Pharmacodynamics and pharmacokinetics
Mig 400 tablets contain ibuprofen , which is an analgesic with antipyretic and anti-inflammatory properties. It indiscriminately inhibits COX-1 and COX-2 , as well as prostaglandin .
The analgesic properties of the drug are most pronounced in cases of inflammatory pain. The analgesic effect is not of the narcotic type.
After taking the tablets orally, the medicine is well absorbed from the gastrointestinal tract. The maximum plasma concentration of the active ingredient is reached approximately 120 minutes after taking tablets at a dosage of 400 mg.
99% bound to plasma The active component is slowly distributed in the synovial fluid . It is biotransformed in the liver through carboxylation and hydroxylation of the isobutyl group. Pharmacologically inactive metabolites .
Plasma half-life is 2-3 hours. in the form of metabolites and their conjugates . A small part of the drug is excreted unchanged in urine and bile.
Indications for use
The drug is indicated for use for:
- headache;
- toothache;
- pain in muscles and joints;
- fever due to colds and flu ;
- migraine;
- neuralgia;
- menstrual pain.
If you need to find out why Mig 400 tablets will help in each specific case, it is advisable to consult a doctor.
Indications for the use of Mig tablets
The main use of Miga is pain relief. Ibuprofen is effective for:
- migraines;
- toothache;
- muscle pain;
- neuralgia;
- periodic female pain;
- fever;
- headache.
Mig is often used for purulent otitis media, when the patient complains of pain and acute inflammation in the ear. The Miga tablet will relieve pain, which means you can sleep peacefully all night, but will not have any effect on the course of treatment for otitis media.
Contraindications
This product is prohibited for use when:
- hemorrhagic diathesis;
- hypersensitivity to the components of the drug;
- erosive and ulcerative lesions of the gastrointestinal tract;
- hemophilia and other bleeding ;
- pregnancy;
- under 12 years of age;
- breastfeeding;
- history of a negative reaction to acetylsalicylic acid and other NSAIDs ;
- aspirin asthma;
- bleeding;
- deficiency of glucose-6-phosphate dehydrogenase ;
- diseases of the optic nerve.
The medicine should be used with caution in the elderly, as well as in cases of arterial hypertension , liver or kidney failure , hyperbilirubinemia , gastritis , colitis , heart failure , liver cirrhosis with portal hypertension , nephrotic syndrome , gastric and duodenal ulcers (including a history ), enteritis , blood diseases.
Contraindications to the use of Miga
First of all, pregnancy should be highlighted as a contraindication to taking any medications, even relatively safe ones. Only with the permission of the obstetrician-gynecologist can the expectant mother take the medicine. But most non-steroidal anti-inflammatory drugs are dangerous for the fetus, especially in the first weeks of pregnancy. Their intake provokes developmental delays and congenital deformities.
In addition, direct contraindications include:
- any bleeding disorders;
- optic nerve diseases;
- stomach ulcer;
- Crohn's disease;
- any bleeding;
- diseases of the duodenum in the acute stage.
If the functioning of the filtering organs is disrupted, Miga is also contraindicated:
- renal failure;
- cirrhosis of the liver;
- liver failure;
- hyperbilirubinemia.
MIG is not prescribed to nursing mothers.
Side effects
The use of Mig 400 can lead to the following adverse reactions:
- Gastrointestinal tract: vomiting, pain in the abdomen, loss of appetite , nausea, flatulence , heartburn , diarrhea , constipation ;
- sensory organs: dry or irritated eyes, decreased hearing, toxic damage to the optic nerve, ringing or noise in the ears, blurred or double vision, swelling of the conjunctiva and eyelids;
- CVS: heart failure , high blood pressure , tachycardia ;
- allergies : rash, Quincke's edema , dyspnea , anaphylactic shock , erythema multiforme , eosinophilia , itching , anaphylactoid reactions , bronchospasm , fever , Lyell's syndrome , rhinitis ;
- changes in laboratory parameters: increased serum creatinine concentration , increased bleeding time, decreased hemoglobin , decreased creatinine clearance liver transaminase activity serum glucose , decreased hematocrit ;
- respiratory organs: shortness of breath , bronchospasm ;
- CNS: insomnia , headache , nervousness, psychomotor agitation , depression , hallucinations , dizziness , anxiety, irritability, drowsiness , impaired consciousness ;
- urinary system: allergic nephritis , acute renal failure , cystitis , nephrotic syndrome , polyuria ;
- hematopoietic system: thrombocytopenic purpura , anemia , leukopenia , thrombocytopenia , agranulocytosis .
In rare cases, ulceration of the gastrointestinal mucosa, pain in the mouth, aphthous stomatitis , hepatitis , irritation or dryness of the oral mucosa, ulceration of the gum mucosa, pancreatitis , and aseptic meningitis .
With prolonged use of the drug in high doses, the likelihood of ulceration of the gastrointestinal mucosa, visual impairment, and bleeding increases.
Adverse reactions after taking Mig
Like any drug of the first group of non-steroidal anti-inflammatory drugs, Mig has a number of side effects. They appear more often in older people. Patients over 60 years of age are at risk. With frequent use of the drug, gastric bleeding may occur.
Exceeding a single dose can lead to swelling of the tongue, larynx and half of the face. Side effects from the digestive system include:
- nausea;
- dry mouth;
- diarrhea;
- lack of appetite;
- stool retention;
- flatulence;
- abdominal pain.
Patients with cardiovascular problems may experience tachycardia and surges in blood pressure. The following adverse reactions occur in the central nervous system:
- pain in the back of the head;
- sleep disorders;
- hallucinations;
- disturbances of consciousness;
- nervousness;
- coordination problems.
The urinary system may also react negatively to ibuprofen. While taking it, nephritis, kidney failure, tissue swelling, cystitis and polyuria occur.
Instructions for use Mig 400 (Method and dosage)
The medicine is used internally. For those who take Mig 400 tablets, the instructions for use indicate that dosages are set individually depending on the indications.
Usually start taking the medicine with 200 mg every day 3-4 times. If necessary, the dosage can be increased to 400 mg, which are taken 3 times a day. When the therapeutic effect is achieved, the daily dosage is reduced to 600-800 mg.
The instructions for use of Mig 400 advise that this product should not be taken for more than a week or in higher dosages without consulting a specialist.
In case of , heart or liver dysfunction, the dose is reduced.
Mig 400: instructions for use
The regimen for taking the drug depends on the individual characteristics of the patient. The initial therapeutic dose for children over 12 years of age and adults is 200 mg. For headaches, as a rule, a single dose is sufficient. If the pain syndrome returns, you can repeat the drug, but not earlier than 2-3 hours after the first dose.
Women with severe menstrual pain can take 1 Miga tablet 3 times a day during the first three days of the cycle. If relief does not occur, or the effect is short-term, you need to seek help from a gynecologist in order to establish the cause of severe pain.
For recurring migraines, take 1 tablet (400 mg of ibuprofen) three times a day. If a patient has a migraine accompanied by an aura, then at the first manifestation of it, you can take one tablet and thereby prevent the development of an attack.
Mig is not indicated for children, despite the fact that its main component ibuprofen is approved for children aged 3 months and older. Doctors recommend using other forms of release for patients under 12 years of age - syrups and suppositories in lower dosages.
As an antipyretic, Mig is taken in the amount of 1 tablet. If, an hour after taking it, the temperature has not begun to decrease, it is necessary to take another antipyretic drug with a different active ingredient, for example, paracetamol.
Overdose
When using the drug in doses above normal, abdominal pain , vomiting, drowsiness , headaches, metabolic acidosis , acute renal failure , bradycardia , atrial fibrillation , nausea, lethargy, depression , tinnitus, coma , marked decrease in blood pressure, tachycardia , respiratory arrest are possible. .
If less than 60 minutes have passed since the overdose, gastric lavage . In addition, alkaline drinking, taking Activated Carbon , and forced diuresis . Treatment is symptomatic.
Instructions for use MIG (MIG)
With regard to the following adverse reactions when using the drug, dose dependence and individual differences should be taken into account. The risk of gastrointestinal bleeding (ulcers, mucosal defects, inflammation of the gastric mucosa) depends on the dose range and duration of use. Frequency data, covering very rare reports, relate to short-term use of the drug in doses of up to 1.2 g of ibuprofen (3 tablets).
When assessing adverse reactions, the following frequency data were used as a basis:
- very often (>1/10), often (>1/100, <1/10), sometimes (>1/1000, <1/100), rarely (>1/10,000, <1/1000), very rare (<1/10,000, including isolated cases).
From the digestive system:
sometimes
-
heartburn, abdominal pain, nausea;
- rarely - diarrhea, bloating, constipation, vomiting;
- very rarely - stomach and/or intestinal ulcers (under certain conditions - with bleeding and perforation). If intense abdominal pain, bloody vomiting, blood in the stool or black coloring occurs, the patient should stop taking the drug and consult a doctor immediately. Very rarely with long-term use - liver damage.
- fever, sore throat, superficial wounds in the mouth, flu-like complaints, severe weakness, nosebleeds and hemorrhages in the skin. In these cases, the patient must immediately stop taking the drug, refrain from any self-medication using analgesics-antipyretics and consult a doctor.
From the central nervous system and peripheral nervous system:
sometimes a headache.
From the immune system:
very rarely - aseptic meningitis, accompanied by severe headache, nausea, vomiting, fever, stiff neck or clouding of consciousness. There is an increased risk in patients with SLE and mixed collagen diseases.
From the urinary system:
very rarely - decreased urination, edema (these symptoms can be an expression of kidney disease, including renal failure - if they appear or intensify, you must stop taking the drug and consult a doctor immediately), damage to renal tissue (necrosis of the papillae) during long-term treatment, increased concentration of urinary acids in the blood.
From the hematopoietic system:
very rarely - anemia, leukopenia, thrombocytopenia, pancytopenia, agranulocytosis. The first symptoms may be:
Dermatological reactions:
very rarely - severe skin reactions (skin rash with redness and blistering - exudative erythema multiforme).
Allergic reactions:
sometimes - skin rash, itching, asthma attacks (possibly with a sharp decrease in blood pressure);
Side effects can be reduced by always taking the minimum effective amount of the drug for the shortest possible time.
Interaction
When taking Mig 400, the effect of Furosemide and thiazide diuretics , which can be caused by sodium retention due to inhibition of prostaglandin .
In addition, the active ingredient of the drug may enhance the effect of oral anticoagulants . Taking them together is not advisable.
Ibuprofen also reduces the antiplatelet effect of acetylsalicylic acid and reduces the effectiveness of antihypertensive drugs.
Mig 400 should be used with caution in combination with NSAIDs and corticosteroids , as this can lead to adverse reactions from the gastrointestinal tract.
The drug also provokes an increase in the level of Methotrexate in the blood plasma .
In HIV-infected patients with hemophilia, the combination of ibuprofen with zidovudine increases the risk of hemarthrosis .
Combination with Tacrolimus increases the likelihood of nephrotoxicity due to inhibition of prostaglandin .
Under the influence of the drug Mig 400, the hypoglycemic properties of oral hypoglycemic drugs and Insulin are enhanced. Dosage adjustments may be necessary.
