Arpeflu tab. p/pl. about. 100 mg No. 30 (Lekpharm/Belarus)

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Arpeflu is an antiviral drug for systemic use. Contains the active substance umifenovir , which suppresses influenza A and B . The specific effect is associated with the inhibition of the fusion of the viral shell with the cell membranes - thus preventing their penetration into the cells of the body. Also, umifenovir increases interferon . Refers to low-toxic drugs. When using it, there is a reduction in the duration of the disease, a decrease in the severity of influenza , ARVI and the frequency of complications.

Pharmacokinetics

When taken orally, it is quickly and completely absorbed and maximum concentrations in the blood are created after 1.5 hours. Metabolism of the active substance occurs in the liver. It is excreted unchanged by the intestines and a small part by the kidneys. The half-life is 17-20 hours; about 90% of the dose is eliminated within 24 hours.

Arpeflu 100 mg 30 pcs. film-coated tablets

pharmachologic effect

Antiviral, immunomodulatory.

Composition and release form Arpeflu 100 mg 30 pcs. film-coated tablets

Film-coated tablets - 1 tablet: 6-bromo-5-hydroxy-1-methyl-4-dimethylaminomethyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester hydrochloride monohydrate - 100 mg.

Tablets 100 mg. 30 pcs.

Description of the dosage form

Coated tablets.

Directions for use and doses

A single dose for adults and children over 12 years of age is 200 mg. Flu and ARVI - 200 mg 4 times a day. Duration of treatment is up to 5 days. For influenza complicated by pneumonia, 200 mg 4 times a day for 5 days, and then once a week, month.

Recurrent herpetic infection 200 mg 4 times a day for 7 days, with a transition to taking 200 mg twice a week for a month. Preventive administration after contact with a patient - 200 mg 1 time per day for 10-14 days. During an epidemic - 200 mg 2 times a week for 3 weeks.

Arpeflu for children from 3 to 6 years old is recommended at a dose of 50 mg and 100 mg from 6 to 12 years old. For rotavirus intestinal infection - a single dose in accordance with age is taken 4 times a day for 5 days.

Pharmacodynamics

Arpeflu is an antiviral drug for systemic use. Contains the active substance umifenovir (arbidol), which suppresses influenza A and B viruses. The specific effect is associated with the inhibition of the fusion of the virus shell with cell membranes - thus preventing their penetration into the body's cells. Arbidol also affects the increase in interferon production. Refers to low-toxic drugs. When using it, there is a reduction in the duration of the disease, a decrease in the severity of influenza and ARVI and the frequency of complications.

Pharmacokinetics

When taken orally, it is quickly and completely absorbed and maximum concentrations in the blood are created after 1.5 hours. Metabolism of the active substance occurs in the liver. It is excreted unchanged by the intestines and a small part by the kidneys. The half-life is 17-20 hours; about 90% of the dose is eliminated within 24 hours.

Indications for use Arpeflu 100 mg 30 pcs. film-coated tablets

• Flu;
• ARVI, pneumonia and bronchitis;
• recurrent herpetic infection;
• secondary immunodeficiency states;
• acute intestinal infections caused by rotavirus.

Contraindications

• Intolerance and hypersensitivity;
• age up to 3 years;
• lactose intolerance.

Effect on the body

Prevention of ARVI and influenza.

Overdose

There are no known cases of overdose. When taking excessive doses, unwanted effects may occur.

Side effects Arpeflu 100 mg 30 pcs. film-coated tablets

In rare cases, allergic reactions occur in patients with individual intolerance.

Drug interactions

Contraindicated for use with ethyl alcohol. When prescribed with other drugs, no interactions were observed.

Arpeflu, instructions for use (Method and dosage)

Arpeflu tablets are taken before meals with plenty of liquid. Treatment regimens depend on the severity of the disease and are determined by the doctor. The duration of treatment is also adjusted by the doctor depending on the dynamics of the disease and concomitant pathology.

• A single dose for adults and children over 12 years of age is 200 mg.
• For influenza and ARVI - 200 mg 4 times a day. Duration of treatment is up to 5 days.
• For influenza complicated by pneumonia - 200 mg 4 times a day for 5 days, and then once a week, month.
• For recurrent herpetic infection - 200 mg 4 times a day for 7 days, with a transition to taking 200 mg twice a week for a month.
• Preventive administration after contact with patients - 200 mg 1 time per day for 10-14 days.
• During an epidemic - 200 mg 2 times a week for 3 weeks.

Arpeflu for children from 3 to 6 years old is recommended at a dose of 50 mg and 100 mg from 6 to 12 years old. For rotavirus intestinal infection - a single dose in accordance with age is taken 4 times a day for 5 days.

Arpeflu 50 mg No. 20 tablet p.p.o.

Instructions for medical use of the drug Arpeflu TRADE NAME ARPEFLUE International nonproprietary name Umifenovir Dosage form Film-coated tablets, 50 mg and 100 mg. Composition One tablet contains the active substance - umifenovir hydrochloride 50 mg or 100 mg, excipients: povidone (K 17), microcrystalline cellulose, modified corn starch (Starch 1500), colloidal anhydrous silicon dioxide, magnesium stearate, lactose monohydrate, opadry II white ( polyvinyl alcohol, titanium dioxide (E 171), polyethylene glycol, talc). Description Film-coated tablets, white, with a biconvex surface. Pharmacotherapeutic group Anti-infective drugs for systemic use. Antiviral drugs for systemic use. Direct acting antiviral drugs. Other antiviral drugs. Umifenovir. ATC code J05AX13 Pharmacological properties Pharmacokinetics Umifenovir hydrochloride is rapidly absorbed and distributed to organs and tissues. The maximum concentration in blood plasma when taken at a dose of 50 mg is achieved after 1.2 hours, at a dose of 100 mg - after 1.5 hours. Metabolized in the liver. The half-life is 17-21 hours. About 40% is excreted unchanged, mainly with bile (38.9%) and in small amounts by the kidneys (0.12%). During the first day, 90% of the administered dose is eliminated. Pharmacodynamics Umifenovir hydrochloride is an antiviral agent and also has a moderate immunomodulatory effect. Specifically suppresses influenza viruses type A and B, as well as other viruses - causative agents of acute respiratory viral infections (ARVI) (coronavirus (Сoronavirus)), associated with severe acute respiratory syndrome (SARS), rhinovirus (Rhinovirus), adenovirus (Adenovirus), respiratory - syncytial virus (Pneumovirus) and parainfluenza virus (Paramyxovirus). According to the mechanism of antiviral action, it belongs to fusion inhibitors, interacts with the hemagglutinin of the virus and prevents the fusion of the lipid membrane of the virus and cell membranes. It has interferon-inducing activity, stimulates humoral and cellular immune responses, the phagocytic function of macrophages, and increases the body's resistance to viral infections. Reduces the incidence of complications associated with viral infection, as well as exacerbations of chronic bacterial diseases. Therapeutic effectiveness for viral infections is manifested in a decrease in the severity of general intoxication and clinical phenomena, and a reduction in the duration of the disease. Refers to low-toxic drugs. Does not have any negative effects on the human body when administered orally in recommended doses. Indications for use - influenza A and B, acute respiratory viral infections (ARVI) - as part of complex therapy of chronic bronchitis, pneumonia and recurrent herpetic infections - prevention of influenza and ARVI during the epidemic season - prevention of postoperative infectious complications - as part of complex therapy of acute intestinal infections infections of rotavirus etiology in children over 6 years of age. Method of administration and dosage: Orally, 30 minutes before meals or 2 hours after meals. Single dose: children from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg (2 tablets of 100 mg or 4 tablets of 50 mg). For nonspecific prophylaxis In direct contact with patients with influenza and other acute respiratory viral infections: - children from 6 to 12 years old - 100 mg once a day, over 12 years old and adults - 200 mg once a day for 10- 14 days. During an epidemic of influenza and other acute respiratory viral infections: - children from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg twice a week for 3 weeks. For the treatment of influenza and other acute respiratory viral infections without complications: - children from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg 4 times a day (every 6 hours) for 5 days. In the complex treatment of chronic bronchitis, pneumonia, herpes infection: - children from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg 4 times a day (every 6 hours) for 5-7 days, then a single dose 2 times a week for 4 weeks. Complex therapy of acute intestinal infections of rotavirus etiology in children over 6 years of age: - children from 6 to 12 years old - 100 mg, over 12 years old - 200 mg 4 times a day (every 6 hours) for 5 days. Prevention of postoperative infectious complications: - children from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg once 2 days before surgery, then in the same dose once on days 2 and 5 after surgery. Side effects Rarely - allergic reactions (rash, anaphylactic reaction) - heartburn, nausea, vomiting, diarrhea Contraindications - hypersensitivity to any component of the drug - children under 6 years of age - pregnancy and lactation - hereditary lactose intolerance, lactose deficiency, glucose malabsorption, galactose Drug interactions When prescribed with other drugs, no negative effects were noted. Special instructions It is necessary to follow the regimen and duration of taking the drug recommended in the instructions. If you miss taking one dose of the drug, the missed dose should be taken as early as possible and continue taking the drug according to the started regimen. Pregnancy and lactation Due to the lack of necessary clinical experience, it is not recommended to take Arpeflu during pregnancy, unless the possible benefit to the mother outweighs the potential risk to the fetus. Due to the lack of necessary clinical experience, it is not recommended to take Arpeflu during breastfeeding. Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms It does not exhibit central neurotropic activity and can be used by people of various professions, incl. requiring increased attention and coordination of movements (transport drivers, operators, etc.). Overdose Not noted. Release form and packaging 10 or 20 tablets in a blister pack made of polyvinyl chloride film and aluminum foil. One, two or three blister packs of 10 tablets, together with instructions for medical use in the state and Russian languages, are placed in a cardboard pack. One contour blister pack of 20 tablets with a dosage of 50 mg, together with instructions for medical use in the state and Russian languages, is placed in a cardboard pack. Storage conditions Store at a temperature not exceeding 25 ºС. Keep out of the reach of children! Shelf life 3 years. Do not use after the expiration date. CONDITIONS OF DISCHARGE FROM PHARMACIES Without a prescription, Republic of Belarus, 223141, Logoisk, st. Minskaya, 2a, room 301. Tel./fax: (01774)-53801, e-mail Registration certificate holder of Lekpharm JLLC, Republic of Belarus, 223141, Logoisk, st. Minskaya, 2a, room 301. Tel./fax: (01774)-53801, e-mail Name, address and contact details (telephone, fax, e-mail) of the organization in the territory of the Republic of Kazakhstan: accepting claims (proposals) for quality of the medicinal product from consumers and responsible for post-registration monitoring of the safety of the medicinal product Representative office of JLLC "Lekpharm" in the Republic of Kazakhstan, 050000, Almaty, Bostandyk district, Al-Farabi Avenue 7, BC "Nurly Tau", building 4a, office 55, tel. 8(727)-3110454, fax 8(727)-3110455, email

Arpeflu's analogs

Level 4 ATX code matches:
Paxlovid

Lagevrio

Veklury

Remdeform

Areplivir

Coronavirus

Avifavir

Triazavirin

Yodantipyrine

Flavoside

Amizon

Altabor

Lavomax

Hyporamine

Anaferon for children

Anaferon

Amiksin

Arbidol

Ferrovir

Tiloron

Arbidol , Arbidol Maximum , Afludol , Arbivir , Mednat , Immusstat , ORVItol NP , Arbimax .

Reviews about Arpeflu

ARVI and influenza are a common group of infectious diseases. They often have a severe course and unfavorable outcomes. One of the reasons for this is reduced immunity . of endogenous interferon and immunomodulators , is relevant . One of these drugs is Arpeflu. It is especially relevant for children, since they have an increased susceptibility to viral infections and an insufficient immune response, which causes a protracted course of the disease. If we compare this drug with amantadine and Remantadine , then their spectrum of action is narrow - they act only on the influenza A virus and side effects are possible when taking them.

This drug has a direct effect on influenza A and B . The use of Arpeflu is also effective for herpes and rotavirus infections . The presence of interferon-inducing, immunomodulatory and antioxidant activity ensures high efficiency in the treatment and prevention of viral diseases, prevents complications and exacerbations of concomitant chronic pathology. The drug is well tolerated and is compatible with antibiotics if there is a need to take them. All these points are reflected in the reviews.

• “... I think it helps. My husband got sick, his temperature was 39. He only took the antiviral drugs Arpeflu and Nimesil. In three days I got myself back on my feet and went to work.”
• “... I was prescribed it for an exacerbation of chronic purulent bronchitis along with antibiotics, I tolerated it well. I recovered faster than usual.”

It is most advisable to use the drug for preventive measures before the rise in the incidence of influenza and ARVI in the fall. Its high effectiveness lasts for 2-3 months. According to observations, after the preventive course, the number of children who fell ill with ARVI was 1.4 times less. A sign of effectiveness is also a reduction in the incidence of acute respiratory viral infections in adults with chronic respiratory diseases.

Arpeflu tablets ppo 50mg No. 30

Compound

6-bromo-5-hydroxy-1-methyl-4-dimethylaminomethyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester hydrochloride monohydrate 50 mg

Pharmacokinetics

Absorption is fast. Quickly distributed throughout organs and tissues. TCmax when taken at a dose of 50 mg - 1.2 hours, 100 mg - 1.5 hours. Metabolized in the liver. T1/2 - 17-21 hours. About 40% is excreted unchanged, mainly with bile (38.9%) and in small amounts by the kidneys (0.12%). During the first day, 90% of the administered dose is eliminated

Indications for use

Prevention and treatment in adults and children: - influenza caused by viruses A and B; — acute respiratory viral infections (ARVI) (including those complicated by bronchitis, pneumonia); - secondary immunodeficiency states. Complex therapy of chronic bronchitis, pneumonia and recurrent herpes infection. Prevention of postoperative infectious complications and normalization of immune status in adults.

Contraindications

- children's age (up to 3 years); - the presence of diseases such as galactose intolerance, lactase deficiency, glucose-galactose malabsorption; - hypersensitivity to the components of the drug

Directions for use and doses

Inside, before meals. Single dose: children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg (2 tablets of 100 mg or 4 tablets of 50 mg). For nonspecific prophylaxis In direct contact with patients with influenza and other acute respiratory viral infections: children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg 1 time a day for 10-14 days. During an epidemic of influenza and other acute respiratory viral infections, to prevent exacerbations of chronic bronchitis, relapse of herpetic infection: children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg 2 times a week. within 3 weeks. Prevention of postoperative complications: children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg 2 days before surgery, then on days 2 and 5 after surgery. For the treatment of influenza, other acute respiratory viral infections without complications: children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg 4 times a day (every 6 hours) for 5 days. Influenza, other acute respiratory viral infections with the development of complications (bronchitis, pneumonia and others): children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg 4 times a day (every 6 hours ) for 5 days, then a single dose once a week for 4 weeks.

Storage conditions

List B. At a temperature not higher than 25°C. Out of reach of children

Best before date

2 years

special instructions

It does not exhibit central neurotropic activity and can be used in medical practice for preventive purposes in practically healthy individuals of various professions, including those requiring increased attention and coordination of movements (transport drivers, operators, etc.)

Conditions for dispensing from pharmacies

Over the counter

Use in children

Contraindicated in children under 3 years of age

Manufacturer and organization accepting consumer complaints

Lekpharm LLC

Pharmacodynamics

An antiviral agent that has an immunomodulatory and anti-influenza effect, specifically suppresses influenza A and B viruses. It has interferon-inducing properties, stimulates humoral and cellular immune responses, the phagocytic function of macrophages, and increases the body's resistance to viral infections. Prevents the development of post-influenza complications, reduces the frequency of exacerbations of chronic diseases, and normalizes immunological parameters. The antiviral effect is due to the suppression of the fusion of the lipid membrane of the virus with cell membranes upon contact of the virus with the cell. Therapeutic effectiveness for influenza is manifested in a decrease in intoxication and the severity of catarrhal phenomena, shortening periods of fever and the overall duration of the disease. Refers to low-toxic drugs (LD 50>4 g/kg). Does not have any negative effects on the human body when administered orally in recommended doses.

Side effects

Allergic reactions

Interaction

No negative effects were noted when prescribed with other drugs

Overdose

Not marked

Arpeflu price, where to buy

You can buy Arpeflu in many pharmacies. The cost of 30 tablets of the drug 50 mg is 150 - 200 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Arpeflu tablets p.p.o.
  100 mg 30 pcs. SOOO "Lekpharm" 389 rub. order
• Arpeflu tablets p.p.o. 100 mg 20 pcs. Lekpharm LLC

  RUB 253 order

Pharmacy Dialogue

• Arpeflu (tab.p.pl.vol. 100 mg No. 20) Lekfarm LLC

  RUB 272 order

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• Arpeflu tablets 100 mg No. 30 Lekfarm LLC

  409 rub. order

• Arpeflu tablets 100 mg No. 20 Lekfarm LLC

  RUB 274 order

• Arpeflu (tab.p.pl.vol. 100 mg No. 30) Lekfarm LLC

  407 rub. order

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PaniPharmacy

• Arpeflu table.
  p/o 100 mg No. 10 + Arpeflu tablet. p/o 50 mg No. 10 PROMOTION 104 UAH. order
• Arpeflu capsule Arpeflu film-coated tablets 100 mg No. 10 Belarus, Lekpharm

  114 UAH order

• Arpeflu capsule Arpeflu film-coated tablets 50 mg No. 10 Belarus, Lekpharm

  55 UAH order

• Arpeflu table. 50 mg No. 10 Promotion 1+1 Ukraine, Lekpharm

  55 UAH order

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