Cefodox, Cefpodoxime, tab. 200 mg No. 6 – Instructions

Compound

The tablets contain the active substance cefpodoxime , as well as a number of auxiliary components: iron oxide, croscarmellose sodium, Opadry OY-L white, microcrystalline cellulose, magnesium stearate , sodium starch glycolate , sodium lauryl sulfate , silicon dioxide .
The composition of the powder from which the suspension is prepared includes the active substance cefpodoxime , as well as additional ingredients: simethicone emulsion , sodium saccharin , carboxymethylcellulose , hydroxypropylcellulose , xanthan dextrin , citric acid , corn starch , microcrystalline cellulose , vanillin flavor , sucrose , silicon dioxide , flavoring .

pharmachologic effect

Cefodox is a semisynthetic antibiotic that belongs to the third generation of cephalosporin drugs. Its bactericidal effect on the body is determined by the ability to acetylate membrane transpeptidases of the cell walls of microorganisms. As a result, the disruption of the formation of microbial cell walls is eliminated.

High sensitivity to Cefodox is observed in many gram-negative microorganisms (Escherichia coli, Klebsiella spp., Proteus mirabilis, Haemophilus influenzae, Serratia spp., Providencia spp., Pseudomonas spp., Citrobacter spp.), as well as in some gram-positive microorganisms . Low sensitivity to the drug is observed in insensitive anaerobes. The active substance of the drug has no effect on most strains of clostridia , enterococci , legionella , mycoplasma , chlamydia , as well as methicillin-resistant strains of staphylococci .

Pharmacological properties of the drug Cefodox

cefpodoxime (1-(isopropoxycarbonyloxy)ethyl (6R, 7R)-7-[2-(2-amino-4-thiazolyl)-(z)-2-(methioxyimino)acetamido]-3-methoxymethyl-3-cephem- 4-carboxylate) is a cephalosporin antibiotic. Active against many gram-positive and gram-negative microorganisms: Staphylococcus aureus (including penicillinase-forming, but not methicillin-resistant strains), Staphylococcus saprophyticus, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus spp. (groups C, F, G), Escherichia coli, Haemophilus influenzae (including strains producing β-lactamases), Klebsiella pneumoniae, Moraxella catarrhalis, Neisseria gonorrhoeae (including penicillinase-producing strains), Proteus mirabilis, Citrobacter diversus, Haemophilus parainfluenzae, Klebsiella oxytoca, Proteus vulgaris, Providencia rettgeri, anaerobes ( Peptostreptococcus magnus ). Cefpodoxime proxetil is absorbed in the digestive tract and deesterified to form cefpodoxime. After taking a dose of 100 mg, 50% is absorbed, the maximum concentration in the blood serum is reached after 2-3 hours and is 1.4 mcg/ml. Simultaneous ingestion of food increases the maximum concentration, but does not increase the time to achieve it when using tablets and increases the time to achieve it, but not the maximum concentration when using a suspension. Binds to plasma proteins (20–30%). Penetrates into liquids and tissues (including tonsils and lungs), forming in them a concentration exceeding MIC50 for most microorganisms. The half-life is 2.09–2.84 hours. About 30–35% of the dose is excreted unchanged in the urine within 12 hours. If renal function is impaired, excretion decreases: with a creatinine clearance of 50–80 ml/min, the half-life is 3. 5 hours, 30–49 ml/min – 5.9 hours, 5–29 ml/min – 9.8 hours.

Indications for use

The drug is used for infectious diseases that are caused by microorganisms that are highly sensitive to Cefodox:

• tonsillitis , sinusitis , laryngitis , otitis media , pharyngitis ;
• bronchitis , pneumonia ;
• pyelonephritis , cystitis (mild or moderate disease);
• infectious lesions of joints, skin, soft tissues, bone tissue;
• proctitis , urethritis , cervicitis , which is of gonococcal origin.

Instructions for use of Cefodox (Method and dosage)

The instructions for Cefodox stipulate that the antibiotic is taken by adults and adolescents over 12 years of age at a dose of 200-400 mg.

Instructions for use of Cefodox 200 stipulate that for infectious diseases of the human genitourinary system and upper respiratory tract, the daily dose is 200 mg of the drug, for bronchitis or pneumonia - 400 mg of the drug. Depending on the dosage, tablets are taken 1-2 times a day. The duration of treatment depends on the characteristics of the disease and is determined by a specialist. Elderly people do not need to adjust the daily dose of Cefodox.

To prepare the suspension, you must initially shake the bottle thoroughly, then add cold, boiled water until the liquid reaches the mark indicated on the bottle. You need to add water in two steps, shaking the bottle periodically so that the mass becomes homogeneous. A homogeneous suspension can be used five minutes after its preparation. Each time before taking, you need to thoroughly shake the bottle of suspension.

If Cefodox 100 suspension is prescribed, the instructions indicate that the drug should be taken simultaneously with food. The interval between doses should be 12 hours. The suspension is prescribed to children from the age of five months, with the daily dose of the drug being 10 mg of suspension per 1 kg of the child’s weight. The maximum dose per day is 400 mg. The drug must be taken in two doses, since the largest single dose is 200 mg.

Cefodox, Cefpodoxime, tab. 200 mg No. 6 – Instructions

Compound

The main active ingredient is cefpodoxime.
Other ingredients: magnesium stearate, calcium carmellose, hydroxypropyl cellulose, sodium lauryl sulfate, lactose, titanium dioxide, talc, hypromellose.

Release form

The drug is in the form of tablets. Supplied in packs of 6 pieces each.

pharmachologic effect

The bactericidal effect of the drug on the body develops due to the ability to acetylate transpeptidase in the membranes of bacterial cells. As a result, the formation of microbial cell walls is disrupted.

Many gram-negative bacteria (eg, Klebsiella, Providencia, E. Coli and, in addition, Proteus mirabilis, Serratia, Pseudomonas, Haemophilus and Citrobacter) are seriously susceptible to Cefodox, as well as some gram-positive bacteria

Anaerobic anaerobes exhibit low sensitivity.

Many strains of streptococci Clostridium, Mycoplasma and Chlamydia, Legionella, as well as relatively stable strains of methicillin Staphylococcus, are resistant to the drug.

Pharmacokinetics

The drug is actively absorbed in the digestive system.

The bioavailability of the substance is approximately 52%. The medicinal component secretly penetrates into most tissues, accumulating in them. Accumulation of cefpodoxime is found in the lungs, liver, muscles, bones and kidneys. In addition, through the abscess capsules it enters the cerebrospinal fluid. The substance does not affect metabolism.

Excreted through the kidneys.

Indications for use

Cefodox is used to treat infectious pathologies that develop due to the action of microorganisms hypersensitive to the drug:

1. sinusitis with laryngitis and tonsillitis, as well as pharyngitis and otitis media;
2. pneumonia or bronchitis;
3. pyelonephritis or cystitis (moderate to mild);
4. infections affecting the epidermis, bones and soft tissues, as well as joints;
5. urethritis with proctitis, in addition, cervicitis of gonococcal etiology.

Contraindications

Use is contraindicated for people with hypersensitivity to the components of the drug.

Side effects

The use of the drug may cause the following side effects:

• the appearance of nausea, diarrhea or vomiting;
• development of headaches;
• development of rash or itching;
• increased values ​​of plasma creatinine with urea;
• increased activity of liver transaminases;
• violation of leukocytopoiesis or thrombocytopoiesis;
• development of eosinophilia.
• Compatibility with other medications

The use of antacids, as well as agents that block the activity of H2-ends, together with Cefodox leads to weaker absorption of the latter.

When combining the drug with nephrotoxic drugs, renal function should be constantly monitored.

The combination of the drug with probenecid increases the value of cefpodoxins in the blood plasma.

Application and dosage

Antibiotic tablets can be prescribed to adolescents over 12 years of age, as well as adults. Dosage 0.2-0.4 g.

When treating diseases of the genitourinary system or upper respiratory tract of infectious origin, 0.2 g of the drug per day is prescribed. For the treatment of pulmonary pneumonia or bronchitis, 0.4 g of the substance is taken. Considering the serving size, take the drug 1-2 times a day.

Overdose

As a result of poisoning, the following symptoms may occur: diarrhea with nausea or vomiting. In people with renal failure, encephalopathy may occur, which disappears when plasma markers of the drug decrease.

To eliminate an overdose, gastric lavage is necessary, as well as hemodialysis and symptomatic therapy.

special instructions

The duration of the treatment cycle depends on the nature of the pathology and is chosen by the doctor.

Use during pregnancy and breastfeeding

Due to the fact that adequate studies of the drug’s effect on pregnant women have not been conducted, it can be prescribed only to women at certain times with strict indications.

Since the active substance of the drug accumulates in breast milk, breastfeeding should be avoided during therapy.

Impact on the ability to drive vehicles and operate machinery

No special precautions are required.

Terms of sale

As prescribed by the doctor.

Storage conditions

In a dry, cool place with limited access for children.

special instructions

People who are allergic to other cephalosporins should be aware of the possibility of developing a cross-allergy to cefpodoxime. If there is a history of hypersensitivity to cephalosporins, the drug should not be prescribed, as the reaction can be severe and sometimes fatal.

For people suffering from gastrointestinal diseases, antibiotics should be prescribed with caution, since microflora disturbances can provoke the development of diarrhea.

With long-term treatment with cefpodoxime, there may be an excessive increase in resistant microorganisms.

During antibiotic , dizziness may periodically occur, which, in turn, can affect the ability to drive and operate major machinery.

Cefodox powder for oral suspension 100 mg/5 ml 50 ml No. 1

Contraindications

Hypersensitivity to drugs from the group of cephalosporins, penicillins, or any components of the drug. Hereditary fructose intolerance or sucrase-isomaltase deficiency.

Interaction with other drugs and other types of interactions

Co-administration of high doses of antacid drugs (sodium bicarbonate and aluminum hydroxide) or H2-receptor blockers leads to a decrease in the degree of absorption by 27-32%, and Cmax by 24-42%. Oral anticholinesterase agents increase Tmax by 47%, but do not affect the extent of absorption. If it is necessary to use it together with ranitidine, the drug should be taken 2-3 hours after taking ranitidine.

Cephalosporins potentially increase the anticoagulant effect of coumarins and reduce the effect of estrogens.

The bioavailability of cefpodoxime is increased when taken with food.

When determining glucosuria using copper reduction methods (Benedict, Fehling), a false positive reaction may be observed, but this does not affect the determination of glucose in urine using enzymatic methods.

Concomitant use of the drug with loop diuretics may increase nephrotoxicity. Close monitoring of renal function is recommended if Cefodox is administered concomitantly with drugs that exhibit nephrotoxic effects. Plasma levels of cefpodoxime are increased when administered with probenecid.

Features of application

Hypersensitivity reactions.

Due to cross-hypersensitivity, before starting treatment, it should be established whether the patient has a history of severe hypersensitivity reactions to cephalosporin or penicillin antibiotics. If an allergic reaction to cefpodoxime develops, you should stop using the drug. Allergic reactions (especially anaphylaxis) observed with the use of beta-lactam antibiotics can be severe and in some cases fatal (see section "Adverse Reactions").

Spectrum of antibacterial activity.

Cefodox is not a primary antibiotic in the treatment of staphylococcal pneumonia and should not be used in the treatment of atypical pneumonia caused by bacteria such as Legionella, Mycoplasma and Chlamydia.

Effect on kidney function.

In patients with renal failure, the dosage regimen should be adjusted depending on creatinine clearance (recommended doses are shown in Table 1). When using Cefodox in combination with aminoglycosides or strong diuretics, renal function may deteriorate. During treatment, it is recommended to monitor kidney function indicators.

Colitis/overgrowth of non-susceptible microorganisms.

Adverse reactions from the digestive tract (for example, vomiting, nausea, abdominal pain) may occur. Antibiotics should always be prescribed with caution to patients with gastrointestinal diseases, especially those with colitis.

When treated with cefpodoxime and other broad-spectrum antibiotics, an imbalance in the intestinal microflora can lead to diarrhea, colitis, including pseudomembranous colitis caused by Clostridium difficile toxin. These adverse reactions, which may occur more frequently in patients treated with large doses of cefpodoxime for a long time, should be considered potentially severe.

It is necessary to do a test for the presence of Clostridium difficile. If colitis is suspected, use of the drug should be stopped immediately. It is necessary to confirm the diagnosis by sigmoidoscopy and rectoscopy and, if clinically necessary, prescribe another antibiotic (vancomycin). The use of medications that cause fecal retention should be avoided.

Long-term use of cefpodoxime can lead to excessive growth of insensitive microorganisms, including disruption of the normal intestinal microflora, which can lead to excessive growth of Candida, and the development of candidiasis of the oral mucosa (see Section "Adverse Reactions"). If superinfection occurs, it is necessary to assess the patient's condition and prescribe appropriate treatment.

Effect on the blood system.

When using beta-lactam antibiotics, neutropenia and agranulocytosis may develop, especially with long-term use of antibiotics. If neutropenia develops, treatment with Cefodox should be discontinued.

Impact on the results of serological studies.

When using cefpodoxime, the Coombs test may give false-positive results. A decrease in hemoglobin levels may also be observed, and very rarely cases of hemolytic anemia are possible.

Use during pregnancy or breastfeeding.

The drug is intended for use in children.

The ability to influence the reaction rate when driving vehicles or other mechanisms.

The drug is intended for use in children.

Directions for use and doses

Cefodox suspension is intended for use in pediatrics. The prepared suspension should be taken orally with meals to enhance absorption.

For children aged 5 months to 12 years, the drug is prescribed at a dose of 10 mg/kg body weight per day (maximum daily dose - 400 mg), which should be administered in 2 doses with an interval of 12:00 (maximum single dose - 200 mg). The duration of treatment depends on the severity of the disease and is determined individually.

Liver dysfunction.

There is no need to change doses for children with liver failure.

Renal dysfunction.

There is no need to change the dose of Cefodox if the creatinine clearance is ˃ 40 ml/min.

If the creatinine concentration is below 40 ml/min, pharmacokinetic studies indicate an increase in half-life and maximum plasma concentration, so the dose of the drug should be adjusted.

Table 1

Patients on hemodialysis are prescribed a single dose calculated depending on body weight after each dialysis session.

Instructions for preparing the suspension

To prepare the suspension, you need to turn the bottle over and shake vigorously to loosen the powder, add boiled water, cooled to room temperature, in 2 additions to the line on the bottle (mark), shaking vigorously each time until a homogeneous suspension is formed. The volume of the finished suspension should reach the line (mark) on the bottle. The suspension can be taken no earlier than 5 minutes after preparation. Before each dose, the prepared suspension must be shaken thoroughly. After preparation, the finished suspension should be stored in the refrigerator for no more than 14 days.

A measuring spoon is included for measuring the suspension.

Children.

The drug is prescribed to children aged 5 months to 12 years.

Overdose

Symptoms: nausea, vomiting, abdominal pain, diarrhea. In case of overdose, especially in patients with renal failure, encephalopathy may occur. Cases of encephalopathy are usually reversible with low plasma levels of cefpodoxime.

Treatment. Hemodialysis, peritoneal dialysis. Features of application.

Adverse reactions

The following classification of the frequency of occurrence of adverse reactions is used: very often (³ 1/10), often (³ 1/100, <1/10), infrequently (³ 1/1000, <1/100), rarely (³ 1/10000, <1/1000), very rare (<1/10000).

Infections and infestations: rarely - superinfection caused by certain fungi of the genus Candida, insensitive to cefpodoxime; very rarely - colitis associated with the use of antibiotics.

From the blood and lymphatic system: rarely - eosinophilia; very rarely - leukopenia, hemorrhage, neutropenia, thrombocytopenia, thrombocytosis, positive Coombs test, agranulocytosis, serum sickness, decreased hematocrit, decreased hemoglobin concentration, hemolytic anemia, increased thrombin and prothrombin time, leukocytosis, lymphopenia, lymphocytosis.

From the immune system: rarely - hypersensitivity, anaphylactic reactions, angioedema.

Metabolism disorders: rarely - dehydration, gout, peripheral edema, weight gain.

From the musculoskeletal system and connective tissue: rarely - myalgia, arthralgia.

From the nervous system: infrequently - cephalalgia; rarely - vertigo; very rarely - dizziness, unsteadiness of gait, headache, weakness, insomnia, drowsiness, sleep disturbance, neurosis, irritability, nervousness, anxiety, unusual dreams, blurred vision, confusion, nightmares, paresthesia.

From the respiratory system, chest and mediastinal organs: rarely - asthma, bronchitis, cough, nosebleeds, sneezing, rhinitis, wheezing, shortness of breath, bronchospasm, sinusitis, pleural effusion, pneumonia.

Gastrointestinal disorders: uncommon - abdominal pain, nausea rare - diarrhea, feeling of thirst, tenesmus, bloating, vomiting, dyspepsia, dry mouth, decreased appetite, feeling of pressure/fullness in the stomach, constipation, candidal stomatitis, toothache, anorexia, belching, gastritis, mouth ulcers, pseudomembranous colitis.

Digestive system disorders: rarely - cholestatic liver damage, increased liver function tests AST, ALT, alkaline phosphatase, bilirubin levels.

From the skin and subcutaneous tissue: rarely - rash, redness, itching, urticaria, increased sweating, macular rashes, fungal dermatitis, peeling, dry skin, hair loss, vesicular rashes, solar erythema, purpura, bullous reactions (including Stevens-Johnson syndrome ), toxic epidermal necrolysis, erythema multiforme.

From the urinary system: rarely - hematuria, urinary tract infections, metrorrhagia, dysuria, frequent urination, nocturia, infections of the male genital organ, proteinuria, vaginal pain, vaginal candidiasis.

In isolated cases of renal dysfunction.

Vascular disorders: rarely - congestive heart failure, tachycardia, vasodilation, hematoma, migraine, hypertension or hypotension.

On the part of the organ of vision: eye irritation.

On the part of the hearing and vestibular apparatus: tinnitus.

General disorders: rarely - discomfort, fatigue, asthenia, chills, drug fever, chest pain (pain may radiate to the lower back), fever, generalized pain, localized edema, localized pain, impaired taste, abscess, allergic reaction, facial edema , candidiasis, bacterial infections, parasitic infections.

Biochemical tests: hyper- or hypoglycemia, hypoalbuminemia, hypoproteinemia, hyperkalemia, hyponatremia.

Research: increased levels of urea and creatinine.

Best before date

2 years (unopened bottle).

After preparation, store the prepared suspension for no more than 14 days in the refrigerator.

Storage conditions

Store at a temperature not exceeding 30 ° C.

Keep out of the reach of children.

Package

Dry powder in a bottle. 1 bottle with dispenser spoon in a cardboard box.

Vacation category

On prescription.

Manufacturer

Pharma International.

Manufacturer's location and address of place of business

Al Qastal, Airport Road, A.S. 334, Al Jubayha 11941, Amman, Jordan.

Applicant

Pharma International.

Applicant's location

A.S. 334 Al Jubayha 11941 Amman, Jordan.

Analogues of Cefodox

Level 4 ATC code matches:
Cephosin

Lendatsin

Medakson

Loprax

Ceftriaxone

Cefixime

Lorakson

Sulperazon

Cefoperazone

Rocephin

Tsedex

Fortum

Ceftazidime

Cefotaxime

Cefix

Ceforal Solutab

Pantsef

Claforan

Suprax Solutab

Similar drugs are medicines that contain the same active substance. In pharmaceutical networks you can buy analogues of Cefodox - the drugs Doccef , Cefpotek , Axef , Zinacef , Zocef , etc. However, you should not independently replace the drug prescribed by your doctor with its analogues.

Reviews of Cefodox

Adult patients, as well as parents who have used Cefodox for children, leave mostly positive reviews online. In particular, the drug has a rapid effect on infectious diseases of the upper respiratory tract, as well as bronchitis and other infections. The reviews talk about the rapid disappearance of symptoms - high temperature, pain, etc.

Side effects after taking the drug are very rare. The inconvenience of using the suspension bottle and dispenser is noted as a negative impression.

Cefodox tablets 200 mg, 10 pcs.

Approximately 5-10% of patients with a penicillin allergy have a cross-reaction to cephalosporins, so before prescribing cephalosporins, it is necessary to determine the patient's possible allergy to penicillin and ensure careful medical supervision from the first day of cefpodoxime use. At the first signs of an anaphylactic reaction, you should stop using the drug.

Cefpodoxime is not recommended for use in patients with hypersensitivity to cephalosporin antibiotics. Allergic reactions (especially anaphylaxis) that occur with beta-lactam antibiotics can be severe and, in rare cases, fatal.

At the first signs of an allergic reaction when using the drug, you should stop taking it and consult a doctor.

If exudative erythema multiforme, Stevens-Johnson syndrome, or Lyell's syndrome appear, the drug should be discontinued.

Cefpodoxime is not an antibiotic for the treatment of staphylococcal pneumonia, and it should not be used to treat atypical pneumonia caused by Legionella, Mycoplasma and Chlamydia microorganisms.

When using the drug, adverse reactions from the digestive tract are possible, including nausea, vomiting, abdominal pain, so cefpodoxime should be prescribed with caution to patients with a history of gastrointestinal diseases, especially colitis. The use of cefpodoxime may lead to the development of diarrhea, antibiotic-associated colitis and pseudomembranous colitis. These adverse reactions, which may occur more frequently in patients treated with large doses of cefpodoxime for a long time, should be considered potentially severe.

It is necessary to conduct a test for the presence of Clostridium difficile. If colitis occurs, treatment with cefpodoxime should be stopped immediately, sigmoidoscopy should be performed and, if further treatment is necessary, appropriate therapy (vancomycin) should be prescribed. Foods that cause constipation should be avoided. Although any antibiotic can cause pseudomembranous colitis, the risk is greater with broad-spectrum drugs such as cephalosporins.

When using beta-lactam antibiotics, neutropenia and agranulocytosis may develop, especially during long-term treatment. If the drug is used for more than 10 days, blood tests should be monitored, and if neutropenia develops, treatment with cefpodoxime should be discontinued.

When treated with cefpodoxime, a positive Coombs test and, very rarely, hemolytic anemia may occur. In these reactions, there is cross-resistance between cephalosporins and penicillins.

Changes in renal function have been observed with simultaneous use with aminoglycosides or strong diuretics, in which case monitoring of renal function is necessary.

Long-term use of cefpodoxime may lead to overgrowth of non-susceptible microorganisms. If superinfection occurs, it is necessary to assess the patient's condition and prescribe appropriate treatment.

This medicine contains lactose. If the patient has an intolerance to certain sugars, a doctor should be consulted before taking this medicine.

Cefodox price, where to buy

The price of Cefodox 200 (14 pcs.) in Russia is about 1600-1700 rubles. The price of Cefodox 100 in Ukraine (Kyiv, Kharkov, Dnepropetrovsk, etc.) averages 130-150 UAH. Powder for preparing a 100 mg suspension can be purchased for an average of 150 UAH.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine

LuxPharma* special offer

• Cefodox (Cefpodoxime) tab.
  200 mg No. 6 1990 rub. order

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