Gepatrombin G, rectal suppositories 10 pcs.

Currently, a wide range of heparin-based drugs are presented on the pharmaceutical market. Their popularity is due to their outstanding anticoagulant properties.

The variety of dosage forms of the drugs allows them to be used for external and internal use, as injections, and also as rectal suppositories with heparin.

Preparations containing heparin can relieve diseases that require eliminating or preventing thrombosis, eliminating inflammatory processes, improving microcirculation or normalizing metabolism.

For the treatment of pathological changes in hemorrhoidal plexuses (hemorrhoids) of internal localization, it is advisable to use heparin suppositories.

Compound

Analogues of Gepatrombin

Analogues of Hepatrombin are drugs containing Heparin, as well as other components, which allow them to be used for thrombosis and other venous diseases of the lower extremities.

One of the varieties of Hepatrombin is Hepatrombin G, which is used topically for hemorrhoids and other diseases of the anus and rectum.

Substitutes for Hepatrombin G ointment are all kinds of creams, ointments and gels, for example, Proctosedyl, Aurobin, Proctosan. Analogues in suppositories are represented by other drugs, such as Natalsid, Nigepan, Hepazolon, Neo-anuzole.

The table shows the average prices of various analogues of Gepatrombin and Gepatrombin G, depending on the form of release:

Venolife

Manufacturer: AKRIKHIN, Russia
Release form: gel for external use

Active ingredient: Heparin sodium + Dexpanthenol + Troxerutin

Synonyms: Troxevasin Neo

The Venolife analogue, in addition to Heparin and Dexpantol, additionally contains the angioprotector Troxerutin, which reduces the fragility and permeability of capillaries, normalizes microcirculation and tissue nutrition, and reduces congestion in the veins.

Phenylethyl alcohol, added to this analogue as a preservative, additionally has an antiseptic and fungicidal effect.

Troxevasin

Manufacturer: Balkanfarma, Bulgaria
Release form: capsules, gel for external use

Active ingredient: Troxerutin

Synonyms: Troxerutin Vramed, Troxerutin Zentiva, Troxerutin VetProm, Phlebopress

Troxevasin is an analogue of Gepatrombin gel, has angioprotective, venotonic and antioxidant effects, relieves swelling, exudation and inflammation.

The analogue Troxevasin is used for venous insufficiency, both acute and chronic. Effective both at the beginning of the disease and even in the later stages.

Proctosedyl

Manufacturer: Sanofi, India
Release form: ointment, rectal capsules

Active ingredient: Benzocaine + Butamben + Hydrocortisone + Framycetin + Esculoside

The analogue Proctosedyl, due to its combined composition, has an anti-inflammatory, local anesthetic and antipruritic effect. Also active against some microorganisms. Used for hemorrhoids and itching in the anal area.

Aurobin

Manufacturer: Gedeon Richter, Hungary
Release form: ointment for external and rectal use

Active ingredient: Prednisolone capronate + Lidocaine hydrochloride + Dexpanthenol

The Hungarian analogue Aurobin primarily has an anti-inflammatory, anti-edematous and antipruritic effect, thanks to the main component, the glucocorticoid – Prednisolone. Lidocaine has a local anesthetic effect. Dexpanthenol provides a healing effect.

Posterisan

Manufacturer: Dr.
Kade, Germany Release form: ointment and rectal suppositories

Active ingredient: Microbial cells of Escherichia coli killed by phenol

The Posterizan analogue is used rectally in the form of ointments and suppositories not only as an anti-inflammatory and antipruritic, but also as an immunostimulant, thanks to its special composition - inactivated bacteria and their metabolic products.

The analogue increases local tissue resistance to the effects of various microorganisms, normalizes capillary permeability and regenerates damage.

Nigepan

Manufacturer: NIZHFARM, Russia
Release form: rectal suppositories

Active ingredient: Heparin sodium + Benzocaine

Domestic Nigepan suppositories are available only by prescription, but are also an analogue of Hepatrombin G, since they are used as an anticoagulant, local anesthetic and anti-inflammatory agent for hemorrhoids.

Proctosan

Manufacturer: STADA, Germany
Release form: ointment and rectal suppositories

Active ingredient: Bufexamac + Bismuth subgallate + Lidocaine hydrochloride

Proctosan suppositories have an astringent, wound-healing, drying, local anti-inflammatory and anesthetic, as well as antihemorrhoidal effect.

This analogue of Gepatrombin G is used not only for hemorrhoids, but also for fissures, ulcers of the anus and rectum to relieve inflammation and itching.

Directions for use and doses

Ointment

Externally, the ointment is applied to the affected areas in a thin layer 2-4 times a day; after the pain disappears - once a day for 7 days.

Rectally. To administer the ointment, use the attached screw-on tip, which is inserted into the rectal cavity, and by lightly pressing the tube, a small amount of ointment is squeezed out.

Suppositories

Rectally, suppositories are administered 1–2 times a day into the rectal cavity after defecation.

Effect

Heparin suppositories have good reviews, cope well with the symptoms of internal hemorrhoids and have an affordable price.

Suppositories owe their positive effect to the main active ingredient - heparin, which is an acidic sulfur-containing glycosaminoglycan with anticoagulant activity. This property of the ingredient leads to blood thinning in hemorrhoids and, as a result:

• to normalize blood circulation in the affected area;
• prevents the process of thrombus formation and resorption of blood clots;
• elimination of pain symptoms, inflammation and swelling;
• accelerating the regeneration of damaged tissues;
• reducing the size of hemorrhoidal formations;
• preventing relapse of the disease;
• reducing vascular permeability, restoring their functionality and tone.

The use of suppositories with heparin is effective for internal hemorrhoids; external hemorrhoids require treatment with heparin ointment, which has an effect identical to that of suppositories

Suppositories are used both for the chronic form of the disease and at the acute stage of the disease. The exception is the bleeding form of hemorrhoids, as well as:

• individual intolerance to the ingredients of the drug;
• tumor processes in the gastrointestinal tract;
• impaired blood clotting;
• infectious processes in the body.

The instructions for each heparin-based drug contain a list of contraindications for its use, which directly depends on the composition.

In addition, rectal administration of the drug has a number of advantages compared to oral and injection use of drugs:

• suppositories have a local effect, which minimizes the risk of side effects;
• inserting suppositories into the rectum prevents the negative effects of the drug’s components on the gastrointestinal tract and liver;
• increased absorption of medicinal substances is ensured by a large number of blood vessels located in the rectum, which significantly increases the effect of the drug.

However, the use of any drug, including rectal suppositories, requires the approval of a doctor.

Release form

Ointment for rectal and external use. In an aluminum tube, sealed with a plastic screw cap, 20 g. The opening of the tube is protected by an aluminum membrane. The lid is a monolithic structure that includes a device for piercing the membrane. The tube together with the tip for rectal administration is packed in a cardboard box.

Rectal suppositories. In PVC blister packaging 5 pcs. 2 blister packs are packed in a cardboard box.

pharmachologic effect

Manufacturer: Hemofarm, Serbia.
Release form: cream, gel and ointment for external use

Active ingredient: Heparin + Allantoin + Dexpanthol

Hepatrombin is a combined drug that has local anticoagulant, anti-inflammatory and regenerative effects. Its therapeutic effect consists of the actions of all the components of the drug.

Heparin counteracts the formation of blood clots, swelling and inflammation, and promotes local blood flow. Allantoin stimulates metabolic processes and proliferation in tissues. Dexpanthenol, in addition to being an excellent healing agent, also improves the absorption of heparin.

Hepazolon

Gepasolone contains three active ingredients:

• heparin;
• prednisolone;
• lidocaine, which has a local anesthetic effect.

Hepazolon (rectal suppositories and ointment) is a Russian drug,

Gepazalon has indications similar to Gepatrombin G, but is prohibited in the case of fungal, viral, tuberculosis and other infectious lesions of the rectal area, as well as in pregnant, lactating women and patients under the age of 12 years.

Side effects of Gepazolon can only be observed with long-term use (more than five weeks) and are expressed in the form of: bradycardia, dizziness, increased sweating, etc.

Clinical studies have shown good effectiveness of the drug in the treatment of hemorrhoids. Complete relief from the disease in its initial stages was observed within a week.

Gepasolone has a pronounced analgesic effect, which determines the advisability of its use in the acute stages of the disease to eliminate pain.

Gepatrombin G

In addition to heparin, the drug consists of the following components:

• prednisolone (corticosteroid hormone) – has an antiallergic effect; fights inflammatory processes; helps eliminate swelling, unpleasant painful sensations, itching and burning sensations; has a strengthening effect on the walls of blood vessels;
• lauromacrogol - has a slight anesthetic effect and also scleroses the venous walls, which leads to a reduction in hemorrhoidal formations.

Gepatrombin G is produced in Serbia in the form of rectal suppositories and ointments

Gepatrombin G is recommended to get rid of:

• internal hemorrhoids;
• thrombophlebitis;
• anal fissures;
• fistulas, eczema, as well as unpleasant sensations (itching, burning, etc.) in the anal area.

It is possible to use the drug before surgery to remove hemorrhoids.

Gepatrombin G, in addition to general contraindications for heparin, is not used for:

• various skin lesions;
• tuberculosis;
• syphilis;
• reactions to the vaccine.

Interestingly, bleeding from hemorrhoids is not a contraindication for the use of Hepatrombin G.

It has few side effects, which can be expressed in the local reaction of the body to the use of the drug.

Nigepan

The composition of the drug Nigepan, in addition to heparin, includes benzocaine, which has a local anesthetic effect.

Rectal suppositories Nigepan are produced by the Russian pharmaceutical company Nizhpharm

The drug belongs to the group of thrombolytic and local anesthetic agents and is recommended for thrombosis of hemorrhoids, which is accompanied by inflammatory processes.

Nigepan is not recommended in case of hypersensitivity to its components, as well as impaired blood clotting.

The use of the drug may cause local allergic reactions.