pharmachologic effect
The main component Bifonazole, being an imidazole, has pronounced antimycotic activity . The fungicidal (destructive) effect manifests itself against dermatophytes . With prolonged exposure (more than 6 hours) to high concentrations (5 μg/ml), a complete fungicidal effect .
Fungistatic activity is recorded against fungi (molds, yeasts). Resistant strains are extremely rare. In primary resistant strains, secondary resistance practically does not occur. The mechanism of action of Bifonazole is based on the suppression of the biological synthesis of ergosterol at two levels at once, which significantly distinguishes it from other antifungal agents. With the double action of the component, the cytoplasmic fungal membrane is damaged not only at the structural level, but also at the functional level.
Urea has a keratoplastic effect, enhances the penetration of bifonazole and softens the keratin membrane of the infected nail plate.
Urea potentiates the action of bifonazole, enhancing the antimycotic effect.
Release form
Cream for external use 1%. 15 g each in an aluminum tube with a screw-on plastic cap. 1 tube is placed in a cardboard box.
Solution for external use 1%. 15 ml in a dark glass bottle, equipped with a plastic dropper, with a screw-on plastic cap. 1 bottle is placed in a cardboard box.
Ointment for external use. 10 g of ointment in an aluminum tube with a screw-on plastic cap. 1 tube is placed in an individual cardboard box; a pack of ointment together with a package of waterproof plaster, a scraper, and a dispenser are placed in a common cardboard box.
Instructions for use (Method and dosage)
Mycospor nail kit is used only topically. The ointment is applied to the entire surface of the infected nail in a thin layer once a day, sealed with a special plaster from the kit. It is recommended to apply a bandage for 1 day. After 24 hours, remove the patch and immerse the nail in warm water. After 10 minutes, begin to remove the softened layer of the nail infected with a fungal infection using the scraper from the kit. After this, the nail is dried, treated with ointment again and sealed with a band-aid. It is not recommended to treat the skin adjacent to the nail. If redness or irritation appears on the skin near the nail plate, it is recommended to pre-treat the adjacent tissues with zinc ointment.
An important point is the daily and timely change of dressings. Treatment is carried out until the nail bed becomes smooth and the infected nail plate is completely removed from the keratinized tissue using a scraper. On average, antifungal therapy lasts 1-2 weeks and depends on the thickness of the nail and the severity of the fungal disease. The medication does not affect healthy tissue.
After complete removal of the nail, the attending doctor evaluates the degree of onycholysis and the effectiveness of the therapy. If there is no expected effect, treatment continues with Mycospor cream for 4 weeks.
Compound
Mycospor®
Cream for external use 1% | 100 g |
active substance: | |
bifonazole micronized | 1 g |
excipients (in 1 g of cream): benzyl alcohol - 2 g; cetostearyl alcohol (cetyl alcohol - 60%, stearyl alcohol - 40%) - 10 g; cetyl palmitate - 3 g; octyldodecanol - 13.5 g; polysorbate 60 - 1.50 g; sorbitan stearate – 2 g; purified water - up to 100 g |
Solution for external use | 100 ml |
active substance: | |
bifonazole | 1 g |
excipients: ethyl alcohol 96% - 30 g; isopropyl myristate - 52.60 g |
Mycospor® Set
Ointment for external use | 100 g |
active substances: | |
bifonazole | 1 g |
urea | 40 g |
excipients: white beeswax - 5 g; white petroleum jelly - 34 g; lanolin - 20 g |
special instructions
When using the drug, it should be borne in mind that the success of therapy largely depends on the thoroughness of removing the affected areas of the nail and subsequent treatment of the nail bed with Mycospor cream or one of the other forms of the drug. In very rare cases, allergic reactions to the patch may occur; in this case, it is possible to use another type of patch or rubber fingertip. — Use in pediatrics Currently, there is insufficient clinical data on the use of Mycospor ointment in children. Despite the fact that there is no clinical evidence of the negative effects of Mycospor in this category of patients, treatment of onychomycosis in children should be carried out only according to strict indications and under medical supervision.
Directions for use and doses
Mycospor®
Cream, solution for external use
Externally. The cream or solution is applied in a thin layer to the infected areas of the skin and rubbed in. A single dose based on a surface area the size of a palm is: for a cream - a column 1 cm long, for a solution - 3 drops. Frequency of use: 1 time per day, at night. Treatment should be continuous and include:
- for mycoses of the feet (dermatophytosis of the skin of the feet and interdigital dermatophytosis of the feet) - 3 weeks;
- mycoses of the hands (dermatophytosis of the skin of the hands and interdigital dermatophytosis), body skin (dermatophytosis of smooth skin) and skin folds (dermatophytosis inguinal) - 2-3 weeks;
— pityriasis versicolor, erythrasma — 2 weeks;
— superficial skin candidiasis — 2–4 weeks.
No separate studies have been conducted in children. Based on a review of clinical data, there was no evidence of adverse side effects when using the drug in children. However, in children, the drug Mikospor®, solution for external use should be used only under the supervision of a physician.
If no improvement is observed within 7 days or the condition worsens, you should consult a doctor.
Mycospor® Set
Ointment for external use
Externally. For adults and children, ointment is applied to the infected nail once a day in an amount sufficient to cover the entire surface of the nail with a thin layer. Then the treated nail is sealed with a plaster and left under the bandage for 24 hours, after which the bandage is changed. After removing the patch, immerse the treated surface in warm water for about 10 minutes and then carefully remove the softened part of the infected nail with a scraper. The nails treated in this way are thoroughly dried, the ointment is applied again and sealed with a plaster. The areas of skin adjacent to the nail should not be covered with ointment. If signs of irritation occur, the skin around the nail can be treated with zinc paste before applying the patch.
The dressing is changed every day. Treatment is continued until the softened nail plate infected with the fungus can no longer be removed with a scraper and the nail bed becomes smooth. This usually takes 7–14 days, depending on the extent of the infection and the thickness of the nail.
Conduct final antifungal therapy of the nail bed using the drug Mikospor®, cream for external use once a day for 4 weeks.
With more pronounced dystrophy of the nail plates, their removal using urea is more effective.
No separate studies have been conducted in children. Based on a review of clinical data, there was no evidence of adverse side effects when using the drug in children. However, in children, the drug Mikospor® Set should be used only under the supervision of a physician.
If no improvement is observed within 7 days or the condition worsens, you should consult a doctor.
Set for the treatment of fungus on nails Bayer "Mikospor" - reviews
Tenebris
https://otzovik.com/review_3460419.html
Advantages:
- treats
Flaws:
- there are no cons. It works just as it says in the instructions.
About 10 years ago I had fungus on several nails on both feet. No matter what treatment I tried, it didn’t help; the fungus persisted deep in the nail. I struggled for about 5 years until I found out that mycosporus completely removes the entire nail. I conducted the course strictly according to the instructions (or almost strictly). And for 10 years there was no fungus. But now, during antibiotic treatment for a cold with Augmentin, probably because I took antifungal drugs rather sluggishly, candidiasis has returned to me, and not only of the nails. Well, not only did I treat my nails with clotrimazole and tablets, but I will treat my nails again with mycospor.
Sarah Bernhardt
https://irecommend.ru/content/effektivno-i-ne-nakladno
My son is a serious swimmer and visits the pool five times a week. Naturally, it is impossible to trace whether he observes precautions. it is quite likely that he walks barefoot because it is more convenient, but this is not even necessary, since descent into the water in pools is carried out along steps, which can become a source of infection. The sick man stepped forward, then the healthy one. So the infection began to spread among the swimmers. I suggested that he take mycospray with him as a preventive measure, but he flatly refused, saying that the children would laugh. As a result, we encountered foot fungus (thankfully, not nails). The skin began to peel off greatly, then some bubbles became noticeable. We went to the doctor and heard the diagnosis, which was not at all a surprise. They treated me only with mycospor, without tablets. Every evening I rubbed it on his sore spots before bed. Additionally, they only made baths with oak bark. In three weeks the fungus was cured! And this was very pleasing, because I didn’t want to take a long break from training. Now we decided to still treat our feet with mycospray during evening classes at home and also bought tar soap for prevention. Whatever one may say, it is easier to prevent a problem than to deal with it later.
Advantages:
- when used correctly, 100% removes fungus
- effective
Alenatzai1
https://irecommend.ru/content/khorosho-i-bez-boli-snimaet-zarazhennyi-nogot
My mother has had nail fungus for a very long time. They treated me with all sorts of means. It is not possible to treat with tablets. Mom says they made my liver hurt. The pills were immediately stopped. Loceryl also doesn’t help much, a relative came from Moscow and told me about mycosporus. That he helped her friend get rid of this misfortune. She bought it herself, smeared it, wrapped it up and went back to Moscow. A day later, my mother took off the patch, began to peel off the softened nail, and half of her nail fell off. She must have pressed really hard.
In general, we are slowly removing sore nails. They come off easily and without pain. There's still a little bit left. The product is used very economically. Even though the tube is small, it will last a long time.
Let's hope that we will completely remove the diseased nail and a healthy one will begin to grow.
I wish everyone great health, getting rid of the fungus, and not catching it in the future.
Advantages:
- when used correctly, 100% removes fungus
- removes the nail plate carefully
nadin
https://gribokotzyv.ru/mikospor/
When my daughter picked up a fungus somewhere, we went to a pediatric dermatologist. We started treatment by purchasing a prescription kit “Mikospor” and a cream with the same name. The doctor recommended this particular remedy, because the ointment not only kills the fungus and its spores, but also contains urea, which softens the nail and the product penetrates deeper into the nail.
The instructions for the drug were clear, everything was done as needed. The procedure is simple: rinse and dry your feet well. Then apply the ointment and cover with a band-aid for 24 hours. Then rinse thoroughly and dry again. I was afraid that the ointment would also corrode the tissues near the nail, because it spreads even like under a plaster. But everything worked out, although the manufacturer warned that there may be irritation of nearby tissues. We couldn't scrape off the nails. I cut my nails as short as possible and filed them with a nail file. There was only a piece of healthy nail left next to the cuticle.
After 10 days, they continued to only apply cream to what was left of the nails. They did this for three weeks. The fungus disappeared and there was no relapse. Overall satisfied!
Vladimir
https://nogivnorme.ru/bolezni/gribok/preparaty-ot-gribka/mikospor-nabor.html
The kit was recommended by a dermatologist for the treatment of fungus on two nails. The visible effect came within a few days. After a course of therapy, relapses no longer occurred, unlike most similar antifungal drugs.
Ruslana
https://lekotzyvy.com/preparat/m/mikospor/
Advantages:
- Gives the expected result
Flaws:
- Price
When I developed a fungus on some of my toes, I first tried all the advertised remedies. None of them gave me positive emotions. All of them are not cheap, so when the pharmacy offered me expensive Mikospor, I was not even surprised at its price. When I opened the box, I realized that you were paying half the price for nothing, since the ointment came with a bunch of unnecessary accessories, except for the patch. Still, I had to buy a file separately to file off the extra layers of the nail. As for the ointment itself, it is really good. After 3 weeks, my nails were almost perfect, but it took 2.5 months to achieve complete beauty.