Compound
The composition of Galazolin nasal gel includes: xylometazoline hydrochloride , sodium chloride, sodium dihydrogen phosphate, sodium hydrogen phosphate, benzalkonium chloride, hydroxyethylcellulose, ethylenediaminetetraacetic acid salt, sorbitol , glycerol, purified water.
The composition of Galazolin nasal drops includes: xylometazoline hydrochloride , sodium hydrogen phosphate, sodium chloride, disodium edetate, benzalkonium chloride, sorbitol, sodium dihydrogen phosphate monohydrate, purified water.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
The active ingredient of the drug is an imidazoline . It affects the adrenergic receptors of blood vessels located in the nasopharyngeal mucosa. Under the influence of the drug, blood vessels narrow, hyperemia and, as a result, swelling of the mucous membrane and the amount of nasal discharge decreases. This helps to facilitate the process of nasal breathing in various diseases (diseases of the paranasal sinuses, rhinitis , allergic conditions). The effect is observed after 10-20 minutes and lasts for 10 hours.
Pharmacokinetics
At recommended therapeutic doses, the drug is practically not absorbed into the systemic circulation, and therefore there is no data on pharmacokinetics.
Pharmacological properties of the drug Galazolin
Pharmacodynamics. Xylometazoline is an imidazoline derivative that has a sympathomimetic effect and is a direct antagonist of α2-adrenergic receptors. Causes a narrowing of the blood vessels of the nasal mucosa, eliminates its hyperemia and swelling, and reduces exudation. Long-term use of the drug (over 2 weeks) can lead to secondary dilation of blood vessels (rhinitis medicamentosa), which may be caused by inhibition of the release of norepinephrine from nerve endings by excitation of presynaptic α2-adrenergic receptors. Pharmacokinetics. The effect of the drug develops after 5–10 minutes; its effect lasts for 5–6 hours, but vasoconstriction persists for another 8–12 hours. When applied to the mucous membrane, the drug causes local constriction of blood vessels and is practically not absorbed into the bloodstream and has no systemic effect. If a significant amount of xylometazoline enters the digestive tract (mainly possible in children), excessive sedation is noted.
Contraindications
High sensitivity to the drug, angle-closure glaucoma , atherosclerosis , atrophic rhinitis hyperthyroidism (for nasal drops), arterial hypertension , age up to 6 years (drops 0.1%) and up to 2 years (drops 0.05%), age up to 12 years (gel 0.1%) and up to 3 years (gel 0.05%).
Take the drug with caution in case of diabetes mellitus , during lactation , prostate adenoma , angina .
Special instructions for the use of the drug Galazolin
the bottle must be used individually; It should not be shared with others for use to prevent the possible spread of infection. The drug in the form of nasal drops should not be used in children under 4 months of age. The drug in the form of a nasal gel should not be used in children under 3 years of age. Use with caution in patients with coronary artery disease, hypertension (arterial hypertension), diabetes mellitus, prostate hypertrophy, hyperthyroidism. The drug can be used during pregnancy only if the expected therapeutic effect for the mother outweighs the potential risk to the fetus. There is no evidence that Galazolin is excreted in breast milk; however, it is not recommended to use the drug during breastfeeding. If the use of the drug is necessary, breastfeeding should be stopped. The drug does not have a negative effect on the ability to drive vehicles or operate potentially dangerous mechanisms.
Instructions for use of Galazolin (Method and dosage)
For adults, Galazolin in gel form is prescribed intranasally, 1 spray into each nostril every 8-10 hours. The course of use of the drug is no more than 5 days.
According to the instructions for use, Galazolin drops are prescribed to adults intranasally in each nostril, 2-3 drops every 8-10 hours.
Children's Galazolin in the form of 0.05% drops is prescribed at the age of 2-6 years, twice a day, 1-2 drops in each nostril. Over six years of age, instill a 0.1% solution of 2-3 drops up to three times a day.
In the form of a 0.05% gel, children 3-6 years old - 1 dose in each nostril twice a day. From the age of 12 years, apply 0.1% gel 3 times a day.
Galazolin nasal drops 0.1% 10ml
Compound
Active substance: xylometazoline hydrochloride 1 mg.
Excipients: sodium hydrogen phosphate dodecahydrate - 2.5 mg, sodium dihydrogen phosphate monohydrate - 3.68 mg, sodium chloride - 3.3 mg, disodium edetate - 0.2 mg, benzalkonium chloride 50% - 0.2 mg, sorbitol - 20 mg, purified water - up to 1 ml.
Pharmacokinetics
When the drug is used in recommended doses, xylometazoline is practically not subject to systemic absorption; plasma concentrations are so small that they cannot be determined by modern analytical methods.
Indications for use
- Acute rhinitis of viral or bacterial origin;
- allergic rhinitis;
- acute sinusitis;
- chronic sinusitis in the acute phase;
- hay fever;
- otitis media (to reduce swelling of the mucous membrane of the nasopharynx and restore patency of the Eustachian tube).
Contraindications
- Hypersensitivity to the components of the drug;
- atrophic rhinitis;
- angle-closure glaucoma;
- arterial hypertension;
- severe atherosclerosis;
- tachycardia;
- hyperthyroidism (for nasal drops);
- surgical intervention on the meninges (history);
- simultaneous use of MAO inhibitors and a period of 14 days after the end of their use;
- simultaneous use of tricyclic antidepressants;
- pregnancy;
- children up to 6 years of age (for 0.1% nasal drops) and up to 2 years (for 0.05% nasal drops);
- children up to 12 years of age (for 0.1% nasal gel) and up to 3 years (for 0.05% nasal gel).
The drug should be used with caution during lactation, with diabetes mellitus, with angina pectoris III-IV functional class, prostatic hyperplasia, pheochromocytoma (for nasal drops), with hyperthyroidism (for nasal gel).
Directions for use and doses
Galazolin® in the form of drops 0.05% is prescribed to children aged 2 to 6 years, 1-2 drops in each nostril 1-2 times a day.
Galazolin® in the form of drops 0.1% is prescribed to adults and children over 6 years of age, 2-3 drops in each nostril 2-3 times a day.
Galazolin® in the form of nasal drops should not be used more than 3 times a day.
Do not exceed the indicated doses. The course of treatment is no more than 3-5 days. The maximum duration of use is 2 weeks.
Storage conditions
The drug should be stored out of the reach of children, protected from light at a temperature not exceeding 25°C.
Best before date
4 years. Do not use after the expiration date stated on the packaging.
special instructions
Before use, it is necessary to clean the nasal passages.
Galazolin®, like other sympathomimetics, should be used with extreme caution in patients with hypersensitivity to adrenergic agonists, manifested by insomnia, dizziness, tremor, cardiac arrhythmias and increased blood pressure.
The drug should not be used in patients with chronic or vasomotor rhinitis, as they tend to use the drug for longer than 5 days.
Prolonged use of the drug (more than 2 weeks) can lead to secondary dilation of blood vessels and subsequently to secondary drug-induced rhinitis. The cause of this disease is inhibition of the release of norepinephrine from nerve endings through stimulation of presynaptic α2 receptors.
Recommended doses should not be exceeded, especially in children and elderly patients.
The drug contains benzalkonium chloride, and therefore may cause irritation of the nasal mucosa.
Description
Anticongestant - alpha-adrenergic agonist.
Use in children
Contraindications: children under 6 years of age (for 0.1% nasal drops) and up to 2 years (for 0.05% nasal drops).
Pharmacodynamics
Vasoconstrictor drug for local use in ENT practice. Alpha adrenergic agonist from the group of imidazole derivatives. In low concentrations it acts on α2-adrenergic receptors, in high concentrations it acts on α1-adrenergic receptors.
When applied topically, it causes a narrowing of blood vessels, which leads to a reduction in swelling and hyperemia of the mucous membranes of the nasopharynx, reduces the amount of nasal discharge, and facilitates nasal breathing with rhinitis.
The effect of the drug begins within 5-10 minutes and lasts for 5-6 hours when used in the form of nasal drops and for 10 hours when used in the form of a nasal gel.
Side effects
Local reactions: with frequent and/or prolonged use - irritation and/or dryness of the mucous membrane of the nasopharynx, burning and paresthesia of the mucous membrane of the nasal cavity, sneezing, hypersecretion of the mucous membrane of the nasal cavity; rarely - swelling of the nasal mucosa.
Systemic reactions: rarely - palpitations, tachycardia, palpitation, arrhythmia, increased blood pressure (especially in patients with diseases of the cardiovascular system), headache, nausea, vomiting, insomnia, weakness, fatigue, drowsiness, blurred vision, allergic reactions (suffocation, vasomotor edema); with long-term use and/or when used in high doses - depression, drug-induced rhinitis.
Use during pregnancy and breastfeeding
Contraindicated during pregnancy.
There is no data on the excretion of xylometazoline in breast milk. It is necessary to prescribe the drug with caution to women during lactation (breastfeeding).
Interaction
Incompatible with MAO inhibitors and tricyclic antidepressants.
When xylometazoline is used simultaneously with other sympathomimetics (for example, ephedrine, pseudoephedrine), the effect is potentiated. This combination should be used with caution.
Overdose
There have been no cases of overdose in adults. If too large a dose is used or used incorrectly, ingestion of drops and absorption of the active substance from the gastrointestinal tract may occur. This occurs mainly in children. In this case, a pronounced sedative effect is observed.
Symptoms: in case of accidental ingestion of the drug (more often in children), tachycardia, arrhythmia, increased blood pressure, drowsiness, confusion, respiratory depression or irregular breathing are observed.
Treatment: carry out symptomatic therapy.
Impact on the ability to drive vehicles and operate machinery
The drug does not affect the ability to drive vehicles and maintain moving machinery if used in the recommended dose and for a short time.
With prolonged use or use in high doses, undesirable effects on the cardiovascular system and central nervous system may occur. If side effects develop, the drug may affect the ability to drive vehicles and machines.
Overdose
If used incorrectly in children and ingestion of the drug or taking too large a dose, severe sedation may occur, manifested by drowsiness , nausea, dilated pupils, cyanosis , vomiting , tachycardia , arrhythmia , hypertension , respiratory failure, mental disorders, confusion , pulmonary edema , depression breathing.
Side effects of the drug Galazolin
Locally, in some cases there may be irritation, burning, an unpleasant feeling of dryness of the nasal mucosa, and sneezing. Very rarely, systemic effects occur - headache, drowsiness, weakness, tachycardia, sedation (after overdose). If a very high dose is used or used incorrectly, the drops can be swallowed, which leads to absorption of the active substance into the gastrointestinal tract. Such cases occur mainly in children, with the main side effect being excessive sedation.
Analogs
Level 4 ATX code matches:
Xymelin Eco
Xymelin
Nazivin
Lazorin
Nazivin Sensitive for children
Otrivin
Naphthyzin
Sanorin
Knoxprey
For the nose
Lazolvan Rino
Afrin
Rhinorus
Eucazoline Aqua
Rinazolin
Grippostad Reno
Farmazolin
Xylometazoline
Nazol Advance
Nazol Baby
Farmazolin , Xylo-Mefa , Otrivin , Meralis , Xylometazoline , Otrivin with eucalyptus and menthol .
Reviews about Galazolin
Reviews about the drug are in most cases favorable. Patients note high efficiency and duration of action, which is especially important if you need to go to work.
However, sometimes on forums not everyone can figure out “what Galazolin drops are for” or what the drops are used for and mistakenly believe that Galazolin is eye drops. This is not true, Galazolin is a nasal drop. But if by chance you drop them into your eyes, then you don’t need to worry; nothing will happen if you drop them once. However, in case of redness or discomfort, you should rinse your eyes or drip Okomistin .
It should be noted that it is relatively difficult to dose Galazolin in drops; part of the solution may enter the pharynx, so the risk of side effects is higher. Many patients report undesirable reactions: insomnia , neurosis , anxiety . Also, people often forget about the short-term use of the drug and use it for more than the time specified in the instructions.
This contributes to the development of drug-induced rhinitis , in which vasoconstriction is replaced by an increased supply of blood to the mucous membrane and the resumption of discharge or nasal congestion, which is difficult to treat. With long-term use of the drug, atrophy of the nasal mucosa .
Galazolin price, where to buy
The price of Galazolin (nasal drops 0.05%) varies between 30-32 rubles per pack; 0.1% - 36-38 rubles; Nasal gel 0.05% - 123-126; 0.1% - 162 -168 rubles per package.
You can buy the drug in any form without difficulty in the pharmacy chain of Moscow and other cities.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Galazolin drops called
0.05% 10mlPolfa Warsaw RUR 35.order - Galazolin drops called 0.1% 10mlPolfa Warsaw
38 rub. order
Pharmacy Dialogue
- Galazolin (vial cap. 0.1% 10ml)Polfa
41 rub. order
- Galazolin (vial cap. 0.05% 10ml)Polfa
34 RUR order
show more
Pharmacy24
- Galazolin 0.1% 10ml No. 1 nasal gel Medana Pharma Aktsionerne Tovaristvo, Poland
71 UAH.order - Galazolin 0.05% 10 ml drops Warsaw Federal Plant, Poland
46 UAH order
- Galazolin 0.05% 10 ml No. 1 nasal gel Medana Pharma Aktsionerne Tovaristvo, Poland
72 UAH order
- Galazolin 0.1% 10 ml drops
46 UAH order
PaniPharmacy
- Galazolin liquid Galazolin 0.1% 10ml Poland, Warsaw Federal Law
53 UAH order
- Galazolin gel Galazolin gel 0.1% 10g Poland, Medana Pharma SA
76 UAH order
- Galazolin gel Galazolin gel 0.05% 10g Poland, Medana Pharma SA
77 UAH order
- Galazolin liquid Galazolin 0.05% 10ml Poland, Warsaw Federal Law
46 UAH order
show more
