Irifrin eye drops: instructions for use, price and reviews. Analogues of the drug

There are restrictions during pregnancy

Has restrictions when breastfeeding

Has restrictions for children

Has restrictions for older people

Prohibited for use if you have liver problems

Has limitations for kidney problems

Irifrin is a medication that is used for the diagnosis and treatment of many ophthalmological diseases. Irifrin has a fairly high price, so there is often a need to find cheaper analogues

The main medicinal component of the drug is phenylephrine. Its action is to stimulate adrenergic receptors. This leads to activation of the sympathetic nervous system. Since Irifrin stimulates predominantly alpha-adrenergic receptors, the main effect is vasoconstriction.

An indirect effect on beta-adrenergic receptors is also observed. A large number of beta-adrenergic receptors are found in the heart. Therefore, the use of Irifrin for severe heart disease is contraindicated. Irifrin is a local remedy; there is practically no systemic effect. This explains the low risk of systemic side effects.

Mechanism of action of phenylephrine

Compound

One bottle of Irifrin 10% contains phenylephrine hydrochloride - 100 mg, and one bottle of Irifrin 2.5% - 25 mg.
Excipients: benzalkonium chloride, disodium edetate, sodium hydroxide, sodium hydrogen phosphate dihydrate, anhydrous sodium dihydrogen phosphate, sodium metabisulfite , citric acid, sodium citrate dihydrate , purified water.

One bottle of Irifrin BK (without preservative) 2.5% contains phenylephrine hydrochloride - 25 mg.

Effect on the body and characteristics of the drug

This ophthalmic drug contains two active components:

Sodium hyaluronate. In the tissues of the body, this substance passes into a more active form - hyaluronic acid. It is a physiological component for the body, but for a number of reasons its concentration begins to decrease. The uniqueness of this substance lies in the fact that its molecule attracts several water molecules at once. Thus, the application of this component makes it possible to achieve truly hydrophilic deposits. Since harmful factors and pathogens are activated precisely when the mucous membrane of the eyeball is dry, constant hydration is a matter of health and maintaining visual acuity. Hyaluronic acid also maintains tissue elasticity and promotes their regeneration.
Heparin sodium. It is also a natural substance, and therefore is very well perceived even by the most sensitive cells of the body (mucous membrane). Its chemical formula is very similar to mucin, which is part of the tear fluid, or rather its film, which is more viscous and thick in structure. These properties enhance the hydrophilic effect of hyaluronic acid and create the best possible conditions for restorative processes at the site of application.

The excipients of the drug include citric acid, glycerol, sodium citrate dihydrate and water.

It is necessary to separately note the unique packaging created by the manufacturer. The special container where the composition is placed is a complex system of valves and reservoirs. This makes it possible to achieve true sterility of the composition and minimal contact with microflora from the surrounding air. This system also allows you to achieve absolute precision (only 1 drop) when dosing. Thus, a 10 ml bottle becomes equivalent to 300 drops of solution, however, a certain amount of the drug remains in the container after dosing is completed.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Phenylephrine is an adrenergic agonist with alpha-adrenergic activity. When taken in normal doses, it does not produce a stimulating effect on the central nervous system.

When used locally in ophthalmology, it stimulates the outflow of intraocular fluid, constricts the vessels of the conjunctiva and causes pupil dilation ( mydriasis ).

Phenylephrine has a strong stimulating effect on alpha-adrenergic receptors in postsynapses, has little effect on beta-adrenergic receptors in the cardiac region, and has almost no positive inotropic and chronotropic effects. The drug has a vasoconstrictor (vasoconstrictor) effect, similar to the effect of norepinephrine , but with phenylephrine it is weaker and longer lasting.

Vasoconstriction occurs 30-90 s after use, duration of action is 2-5 hours. Once administered (instilled), phenylephrine promotes contraction of the pupillary dilator, causing mydriasis . Pupil dilation is achieved within 20-60 minutes after instillation; continues after instillation of a 2.5% solution for 2 hours, 10% solution - 3-5 hours.

Pharmacokinetics

Phenylephrine freely penetrates into the tissues of the organ of vision. The maximum concentration in the blood occurs 10–20 minutes after local application. Pre-instillation of anesthetics increases absorption into the systemic circulation and prolongs mydriasis . The drug is excreted in the urine in its original form (less than 20%) and in the form of inert metabolites.

Indications for use

The need for pupil dilation during ophthalmological diagnostic procedures (control of the posterior segment of the eye).
Iridocyclitis (prevention of the appearance of posterior synechiae and weakening of exudation in the iris).
Conducting a provocative study in individuals with a narrow anterior chamber angle and possible angle-closure glaucoma .
In surgical ophthalmology during preoperative preparation for the purpose of pupil dilation.
Differential diagnosis of deep and superficial eye injection .
Therapy of glaucomocyclic crises .
Performing laser interventions on the fundus of the eye and in vitreoretinal surgery .
Therapy for red eye syndrome (to relieve hyperemia and sensitivity of the eye membranes).
Orally and locally: to reduce swelling of the mucous membranes of the nasopharynx and conjunctiva in case of allergic and colds (as part of a combination treatment; only for Irifrin BK).
Parenteral: to increase blood pressure during collapse and hypotension caused by a decrease in vascular tone (only for Irifrin BC).

Contraindications

Allergy to the components of the drug.
Angle-closure or narrow-angle glaucoma.
Diabetes.
Severe disorders of the cardiovascular system ( arterial hypertension , heart disease, aneurysm , tachycardia ).
Thyrotoxicosis, hyperthyroidism.
Use together with and within 14 days after stopping therapy with MAO inhibitors.
Dilation of the pupil during surgery in patients with a defect in the integrity of the eye or in cases of impaired outflow of tear fluid.
Concomitant use with tricyclic antidepressants, antihypertensive drugs (including beta blockers ).
Congenital deficiency of glucose-6-phosphate hydrogenase .
Porphyria.
Low birth weight newborns.

Neosynephrine-Pos

This drug also belongs to the list of Irifrin analogues, which are cheaper than the main drug in cost.
The analogue is available in the form of eye drops, the active substances of which are: A cheap analogue of the drug Irifrin is indicated for use in the following cases:

iridocyclitis;
the need to achieve pupil dilation (surgeries and diagnostics);
testing for suspected glaucoma;
conducting an examination of the eyeball.

The medicine has contraindications:

presence of glaucoma;
arterial hypertension;
heart diseases, including ischemia;
aneurysms;
arrhythmias;
tachycardia;
diabetes;
sweating;
atrioventricular block (1-3 degrees);
congenital deficiency of glucose-6-phosphate dehydrogenase;
rhinitis;
pregnancy and lactation;
elderly or childish age of the patient;
intolerance to individual components of the drug.

A cheap analogue, in some cases, has side effects:

local type reactions;
periorbital edema;
the occurrence of a burning sensation;
pain in the eyeball;
conjunctivitis;
keratitis;
tachycardia;
high blood pressure;
heart attacks;
dermatitis;
“hazy” vision;
irritation of the eye membranes;
increased lacrimation;
increased pressure inside the eye;
discomfort;
allergy;
miosis;
migraine;
loss of sleep;
weakness;
gagging;
sweating;
nervousness;
dizziness;
labored breathing.

Doctors recommend refraining from driving after using the drug, as it temporarily impairs vision.

Side effects

From the eyes: conjunctivitis , swelling of the tissues of the periorbital region; possible burning sensation, irritation, blurred vision, lacrimation, discomfort, increased intraocular pressure.
After taking Irifrin, reactive miosis . When using the drug again at this time, mydriasis is usually less pronounced. This effect is typical for older people.
From the cardiovascular system: palpitations, tachycardia , reflex bradycardia , arrhythmia , arterial hypertension , occlusion of the coronary arteries of the heart, pulmonary embolism .
Due to the strong contraction of the pupillary dilator caused by the action of phenylephrine, small grains of pigment from the iris . This suspension must be differentiated from anterior uveitis or the presence of blood cells in the anterior chamber cavity.
Skin: dermatitis .
Very rarely, when using Irifrin (10% eye drops), severe disorders occur, including vascular collapse, myocardial infarction and intracerebral hemorrhage .

Mezaton or irifrin

Another fairly cheap analogue of eye drops is Irifrin. Available in the form of an injection solution, colorless or transparent. The drug has a pronounced vasoconstrictor effect.

An analogue of the drug Irifrin is indicated for use in patients who have the following conditions:

severe vascular insufficiency;
arterial hypotension;
rhinitis – allergic and vasomotor;
as a vasoconstrictor drug during local anesthesia;
shock.

The medicine has contraindications:

detection of pheochromocytoma;
arterial hypertension;
cardiomyopations;
ventricular fibrillations;
acute infarction conditions;
the patient has a history of vascular diseases;
acidosis;
hypoxia;
renal dysfunction;
general anesthesia;
childhood or old age;
lactation;
pregnancy;
intolerance to the main substances of the drug.

A cheap analogue of the drug Irifrin has possible side effects:

ischemia of the skin (injection sites);
pronounced pallor;
allergic manifestations;
tissue necrosis;
sleep disorders;
anxiety;
general weakness;
dizziness;
migraines of various etiologies;
convulsive muscle contractions;
tremor;
cerebral hemorrhages;
high blood pressure;
arrhythmias;
cardialgia;
bradycardia.

When using the drug, you must refrain from using vehicles that require rapid psychomotor reactions.

Irifrin eye drops, instructions for use

The instructions for Irifrin prescribe the use of drops topically.

For ophthalmoscopy, a single use of a 2.5% solution is used. For mydriasis , instillation of one drop of Irifrin 2.5% into the conjunctival sac is sufficient. Expansion of the maxillary force is achieved after 20–30 minutes and lasts for 1–3 hours. If necessary, it is possible to prolong mydriasis , for which another instillation .

In children over 12 years of age and adults with weak pupil dilation to provoke diagnostic mydriasis , the use of a 10% solution without dose adjustment is justified.

When conducting diagnostics, a single use of a 2.5% solution can be used for:

provocative test in individuals with a narrow anterior chamber angle and possible angle-closure glaucoma ;
differential diagnosis of the type of eye injection (superficial or deep);
iridocyclite solution 2.5 or 10% is used to prevent the development and rupture of posterior synechiae; to reduce exudation in the anterior ocular chamber (one drop of Irifrin is instilled into the conjunctival sac 2-3 times a day);
relief of glaucomocyclic crises . Phenylephrine produces a hypotensive effect in this pathology. A 10% solution is used 2–3 times a day;
preparing patients for surgical interventions in 40–60 minutes to achieve pupil dilation, a single injection of a 10% solution is performed; After the integrity of the eye membranes is damaged, re-use of the drug is prohibited.

The 10% solution should not be used to soak tampons during surgery.

Irifrin BC is also used:

for hypermetropia with a tendency to accommodation spasms, accompanied by high eye strain, the drug is instilled in the evening along with a 1% solution of cyclopentolate . With standard visual load, Irifrin BC is used before bedtime 3 times a week;
in the treatment of true and false myopia - 1 drop before bedtime every 3 days for one month.

Forms of release, structural analogues, prices

Irifrin is available in the form of eye drops. This is a local remedy that acts primarily on the ocular vessels. Systemic exposure is minimal, since the drug is not absorbed into the systemic circulation.

All structural analogues contain the same active substance. They differ in the manufacturer and some additional components. Structural analogues are interchangeable because they have the same composition and action. List of structural analogues of Irifrin:

Irifrin BK. The medication is also available in the form of drops and contains the same active ingredient. The only difference is the absence of preservatives in the composition (and therefore the shelf life of the medicine is shorter).
Visofrine. The active ingredient of the drug is phenylephrine. The only difference between medications is the manufacturer.
Vistosan. It has the same composition as the main drug. Release form: eye drops.
Phenefrine. Available as an eye solution.
Mezaton. Another complete analogue of Irifrin. Mezaton contains phenylephrine at a concentration of 25 mg/ml. The action of Mezaton is the same as that of Irifrin.

The table below presents a list of drugs that have a similar effect, but differ in composition. Analogues of action do not always have the same drug group, this should be taken into account when choosing a medication, and may also differ slightly in effectiveness.

Atropine

Atropine is one of the cheapest analogues of Irifrin. It belongs to a different medicinal group, but has a similar effect. The drug does not contain an adrenergic agonist, but an m-anticholinergic blocker. The main medicinal substance of the drug is atropine. It binds to cholinergic receptors, resulting in a cholinolytic effect, including relaxation of the eye muscles.

As a result of the use of drops, the main effect develops - pupil dilation. Atropine is used in the form of complex therapy for inflammatory diseases of the eyeball, for injuries and accommodation spasms. Atropine drops are also used to dilate the pupil when performing diagnostic and therapeutic procedures.

Action of atropine

Atropine, despite its local application, can cause many systemic reactions. This explains the wide range of side effects:

ocular hypertension;
redness of the eyes;
swelling;
dryness of the oral mucosa;
decreased intestinal motility;
urinary retention;
acceleration of heart rate.

Before using Atropine, you should definitely consult with your doctor, since there are a number of contraindications to using the drug. The use of Atropine drops is contraindicated for the following diseases:

heart rhythm disturbances, which are accompanied by tachycardia;
glaucoma;
diseases of the digestive tract, which are accompanied by slow motility - intestinal atony, pylorus stenosis;
hyperthyroidism;
intestinal obstruction.

The dosage and method of application of the drops depends on their purpose.

For therapeutic purposes, Atropine is prescribed 3-6 times a day, 1 drop. The effect occurs in approximately 30 minutes. For diagnostic purposes, Atropine is used once. Before carrying out the diagnostic procedure, 1-2 drops of the drug are instilled into the eye.

Analogue of Irifrin BK Vizin

For hypersensitive eyes, doctors often prescribe Irifrin BC, whose analogues include the cheaper Vizin. This is a topical drug that comes in the form of eye drops. The main component of the drug is tetrizoline. Tetrizoline is an adrenergic agonist by nature and stimulates alpha-adrenergic receptors, which are located primarily in the vascular area. When instilled into the eyes, vasoconstriction occurs. Thanks to this action, the drug also fights swelling, inflammation and increased tearing.

Visine is used to treat certain ophthalmic diseases. Indications for the use of the drug are the presence of the following conditions:

redness of the eye;
edema;
allergic lesion;
increased tearfulness.
Irifrin BK

Visine has a local effect and is practically not absorbed into the general bloodstream. Therefore, systemic complications are rare. Local undesirable reactions may occur in the form of pupil dilation, redness, and burning sensation.

The use of Visin is contraindicated for the treatment of children under 3 years of age. Contraindications also include glaucoma and corneal dystrophy. There are also relative contraindications that require special caution when using the drug: hypertension, thyrotoxicosis, endocrine diseases.

Visine begins to act in 15-20 minutes. The vasoconstrictive effect lasts for 5-8 hours. Considering the duration of action of the drug, you need to instill Visin about 3 times a day.

Visine is instilled into each eye, 1-2 drops. The duration of the course of treatment is determined individually, but Vizin is not recommended for use for more than 4-5 days in a row. Usually, several techniques are enough to achieve the effect.

Tropicamide

An analogue that is often used in ophthalmology is Tropicamide. It is a local drug, available in the form of eye drops. The main component of the drug is tropicamide, which is an anticholinergic in nature.

The main area of application of the drug is diagnostic procedures in ophthalmology. The use of the drug leads to relaxation of the ciliary muscle and sphincter of the pupil, resulting in prolonged mydriasis.

The onset of action of the medicine is about 10 minutes. The action lasts up to 2 hours. Before the procedure, 15-20 minutes before you need to drop 1 drop of the drug into the eye.

Less commonly, Tropicamide is used for therapeutic purposes, as part of complex therapy for inflammatory eye diseases. When using Tropicamide, relaxation of the eye muscles is observed, which contributes to a faster recovery.

When using Tropicamide, a number of side effects may develop. Local reactions include redness of the mucous membrane of the eye, burning in the eye, dry mucous membranes, photophobia, and swelling.

Systemic reactions develop less frequently. These include:

decreased salivation, dry mouth;
decreased intestinal motility – constipation, intestinal obstruction;
urinary retention;
increased heart rate;
feeling of heat in the face.

If systemic reactions develop, you should stop taking the medication and consult your doctor.

There are a number of contraindications to the use of Tropicamide. The medicine is not prescribed for:

history of allergies;
glaucoma;
intolerance to the components of the drug;
suspected increased intraocular pressure.
Glaucoma

Cyclomed

Cyclomed has a similar effect to Irifrin, but belongs to a different drug group - m-anticholinergics. The main active ingredient is cyclopentolate. The action of the medication is associated with the relaxation of 2 muscles - the ciliary muscle and the sphincter, which constricts the pupil. Thus, mydriasis occurs.

Rarely, the medication can provoke the following common adverse reactions:

nausea;
dry mouth;
constipation;
dizziness.

Local adverse reactions may develop - redness of the eyes, foreign body sensation, burning, photophobia. If these reactions occur, you should stop taking the drug and seek medical help.

The use of the medication is possible for diagnostic or therapeutic purposes. Cyclomed is used to achieve persistent mydriasis during diagnostic procedures requiring visualization of the fundus, or before surgery.

Less commonly, Cyclomed is prescribed for therapeutic purposes. Indications for the use of the drug are inflammatory diseases in which it is necessary to achieve functional rest of the eyes. For example, in complex therapy of iridocyclitis, uveitis, keratitis.

The method of application depends on the purpose. When carrying out diagnostic procedures, you need to instill drops 3 times with an interval of 10 minutes. If Cyclomed is used for medicinal purposes, the drops should be instilled 3-4 times a day, 1 drop. The duration of the treatment course is determined individually, but is usually 10-14 days.

Contraindications for use are glaucoma, intestinal obstruction, severe heart disease, and a history of allergic reactions to the components of the drug.

Cyclomed

Midriacil

The drug contains one active ingredient – tropicamide. It belongs to the drug group of anticholinergic drugs. Its action is to relax the muscles that are responsible for the constriction of the pupil. This is achieved due to the blockade of m-cholinergic receptors. As a result of the action of the drug, the diameter of the pupil expands.

Midriacil is prescribed before examining the fundus, carrying out various diagnostic measures or operations. In this case, you need to instill Midriacil 15 minutes before the start of the procedure. Taking the drug can be repeated after 15-20 minutes. The effect lasts for 2 hours.

Midriacil can be used in complex therapy of eye diseases. It is prescribed to relax the muscles of the eye, which improves the prognosis of the disease and speeds up recovery. In the treatment of diseases, Midriacil is prescribed 1 drop 2-3 times a day for 7-10 days.

Midriacil is a local drug. In most cases, the effect of the drug is local, but the following adverse reactions may develop: tachycardia, decreased salivation, decreased intestinal motility. If these symptoms develop, you should stop taking the drug and consult a doctor.

It is not recommended to use Midriacil if there is high intraocular pressure, an allergy to tropicamide or other components, or if there is a traumatic injury.

Interaction

Pupil dilation increases when phenylephrine and atropine .

The use of a 2.5 or 10% solution of the drug with MAO inhibitors and for three weeks after their discontinuation should be done with caution, since in this case an uncontrolled increase in blood pressure is possible.

The use of Irifrin 10% in combination with beta-blockers can provoke acute arterial hypertension .

Use together with sympathomimetics may enhance the cardiovascular effects of phenylephrine.

special instructions

Since the duration of pupil dilation can reach 1-3 hours, patients may experience a feeling of photophobia, therefore, until vision function is restored, you need to protect your eyes from strong sunlight. Reading and watching TV programs are prohibited.

It is possible to develop reactive miosis , which is more often observed in older people after using phenylephrine, and repeated use of the drug leads to a weakening of pupil dilation.

benzalkonium chloride as a preservative , it may cause discoloration of soft contact lenses. Before using Irifrin, the patient must remove the lenses and wait 15 minutes after instillation before using them again.

All analogues of Irifrin

Analogues in composition and indications for use

Name	Price in Russia	Price in Ukraine
Phenephrine phenylephrine	—	86 UAH
Babyfrin phenylephrine	118 RUR	—
Irifrin BK phenylephrine	486 RUR	—

The above list of drug analogues, which indicate Irifrin substitutes, is the most suitable, since they have the same composition of active ingredients and coincide in indications for use

Different composition, may have the same indication and method of use

Name	Price in Russia	Price in Ukraine
Cyclomed cyclopentolate	595 RUR	104 UAH
Cycloptic Cyclopentolate	278 RUR	—
Tropicamide tropicamide	69 RUR	16 UAH
Tropicamide farmak tropicamide	—	—
Midriacil Tropicamide	315 RUR	—
Unitropic tropicamide	—	—
Midax	—	—
Midrimax Phenylephrine, Tropicamide	602 RUR	950 UAH

To compile a list of cheap analogues of expensive drugs, we use prices that are provided to us by more than 10,000 pharmacies throughout Russia. The database of drugs and their analogues is updated daily, so the information provided on our website is always up to date as of the current day. If you have not found the analogue you are interested in, please use the search above and select the medicine you are interested in from the list. On the page of each of them you will find all possible analogues of the drug you are looking for, as well as prices and addresses of pharmacies where it is available.

Irifrin price, where to buy

The price of Irifrin 2.5% eye drops in Russia ranges from 333 to 409 rubles, Irifrin BC will cost 484-510 rubles.

In Ukraine, eye drops Irifrin 2.5% will cost 58-83 hryvnia, and the price of Irifrin BC will average 78 hryvnia.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Irifrin eye drops 2.5% 5ml Sentiss Pharma Pvt.
Ltd. / Sentiss Pharma Pvt. Ltd. RUR 637 order
Irifrin BK eye drops 2.5% 0.4 ml 15 pcs. Sentiss Pharma Pvt. Ltd. / Sentiss Pharma Pvt. Ltd.
RUR 669 order

Pharmacy Dialogue

Irifrin (eye drops 2.5% 5ml)Sentiss
RUR 649 order
Read also: Complex of extracts of ginseng, eleutheroccus and green tea capsules 30 pcs. in Moscow
Irifrin (eye drops 2.5% 5ml)Promed Exports
RUR 554 order
Irifrin BK 2.5% eye drops 0.4ml No. 15Sentiss
RUR 697 order

Pharmacy24

Irifrin 2.5% 5 ml No. 1 drops Sentiss Pharma PVT.LTD, India
143 UAH order

PaniPharmacy

Irifrin liquid Irifrin eye drop bottle 2.5% 5ml India, Sentiss Pharma
177 UAH order

Visine or irifrin – what to choose

Ophthalmic vasoconstrictor, a cheap analogue of the drug Irifrin. Release form: liquid (eye drops).

The analogue is indicated for use in the following cases:

swelling of the eyes;
conjunctive hyperemia.

The cheap drug is contraindicated if:

angle-closure glaucoma;
the patient's childhood;
cardiac ischemia;
arterial hypertension;
intolerance to the main active ingredient of the drug.

The analogue has side effects:

burning and redness of the eyes;
conjunctive irritation;
dilated pupils;
"foggy" vision.

Since the effect of the drug is such that, when used, visual acuity is significantly reduced, it is recommended to postpone driving until you stop using Vizin.

Table – existing forms of the drug Vizin with prices *

Name
Manufacturer Active ingredient Price
VIZIN PURE TEAR 10ML BOTTLE OF GLASS DROPS Johnson&Johnson Consumer France SAS Levocabastine 472.40 RUR VIZIN PURE TEAR 0.5ML N10 AMP GL CAP / FOR 1 DAY Johnson & Johnson Sante Beaute France SAS Tetrizoline 477.70 RUR VIZIN ALERGI 0.05% 4M L GL DROPS FLAC/CAP Famar S.A. Tetrizoline 295.20 RUR VIZIN CLASSIC 0.0005/ML 0.5ML N10 AMP GL CAP Laboratuar Uniter Tetrizoline 339.70 RUR VIZIN CLASSIC 0.05% 15ML GL DROPS Janssen Pharmaceuticals N.V.

294.70 RUR MONTEVIZIN 0.05% 10ML GL DROPS Hemomont d.o.o./Hemofarm A.D.

138.30 RUR

Each product has a unique composition, so use must be coordinated with your doctor.