Cerebrum Compositum N 2.2 ml N5 injection solution

Compound

Side effects

Allergic reactions are possible, incl. skin allergic reactions. With known individual sensitivity to plants of the Asteraceae family, hypersensitivity reactions (including anaphylactic reaction) may occur. Temporary redness, swelling and pain at the injection site. In very rare cases, after taking drugs containing quinine, allergic skin reactions or feverish conditions (hypersensitivity reactions) may occur. If side effects occur, you should stop taking the drug and consult your doctor.

Cerebrum Compositum N ampoules 2.2 ml No. 5

A country

Germany
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.

Compound

per ampoule 2.2 ml (=2.2 g): Active components: Cerebrum Suis D8 22 µl, Embryo totalis suis D10 22 µl, Hepar suis D10 22 µl, Placenta totalis suis D10 22 µl, Kalium phosphoricum D6 22 µl, Selenium D10 22 µl, Thuja occidentalis D6 22 µl, Strychnos ignatia D8 22 µl, Bothrops lanceolatus D10 22 µl, Acidum phosphoricum D10 22 µl, Cinchona pubescens D4 22 µl, Sulfur D10 22 µl, Kalium bichromicum D8 22 µl, Gelsemium sempervirens D4 22 µl, Ruta graveolens D4 22 µl, Arnica montana D28 22 µl, Aesculus hippochestanum D4 22 µl, Manganum phosphoricum D8 22 µl, Magnesium phosphoricum D10 22 µl, Semecarpus anacardium D6 22 µl, Conium maculatum D4 22 µl, Medorrhinum- Nosode D13 22 µl , Hyoscyamus niger D6 22 µl, Aconitum napellus D6 22 µl, Anamyrtha cocculus D4 22 µl, Ambergris grisea D10 22 µl;
Excipients: sodium chloride qs to establish isotonia about 9 mg/ml, water for injection up to 2.2 ml.

Description

Colorless, transparent, odorless liquid.

Pharmacotherapeutic group

Homeopathic remedy

pharmachologic effect

A multicomponent homeopathic medicine, the effect of which is determined by the components included in its composition.

Indications for use

Encephalopathy of various origins (disorders of memory, attention); stimulation of regeneration processes and nonspecific immunity.

Contraindications

Increased individual sensitivity to the components of the drug. Known hypersensitivity to quinine. Children under 18 years of age due to insufficient clinical data.

Use during pregnancy and lactation

The use of the drug is possible if the expected benefit to the mother outweighs the potential risk to the fetus and child. A doctor's consultation is required.

Directions for use and doses

Intramuscularly, intradermally, subcutaneously, 1 ampoule 1-3 times a week. The course of treatment is 4-6 weeks. Repeated courses of treatment are possible after agreement with the attending physician. The contents in the ampoule head should be shaken off by lightly tapping. After this, break off the upper part of the ampoule by pressing where the colored dot was applied.

Side effect

Allergic reactions, including allergic skin reactions, are possible. With known individual sensitivity to plants of the Asteraceae family, hypersensitivity reactions (including anaphylactic reactions) may occur. Temporary redness, swelling and pain at the injection site. In very rare cases, allergic skin reactions or feverish conditions (hypersensitivity reactions) may occur after taking medications containing quinine. If side effects occur, you should stop taking the drug and consult your doctor.

Overdose

Cases of overdose have not been reported to date.

Interaction with other drugs

The use of homeopathic medicines does not exclude treatment with other medicines.

special instructions

When taking homeopathic medicines, existing symptoms may temporarily worsen (primary worsening). In this case, you should stop using the drug and consult your doctor.

Impact on the ability to drive vehicles and machinery

The drug does not affect the ability to perform potentially hazardous activities that require increased concentration and speed of psychomotor reactions (driving vehicles, working with moving mechanisms, working as a dispatcher, operator).

Release form

Homeopathic solution for injection. 2.2 ml in ampoules made of colorless glass of hydrolytic class 1. Each ampoule has a notch and a colored dot. 5 ampoules are placed in an open plastic blister pack. 1 or 20 open plastic blister packs with 5 or 100 ampoules are placed together with instructions for use in a cardboard pack.

Storage conditions

Store in a place protected from light, at a temperature not exceeding 30 °C. Keep out of the reach of children!

Best before date

5 years. Do not use after the expiration date indicated on the package!

Dispensing conditions in pharmacies

On prescription

special instructions

When taking homeopathic medicines, existing symptoms may temporarily worsen (primary deterioration). In this case, you should stop using the drug and consult your doctor.

Impact on the ability to drive vehicles and operate machinery. The drug does not affect the performance of potentially hazardous activities that require special attention and quick reactions (driving a car and other vehicles, working with moving mechanisms, working as a dispatcher and operator, etc.).

The attitude of the broad mass of doctors towards homeopathy is ambiguous: from benevolently interested to irritably skeptical. The latter especially applies to psychiatrists, who look at homeopathic therapy with a certain wariness, believing that ultra-low doses are unacceptable in psychiatry, and the principle of similarity is applicable only to intoxication psychoses. However, every year interest increasingly prevails over skepticism, since a huge arsenal of psychopharmacological agents is not always able to cope with mental disorders, and often psychopharmacotherapy itself becomes the cause of new types of pathology. In psychiatry, there are increasingly calls to compare the benefits and harms caused by psychopharmacological treatment, and to be guided by this principle in the treatment of each individual patient.

In their practice, homeopathy (usually in its modern form, which consists in prescribing complex drugs according to the stated indications for use, and not in the form of classical monogomoeopathy) is used by 25% of doctors in Germany, 45% of doctors in England, 32% in France.

In the USA in the 1980s. Sales of homeopathic medicines increased by 500%. In 1995, the Ministry of Health of the Russian Federation also legalized the use of homeopathic methods in medical practice.

However, the use of classical homeopathy for the treatment of mental illness does present some difficulties due to the need for the patient’s active participation in treatment, adherence to a certain therapeutic discipline when using several single homeopathic remedies, which is not always possible in cases of mental pathology. In addition, the long duration of treatment and the delayed onset of effect also did not contribute to the spread of homeopathy in psychiatry.

The situation changed after Dr. H.-H. Reckeweg in Germany in the 1960s. The doctrine of homotoxicology was developed, which essentially combined homeopathy and allopathy. The idea that diseases arise as biologically expedient protective actions of the body directed against endogenous and exogenous homotoxins does not contradict existing theories of the occurrence of mental disorders. Moreover, for a long time there was even a theory of the toxic origin of schizophrenia, and epidemiological studies of recent decades have stated the possibility of an increase in the number of cases of schizophrenia under the influence of changed environmental conditions.

In turn, borderline neuropsychiatric disorders are, as it were, nonspecific precursors of the initial phase of various pathological processes (including exogenous toxic ones) and can be associated with autoimmune processes, the formation of endogenous toxins and retoxins.

Proposed by H.-H. Reckeweg's 6-phase pathway of interaction between homotoxins and the body can also be applied to the clinical and pathogenetic mechanisms of mental disorders. Thus, neurotic conditions, as well as acute intoxication disorders, can be attributed to the humoral stages of the pathological process, while chronic forms of schizophrenia, debilitating processes and neuroleptic syndromes are the cellular phases of the disease. Here it is appropriate to recall that the idea of ​​a single psychosis, in which individual nosological forms are only stages of the development of a single disease process, has been expressed more than once. One of the greatest neurochemists of our time, Professor N.M. van Praag, believes that individual psychiatric nosologies can be different forms of reactions.

The great merit of H.-H. Reckeweg not only created the theory of homotoxicology, but also developed a number of complex drugs called antihomotoxic. They take into account the possibilities of potentiation, synergism and counteraction of individual components. But the most important thing is that complex preparations can be prescribed not only for homeopathic symptoms, but also depending on the allopathic diagnosis and the phase in which the process is located. A priori, it can be assumed that antihomotoxic drugs can be used in psychiatry for detoxification, stimulation of the body's defenses, and restoration of impaired regulatory processes.

The most studied of the antihomotoxic drugs, the use of which is effective for mental disorders, is Cerebrum compositum N. The drug contains 26 components of plant, mineral and animal origin. More than 10 works published only in Russian in recent years have been devoted to the study of the action of Cerebrum compositum N. According to a multicentric study by M. Weiser and S. Zenner [4], based on the treatment of 731 patients with various, incl. mental illnesses, the drug is indicated for various disorders of brain function, and its action is aimed at preventing atherosclerotic circulatory disorders that cause weakening of brain activity. The authors identified clinical groups of patients with nervous exhaustion, memory loss, atherosclerosis, depression, and conditions after a concussion. The greatest effectiveness of the drug Cerebrum compositum N was noted in conditions after a concussion - 98% of the results were rated as good or excellent, with nervous exhaustion - 95%, with depression - 91%, with weakened memory - 90%, with states of excitement - more 90%, with vegetative dystonia - more than 95% of good and excellent grades.

Subsequent studies of the therapeutic activity of the drug Cerebrum compositum N deepened knowledge about its action and expanded the indications for its use.

In the study by S.E. Fursova [5] noted that the most clinically pronounced effect of Cerebrum compositum N in patients with asthenic disorders of various origins was anti-asthenic and psychostimulating effects, manifested in a decrease in feelings of weakness, fatigue, daytime sleepiness, the appearance of physical vigor, increased initiative and performance. Along with this, a decrease in anxiety, irritability, affective instability, and hyperesthesia was noted. Analysis of clinical, psychological, encephalo- and rheographic data allowed the authors [6] to suggest that the target for the drug Cerebrum compositum N is primarily anxiety, the reduction of which determines the further reduction of all other neurotic symptoms, incl. vegetative disorders. However, the authors do not deny the direct anti-asthenic effect of the drug, which is confirmed not only by the subjective change in the condition of patients, but also by changes in psychological testing indicators in critical sections of the performance curve for asthenic syndrome - in the phases of workability and fatigue.

The antiasthenic, redynamizing effects of the drug Cerebrum compositum N were also noted in the works of G.A. Zubovsky [7, 8], V.V. Nikolaev [18], who drew attention to the positive effect of the drug on mnestic functions, attention and the ability to concentrate. The effect of Cerebrum compositum N on short-term memory is especially pronounced, in which, in particular, the function of retaining traces significantly improves.

An electroencephalographic study of Cerebrum compositum N revealed a statistically significant decrease in spectral density in the narrow-band spectrum of the EEG electroencephalogram. Moreover, a comparison of the EEG profile of Cerebrum compositum N and some nootropics and tranquilizers made it possible to classify the drug as a mild antipsychotic with an anticholinergic component and antidepressant properties. G.A. Zubovsky, N.B. Kholodova et al. [8] claim that under the influence of treatment with this drug in patients with vascular pathology of the brain, not only positive clinical dynamics are observed, but also cortical irritation decreases and the severity of paroxysmal forms of activity decreases, and cortical rhythms are normalized.

The drug has a mild modulating effect on monoamine metabolism without causing depletion of neurotransmitter systems. The drug has an asymmetrical effect on the cerebral hemispheres: on the right - light sydnocarb-like, on the left - obsidan-like. The effectiveness of the drug Cerebrum compositum N is also confirmed by rheoencephalography data. During the treatment process, pulse blood filling and the intensity of venous outflow change, as evidenced by the diastolic index.

A detailed clinical study of the drug revealed that in some cases it has an exciting effect, the mood of patients becomes hyperthymic, and when performing psychological tests the number of errors increases and concentration of attention decreases. It is possible that these effects are associated with the anticholinergic effect of the drug, which may be excessive if there is increased individual sensitivity to it. In addition, the anticholinergic effect is dose-dependent and changing the frequency of drug administration quickly relieves side effects.

The presence of an anticholinergic component in the action of Cerebrum compositum N explains its effectiveness in another very important area of ​​psychiatry - the treatment of neuroleptic complications [9]. Neurolepsy as a complication of psychopharmacotherapy occurs, according to various authors, in more than 50% of patients. At the same time, the most common correctors - anticholinergics (cyclodol, parkopan, etc.) themselves create side effects, incl. and pathological dependence.

The authors observed 18 patients with schizophrenia aged from 19 to 47 years with a disease duration of one to 26 years, who received hospital treatment with various antipsychotics. Side effects manifested themselves in the form of tremor, hypertonicity, akathisia, hyperkenetic and dyskinetic disorders, tachycardia, hypersalivation and other somatovegetative disorders. All patients were prescribed Cerebrum compositum N as intramuscular injections every other day. After 9 days, the patients' condition was assessed on a 3-point scale. The symptoms of akathisia and tasykinesia, tremor, coordination disorders and hyperkinesis significantly decreased. These clinical findings appear to merit further study, as neurolepsy often makes achieving therapeutic efficacy difficult.

One of the important areas of use of antihomotoxic drugs is the treatment of Alzheimer's disease [10, 11]. The authors assume that biological therapy, through detoxification and metabolic activation, can cause symptomatic improvement. A description of a case of treatment of a patient with Alzheimer's disease shows that in the 4th–5th week of treatment with the drug Cerebrum compositum N, her health improved, the patient began to cope with practical tasks, and her ability to count and abstract logical thinking improved. Küstermann [10] included the catalyst Ubiquinone compositum in the treatment plan, as well as preparations with Ginkgo Biloba extract. And in the treatment regimens given by Ivo Bianchi [12], Cerebrum compositum N is named as the main stimulating and regenerative drug indicated for various mental disorders of late age.

Complex homeopathic medicines can be used as an auxiliary therapy in the treatment of epilepsy [17] to normalize the psycho-emotional and somatic status. Special attention should be paid to the use of biological drugs in child psychiatry. In the work of E.I. Ivanova et al. [16] provide data on the effective treatment of mental retardation with behavioral disorders using therapy with the drugs Cerebrum compositum N and Nervohel. The authors believe that biological drugs are highly effective therapies and can be used either alone or in combination with allopathic drugs.

Thus, the scope of effective use of complex homeopathic medicines in psychiatry is quite wide. At the same time, biological therapy can be used as the main therapy in the treatment of mental illnesses of intoxication, traumatic, atherosclerotic, and vascular origins.

The most curable syndromes are: asthenic, cerebrasthenic, anxiety, as well as intellectual-mnestic disorders. Biological therapy is effective as a primary or parallel therapy to relieve the toxic load - a side effect of psychopharmacotherapy - neurolepsy.

Complex homeopathic preparations are quite compatible with conventional psychopharmacotherapy and, possibly, increase sensitivity to psychopharmacological drugs. In addition, according to available data [20], the use of biological therapy can reduce healthcare costs with high efficiency and almost complete safety of such treatment methods, which should also increase interest in the use of complementary treatment methods (in this case, antihomotoxic drugs) in practical healthcare .