POLYOXIDONIUM instructions for use, description of the drug POLYOXIDONIUM: contraindications, side effects, dosages, composition – lyophilisate for preparation. solution for injection and local p

Instructions for use POLYOXIDONIUM lyophilisate 6 mg

Methods of using the drug Polyoxidonium®:

parenterally, intranasally. Methods of application are selected by the doctor depending on the severity of the disease and the age of the patient.

IM or IV (drip):

the drug is prescribed in doses of 6-12 mg 1 time/day daily, every other day, or 1-2 times a week, depending on the diagnosis and severity of the disease.

For intramuscular administration

add 1-2 ml of 0.9% sodium chloride solution or water for injection to the contents of the bottle and leave for 2-3 minutes to swell, then mix the contents with rotational movements.

For IV drip administration

2 ml of 0.9% sodium chloride solution is added to the contents of the bottle and left for 2-3 minutes to swell, then mixed with rotational movements and sterilely transferred into a bottle/bag with a 0.9% sodium chloride solution with a volume of 50-400 ml.

The prepared solution for parenteral administration cannot be stored.

Intranasally:

a dose of 6 mg is dissolved in 1 ml (20 drops) of distilled water, 0.9% sodium chloride solution or boiled water at room temperature.

The prepared solution can be stored at room temperature in the manufacturer’s original packaging for up to 48 hours.

Recommended treatment regimens for adults

Parenteral (IM and IV drip)

For acute inflammatory diseases:

6 mg daily for 3 days, then every other day with a total course of 5-10 injections.

For chronic inflammatory diseases:

6 mg every other day for 5 injections, then 2 times a week for a course of at least 10 injections.

For tuberculosis:

6-12 mg 2 times a week for a course of 10-20 injections.

In patients with acute and chronic urogenital diseases:

6 mg every other day for a course of 10 injections as part of complex therapy.

For chronic recurrent herpes:

6 mg every other day for a course of 10 injections in combination with antiviral drugs, interferons and/or inducers of interferon synthesis.

For the treatment of complicated forms of allergic diseases:

6 mg each, course of 5 injections - the first two injections daily, then every other day.

For acute allergic and toxic-allergic conditions:

6-12 mg intravenously in combination with antiallergic drugs.

For rheumatoid arthritis:

6 mg intramuscularly every other day for 5 injections, then 2 times a week for a course of at least 10 injections.

In cancer patients:

before and during chemotherapy to reduce the immunosuppressive, hepato- and nephrotoxic effects of chemotherapeutic agents, 6-12 mg every other day for a course of at least 10 injections; further, the frequency of administration is determined by the doctor depending on the tolerability and duration of chemotherapy and radiation therapy;
for the prevention of the immunosuppressive effect of the tumor, for the correction of immunodeficiency after chemotherapy and radiation therapy, after surgical removal of the tumor, long-term use of the drug Polyoxidonium® is indicated (from 2-3 months to 1 year) at a dose of 6-12 mg 1-2 times a week.

Intranasally

For treatment and prevention:

acute and chronic infections of the ENT organs (rhinitis, sinusitis, otitis media);
to enhance the regenerative processes of mucous membranes;
for the prevention of complications and relapses of diseases;
for the prevention of influenza and acute respiratory infections.

Prescribe 3 drops in each nasal passage every 1-2 hours (at least 3 times a day) for 5-10 days.

Before using the drug, it is necessary to clean the nasal cavity

Directions for use and doses for children

Methods of using the drug Polyoxidonium®:

parenterally, intranasally, sublingually. Methods of application are selected by the doctor depending on the diagnosis, severity of the disease, age and body weight of the patient.

IM or IV (drip):

prescribed to children from 6 months at a dose of 0.1-0.15 mg/kg daily, every other day or 2 times a week with a course of 5-10 injections (dose calculation is indicated in Table 1).

For intramuscular administration

the drug Polyoxidonium® 6 mg is dissolved in 2 ml of water for injection or 0.9% sodium chloride solution. After adding the solvent, the drug is left for 2-3 minutes to swell, then mixed with rotational movements.

For IV drip

administration, the drug Polyoxidonium® is dissolved in 1.5-2 ml of sterile 0.9% sodium chloride solution. After adding the solvent, the drug is left for 3-5 minutes to swell, then mixed with rotational movements. The dose calculated for the patient is sterilely transferred into a bottle/bag with 0.9% sodium chloride solution with a volume of 25-50-100-200 ml.

The prepared solution for parenteral administration cannot be stored.

Table 1. Calculation of the dose of Polyoxidonium® for intramuscular or intravenous administration for children

Child's body weight	Volume of injected solution in ml
5 kg	0.25 ml
10 kg	0.5 ml
15 kg	0.75 ml
20 kg	1.0 ml

Intranasal and sublingual:

daily at a daily dose of 0.15 mg/kg for 5-10 days. The drug is administered 1-3 drops into one nasal passage or under the tongue with an interval of 1-2 hours, in 2-3 doses per day.

To prepare the solution

for intranasal and sublingual use, a dose of 6 mg is dissolved in 2.0 ml (40 drops) of distilled water, 0.9% sodium chloride solution or boiled water at room temperature. One drop (0.05 ml) of the prepared solution contains 0.15 mg of the drug. The indicated dose is 0.15 mg, contained in 1 drop, prescribed per 1 kg of child’s body weight. Calculation of the daily dose for intranasal and sublingual use is presented in Table 2.

Table 2. Calculation of the dose of Polyoxidonium® for intranasal or sublingual use for children

Child's body weight	Number of drops per day
5 kg	5 drops
10 kg	10 drops
15 kg	15 drops
20 kg	20 drops

The prepared solution for intranasal and sublingual use can be stored at room temperature in the manufacturer’s original packaging for up to 48 hours.

Recommended treatment regimens for children

Parenterally

For acute inflammatory diseases:

0.1 mg/kg every other day for a course of 5-7 injections.

For chronic inflammatory diseases:

0.15 mg/kg 2 times a week for a course of up to 10 injections.

For acute allergic and toxic-allergic conditions:

IV drip at a dose of 0.15 mg/kg in combination with antiallergic drugs.

For the treatment of complicated forms of allergic diseases

in combination with basic therapy:

IM 0.1 mg/kg in a course of 5 injections with an interval of 1-2 days.

Intranasally:

daily 1-2 drops in one nasal passage every 1-2 hours (2-3 times/day) for a course of 5-10 days.

For acute and chronic rhinitis

(treatment and prevention of exacerbations).

For rehabilitation

frequently and long-term ill children.

For preoperative preparation

patients for surgical interventions for ENT pathology, as well as in the postoperative period in order to prevent infectious complications or relapses of the disease.

Treatment and prevention of influenza and other acute respiratory viral infections

(at any time after the onset of the disease and during the period of convalescence).

Sublingual for infants and young children:

daily at a daily dose of 0.15 mg/kg in 1-2 doses for 10 days.

For adenoiditis, hypertrophy of the tonsils:

as a component of conservative treatment.

For preoperative preparation

and postoperative rehabilitation for ENT pathology.

For seasonal prevention of exacerbations

chronic foci of infections of the oropharynx, upper respiratory tract, inner and middle ear.

For the treatment of intestinal dysbiosis

(in combination with basic therapy) for 10-20 days.

Special categories of patients

Patients with impaired renal function

in the presence of chronic renal failure, the drug is prescribed no more than 2 times a week.

Patients with impaired liver function:

no dose adjustment is required.

Elderly patients:

6 mg every other day - 5 injections, then 2 times a week for a course of at least 10 injections

Polyoxidonium®

Methods of using the drug Polyoxidonium®: parenteral (intramuscular, intravenous), intranasal, sublingual.

Methods of application, dosage regimen, need and frequency of subsequent courses of therapy are selected by the doctor depending on the severity of the disease and the age of the patient.

For intravenous drip administration, the dose of the drug calculated for the patient is sterilely transferred from a syringe into a bottle/bag with 0.9% sodium chloride solution. The prepared solution for intravenous administration cannot be stored.

Recommended treatment regimens for adults:

Parenteral (intramuscular or intravenous): the drug is prescribed to adults in doses of 6-12 mg 1 time per day every day, every other day, or 1-2 times a week, depending on the diagnosis and severity of the disease.

For acute viral and bacterial infections of the ENT organs, upper and lower respiratory tract, gynecological and urological diseases: 6 mg daily for 3 days, then every other day for a total course of 10 injections.

For chronic recurrent infectious and inflammatory diseases of various localization, bacterial, viral and fungal etiology, in the acute stage: 6 mg every other day for 5 injections, then 2 times a week for a total course of 10 injections.

For acute and chronic allergic diseases (including hay fever, bronchial asthma, atopic dermatitis), complicated by bacterial, viral and fungal infections: 6-12 mg, course of 5 injections, every other day.

For rheumatoid arthritis, complicated by bacterial, viral and fungal infections, against the background of long-term use of immunosuppressants: 6 mg every other day for 5 injections, then 2 times a week for a total course of 10 injections.

For generalized forms of surgical infections: 6 mg daily for 3 days, then every other day for a total course of 10 injections.

To activate regenerative processes (fractures, burns, trophic ulcers): 6 mg for 3 days, then every other day, for a total course of 10 injections.

For the prevention of postoperative infectious complications: 6 mg every other day, 5 injections.

For pulmonary tuberculosis: 6 mg 2 times a week for a course of 20 injections.

In cancer patients:

before and during chemotherapy to reduce the immunosuppressive, hepato- and nephrotoxic effects of chemotherapeutic agents, mg every other day for a course of 10 injections; further, the frequency of administration is determined by the doctor depending on the tolerability and duration of chemotherapy and radiation therapy;
to prevent the immunosuppressive effect of the tumor, to correct immunodeficiency after chemotherapy and radiation therapy, after surgical removal of the tumor, long-term use of the drug Polyoxidonium® (from 2-3 months to 1 year) 6 mg 1-2 times a week is indicated. When prescribing a long course, there is no effect of accumulation, toxicity or addiction.

Intranasal or sublingual (see section “Rules of use for sublingual and intranasal administration”):

for the treatment of acute and exacerbations of chronic infections of the ENT organs;
for the treatment and prevention of influenza and ARVI;
to enhance the regenerative processes of mucous membranes;
for the prevention of complications and relapses of chronic diseases. The total volume of the drug per day is 1 ml (20 drops) - 6 mg/ml syringe.

The daily dose of the drug is administered intranasally or sublingually in 3-4 doses per day.

Recommended treatment regimens for children:

Parenterally (intramuscularly or intravenously): prescribed to children from 6 months at a dose of 0.1-0.15 mg/kg daily, every other day or 2 times a week for a course of 5-10 injections.

For acute and exacerbations of chronic inflammatory diseases of any localization (including ENT organs - sinusitis, rhinitis, adenoiditis, hypertrophy of the pharyngeal tonsil, ARVI), caused by pathogens of bacterial, viral, fungal infections: 0.1 mg/kg 3 days in a row, then every other day with a total course of 10 injections.

For acute allergic and toxic-allergic conditions (including bronchial asthma, atopic dermatitis), complicated by bacterial, viral and fungal infections: 0.1 mg/kg 3 days daily, then every other day, a total course of 10 injections in combination with the basic therapy.

Intranasal or sublingual (see section “Rules of use for sublingual and intranasal administration”):

for acute and chronic rhinitis, rhinosinusitis, adenoiditis (treatment and prevention of exacerbations);
for preoperative preparation of patients during surgical interventions for ENT pathology, as well as in the postoperative period for the purpose of preventing infectious complications or relapses of the disease;
treatment and prevention of influenza and other acute respiratory viral infections (within 1 month before the expected epidemic), at any time after the onset of the disease and during the period of convalescence).
for the treatment of intestinal dysbiosis (used sublingually) in combination with basic therapy - for 10 days.

For children from 6 months to 18 years, it is recommended to use syringes with a dosage of 3 mg/ml.

The total volume of the drug per day is prescribed at the rate of 1 drop (0.15 mg) per 1 kg of weight.

For a child weighing up to 20 kg, no more than 20 drops (3 mg of active ingredient).

For a child weighing more than 20 kg, no more than 40 drops (6 mg of active ingredient).

Table 1. Calculation of doses for intranasal and sublingual administration in children.

See Fig.

The daily dose of the drug is administered intranasally or sublingually in 3-4 doses per day.

Course duration is 5-10 days.

Rules of use for sublingual and intranasal administration

Preparation for use

Figure 1: Wash your hands thoroughly.

Compound

One tablet of Polyoxidonium contains 12 mg of the active substance azoximer bromide , as well as potato starch (Amylum solani), lactose monohydrate (Lactose monohydrate), stearic acid (Acidum stearicum) as auxiliary components.
One bottle of lyophilisate contains 6 mg of active ingredient, as well as mannitol (E421 Mannit), povidone (Povidonum) and beta-carotene (Betacarotenum) as auxiliary components.

To make one rectal-vaginal suppository, 6 or 12 mg of active ingredient and auxiliary components are used: mannitol (E421 Mannit), povidone (Povidonum), beta-carotene (Betacarotenum), cocoa butter (Butyrum Cacao).

Indications and contraindications

Depending on the dosage form, Polyoxidonium can be prescribed for various pathological conditions. Doctors recommend taking the tablets for:

Diseases of an inflammatory and infectious nature localized in the mouth, sinuses, ear, and upper respiratory tract.
Secondary immunodeficiencies as a prophylactic agent during periods of increased incidence of viral and bacterial infections.

Indications for use of lyophilized powder:

Intravenous or intramuscular administration for diseases of inflammatory or infectious nature.
Rheumatoid arthritis (if the patient was treated with drugs that suppress the immune system).
Tuberculosis.
Allergic diseases complicated by severe, recurrent infection.
After radiation or chemotherapy for oncological conditions.
Reducing nephro- and hepatotoxicity of drugs.
Prevention of influenza and acute respiratory viral infections during epidemics.
Complicated bronchial asthma.
Atopic dermatitis accompanied by purulent infection.
Gastrointestinal diseases with dysbacteriosis.

Indications for the use of rectal and vaginal suppositories are the same as for lyophilisate. In addition, they are used to treat a wide range of gynecological pathologies (erosion, colpitis, endometritis, etc.).

There is only one contraindication to the use of Polyoxidonium. It should not be taken only by persons with high hypersensitivity to the components of the drug. It is also rarely prescribed to pregnant women due to the lack of data on the effect of the drug on the fetus.

Pharmacological action, pharmacodynamics and pharmacokinetics

Polyoxidonium has detoxification and immunocorrective effects. It increases the body's immune defense and helps it more effectively fight diseases of viral, fungal and bacterial etiology.

The mechanism of action of the drug is based on the ability of the main substance to influence natural killer cells and phagocytes, as well as stimulate antibody formation.

Taking Polyoxidonium together with other medications makes treatment more effective, reduces its duration, and sometimes allows you to completely stop using antibacterial, bronchodilator and hormonal drugs.

The main active ingredient has a high bioavailability of up to 90%. Azoximer bromide quickly enters and distributes into tissues. Excreted from the body through the kidneys.

Release form

Polyoxidonium has three dosage forms:

pills;
rectal-vaginal suppositories;
lyophilized powder.

The suppositories are torpedo-shaped, light yellow in color and have a specific smell of cocoa butter.

The tablets are flat-cylindrical, each of them has a chamfer. Their color can vary from yellowish-white to orange-yellow. The presence of slightly noticeable particles of more intense color is allowed in tablets.

Polyoxidonium lyophilisate for the preparation of solution for and local application 6 mg fl 5 pcs

Methods of using the drug Polyoxidonium®: parenteral, intranasal, sublingual. Methods of application, dosage regimen, need and frequency of subsequent courses of therapy are selected by the doctor depending on the severity of the disease and the age of the patient.

Preparation of solutions for parenteral administration (intramuscular and intravenous): For intramuscular administration, the drug Polyoxidonium® 3 mg is dissolved in 1 ml (dose 6 mg in 2 ml) of water for injection or 0.9% sodium chloride solution. After adding the solvent, the drug is left for 2-3 minutes to swell, then mixed with rotational movements without shaking.

For intravenous drip administration, the drug Polyoxidonium® is dissolved in 2 ml of sterile 0.9% sodium chloride solution. After adding the solvent, the drug is left for 2-3 minutes to swell, then mixed with rotational movements. The dose calculated for the patient is sterilely transferred into a bottle/bag with 0.9% sodium chloride solution.

The prepared solution for parenteral administration cannot be stored.

Preparation of a solution for intranasal and sublingual use: for children, a dose of 3 mg is dissolved in 1.0 ml (20 drops).

Method of administration and dosage in adults Parenteral (intramuscular or intravenous): the drug is prescribed to adults in doses of 6-12 mg once a day every day, every other day or 1-2 times a week, depending on the diagnosis and severity of the disease.

For acute and chronic allergic diseases (including hay fever, bronchial asthma, atopic dermatitis), complicated by bacterial, viral and fungal infections: 6-12 mg, course of 5 injections.

For generalized forms of surgical infections: 6 mg daily for 3 days, then every other day for a course of 10 injections.

To activate regenerative processes (fractures, burns, trophic ulcers): 6 mg for 3 days, then every other day, a course of 10 injections.

For the prevention of postoperative infectious complications: 6 mg every other day, 5 injections.

For pulmonary tuberculosis: 6 mg 2 times a week for a course of 20 injections.

In cancer patients: before and during chemotherapy to reduce the immunosuppressive, hepato- and nephrotoxic effects of chemotherapeutic agents, 6 mg every other day for a course of 10 injections; further, the frequency of administration is determined by the doctor depending on the tolerability and duration of chemotherapy and radiation therapy; to prevent the immunosuppressive effect of the tumor, to correct immunodeficiency after chemotherapy and radiation therapy, after surgical removal of the tumor, long-term use of the drug Polyoxidonium® (from 2-3 months to 1 year) 6 mg 1-2 times a week is indicated. When prescribing a long course, there is no effect of accumulation, toxicity or addiction.

Intranasal dosage is prescribed at 6 mg per day (3 drops in each nasal passage 3 times a day - for 10 days): for the treatment of acute and exacerbations of chronic infections of the ENT organs; to enhance the regenerative processes of mucous membranes; for the prevention of complications and relapses of chronic diseases; for the prevention of influenza and ARVI.

Methods of administration and doses in children Methods of use of the drug Polyoxidonium®: parenteral, intranasal and sublingual. Methods of application are selected by the doctor depending on the severity of the disease and the age of the patient.

Parenterally (intramuscularly or intravenously): prescribed to children from 6 months at a dose of 0.1-0.15 mg/kg daily, every other day or 2 times a week for a course of 5-10 injections.

Intranasal and sublingual: daily at a daily dose of 0.15 mg/kg for a course of up to 10 days.

The drug is administered 1-3 drops into one nasal passage or under the tongue with an interval of at least 1-2 hours, in 2-3 doses per day.

One drop (0.05 ml) of the prepared solution contains 0.15 mg of the drug.

The calculation of the daily dose for intranasal and sublingual use is presented below: 5 kg - 5 drops 10 kg - 10 drops 15 kg - 15 drops 20 kg - 20 drops

If the child weighs more than 20 kg, the daily dose is calculated at the rate of 1 drop per 1 kg of body weight, but not more than 40 drops (6 mg of active substance).

The prepared solution for intranasal and sublingual use can be stored at room temperature in the manufacturer's packaging for up to 48 hours.

Recommended treatment regimens for children Parenteral: For acute and exacerbations of chronic inflammatory diseases of any location (including ENT organs - sinusitis, rhinitis, adenoiditis, hypertrophy of the pharyngeal tonsil, acute respiratory viral infections) caused by pathogens of bacterial, viral, fungal infections: 0 each .1 mg/kg for 3 days in a row, then every other day with a course of 10 injections.

For acute allergic and toxic-allergic conditions (including bronchial asthma, atopic dermatitis), complicated by bacterial, viral and fungal infections: intravenous drip at a dose of 0.1 mg/kg, 3 days daily, then every other day, a course of 10 injections per combination with basic therapy.

Intranasal: daily 1-2 drops in each nasal passage 3 times a day for up to 10 days For acute and chronic rhinitis, rhinosinusitis, adenoiditis (treatment and prevention of exacerbations); For preoperative preparation of patients during surgical interventions for ENT pathology, as well as in the postoperative period in order to prevent infectious complications or relapses of the disease; Treatment and prevention of influenza and other acute respiratory viral infections (within 1 month before the expected epidemic), at any time after the onset of the disease and during the period of convalescence);

Sublingually, for children of early, preschool and primary school age: daily at a daily dose of 0.15 mg/kg in 2 divided doses for 10 days: For adenoiditis, tonsil hypertrophy: (as a component of conservative treatment); For preoperative preparation and postoperative rehabilitation; For seasonal prevention of exacerbations of chronic foci of infections of the oropharynx, upper respiratory tract, inner and middle ear; For the treatment of intestinal dysbiosis (in combination with basic therapy) for 10 days.