Chloe, 2 mg+35 mcg, film-coated tablets, 28 pcs.

Compound

Price of birth control pills for Chloe

Chloe contraceptives are available in small packs designed for a month of use, as well as in large packs designed for 3 months of use. The price of the contraceptive "Chloe" depends on the pharmacy chain and region of sale:

• pack of 28 tablets – from 820 rubles;
• pack of 84 tablets – from 1970 rubles.

It is beneficial to purchase a large package only if the gynecologist has prescribed treatment for a long time. If Chloe is taken for the first month, going through an adaptation period, then it is better to buy a small package.

Pharmacodynamics

Combined low-dose monophasic oral contraceptive drug with antiandrogenic activity. The mechanism of action is due to its constituent antiandrogenic steroid drug - cyproterone acetate - and oral estrogen - ethinyl estradiol.

Cyproterone acetate has the ability to competitively bind to the receptors of natural androgens (including testosterone, dihydroepiandrosterone, androstenedione), formed in small quantities in the body of women, mainly in the adrenal glands, ovaries and skin. By blocking androgen receptors in target organs, it reduces the phenomenon of androgenization in women (due to disruption of processes mediated by hormone-receptor complexes at the level of basic intracellular mechanisms). Thus, it becomes possible to treat diseases caused by increased production of androgens or specific sensitivity to these hormones.

While taking CHLOE®, the increased activity of the sebaceous glands, which plays an important role in the occurrence of acne and seborrhea, decreases. After 3–4 months of therapy, this usually leads to the disappearance of the existing rash. Excessive oiliness in hair and skin disappears even earlier. Hair loss, which often accompanies seborrhea, is also reduced. CHLOE® therapy in women of reproductive age reduces the clinical manifestations of mild forms of hirsutism; however, the effect of treatment should be expected only after several months of use.

Along with antiandrogenic properties, cyproterone acetate has gestagenic activity that imitates the properties of the corpus luteum hormone. It, like other drugs with gestagenic activity, inhibits the pituitary secretion of gonadotropic hormones and inhibits ovulation, which determines its contraceptive effect.

Ethinyl estradiol enhances the central and peripheral effects of cyproterone acetate on ovulation, maintains the high viscosity of cervical mucus, which makes it difficult for sperm to penetrate into the uterine cavity and helps ensure a reliable contraceptive effect.

While taking the drug, the cycle becomes more regular, painful menstruation is observed less frequently, the intensity of bleeding will decrease, resulting in a reduced risk of iron deficiency anemia.

Positive property of the drug

Forgetfulness often plays a cruel joke with younger people. The instructions for use for Chloe warn about strict control over the intake of pills. Discontinuation of use is recommended if pregnancy has already occurred or if ectopic fetal development is diagnosed.

The two-color nature of the pills is very convenient. Continuous use of these allows you to start the second pack on time and not worry about taking the first tablet from the next pack late. Women really like this convenient method of contraception, especially since it is the most affordable and extremely effective if everything is done as the instructions for use for the drug “Chloe” recommend.

Reviews from many ladies include information that in the initial stages of using a contraceptive, some unpleasant symptoms may occur. If they are not too pronounced, you can continue to use the drug, but if the drug has a detrimental effect on your well-being, you should refuse it. A gynecologist should also prescribe another contraceptive.

The blister of birth control pills is invisible and fits in the pocket of even the smallest women's handbag.

Pharmacokinetics

Cyproterone acetate

Suction. After taking CHLOE® cyproterone acetate, it is completely absorbed from the gastrointestinal tract. After oral administration, 1 tablet. CHLOE®Cmax is 15 ng/ml and is achieved after 1.6 hours. Bioavailability is 88%.

Distribution. Cyproterone acetate is almost completely bound to plasma albumin, approximately 3.5–4% is in the free state. Since protein binding is nonspecific, changes in sex steroid binding globulin (SGBS) levels do not affect the pharmacokinetics of cyproterone acetate. Up to 0.2% of the dose of cyproterone acetate is excreted in breast milk.

Metabolism and excretion. The pharmacokinetics of cyproterone acetate is biphasic, T1/2 is 0.8 hours and 2.3 days, respectively, for the first and second phases.

The total plasma clearance is 3.6 ml/min/kg. Biotransformed by hydroxylation and conjugation, the main metabolite is the 15b-hydroxyl derivative. It is excreted mainly in the form of metabolites by the kidneys and through the intestines in a ratio of 1:2, a small part - unchanged through the intestines.

T1/2 for cyproterone acetate metabolites is 1.8 days.

Ethinyl estradiol

Suction. After taking CHLOE® ethinyl estradiol is quickly and completely absorbed from the gastrointestinal tract. During absorption and first passage through the liver, ethinyl estradiol undergoes extensive metabolism, which results in a bioavailability of approximately 45% and its significant individual variability. After oral administration of 1 tablet, film-coated CHLOE® Cmax is approximately 80 pg/ml and is achieved after 1.7 hours.

Distribution. The connection with proteins (albumin) of the blood plasma is high (2% are found in free form in the plasma).

Up to 0.02% of the dose of ethinyl estradiol is excreted in breast milk. Ethinyl estradiol increases the hepatic synthesis of SHBG and corticosteroid binding globulin (CBG) during continuous use. During treatment with CHLOE®, the serum SHG concentration increases from approximately 100 to 300 nmol/l, and the serum concentration of DRG increases from approximately 50 to 95 μg/ml.

Metabolism and excretion. The pharmacokinetics of ethinyl estradiol is biphasic, with T1/2 1–2 and approximately 20 hours, respectively. Plasma clearance is about 5 ml/min/kg. Ethinyl estradiol is excreted from the body in the form of metabolites; about 40% - by the kidneys, 60% - through the intestines.

Experts' opinion

Before you start using mini-pills, you need to consult with the gynecologist you are seeing. After all, the effectiveness of their action depends not only on the components included in the composition, but also on many physiological processes of the female body.

If you evaluate the effectiveness of the mini-pill, you should consider only professional reviews from doctors about the drug “Chloe”. It is their destiny to identify the pros and cons, because many years of practice and observations provide the basis for constructive conclusions and recommendations for the most effective treatment.

If you do not take all contraindications into account when taking it, you can cause serious damage to your health. This contraceptive is assessed by doctors as a reliable remedy that helps get rid of many women's health problems. It’s just that it is prescribed after a thorough examination of the patient. For most, it is ideal for protecting against unwanted pregnancy.

Contraindications

hypersensitivity to the components of the drug;

simultaneous use with another hormonal contraceptive;

thrombosis (venous and arterial) or thromboembolism currently or in history (including deep vein thrombosis, pulmonary embolism, myocardial infarction, cerebrovascular disorders, such as stroke);

conditions preceding thrombosis (including angina pectoris, transient ischemic attacks);

multiple or severe risk factors for venous or arterial thrombosis (including complicated heart valve defects, atrial fibrillation, cerebral or coronary artery disease; uncontrolled arterial hypertension, severe dyslipoproteinemia, subacute bacterial endocarditis, prolonged immobilization, surgical interventions on the lower limbs, neurosurgical operations, extensive trauma, smoking over the age of 35, obesity with a body mass index of more than 30 kg/m2);

identified hereditary or acquired predisposition to venous or arterial thrombosis, for example, resistance to activated protein C (APC), antithrombin III deficiency, protein C deficiency, protein S deficiency, hyperhomocysteinemia and the presence of antiphospholipid antibodies (anticardiolipin antibodies, lupus anticoagulant);

diabetes mellitus with diabetic angiopathy;

severe liver disease currently or in history or severe liver dysfunction - no earlier than 6 months after normalization of liver function indicators;

liver tumors (benign and malignant);

hormone-dependent malignant tumors or suspicion of them, incl. tumors of the breast or genital organs (including in history);

bleeding from the vagina of unknown etiology;

pancreatitis with severe hypertriglyceridemia (including a history);

a history of migraine, which was accompanied by focal neurological symptoms;

breastfeeding period;

congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes);

age over 40 years;

hyperprolactinemia;

lactose intolerance, lactase deficiency, glucose-galactose malabsorption;

pregnancy or suspicion of it.

If any of these conditions develop for the first time while taking CHLOE®, the drug should be discontinued immediately.

CHLOE® is not intended for use in men.

With caution: epilepsy, depression, ulcerative colitis, liver and gallbladder diseases, uterine fibroids, mastopathy, chorea, tetany, porphyria, multiple sclerosis, varicose veins, tuberculosis, kidney disease, adolescence (without regular ovulatory cycles), dyslipoproteinemia, sickle cell anemia, idiopathic jaundice or pruritus during a previous pregnancy, otosclerosis with hearing impairment during a previous pregnancy.

Possible side effects when taking the mini-pill

Like any medical drug, birth control pills “Chloe” (instructions for use, reviews from doctors confirm this) are not without properties to cause poor health. The main recorded side effects from taking include nausea, vomiting, diarrhea, tension and pain in the chest area, increased volume of the nipples, bloody discharge from them, headaches, depression, allergic skin rashes, intolerance to contact eye lenses, fluid retention in the body , manifested by edema.

Side effects

The side effects listed below are presented in accordance with the following gradations of frequency of their occurrence: very often (≥1/10); often (≥1/100 to <1/10); uncommon (≥1/1000 to <1/100); rare (≥1/10000 to <1/1000); very rare (<1/10000); frequency unknown (frequency cannot be estimated from available data).

From the nervous system: often - headache; uncommon - migraine: frequency unknown - worsening of epilepsy.

On the part of the organ of vision: rarely - intolerance to contact lenses.

From the gastrointestinal tract: often - nausea, abdominal pain; infrequently - vomiting, diarrhea.

From the skin and subcutaneous tissues: infrequently - rash, urticaria; frequency unknown - erythema nodosum, erythema multiforme.

Metabolism and nutrition: often - weight gain; uncommon - fluid retention; rarely - weight loss.

From the immune system: rarely - hypersensitivity reactions.

From the genital organs and mammary gland: often - pain/tenderness in the mammary glands, engorgement of the mammary glands; infrequently - enlargement of the mammary glands; rarely - vaginal discharge, discharge from the mammary glands*; frequency unknown - acyclic spotting/bleeding (metrorrhagia).

Mental disorders: often - decreased mood, mood swings; infrequently - decreased libido; rarely - increased libido; frequency unknown - worsening of endogenous depression.

From the side of blood vessels: rarely - thromboembolism.

*In post-marketing studies, painful menstrual-like bleeding and absence of menstrual-like bleeding were reported, the frequency of which could not be assessed.

The following serious adverse events have been reported in women using COCs (which include CHLOE®):

- venous thromboembolic disorders;

- arterial thromboembolic disorders;

- stroke;

- increased blood pressure;

- hypertriglyceridemia;

- impaired glucose tolerance or effect on peripheral insulin resistance;

- liver tumors (benign and malignant);

- violation of liver functional parameters;

- chloasma;

- in women with hereditary angioedema, exogenous estrogens can cause or intensify the symptoms of angioedema;

- the onset or worsening of conditions for which the connection with the use of COCs (which includes the drug CHLOE®) is not indisputable: jaundice and/or itching associated with cholestasis; formation of gallstones; porphyria; systemic lupus erythematosus; hemolytic-uremic syndrome; chorea; herpes during a previous pregnancy; hearing loss associated with otosclerosis; Crohn's disease; ulcerative colitis; cervical cancer;

- visual impairment;

- dizziness;

- pancreatitis;

- cholecystitis;

— the frequency of diagnosis of breast cancer in women using COCs (which includes the drug CHLOE®) is increased very slightly. Breast cancer is rarely observed in women under 40 years of age, the excess incidence is insignificant in relation to the overall risk of breast cancer. The cause-and-effect relationship between the occurrence of breast cancer and the use of COCs has not been established. For additional information, see the “Contraindications” and “Special Instructions” sections.

What you should pay attention to?

So, firstly, the instructions for the drug “Chloe” (analogs of it too) recommend taking it strictly without skipping in order to achieve a high degree of protection at the hormonal level.

Secondly, signs of poor health may be temporary at the beginning of treatment.

Thirdly, if the side effects are severe, the mini-pill is abandoned and another effective drug is selected together with the gynecologist.

Do not forget that oral contraceptives are prescribed to women who already have children. It is not advisable for women who have not given birth to use this product as a contraceptive.

If you want to get pregnant, refuse the drug. Restoration of reproductive function occurs during a three-month break from taking birth control pills.

The drug in question is designed for contraception and treatment of women only.

Interaction

With simultaneous use of CHLOE® with inducers of microsomal liver enzymes (hydantoins, barbiturates, primidone, carbamazepine and rifampicin; and possibly oxcarbazepine, topiramate, felbamate and griseofulvin), the clearance of ethinyl estradiol and cyproterone increases, which can lead to breakthrough uterine bleeding or decreased reliability contraception.

When used simultaneously with ampicillin, rifampicin and tetracyclines, the contraceptive reliability of CHLOE® is reduced.

Analogues of birth control pills Chloe

The drug "Chloe" currently has only two analogues with a similar active composition:

1. Modell Pure tablets. A contraceptive with a similar active composition is equivalent in price to the cost of the drug "Chloe". Produced in German in packs of 21 and 63 pieces.
2. Contraceptive pills "Diane-35". Available in packs of 21 pieces, they contain cyproterone and ethinyl estradiol. The cost of "Diane-35" is much higher than the "Chloe" tablets. Country of origin: Germany, manufactured by Bayer Pharma. The amount of active ingredient is equivalent to its amount in Chloe tablets.

The gynecologist can prescribe the listed drugs to replace Chloe tablets. They can also be purchased if the prescribed medicine is not available at the pharmacy.

Directions for use and doses

Orally, 1 tablet/day. The tablet is taken without chewing and washed down with a small amount of liquid. The time of taking the drug does not matter, however, subsequent doses should be taken at the same selected hour, preferably after breakfast or dinner.

If you have not taken any hormonal contraceptives in the previous month. Taking the drug CHLOE® begins on the 1st day of the menstrual cycle (i.e. on the 1st day of menstrual bleeding), using a tablet of the corresponding day of the week from the calendar package. It is possible to start taking it on the 2nd–5th day of the menstrual cycle, but in this case it is recommended to additionally use a barrier method of contraception during the first 7 days of taking the tablets from the first package.

Daily administration of the drug is carried out using tablets from the calendar package sequentially in the direction of the arrow marked on the foil until all the tablets have been taken. After finishing taking 21 tablets. yellow-orange color from the calendar package, you must take the remaining white tablets over the next 7 days. During the last 7 days of the treatment cycle (28 days), menstrual-like bleeding (bleeding as a result of discontinuation of treatment) should occur. Menstrual-like bleeding usually begins 2-3 days after the 21st day of the CHLOE® treatment cycle. The next package must be started the next day after taking the tablets from the previous package, regardless of whether bleeding continues or not.

When switching from combined contraceptive drugs (COCs, vaginal ring or contraceptive patch). Taking CHLOE® should be started the day after taking the last active tablet of the previous drug, but in no case later than the next day after the usual 7-day break in taking it (for drugs containing 21 tablets). Next - according to the scheme described above. If the patient took the previous contraceptive daily for 28 days, taking CHLOE® should be started after taking the last inactive tablet. Taking CHLOE® should be started on the day the vaginal ring or contraceptive patch is removed, but no later than the day when a new ring is to be inserted or a new patch is applied.

When switching from contraceptives containing only gestagens (mini-pills, injectable forms, implants, gestagen-releasing intrauterine contraceptive). When switching from a mini-pill, you can start taking CHLOE® without interruption.

When using injectable forms of contraceptives, taking CHLOE® begins on the day when the next injection is due. When switching from an implant - on the day of its removal. In all cases, it is necessary to use an additional barrier method of contraception during the first 7 days of taking the drug.

After an abortion in the first trimester of pregnancy, a woman can start taking the drug immediately. In this case, the woman does not need additional methods of contraception.

After childbirth, in the absence of breastfeeding or abortion in the second trimester of pregnancy, taking the drug should begin on the 21st–28th day. If use is started later, it is necessary to use an additional barrier method of contraception during the first 7 days of taking the drug.

If a woman was sexually active in the period between childbirth or abortion and the start of taking CHLOE®, then pregnancy should first be excluded or you should wait until your first menstruation.

Taking missed pills

A woman should take the missed pill as soon as possible, and the next pill should be taken at the usual time. If the delay is less than 12 hours, the reliability of contraception does not decrease. If the delay in taking pills is more than 12 hours, the reliability of contraception may be reduced. The more pills are missed and the closer the missed pill is to the 7-day break in taking pills, the greater the likelihood of pregnancy. In this case, you can be guided by the following two basic rules:

- taking the drug should never be interrupted for more than 7 days;

— to achieve adequate suppression of hypothalamic-pituitary-ovarian regulation, 7 days of continuous use of the drug are required.

Accordingly, the following recommendations can be given if the delay in taking the pills is more than 12 hours (the interval since the last pill was taken is more than 36 hours).

The first week of taking the drug. A woman should take the last missed tablet as soon as she remembers (even if this means taking two tablets at the same time). The next tablet is taken at the usual time. Additionally, you should use a barrier method of contraception for the next 7 days. If sexual intercourse took place during the week before missing the pill, the possibility of pregnancy must be taken into account.

Second week of taking the drug. A woman should take the last missed tablet as soon as she remembers (even if this means taking two tablets at the same time). The next tablet is taken at the usual time.

Provided that the woman has taken the pills correctly for the 7 days preceding the first missed pill, there is no need to use additional contraceptive measures. Otherwise, as well as if you miss 2 or more tablets, you must additionally use barrier methods of contraception (for example, a condom) for 7 days.

Third week of taking the drug. The risk of pregnancy increases due to the upcoming pill break, but if all pills have been taken correctly in the 7 days preceding the first missed pill, there is no need to use additional contraceptive methods.

1. A woman should take the last missed pill as soon as she remembers (even if this means taking two pills at the same time). The next tablets are taken at the usual time until the tablets in the current pack are gone. The next pack should be started immediately. Withdrawal bleeding is unlikely until the second pack of tablets is gone, but spotting and breakthrough bleeding may occur while taking the tablets.

2. A woman can also stop taking pills from the current package. She should then take a break of 7 days, including the day she missed the pill, and then start taking the pills from a new pack.

If a woman misses a pill and then does not have withdrawal bleeding during the break, pregnancy must be ruled out.

Recommendations for gastrointestinal disorders. If a woman has vomited within 3 to 4 hours after taking the drug, absorption of the active substances may be incomplete. In this case, you need to follow the recommendations when skipping a pill.

Changing the day of menstrual bleeding. In order to delay the onset of menstrual bleeding, a woman should continue taking tablets from a new package of the drug immediately after taking all the tablets from the previous package, without interruption. The tablets from this new pack can be taken for as long as the woman wishes (until the pack runs out). While taking the drug from the second package, a woman may experience spotting or breakthrough uterine bleeding. You should resume taking CHLOE® from a new pack after the usual 7-day break.

In order to move the day of the onset of menstrual-like bleeding to another day of the week, a woman should shorten the next break in taking pills by as many days as she wants. The shorter the interval, the higher the risk that she will not have withdrawal bleeding and will continue to have spotting and breakthrough bleeding while taking the second package (the same as in the case when she would like to delay the onset of menstrual-like bleeding).

When treating hyperandrogenic conditions, the duration of use is determined by the severity of the disease. After the symptoms disappear, it is recommended to take the drug for at least another 3-4 months. If a relapse occurs several weeks or months after completion of the course, repeated therapy with CHLOE® can be performed. If you resume taking the drug (after a 4-week break or more), the increased risk of VTE should be taken into account (see also “Special Instructions” and Precautions).

Children and teenagers. The drug CHLOE® is indicated only after the onset of menarche.

Postmenopausal patients. Not applicable. CHLOE® is not indicated after menopause.

Patients with liver disorders. CHLOE® is contraindicated in women with severe liver disease until liver function tests return to normal (see also Contraindications).

Patients with kidney disorders. CHLOE® has not been specifically studied in patients with renal impairment. Available data do not suggest changes in treatment in these patients.

The importance of proper family planning

Of course, in modern times, open relationships are conditioned by the early maturation of adolescents, both physically and psychologically, so early intimate relationships are a fact of today. Most people, even with many types of contraception, treat this issue negligently. But what can we say about young people, when even mature women pay little attention to their health! Without taking into account the fact how dangerous abortion is for the functioning of the body, many make mistake after mistake. The result is infertility, psychological disorders and a whole bunch of female diseases.

The issue of contraception is very ancient, in modern times there are a lot of contraceptive methods that you need to know about. These are barrier products such as a condom (may be unreliable, use both before and after childbirth is acceptable), female uterine device (implanted into the uterus and may not be suitable for every female, installed after childbirth), oral suppositories (most often used before childbirth ), oral contraceptives (often prescribed after childbirth). The latter are the most acceptable and easy to use for women who have already given birth.

About the brand

The fashion house was founded by a young aristocrat named Gaby Aghien. It all started when in 1945 she returned to her homeland in France from Egypt, where she had lived before. A time of change reigned in post-war Paris, and Gabi managed to catch this wave, ignited by the idea of ​​​​creating a new fashion for the female half of society. One of the inspirations of the young aristocrat was the famous Christian Dior, who was already bringing beautiful and elegant clothing collections to the catwalks. The brand she created received a famous name - many believe that it is in honor of the goddess of spring and blooming nature, called Demeter by the Greeks. In fact, the creator of the brand considered her own name not very euphonious and took it from her friend, Chloe de Brumeton. In this way, Gabi Aghien hoped to restore hope for a new cultural revival to the residents of post-war France. She developed the very first models with her own hands: these were six dresses made of cotton fabric. She offered her creations for sale to boutiques in Paris. The girl was lucky: the great Dior himself noticed her collection. Inspired by success, she opened a sewing factory and began producing clothes, and this is how the famous brand began to exist. The dresses, blouses, and jackets created were simple and at the same time elegant, surprising with smooth lines and ease of cut, without ostentatious luxury. These items were not intended for the catwalk, but for ordinary women who could purchase them and wear them every day. In the difficult and boring post-war times, they helped many young fashionistas to be beautiful every day, creating a mood of joy, lightness and enjoyment of youth.

Famous designers Gerard Pipart and Christian Bailey took part in the work on the brand, and since 1966, the famous Karl Lagerfeld himself has been developing collections for the company. Since 1995, the daughter of the famous musician, Stella McCartney, has become the designer of the brand. With her, the fashion house expected a rise in style ratings. Now under this name they produce designer women's clothing and shoes, luxury goods, accessories and perfumes. Since 2013, Chloe has been a member of the Paris Syndicate of Haute Couture. It is currently led by Phoebe Philo, assisted by creative director Hannah McGibbson. Together they revived the original concept of youth, lightness and freedom, while at the same time introducing modern ideas and sophisticated design concepts. But the main qualities of all samples remain softness, femininity and tenderness. The company's products are chosen by the wives of billionaires and high-ranking officials, pop stars and first ladies: among them were Jacqueline Kennedy and Brigitte Bardot, Grace Kelly and Maria Callas.

Eau de Parfum Intent

For Chloe it is quite unusual: if in previous works the predominant theme was flowers, then here pepper became the central note. This is a real adventure contained in the idea of ​​Eau de Parfum: Intence is created for strong and independent girls, capricious, bright and a little extravagant. It is for those who are not afraid to be the center of attention.

Year of appearance: 2009

Composition pyramid: pink Madagascar pepper makes the smell primarily spicy, but without oriental richness and sweetness. It remains light, and is set off by seemingly incompatible components: the basic ones are rose and southern beauty magnolia, the additional ones are sandalwood and tonka bean. The amber organically combines sweet-spicy spices and honey.

Perfumer: The creator of this famous bottle is French master Christophe Rainaud.

Group: spicy, floral.

Characteristics: daytime, evening, sweet, warm, piquant.

Longevity: long lasting.

Sillage: strong, very rich.

Suitable for: bright and extravagant girls, bohemian, original, real ladies.

Reviews. Despite its richness, it does not irritate others, which means you can use it during the day. Many hear a bouquet of roses and expensive powder in it. The perfume is described as very long-lasting: one spritz lasts all day, and on clothes it lasts up to six months. It is associated primarily with elegance, the appearance of a true lady, which is somewhat different from how its creators position it. It sounds brighter in the cold season.