Instructions for use TRI-REGOL

Compound

The tablets include active ingredients such as ethinyl estradiol and levonorgestrel .
Additional components include: talc, colloidal silicon dioxide, lactose monohydrate, corn starch, magnesium stearate.

The shell consists of sucrose, talc, titanium dioxide, macrogol 6000, red iron oxide, calcium carbonate, copovidone, colloidal silicon dioxide, povidone, carmellose sodium.

Pharmacodynamics and pharmacokinetics

The drug belongs to the contraceptive combination drugs.

Levonorgestrel reduces the production of gonadotropic hormones , as a result of which the egg matures more slowly and ovulation does not occur.

Ethinyl estradiol , in turn, increases the viscosity of cervical mucus and reduces the likelihood of sperm passing into the uterus.

In addition, Tri-Regol helps normalize the menstrual cycle, as it supplements the level of endogenous hormones .

The drug is well absorbed in the intestine when administered orally. It is processed in the intestines and liver, then excreted through the kidneys and intestines.

Pharmacological properties of the drug Tri-regol

Tri-Regol is a three-phase oral hormonal contraceptive that has an inhibitory effect on ovulation. Contains levonorgestrel (D-13β-ethyl-17α-ethynyl-17β-hydroxy-4-gonen-3-one) and ethinyl estradiol (17α-ethinyl estratriene-1,3,5(10)-diol-3,17β). Consecutive administration of tablets of the drug containing different amounts of gestagen (levonorgestrel) and estrogen (ethinyl estradiol) ensures a concentration of these hormones in the blood that corresponds to their concentration during the normal menstrual cycle and promotes the secretory transformation of the endometrium. When taken orally, the drug is quickly and completely absorbed into the gastrointestinal tract. The maximum concentration of ethinyl estradiol in the blood plasma is achieved after 90 minutes, and levonorgestrel - after 2 hours. Metabolized in the liver. The half-life is 2–7 hours. The active substances are excreted: levonorgestrel - 60% in urine, 40% in feces; ethinyl estradiol - 40% in urine, 60% in feces. Both components pass into breast milk.

Contraindications

The use of the drug is contraindicated in:

• over 40 years of age;
• pregnancy and breastfeeding ;
• history of severe itching and idiopathic jaundice
• gallbladder diseases;
• smoking at the age of 35 years;
• thromboembolism and thrombosis , as well as predisposition to them;
• diabetes mellitus in severe form;
• improper fat metabolism;
• hydatidiform mole;
• migraine;
• otosclerosis with hearing problems;
• recent surgical operations;
• deficiency of the enzyme that is needed to digest lactose in milk;
• hypersensitivity to the components of the drug;
• liver diseases;
• history of severe cardiovascular and cerebrovascular changes;
• vaginal bleeding of unknown etiology;
• sickle cell and hemolytic anemia ;
• malignant tumors;
• chronic colitis;
• Marfan syndrome;
• phlebitis;
• extensive injuries.

This medicine should be used with caution when:

• bronchial asthma;
• chronic venous insufficiency of the lower extremities;
• epilepsy;
• chorea minor;
• porphyria;
• uterine fibroids;
• depression;
• diabetes mellitus at the stage of compensation (in the absence of vascular complications);
• multiple sclerosis;
• arterial hypertension (BP up to 160/100 mm Hg);
• tetany;
• mastopathy;
• tuberculosis;
• lack of a regular menstrual cycle during adolescence.

Contraindications to the use of the drug Tri-regol

Pregnancy and lactation, recent hepatitis, liver dysfunction (including Gilbert, Dubin-Johnson, Rotor syndromes), a history of jaundice or severe skin itching, cholelithiasis, cholecystitis, chronic colitis, herpes during previous pregnancies, severe organic heart disease, severe hypertension (arterial hypertension), severe diabetes mellitus and other endocrine diseases, lipid metabolism disorders, predisposition to thrombosis, a history of indications of cerebrovascular diseases, malignant tumors, primarily of the breast and genital organs, sickle-shaped cellular anemia, chronic hemolytic anemia, convulsions, vaginal bleeding of unknown etiology, migraine, otosclerosis, history of idiopathic jaundice of pregnant women, hypersensitivity to the drug.

Side effects

Side effects of Tri-Regol are usually the following: discomfort when using contact lenses, intermenstrual bleeding, weight changes, nausea, fluid retention, changes in libido, a feeling of tension in the mammary glands, acne, irritability , depression , increased excitability, pain in the mammary glands, headache , migraine , blurred vision, hypomenorrhea , amenorrhea .

These side effects are temporary and go away without special treatment. In rare cases, tumors may develop, lupus erythematosus , ulcerative colitis , hepatitis , Crohn's disease , and jaundice may .

In addition, an increase in the amount of triglycerides in the blood plasma, a decrease in glucose tolerance, fatigue, increased blood sugar, chorea , otosclerosis , pulmonary embolism thrombophlebitis of the deep veins of the lower extremities, increased blood pressure, venous thrombosis , vomiting , cholelithiasis were rarely observed. , diarrhea , pancreatitis , skin rashes exudative erythema multiforme , hair loss, urticaria , erythema nodosum , changes in vaginal secretion, chloasma , the appearance of secretions from the mammary glands, vaginal mycoses

Adverse reactions such as dizziness , worsening epilepsy , hypertrichosis , seborrhea , and a feeling of heaviness in the legs are also possible.

Side effects of the drug Tri-regol

At the beginning of using the drug, gastrointestinal disorders, nausea, vomiting, engorgement of the mammary glands, headache, mood changes, increased fatigue, skin rash, cramps of the calf muscles, libido disorders, intermenstrual bleeding, and in some cases - discomfort when wearing contact lenses may sometimes occur. lenses Subsequently, the severity of these phenomena decreases or they disappear. Slight bleeding from the vagina, which sometimes occurs during the first 3 months of using the drug, does not require stopping taking Tri-Regol . If bleeding is more intense or prolonged, the use of tablets should be stopped and a gynecological examination should be performed. If no contraindications to continuing to take the drug are identified, you can start the next 21-day course from the 1st day of menstruation. With subsequent courses of taking the drug, uterine bleeding occurs less frequently and, as a rule, stops. Tri-Regol can cause both an increase and a decrease in body weight. Possible impaired glucose tolerance. With longer use, chloasma can very rarely occur. Less commonly noted are increased levels of TG in the blood plasma, blood pressure, thrombosis and thromboembolism of various localizations, hepatitis, gallbladder disease, jaundice, hair loss, changes in the composition of vaginal secretion, vaginal mycosis, and diarrhea.

Instructions for use of Tri-Regol (Method and dosage)

The instructions for Tri-Regol describe that you should take one tablet per day at the same time. The course begins on the first day of menstruation and lasts 21 days. After this there should be a week's break for menstrual bleeding. After this, the tablets are started again from the first package (even if there is still bleeding). First you need to take 6 pink tablets, then 5 white ones and then 10 yellow ones.

In the package, the order of taking the medicine is indicated by numbers and arrows. If one package contains 28 tablets, after taking the dark yellow ones, you should move on to the brown ones (they do not contain hormones), and the next course of 28 days should be started without interruptions.

If a pill is missed (more than 36 hours have passed), the reliability of contraceptive protection is not guaranteed. In the first and second weeks of the cycle, in case of such a miss, the instructions for using Tri-Regol advise taking 2 tablets at once the next day.

If you miss 2 tablets in a row, you need to take 2 tablets for the next 2 days, then continue the course as usual. If you miss a course in the third week, there is no seven-day break.

Skipping pills does not apply to browns. They contain iron and are used to maintain continuity.

If the drug is prescribed for treatment, its dosage is adjusted individually.

Special instructions for the use of the drug Tri-regol

Before starting to use the drug, it is necessary to conduct a general medical and gynecological examination (primarily measuring blood pressure, determining the level of sugar in the urine, testing liver function, examining the mammary glands, cytological smear analysis) to exclude risk-related diseases and pregnancy. In women with a family history of thromboembolic diseases at a young age or bleeding disorders, the use of Tri-Regol is not allowed. Particular caution should be observed when prescribing the drug to patients with diabetes mellitus, heart disease of non-ischemic etiology, impaired renal function, hypertension (arterial hypertension), varicose veins, phlebitis, otosclerosis, multiple sclerosis, epilepsy and migraine (or if there is a history of these diseases). ); in the presence of minor chorea, intermittent porphyria, hidden tetany, asthma, benign uterine tumors, endometriosis or mastopathy. While taking the drug, medical monitoring is necessary approximately every 6 months. Oral hormonal contraception can be used no earlier than 6 months after viral hepatitis, provided that liver function indicators are normalized. With long-term use of sex hormones, benign and very rarely malignant liver tumors were rarely detected. If acute abdominal pain or bleeding occurs, the presence of a hepatocellular tumor should be excluded. If sharp pain appears in the upper abdomen, hepatomegaly and signs of intra-abdominal hemorrhage, a suspicion of a liver tumor may arise. If necessary, stop taking the drug. If there is no bleeding when stopping the drug, you can continue taking it only after pregnancy has been ruled out. While using the drug, patients with impaired liver function should undergo therapeutic examination every 2–3 months. If intermenstrual bleeding occurs, Tri-Regol should be continued, since in most cases this bleeding stops spontaneously. If intermenstrual bleeding does not stop or recurs, a gynecological examination should be performed to exclude gynecological pathology. In cases of vomiting or diarrhea, taking pills should be continued, but an additional method of contraception must be used. Women who have used oral contraceptives containing estrogens may have an increased risk of developing thromboembolism and thrombosis of various locations. This risk increases with age and mainly in women who smoke. Therefore, women over the age of 30 are advised to completely stop smoking. The drug must be stopped at least 3 months before the planned pregnancy. You should stop taking the pills immediately:

• if pregnancy is suspected;
• in case of development of a migraine-type headache, with a significant deterioration in visual acuity, if thrombosis or myocardial infarction is suspected;
• with a sharp increase in blood pressure, jaundice or hepatitis without jaundice, with intense itching of the whole body, epilepsy or increased frequency of epileptic seizures;
• during a planned operation (6 weeks before surgery), during prolonged immobilization.

Interaction

Tri-Regol should be taken with caution in combination with:

• Ampicillin , chloramphenicol , Penicillin B , tetracyclines , Dihydroergotamine , Phenylbutazone , Rifampicin , Neomycin , sulfonamides , some anticonvulsants and tranquilizers, Ketonazole - may reduce the effectiveness of the contraceptive;
• tricyclic antidepressants , beta blockers , Maprotiline - it is possible to increase the bioavailability and toxicity of these drugs;
• Bromocriptine – effectiveness may decrease;
• anticoagulants , derivatives of indandione or coumarin - there may be a need to monitor prothrombin time and adjust dosages;
• antidiabetic medications for oral use, insulin - dosage adjustment may be necessary;
• hepatotoxic agents – increased risk of increased hepatotoxicity.

Reviews about Tri-Regol

birth control pills receive very different reviews, like most other hormonal contraceptives. For some they are ideal, but for others they experience many unwanted side effects. Although the majority of reviews about Tri-Regol are still positive. Some girls even “prescribe” it to themselves, without consulting specialists. And in most cases, problems with pregnancy are not observed after stopping the course.

Doctors' opinions about Tri-Regol are usually positive. They are often prescribed to patients to normalize the menstrual cycle. Reviews from doctors about Tri-Regol boil down to the fact that it is a relatively harmless remedy for little money. However, the effect of oral contraceptives is very individual. Some specialists neglect the necessary tests, so it also happens that the drug is not suitable for a number of indicators for the patients to whom it was prescribed. This leads to the appearance of unwanted side reactions. So Tri-Regol should be prescribed only after appropriate tests.

Tri-Regola price, where to buy

The price of Tri-Regol in comparison with a number of similar products is considered very affordable. That is why it is often recommended by experts. The price of Tri-Regola in a package for 21 tablets is on average about 200 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Tri-Regol tablets 21 pcs. JSC Gedeon Richter
  RUB 301 order

Pharmacy Dialogue

• Tri-regol (tab. No. 21) Gedeon-Richter

  RUB 292 order

• Tri-regol (tab. No. 21x3)Gedeon-Richter

  RUR 737 order

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Pharmacy24

• Tri-regol No. 63 tablets VAT "Gedeon Richter", Ugorshchina
  672 UAH. order
• Tri-regol No. 21 tablets VAT "Gedeon Richter", Ugorshchina

  220 UAH order

PaniPharmacy

• Three Regol tablets Tri-Regol tablets. p/o No. 63 Hungary, Gedeon Richter

  798 UAH. order

• Three Regol tablets Tri-Regol tablets. p/o No. 21 Hungary, Gedeon Richter

  257 UAH order

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