Novigan, 400 mg+5 mg+0.1 mg, film-coated tablets, 20 pcs.

The combined drug Novigan quickly eliminates the painful symptoms of algomenorrhea, colic in the stomach and abdominal cavity, and can be used for fever and migraines. The formula of the drug provides improved well-being with cramps, elevated body temperature, and headaches of various origins.

Composition, dosage form

Novigan is available in the form of tablets for oral use: film-coated, packaged in metallized blisters. Each pill contains:

• ibuprofen: 0.4 g;
• fenpiverinium bromide: 0.005 g;
• pitofenone: 0.1 g.

Auxiliary compounds that stabilize the state of the drug and give it shape:

• glycerol;
• talc;
• starch;
• magnesium stearate;
• polysorbate and others.

The secondary cardboard packaging of the medicine contains from 2 to 10 blisters with tablets and detailed instructions included.

Pharmacological properties

According to the instructions for use, Novigan contains components with the following properties.

Ibuprofen is a non-steroidal anti-inflammatory drug that can inhibit the formation of prostaglandins. It reduces elevated body temperature, relieves attacks of pain, and has an anti-inflammatory effect.

Prostaglandins are a group of substances produced in all tissues of the human body. They provoke inflammation and also increase the sensitivity of cells to painful sensations. Ibuprofen has a good therapeutic effect by reducing the production of prostaglandins.

Pitophenone hydrochloride is an antispasmodic drug that can relax the smooth muscles of all organs, even the muscular layer of the uterus. The effect of this substance is comparable to the effect of papaverine.

Fenpiverinium bromide is a central M-anticholinergic blocker, which also has an antispasmodic effect on smooth muscles, but in a different way.

The combination of these three drugs potentiates the effect of each and as a result leads to the achievement of greater analgesic, antipyretic and anti-inflammatory effects, in contrast to their separate use at the same dose.

The high effectiveness of the drug Novigan for menstruation has been proven by numerous clinical studies.

The mechanism of action of the drug Novigan

Novigan tablets effectively relieve various types of pain and physical discomfort. The drug is used as an analgesic, antispasmodic and anti-inflammatory. Ibuprofen in its composition provides a blockade of prostaglandins, including those in the peripheral nervous system and tissues of internal organs. At the same time, the substance affects the thermoregulation center, reducing fever and associated discomfort.

Pitophenone hydrochloride is a myotropic antispasmodic that relaxes smooth muscle fibers. Its use helps relieve painful contractions of vascular walls and cavitary organs. Fenpiverinium bromide complements and prolongs its action, having an anticholinergic effect.

The tablet shell quickly dissolves in the stomach cavity, the active substances are absorbed into the blood and distributed in the body fluids, partially binding to plasma proteins. The maximum concentration is usually achieved within 1 hour, and the pharmacological effect develops within 15–20 minutes after administration. The drug is transformed by liver cells, metabolites leave the body along with urine. Residues of the drug remain in tissues and blood for no more than 12 hours.

Novigan has a symptomatic effect, reducing the painful manifestations of pathological conditions. It does not affect the course and causes of chronic diseases.

Novigan Neo 400 mg No. 20 tablet p.o.

Instructions for medical use of the drug Novigan Neo Trade name Novigan Neo International nonproprietary name Ibuprofen Dosage form Film-coated tablets 400 mg Composition One tablet contains the active substance - ibuprofen 400 mg excipients: core composition: microcrystalline cellulose, croscarmellose sodium, tricalcium phosphate, povidone , hypromellose, stearic acid, talc coating composition: hypromellose, macrogol 6000, talc, titanium dioxide (E 171) Description Film-coated tablets of white or almost white color, oblong shape, with a biconvex surface, marked “I400” on one side . Pharmacotherapeutic group Anti-inflammatory and antirheumatic drugs. Non-steroidal anti-inflammatory drugs. Propionic acid derivatives. Ibuprofen. ATC code: M01AE01 Pharmacological properties Pharmacokinetics Absorption: When taken orally, ibuprofen is partially absorbed in the stomach, and then completely in the small intestine. When administered orally with a regular-release dosage form, peak plasma concentrations are achieved within 1 to 2 hours. Distribution: Plasma protein binding is about 99%. Biotransformation: Ibuprofen is metabolized in the liver (hydroxylation, carboxylation). Excretion: Pharmacologically inactive metabolites are completely excreted, mainly in the urine (90%), as well as in bile. The half-life in healthy people and patients suffering from liver and kidney diseases is 1.8-3.5 hours. Linearity/nonlinearity: Linear ibuprofen kinetics were observed at doses ranging from 200 to 400 mg. At higher doses, nonlinear drug kinetics were observed. Pharmacodynamics Mechanism of action: Ibuprofen is a non-steroidal anti-inflammatory drug with an effective effect based on the suppression of prostaglandin synthesis, as evidenced by the results of traditional animal studies. In humans, ibuprofen has an antipyretic effect, reduces inflammatory pain and swelling. In addition, ibuprofen inhibits platelet aggregation caused by ADP and collagen. Clinical efficacy and safety: Experimental data suggest that when used concomitantly with ibuprofen, an inhibitory effect on the effect of low doses of acetylsalicylic acid on platelet aggregation may be observed. In one study, when a single dose of ibuprofen 400 mg was taken 8 hours before or 30 minutes after a dose of instant aspirin (81 mg), a decrease in the effect of acetylsalicylic acid on thromboxane formation or platelet aggregation was observed. However, the insufficiency of these data and the uncertainty regarding the applicability of data obtained from ex vivo studies to the clinical setting suggest that definitive conclusions cannot be drawn for regular ibuprofen use and that any clinically significant effects are considered unlikely for non-regular use. It has been proven that the antipyretic effect of ibuprofen occurs within 15 minutes after taking the drug and lasts up to 8 hours. Indications for use - headache, toothache and other types of pain - migraine - neuralgia - muscle pain and joint pain in rheumatoid arthritis - symptomatic treatment of colds and flu Method of administration and dosage The drug is intended only for short-term oral use, the tablet must be washed down with water. Adults and adolescents weighing over 40 kg (12 years and above). Take one tablet with water up to 3 times daily. The drug should be used during or after meals. Allow at least 4 hours between doses and do not take more than 3 tablets in any 24-hour period. If children and adolescents aged 12 to 18 years require more than 3 days of use of this drug, or if symptoms worsen, consult a doctor. Adults should consult a physician if symptoms persist or worsen or if use of this product is required for more than 10 days. It has been proven that the antipyretic effect of ibuprofen occurs within 15 minutes after taking the drug and lasts up to 8 hours. The interval between doses depends on the symptoms and the maximum daily dose; it is not recommended to repeat the dose earlier than after 6 hours. For short-term therapy only! If you have complaints that last for more than 3 days in children and adolescents, more than 3 days when treating fever, or 4 days when treating pain in adults, you should consult a doctor. Novigan Neo should be taken without chewing and with plenty of liquid, during or after meals. Patients with diseases of the gastrointestinal tract are recommended to take Novigan Neo with meals. The occurrence of side effects can be minimized by using the lowest effective dose for the shortest duration of use necessary to improve the condition. Special groups of patients Elderly patients No special dose adjustment is required. In elderly patients, especially careful monitoring of the condition is necessary due to possible side effects. Renal failure For patients with mild to moderate renal impairment, it is not necessary to reduce the dose of the drug. The use of the drug in patients with severe renal failure is contraindicated. Liver failure For mild to moderate liver dysfunction, no dose reduction is required. The use of the drug in patients with severe liver dysfunction is contraindicated. Children and adolescents The drug is not intended for use in children under 12 years of age. If children over 12 years of age and teenagers need to take this drug for more than 3 days, or symptoms get worse, consult a doctor. Side effects The most commonly observed adverse effects of the drug are reactions from the gastrointestinal tract. Adverse reactions are dose-dependent. The risk of gastrointestinal bleeding depends on the dose range and duration of treatment. Clinical studies suggest that the use of ibuprofen, especially at high doses of 2400 mg/day, may be associated with a small increase in the risk of arterial thrombotic complications (eg, myocardial infarction or stroke). Undesirable side reactions, frequency distribution: very often (≥ 1/10), often (≥1/100 and ≤1/10), infrequently (≥1/1000 and ≤ 1/100), rarely (≥1/10000 and ≤ 1/1000), very rarely (≤ 1/10000). consult a doctor immediately. Organ system classification Frequency Adverse reaction Blood and lymphatic system disorders Very rare: Blood formation disorders Immune system disorders Uncommon Very rare Hypersensitivity reactions, including urticaria and itching. Severe hypersensitivity reactions, symptoms of which may include swelling of the face, tongue and larynx, shortness of breath, tachycardia, hypotension, anaphylactic reactions, angioedema, or severe shock Nervous system disorders Uncommon, very rare Headache aseptic meningitis Heart disease Unknown Heart failure and cardiac edema Vascular disease Unknown Hypertension Respiratory disorders Unknown Airway hyperresponsiveness including asthma, bronchospasm or dyspnea Gastrointestinal disease Uncommon Rare Very rare Unknown Stomach pain, nausea, gastrointestinal disorder Diarrhea , flatulence, constipation and vomiting Gastric ulcer, gastro-perforation or gastrointestinal bleeding, melena and hematemesis. Ulcerative stomatitis, gastritis Exacerbation of colitis and Crohn's disease Disorders of the hepatobiliary system Very rare Impaired liver function Disorders of the skin and subcutaneous tissue Uncommon Severe forms of skin reactions, including Steven-Johnson syndrome, erythema multiforme and toxic epidermal necrolysis Renal disorders and urinary system Very rare Acute renal dysfunction Laboratory tests Very rare Decreased hemoglobin levels Contraindications - hypersensitivity to the active substance or any of the excipients - a history of reactions of bronchospasm, asthma, rhinitis or urticaria after taking acetylsalicylic acid or other non-steroidal anti-inflammatory drugs - hematopoietic disorders of unknown origin - present or past presence of recurrent peptic ulcers/bleedings (two or more separate episodes of confirmed peptic ulcer disease or bleeding) - a history of gastrointestinal bleeding or ulcer perforation associated with previously prescribed therapy with non-steroidal anti-inflammatory drugs; - cerebrovascular hemorrhage or other current bleeding - severe renal or liver dysfunction - severe heart failure - third trimester of pregnancy - children weighing less than 40 kg (children under 12 years of age) Drug interactions The combined use of ibuprofen with drugs should be avoided: Other NSAIDs, including selective cyclooxygenase-2 inhibitors: simultaneous use of several NSAIDs may increase the risk of adverse reactions Acetylsalicylic acid (at a dose exceeding 75 mg per day): Increases the risk of adverse reactions. Experimental data indicate that when used concomitantly with ibuprofen, an inhibitory effect on the effect of low doses of acetylsalicylic acid on platelet aggregation may be observed. However, the limitations of these data, as well as the uncertainty regarding the transfer of ex vivo data to the clinical situation, do not allow definitive conclusions to be drawn regarding the regular use of ibuprofen, and if it is not used regularly, clinically significant reactions seem unlikely. Ibuprofen should be used with caution in combination with : Corticosteroids: increased risk of ulcers and bleeding in the digestive tract Antihypertensives and diuretics: NSAIDs may reduce the therapeutic effect of these drugs. In some patients with compromised renal function (eg, dehydrated patients or elderly patients with compromised renal function), concomitant use of an ACE inhibitor or angiotensin II antagonist and cyclooxygenase inhibitor drugs may result in further deterioration of renal function, including possible acute renal failure. , which is usually reversible. Therefore, such combinations should be prescribed with caution, especially in elderly patients. If long-term treatment is necessary, adequately hydrate the patient and consider monitoring renal function at the beginning of combination treatment, as well as at regular intervals thereafter. Diuretics may increase the risk of nephrotoxicity from NSAIDs. Anticoagulants: NSAIDs may increase the effect of anticoagulants such as warfarin. Antiplatelet agents and selective serotonin reuptake inhibitors (SSRIs): increased risk of gastrointestinal bleeding. Cardiac glycosides: NSAIDs may increase the symptoms of heart failure, reduce glomerular filtration function of the kidneys and increase the level of glycosides in the blood plasma. Lithium: There is evidence of a potential increase in plasma lithium levels. Methotrexate: there is a possibility of increased plasma levels of methotrexate. Cyclosporine: increased risk of nephrotoxicity. Mifepristone: NSAIDs should not be used earlier than 8 to 12 days after using mifepristone as they may reduce its effectiveness. Tacrolimus: There may be an increased risk of nephrotoxicity when NSAIDs are used concomitantly with tacrolimus. Zidovudine: Increased risk of hematological toxicity when zidovudine is used in combination with NSAIDs. There is evidence of an increased risk of developing hemarthrosis and hematoma in HIV-infected patients with hemophilia in the case of combined treatment with zidovudine and ibuprofen. Quinolone antibiotics: Data from animal testing indicate that use of NSAIDs may increase the risk of seizures associated with quinolone antibiotics. Patients who use ibuprofen and quinolone antibiotics concomitantly may have an increased risk of seizures. Special instructions Adverse effects can be minimized by using the lowest effective dose for the shortest period necessary to control symptoms. Elderly patients have an increased incidence of adverse reactions to NSAIDs, especially gastrointestinal bleeding and perforation, which can be fatal. Effect on the respiratory system In patients with bronchial asthma or allergic diseases, bronchospasm may occur. Other non-steroidal anti-inflammatory drugs (NSAIDs) Concomitant use of ibuprofen with other NSAIDs, including selective COX-2 inhibitors, should be avoided. Systemic lupus erythematosus and mixed connective tissue disease: Systemic lupus erythematosus and mixed connective tissue disease - increased risk of aseptic meningitis. Effect on the kidneys Risk of renal failure due to further deterioration of renal function. There is a risk of kidney failure in children and adolescents if they are dehydrated. Effect on the liver Liver dysfunction. Effects on the cardiovascular and cerebrovascular system Patients with hypertension and/or heart failure should initiate treatment with caution (consult a doctor or pharmacist), since cases of fluid retention, hypertension and edema have been reported with NSAID therapy. The results of a clinical study indicate that the use of ibuprofen, especially in high doses (2400 mg/day), may lead to an increased risk of arterial thrombotic complications (for example, myocardial infarction or stroke). In general, data from epidemiological studies do not suggest that low dose ibuprofen (eg, ≤1200 mg/day) may increase the risk of arterial thrombosis. In patients with uncontrolled hypertension, congestive heart failure (NYHA II-III) coronary artery disease, peripheral vascular disease and/or cerebrovascular disease have been noted, the disease should be treated only with ibuprofen after careful consideration, and high doses should be avoided (2400 mg/day). Particular attention should also be paid before starting long-term treatment in patients with risk factors for cardiovascular disease (eg, hypertension, hyperlipidemia, diabetes mellitus, smoking), especially if the use of ibuprofen in high doses (2400 mg/day) is necessary. Effect on the gastrointestinal tract NSAIDs should be prescribed with caution to patients with a history of gastrointestinal diseases (ulcerative colitis, Crohn's disease), due to a possible exacerbation of the disease. There are reports of cases of gastrointestinal bleeding, perforation, ulcers, which can be fatal, occurring at any stage of treatment with NSAIDs, regardless of the presence of warning symptoms or a history of severe disorders of the gastrointestinal tract (GIT). The risk of gastrointestinal bleeding, perforation or ulcer increases with increasing doses of NSAIDs in patients with a history of ulcers, especially those complicated by bleeding or perforation, as well as in the elderly. These patients should begin treatment with low doses. Patients with a history of gastrointestinal diseases, especially the elderly, should be informed of any adverse gastrointestinal symptoms (especially gastrointestinal bleeding), particularly during the initial stages of treatment. Caution should be exercised when treating patients concomitantly using concomitant medications that may increase the risk of ulceration or bleeding, such as oral corticosteroids, anticoagulants (eg, warfarin), selective serotonin reuptake inhibitors, or antiplatelet agents (eg, acetylsalicylic acid). In the event of gastrointestinal bleeding or ulceration in patients receiving ibuprofen, treatment should be discontinued immediately. Skin reactions Very rarely, severe skin reactions that can be fatal may occur with the use of NSAIDs, including exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis. The high risk of these reactions exists at the beginning of therapy, in most cases, such reactions began during the first month of treatment. At the first signs of a skin rash, pathological changes in the mucous membrane or any other signs of hypersensitivity, the use of ibuprofen should be stopped. Recommendations for patients on a controlled sodium diet ≥ 1 tablet per day: this drug contains 1.09 mmol (or 25.1 mg) of sodium in 1 dose (1 tablet), which should be taken into account when prescribing the drug to patients who show a diet With a low sodium content. Farmers are limited evidence that the drug can suppress the synthesis of cyclooxygenase/prostaglandin and lead to a decrease in female fertility due to the effect on ovulation. This phenomenon is reversible upon cessation of treatment. Pregnancy and lactation period inhibition of the synthesis of prostaglandins can negatively affect pregnancy and/or the development of the embryo/fetus. Data of epidemiological studies indicate an increased risk of miscarriage, congenital malformations after the use of prostaglandins synthesis at an early stage of pregnancy. It is believed that the risk increases with an increase in the dose and duration of therapy. The absolute risk of cardiovascular developmental malformations was increased by less than 1%, to about 1.5%. Risk is believed to increase with an increase in the dose and duration of therapy. In animals, the introduction of an inhibitor of the synthesis of prostaglandins, as was shown, leads to an increase in the risk of pre- and postplantation loss and mortality of the embryo. In addition, an increase in the number of cases of various malformations, including the cardiovascular system, was registered in animals that received an inhibitor of prostaglandin synthesis during an organogenesis period. Ibuprofen should be avoided during the 1st and 2nd trimesters of pregnancy, if there is no obvious necessity. If Nurofen is used by a woman planning pregnancy, or during the first and second trimester of pregnancy, the dose should be as low as possible, and the duration of treatment is as short as possible. In the 3rd trimester of pregnancy, all synthesis inhibitors of prostaglandin can be the following risks: for the fetus: - cardiopulmonary toxicity (which is characterized by premature closure of the arterial duct and pulmonary hypertension); - impaired renal function, which can progress to renal failure, which is accompanied by oligohydramnion; for the mother and the newborn at the end of pregnancy: - it is possible to increase the time of bleeding, the antitromobocytic effect, which can develop even with very low doses; - inhibition of uterine contractions, which leads to a delay or increase in the duration of childbirth. Ibuprofen is contraindicated in the third trimester of pregnancy. Lactation / breastfeeding: use during lactation, ibuprofen is found in breast milk in a very low concentration and this is unlikely to affect children with breastfeeding. The impact on the ability to drive a vehicle or potentially dangerous mechanisms when taking Novigan Neo in high doses is possible such undesirable effects from the central nervous system as increased fatigue and dizziness, therefore, in some cases, a violation of the reaction, the ability to control the car and work with mechanisms. These phenomena intensify when the drug is combined with alcohol intake. An overdose in children, symptoms can occur after taking a dose exceeding 400 mg/kg body weight. In adults, the dose -dependent effect is less pronounced. The half -life of the drug during an overdose is 1.5 - 3 hours. Symptoms: in most patients who used clinically significant doses of NSAIDs, the symptoms of overdose are limited to nausea, vomiting, pain in the epigastric or, less often, diarrhea. Symptoms such as the noise in the ears, headache and gastrointestinal bleeding may occur. In more severe cases, manifestations of toxicity from the central nervous system are observed, in particular, drowsiness, occasionally - excitement, as well as disorientation or coma, in rare cases there are convulsions. In cases of severe poisoning, metabolic acidosis and an increase in prothrombin time can develop, which is probably associated with the interaction of the drug and circulating blood coagulation factors. Acute renal failure and liver damage may develop. In patients with bronchial asthma, exacerbation of this disease is possible. Treatment: gastric lavage, oral intake of activated coal, if necessary, symptomatic and maintaining treatment with the obligatory ensuring free patency of the respiratory tract, monitoring of cardiac activity and the main indicators of life before normalizing the patient's condition. Frequent or prolonged seizures should be treated with intravenous diazepam or lorazepam. With bronchial asthma, the use of bronchodilators is recommended. The output and packaging form of 10 tablets are placed in a contour cell package from a white hard film of polyvinyl chloride and soft foil of aluminum, millled paper. 1 (2 or 3) contour cell packages along with instructions for medical use in the state and Russian languages ​​are invested in a pack of cardboard. Storage conditions in a dry place protected from light at a temperature of not higher than 25 0C. Keep out of the reach of children! Shelf life 3 years. Do not use after the expiration date. Conditions of vacation from pharmacies according to the recipe, Spain, the owner of the registration certificate "Dr. Reddy's Laboratories Ltd., India Organizer-IPARPER “Laboratorios Normon, SA”, Spain, the address of the organization that accepts in the territory of the Republic of Kazakhstan, claims from consumers on the quality of products (goods) and responsible for post-passing monitoring of the safety of the drug: representation in the Republic of Kazakhstan : 050057 Almaty, st. 22 Line, 45

Indications for use

It is recommended to take Novigan for any pain syndrome, including those accompanied by spasms or colic:

• for painful menstruation: active components significantly reduce the production of prostaglandins in the female myometrium, relieve pressure in the vessels of the uterus and appendages, help get rid of cramping attacks before the start of the cycle and throughout menstruation;
• with inflammatory processes in the pelvic and abdominal organs: adnexitis, renal colic, pain in the liver, intestines, gall bladder;
• with cystitis;
• for tension headaches caused by poor circulation due to cervical osteochondrosis, for migraines, and meteosensitivity;
• with myositis;
• with neuralgic syndrome;
• for inflammation and degenerative processes in the joints and spine: arthritis, osteoarthrosis, sciatica, lumbodynia;
• for mechanical injuries of joint structures and muscles: bruises, pinching, dislocations, sprains and torn ligaments;
• during the recovery period after surgical interventions.

If necessary, Novigan can be used to relieve toothache. Ibuprofen in its composition reduces the sensitivity of nerves, reducing unpleasant symptoms.

Who should take it?

Novigan is used as an anti-inflammatory, antispasmodic and antipyretic medicine in women.

Dysmenorrhea occurs, according to various sources, in 60 - 70% of girls. Moreover, sometimes the fact of pain during menstruation is often taken as the norm, since all women in the family may have it. Novigan is suitable for the treatment of both primary and secondary dysmenorrhea.

They can also stop attacks of pain in the lower abdomen on the eve of menstruation.

If you experience discomfort in the middle of the cycle due to ovulation, you can use this drug.

Caution should be exercised in the following conditions:

• If the pain is unusual, more intense, and localized in an atypical location.
• If there is much more discharge, you can even say that it is bleeding.
• If you suspect an acute abdominal pathology, for example, appendicitis, etc. There is severe bloating and other symptoms.
• If the pain is accompanied by severe nausea, vomiting, diarrhea.

Contraindications

The use of the drug is prohibited for the following health conditions:

• bronchial asthma;
• hypersensitivity to acetylsalicylic acid and other NSAIDs;
• for disorders of blood coagulation and composition, pathologies of the hematopoietic organs;
• for diseases and dystrophy of the optic nerve, glaucoma;
• gastric ulcer, acute colitis, pancreatitis, gastritis, erosive lesions of the gastrointestinal mucosa;
• with a tendency to internal bleeding;
• in the period after heart surgery, with acute cardiac arrhythmias.

Novigan is also not applicable in the early stages of pregnancy - in the first trimester, and in the last month before childbirth. It is contraindicated for nursing women and children under 14 years of age.

The drug is prescribed with caution to the elderly, patients with diabetes mellitus, angina pectoris, hypertension, renal or liver failure.

Features of the drug use

The drug has high bioavailability, in other words, it is able to be quickly absorbed and penetrate into sore spots. The maximum concentration in the blood is recorded an hour and a half after oral administration. The method of administration of the drug is determined by its pharmacokinetics. Novigan has a long period of action (about 6 hours). It is this group of drugs that is recommended in the fight against dysmenorrhea.

The medicine can be used without a prescription from a specialist. The maximum dosage is three tablets per day. The course of treatment is from 3 to 5 days. These recommendations should not be exceeded, as this may lead to the development of adverse reactions.

It is recommended to take Novigan immediately before a meal or three hours after it. If you have stomach diseases (for example, acute gastritis or ulcers), the medicine can be taken immediately after meals. This method helps protect the gastric mucosa from negative effects. This is confirmed by the instructions for use. Now we know what Novigan helps with.

Side effects

While taking the drug, reactions from the gastrointestinal tract and nervous system are possible:

• loss of appetite, dry mouth, unpleasant taste, nausea, epigastric pain;
• dizziness, insomnia or increased drowsiness;
• decreased urine volume;
• increased sweating;
• visual disturbances;
• increased level of leukocytes in the blood, decreased clotting;
• bronchospasm;
• tachycardia, increased blood pressure.

Possible signs of an allergy to the drug: swelling of the mucous membranes of the eyes and eyelids, lacrimation, urticaria, itching, aphthous stomatitis, vasomotor rhinitis, laryngeal edema. In such cases, immediate discontinuation of the medication is required.

How to use Novigan: instructions

It is recommended to take the drug in short courses: no more than 5 days in a row. The maximum dose of tablets is 3 pieces: 1 three times a day. If well tolerated, Novigan can be taken between meals: 2–3 hours after meals or 1 hour before meals. If you have stomach problems, it is not advisable to take the tablets on an empty stomach. It is safer to take them with food.

Treatment should not be combined with taking tranquilizers, other NSAIDs, drinking alcohol or caffeine-containing products. This may increase side effects and cause intoxication.

Medicinal effect for dysmenorrhea

Dysmenorrhea is a cyclic pathological condition during which, during menstruation, painful sensations in the lower abdomen of varying severity appear. There are primary and secondary forms of dysmenorrhea. The treatment for each of them is not significantly different from each other.

A possible cause of primary dysmenorrhea is excessive production of prostaglandins. They lower the threshold of pain sensitivity in the weaker half of humanity, as a result of which even minor complications provoke severe discomfort. In such situations, drugs that can inhibit the synthesis of prostaglandins help combat these conditions.

According to reviews, Novigan quickly relieves menstrual pain.

Unpleasant sensations can be caused by excessive contractions of the muscles of the uterus. Prostaglandins increase symptoms by stimulating such activity. Fenpiverinium bromide and pitofenone hydrochloride influence the mechanism of these unpleasant sensations in different ways. And ibuprofen enhances the effect of previous substances by reducing the concentration of prostaglandins.

Dysmenorrhea of ​​the secondary form occurs in the presence of any diseases. For example, such pain occurs with uterine fibroids, endometriosis, abnormal development of the genital organs and other pathologies. These diseases provoke abnormal contractile activity of the uterus. Antispasmodic drugs normalize this process and help relax the muscle fibers of the uterus.

Is Novigan indicated for menstruation? Yes, it relieves pain quickly.