Dermatologist SM-Doctor told how a teenager can get rid of acne

From this article you will learn:

• Baziron AC gel for acne – composition analysis,
• instructions for use,
• reviews of Baziron AS from dermatologists.

Baziron AS is an antimicrobial drug in the form of a gel for external use, which is intended for the treatment of acne (papulopustular form of acne). The active component of the drug is a bactericidal component such as “benzene peroxide”, which effectively affects the bacteria involved in the formation of acne. These include primarily the bacteria Propionibacterium acnes (P.acnes) and Streptococcus epidermidis.

Reviews from dermatologists about the drug Baziron for acne indicate that this drug is the gold standard for acne treatment. To date, there are no strains of P. acnes or S. epidermidis bacteria that are resistant to benzoyl peroxide, but you should understand that acne cannot be treated with benzoyl peroxide alone. And we will always combine the drug Baziron with topical retinoids (Klenzit or Differin), and sometimes also with antibiotics.

Photos of Baziron AS gel packaging –

The Baziron AS® trademark belongs to a pharmaceutical company (Switzerland), but production is located in Italy. There are 3 versions of the release form - gel with a concentration of benzoyl peroxide of 2.5, 5.0 and 10%. The drug is available over-the-counter and can also be used in patients over 12 years of age.

How much does Baziron AS cost in pharmacies, analogues:

For Baziron AS, the price in pharmacies will average from 800 rubles (per tube of 40 g). It should be noted that all forms of release cost almost the same - regardless of the concentration of benzoyl peroxide. The price is for 2022. This drug has no cheap analogues in Russia, or indeed any direct analogues. Cheaper, you can only buy cleansers with benzoyl peroxide, but this is not very effective and is more suitable for prevention than treatment.

However, there are several combination preparations also for external use, which also contain benzoyl peroxide. This, for example, is the drug “Indoxyl” (Great Britain) - it contains a combination of benzoyl peroxide 5% and the antibiotic clindamycin 1% (it costs 800 rubles per 25 g tube). And the drug Effezel (France) - it contains benzoyl peroxide 2.5% in combination with the retinoid adapalene 0.1%. This drug is already significantly more expensive than Baziron - the price for it will be at least 1,300 rubles (for a 30 g tube).

Indications for use of the drug Baziron:

According to the instructions, it has only 1 indication for use:

• acne.

But the fact is that the indications in the official instructions for use are written incorrectly. The fact is that the term acne can imply the presence of only non-inflammatory elements - acne vulgaris (comedones). Such non-inflammatory elements do not require the use of antimicrobial agents, but are treated only with topical retinoids (Differin, Klenzit) or drugs with azelaic acid (Skinoren, Azelac).

Preparations with benzoyl peroxide are used when there are inflammatory elements (acne). The latter can be either in the form of pustules with pus, or papules without pus. Therefore, the correct indication for the use of Baziron should be “Papulopustular acne of mild, moderate or severe degree.”

Baziron AS: instructions for use, composition

Pharmacological action of the drug Baziron AS:

• Antimicrobial effect - benzoyl peroxide has a pronounced bactericidal effect against all known strains of bacteria Propionibacterium acnes and Streptococcus epidermidis, which play a large role in the development of inflammation and the appearance of inflammatory elements - papules and pustules (i.e. acne).

• Keratolytic effect - the drug dissolves intercellular cement in the stratum corneum of the epidermis and, accordingly, facilitates the desquamation of cells of the stratum corneum. This helps to expand the mouths of the follicles and facilitates the release of fatty secretions (sebum) from them to the surface of the skin.

• Reduces oily skin - according to the instructions for use, the drug suppresses the function of the sebaceous glands, thereby reducing oily skin.
  Reviews on Baziron AC indicate that skin oiliness actually decreases slightly, but why this happens is actually a debatable question. On the one hand, there is no clear evidence in the scientific literature that benzoyl peroxide directly affects the sebocytes of the sebaceous glands, suppressing the hypersecretion of sebum. However, on the other hand, among the auxiliary components of the drug there are substances that simply neutralize the fatty acids themselves on the surface of the skin. And most likely, the reduction in fat content may be associated with this. In addition, drugs with benzoyl peroxide are almost always prescribed only in combination with topical retinoids, which in turn tend to suppress hypersecretion of the sebaceous glands.

• Reduces the content of free fatty acids - this effect is again associated with the antimicrobial activity of the drug.
  The fact is that normally the secretion of the sebaceous glands does not contain free fatty acids (it contains only triglycerides). But when the ducts of the sebaceous glands are colonized by the bacteria P.acnes, the enzymes of these bacteria begin to break down triglycerides into monoglycerides (free fatty acids). As a result, the amount of the latter increases to 20% of the total volume of lipids produced by the sebaceous glands. Free fatty acids are comedogenic, i.e. they promote the formation of fat plugs (comedones) in the follicles. In addition, they change the process of keratinization - not only in the epidermis on the surface of the skin, but also in the depths of the hair follicles. In addition, free fatty acids have so-called “chemotaxis,” which means that they cause the migration of neutrophils to the follicles. In turn, the migration of neutrophils already leads to the formation of papules and pustules (pimples).

Baziron: composition and release form

The main active ingredient is the component “benzoyl peroxide”. There are 3 forms of the drug: the gel can have a concentration of benzoyl peroxide of 2.5%, 5% or 10% (each form is available in 40 g tubes). Externally, the gel has a uniform white color and is easily applied in a thin layer.

Gel composition (in terms of 100 g):

→ Baziron AS official instructions (PDF)

What concentration of gel to choose -

For Baziron AS, the instructions for use do not contain detailed information about what concentration of gel is preferable to use. However, clinical studies have shown that the drug is approximately equally effective at concentrations of 2.5, 5.0 and 10%. But at the same time, skin irritation (contact dermatitis) will be more pronounced, the higher the concentration you use. Therefore, you should not immediately start even with 5.0% concentration.

If you are going to use a drug with benzoyl peroxide, then we recommend starting with a 2.5% gel. This will allow the skin to get used to this component. But in case of repeated courses of therapy, you can safely use 5.0% gel. As for the gel with 10% benzoyl peroxide, in fact it is only present in the instructions and is not sold in pharmacies. This concentration will cause very severe contact dermatitis.

How to apply the drug and how long the course of treatment lasts -

The drug is intended for external use only.
According to the instructions for use, the gel should be applied to the affected areas of the skin 1 or 2 times a day (morning and evening) with light massaging movements. First you need to cleanse the skin with mild detergents and dry it well. The course of treatment is 3 months. The effect of using the drug is usually noticeable within 4 weeks from the start of use. However, in no case should you stop using the drug at this point. To get a lasting effect for a long period of time, you need to complete a full 3-month course of treatment. At the same time, if you managed to achieve the disappearance of acne much earlier than this period, then at some point you can start using the drug only once a day.

Important: but the instructions for Baziron AS are one thing, and international protocols for the treatment of acne (papulopustular acne) are completely different. The instructions are compiled in such a cunning way that a person who decides to self-medicate gets the impression that to treat acne, monotherapy with only one drug, Baziron AS, is sufficient. But this is not at all true, and below we will talk about international acne treatment protocols, which are also used in Russia.

Why do acne appear?

Acne is a serious skin disease that can occur with varying degrees of severity. The following can lead to the development of acne:

• Hormonal changes in the body.
• Poor nutrition (consumption of dairy products, sweets, soda, fast food), as well as taking certain medications. By the way, various steroid drugs, which athletes who visit gyms especially like to take, are dangerous. Muscles will appear along with acne on the face.
• Incorrectly selected care products and external therapy (a number of creams contain substances that can worsen rashes).
• Genetic predisposition plays a big role in the occurrence of acne. It has been proven that if one of the parents suffered from acne, then the child may also develop acne. And if both parents had this disease, then the child is much more likely to also have complexes due to acne.
• Stress associated with passing exams, unrequited love, etc., have a negative impact on the condition of the skin.
• Self-squeezing pimples further aggravates the skin condition. A teenager’s desire to solve problems in such a radical way can lead to irreversible consequences. This is primarily due to the structural features of the pustules. By getting rid of one, you will only contribute to the spread of infection into the deeper layers of the skin, and more pronounced inflammation and even more pimples will most likely appear in this place.
• “Irrational treatment and self-medication can lead to deterioration of the skin condition,” warns the doctor. - Progression of the disease, as well as serious complications, including the appearance of marks (scars) on the facial skin, which the child will then have to live with. Therefore, in case of such problems, you should definitely consult a doctor for an individual selection of treatment.”

Important! Overly clean children also suffer from acne. Often, teenagers, in the fight against acne, begin to fanatically wash their faces and wipe their skin with various lotions. But they usually contain alcohol, which dries the skin and causes active work of the sebaceous glands.

Baziron: reviews of dermatologists about the drug

As we said above, reviews of Baziron AS from dermatologists allow us to deservedly classify this drug as the gold standard for the treatment of acne.
But, only as part of complex therapy! International protocols for the treatment of acne are well described in the most famous textbook on dermatology - Fitzpatrick's Dermatology (we use the 8th edition). What does this textbook tell us? 1) We have already said that acne can be of 2 types. Firstly, these are papules (without pus inside), and secondly, they are pustules with pus. A patient may have both types of acne well expressed at the same time, or one type may dominate the other. And this is very important for us, because... When prescribing a treatment regimen, we will take into account what type of inflammatory elements dominates in the patient.

2) If the patient is dominated by papules, then we will prescribe him the drug Baziron AS once a day (in the morning) + one of the topical retinoids based on adapalene. For example, it could be Differin or Clenzit (optional). Topical retinoids are also used externally once a day, but at night (24stoma.ru).

3) If the patient has pustules with pus, then this is a clear indication for using not only the combination of “benzoyl peroxide + topical retinoid”, but also adding an antibiotic. For mild to moderate severity, the antibiotic is prescribed externally; for severe acne, it is prescribed orally. Thus, for mild to moderate severity, we must use a combination of drugs. And here there are many possible combinations of different drugs.

For example, we can still use the drug Baziron AS 1 time a day (in the morning) + the drug Klenzit-S in the evening (it contains the retinoid adapalene + the antibiotic clindamycin). Another option may involve the use not of Baziron, but of combination drugs where benzoyl peroxide is combined with antibiotics or retinoids. Examples of combination drugs for acne treatment:

• Indoxyl (UK) – benzoyl peroxide 5% + clindamycin 1%.
• Effezel (France) – benzoyl peroxide 2.5% + retinoid adapalene 0.1%.

Those. we can, for example, use the combination drug Indoxyl once a day (in the morning), and in the evening use one of the topical retinoids (Differin or Clenzit - to choose from). Another option is that we can use the combined drug Effezel once a day (in the evening), but in the morning of that day we then have to use one of the antibiotic gels - it could be Dalatsin, Clindavit or others. As you can see: the abundance of different drugs gives us room for maneuver.

Important: But we want to assure you that acne treatment is not limited to just prescribing benzoyl peroxide, topical retinoids or antibiotics. Phototherapy, laser treatment, and in women, oral contraceptives to reduce the production of androgens can play a major role in treatment. You can read about all these methods using the links below.

→ International acne treatment protocols → Acne treatment protocols

Where to start caring for a cosmetologist?

With skin cleansing (superficial and deep) depending on skin type, which is determined after examination through a magnifying glass.
Cleaning is carried out in several stages: cleansing with foam, disinfection with antiseptics, skin peeling, mechanical cleaning, applying a mask. The frequency of procedures is strictly individual and depends on the severity of the condition, skin type, season, effect of therapy and other factors. Typically, the course of treatment with timing and procedures is discussed at an appointment with a doctor. On average, facial cleansing is carried out once every 2-3-4 months. If this is a course of chemical peelings, then the procedure is usually carried out (also depending on the type of peeling) once every 2 weeks. A total of 3-5 procedures are required.

Perhaps a visit to a cosmetologist will not be enough; to combat acne you will have to involve other specialists: a dermatologist, gynecologist, gastroenterologist, endocrinologist. Acne treatment should ideally begin with a diagnosis of the body. You will need to take a general blood test, a stool test for dysbacteriosis, microscopy of skin scrapings and a number of other studies.

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Side effect of the drug -

When using the drug, local skin irritation is possible, which is normal. Frequent symptoms of irritation include flaking and dry skin, redness, and a burning sensation. More rare symptoms include skin soreness and contact dermatitis. Rarely, allergic contact dermatitis may occur, which will require discontinuation of the drug.

In order to prevent or reduce the symptoms of irritation, we recommend that you start using Baziron AS with a 2.5% concentration of benzoyl peroxide. If symptoms of irritation do occur, then within 1-2 weeks you can switch to a single use of the drug (once a day), then returning to use 2 times a day (of course, if this was initially necessary).

Important : Benzoyl peroxide increases skin sensitivity to the sun. This means that when using the drug during periods of high solar activity, hyperpigmentation of the skin in the areas where the drug is applied is highly likely. Therefore, you will need to use sun protection products - no less than SPF 50; face-shading glasses, a Panama hat or a cap will also be useful. Let us remind you that products with SPF must be non-comedogenic (not clog pores), otherwise we will get an exacerbation of acne.

A good product SPF 50 for acne (in the form of a suspension) –

Contraindications for use –

• allergy to one of the components of the drug,
• children's age up to 12 years.

Special instructions - the drug can only be applied to the skin (not to the mucous membrane and red border of the lips). In case of contact with the mucous membranes of the nose, eyes, or mouth, rinse immediately with water. In addition, it is undesirable to use Baziron AC in parallel with products that have a drying, exfoliating effect, or alcohol-based products, because this will increase the irritant effect of the drug.

Use during pregnancy and lactation –

The drug has extremely low absorption from the surface of the skin, due to which it practically does not enter the bloodstream and does not have a systemic effect on the body. However, a large amount of breakdown products of benzoyl peroxide, namely benzoic acid, enters the body. No safety studies have been conducted during pregnancy and lactation. We hope that our article on the topic: Baziron AS price reviews was useful to you!

Sources:

1. Textbook on dermatology “Fitzpatrick's Dermatology” (8th edition), 2. “Etiology, pathogenesis, classification and clinical picture of acne vulgaris” (Barinova A.N.), 3. “Acne from the position of evidence-based medicine” (Anisimova M. .Yu.), 4. “Modern methods of treatment and rehabilitation of patients with acne vulgaris” (Barinova A.N.).