anxiolytics, tricyclic antidepressants, theophylline, caffeine, clofibrate, glucocorticosteroids, and antidiabetic drugs.

Contraindications for use

The main contraindications that may interfere with the use of the drug include:

1. A history of thrombosis of large blood vessels (arteries and veins).
2. Marked diabetes mellitus, accompanied by damage to blood vessels.
3. A history of coronary artery disease, angina pectoris or other clinical manifestations of thrombosis.
4. Present or pronounced risk factors for thrombosis of arteries and veins.
5. Suspected or established pregnancy.
6. Breastfeeding period.
7. Vaginal bleeding, the nature of which has not been established.
8. Severe liver diseases (if liver function indicators differ from the norm).
9. Diseases of a tumor nature (both existing and previously noted). The drug is contraindicated for both malignant and benign tumors.
10. Suspicion or presence of malignant tumors in the reproductive system or breasts.
11. Migraine, which is accompanied by neurological deficit.
12. Individual intolerance to any component of the drug.
13. Triglyceridemia (increased levels of triglycerides in the blood).