Proteflazid

Compound

The composition of 100 ml of the drug includes a liquid extract of a mixture of plants: turfgrass grass and ground reed grass .
It contains no less than 0.32 mg of flavonoids in terms of rutin , as well as no less than 0.3 mg of total carboxylic acids in terms of malic acid.

In addition, the product contains ethyl alcohol 96% as an additional ingredient.

pharmachologic effect

Flavonoids of wild cereals, which are part of this product, have the ability to inhibit DNA polymerase and thymidine kinase (they are specific enzymes of viruses). These processes occur in body cells that have been infected by viruses. Due to the inhibition of these enzymes, viral DNA replication is suspended. As a result, it stops reproducing in cells.

nonspecific immunity is strengthened . interferon in the body increases . This increases the body's overall resistance to both viruses and bacteria.

The product has antioxidant , which means it stops the accumulation of lipid peroxidation products in the body. With prolonged daily treatment with the drug, indicators of a person’s immune status are normalized. Therefore, Proteflazid can be used over a long period for the treatment of chronic recurrent infectious diseases.

Pharmacological properties of the drug Proteflazid

The drug contains flavonoid glycosides isolated from wild cereals Deschampsia caespitosa L. and Calamagrostis epigeios L., which are capable of inhibiting virus-specific enzymes DNA polymerase and thymidine kinase in virus-infected cells. This disrupts or stops viral DNA replication and prevents viruses from multiplying. At the same time, Proteflazid increases the production of endogenous interferon alpha and gamma, increasing the body's nonspecific resistance to viral and bacterial infections, as well as the body's immune status. The drug has antioxidant activity because it prevents the accumulation of lipid peroxidation products and thereby inhibits the course of free radical processes. The pharmacokinetics of the drug has not been studied.

Pharmacodynamics and pharmacokinetics

After taking the drug, partial absorption occurs in the stomach, and after that the rest of it is absorbed in the small intestine.

A small part of flavonoids is broken down due to first-pass metabolism , that is, during the initial passage through the liver. Their main quantity enters the cells of organs and tissues, penetrating into those cells that have been infected with the virus.

The drug has no effect on those cells that have not been infected and, therefore, do not have a high level of activity of virus-specific enzymes. Enzymes are inhibited exclusively in infected cells.

The half-life in an adult is from 5 to 9 hours, so it is advisable to take the drug three times a day.

Proteflazid

Proteflazid is an antiviral herbal medicine based on flavonoid glycosides. Used for herpetic infections of the skin and mucous membranes, incl. genitals. For Russia, as well as for all countries of the former USSR, the problem of treating viral infections is steadily gaining relevance. A person’s natural resistance to viral infections is increasingly influenced by factors such as chronic psycho-emotional stress, deteriorating environmental conditions, and dietary errors. The result is a progressive deterioration of the immune system, which has fewer and fewer reserves to fight viral agents, incl. herpes simplex virus. The latter infected 9 out of 10 inhabitants of the earth. The drug Proteflazid based on flavonoid glycosides extracted from wild cereal plants is effective against infection with the herpes virus, because suppresses the activity of viral DNA polymerase and activates mononuclear phagocytes, which “devour” the virus. Proteflazid exhibits a direct antiviral effect at all stages of disease development. It also has an immunotropic effect, acts as a detoxicant and antioxidant (suppresses free radical oxidation processes). The drug has a favorable safety profile: it can be used in children, pregnant and lactating women (in consultation with a doctor after assessing the benefit/risk ratio).

It is well tolerated by patients and does not cause any unwanted side effects. In patients infected with HIV, the use of Proteflazide can improve appetite, restore body weight, eliminate asthenic phenomena, and increase immunity. The drug also has a general strengthening effect, acting as an adaptogen. Absorption of the drug into the bloodstream occurs mainly in the small intestine and to a small extent in the stomach. A small part of flavonoid glycosides undergoes a first-pass effect through the liver, but the bulk of the active components are distributed in the tissues and enter the affected cells. The half-life of the drug is on average 7 hours. The frequency of use of Proteflazide is 3 times a day. The drug is contraindicated in persons with individual intolerance to the active substances, ulcerative and erosive lesions of the gastric and duodenal mucosa. The duration of the medication course is 1 month. After a month, according to indications, a second course is possible. Drops can be used both internally and externally using tampons or gauze pads soaked in Proteflazid drops (for example, for genital herpes). For external use, the duration of treatment is 2 weeks. The drug does not interact with other drugs.

Indications for use

The product is used for the following diseases and conditions:

• viral infections that were provoked by the herpes of the first and second types ( vesicular dermatitis , eczema , pharyngotonsillitis , gingivostomatitis , meningitis and encephalitis , herpetic eye diseases, genital herpes );
• herpes zoster;
• infectious diseases that manifest themselves as a result of exposure to the fourth type of herpes , both acute and chronic;
• infectious diseases provoked by the fifth type of herpes ;
• hepatitis B and C (complex therapy);
• viral, fungal, bacterial infections (complex therapy);
• influenza , ARVI (prevention, treatment);
• HIV infection and AIDS (complex therapy).

Indications for use of the drug Proteflazid

Prevention and treatment of infections caused by herpes simplex virus types 1 and 2 (herpetic eczema, herpetic vesicular dermatitis, herpetic gingivostomatitis and pharyngotonsilitis, herpetic keratoconjunctivitis, herpetic meningitis and encephalitis, genital herpes); shingles; complex treatment of hepatitis B and C; to prevent viral and bacterial infections that occur in patients with immunodeficiency; as part of complex therapy for patients with AIDS and HIV infected.

Side effects

In most cases, there are no side effects during treatment with the drug. In isolated cases, gastrointestinal disorders , which were accompanied by vomiting , nausea , and pain in the epigastric region. On days 3-10 of therapy, an increase in body temperature to 38 °C was noted.

In rare cases, the development of allergic reactions , mainly they manifested themselves in the form of an erythematous rash on the skin. headaches occurred , which disappeared after the dose of the drug was adjusted.

During treatment for hepatitis, activity increased cytolytic syndrome .

People suffering from a chronic form of gastroduodenitis experienced an exacerbation of the disease, the development of gastroesophageal reflux .

If Proteflazid is applied topically, a feeling of itching , burning , and dry skin may develop. In this case, it is necessary to reduce the concentration of the drug.

Special instructions for the use of the drug Proteflazid

Preclinical studies did not reveal any teratogenic, mutagenic or carcinogenic effects. When using the drug Proteflazid in the second and third trimester of pregnancy and during breastfeeding, no undesirable side effects were identified. However, it is necessary to adhere to the general rules for prescribing medications during pregnancy, assessing the benefit/risk ratio. When treating viral hepatitis, 10–15% of patients with severe cytolytic syndrome experience an increase in aminotransferase activity (less frequently, bilirubin level), which does not significantly affect the course of recovery processes in the liver and does not require discontinuation of the drug. No negative impact on the performance of potentially hazardous activities that require special attention and quick response has been identified.

Instructions for use Proteflazid (Method and dosage)

The instructions for Proteflazid stipulate that the drops should be applied to sugar or a piece of bread before oral administration. The doctor describes in detail how to take the drug when prescribing a course of treatment.

Standard treatment with Proteflazid is described in the instructions for use as follows: in the first week of treatment, you need to take 15 drops of the drug daily, this dose is divided into three doses. The second and third weeks of treatment - 30 drops each, which should be divided into 3 doses. Starting from the fourth week of treatment, you need to take 24 drops every day, and they are also divided into three doses.

In general, treatment continues for one month; if necessary, a second course of therapy can be carried out.

For children, the dosage of Proteflazide is determined by the doctor. As a rule, a child receives 1 drop per day from birth until the age of two. Children aged 2-4 years receive 1 drop twice a day in the first week of therapy, and 2 drops twice a day in the second week. Children aged 4-6 years receive 2 drops three times a day in the first week of therapy, and 3 drops three times a day in the second week. Children aged 6-9 years receive 3 drops three times a day in the first week of therapy, and 6 drops three times a day in the second week. Children aged 9-12 years receive 4 drops three times a day in the first week of therapy, and 7 drops three times a day in the second week. After 12 years of age, the child receives 5 drops three times a day in the first week of therapy, and 8 drops three times a day in the second week.

Due to the presence of ethyl alcohol in the composition, children under six years of age are given drops after dissolving the required dose in a small amount of sweetened water.

If the patient experiences frequent relapses of infectious diseases, 3-4 courses of taking Proteflazide per year are practiced. If the infection is latent, two such courses of treatment per year are indicated.

Locally, Proteflazid is used to treat herpetic lesions on the mucous membranes and skin. For this purpose, 1.5 ml of the product is dissolved in 10 ml of 0.9% NaCl, after which it is applied as a lotion to the affected area. Patients with genital herpes can use the product to make vaginal tampons. For this purpose, 3 ml of the drug is dissolved in 20 ml of 0.9% NaCl. In the resulting solution, you need to moisten a gauze tampon, which is then inserted into the vagina. This procedure is repeated twice a day for at least two weeks.

Use of the drug Proteflazid

Inside, drops are applied to a piece of sugar or bread. Adults: 1st week - 5 drops 3 times a day, 2-3 weeks - 10 drops 3 times a day, 4th week - 8 drops 3 times a day. After 1 month, the course of treatment can be repeated. The average therapeutic dose for adults is 30 drops. Scheme of use of the drug Proteflazid in pediatric practice

Due to the presence of at least 85% ethyl alcohol in the drug, for children under the age of 6 years the required amount of the drug is diluted with sugar in 50 ml of boiled water. In case of recurrent infection, courses of treatment with Proteflazid are carried out 3-4 times a year, and in case of latent infection - 2 times a year. When treating chronic, often recurrent herpetic infections in adults, the following dosage regimen is recommended: 5 drops 3 times a day for 3 days; then 7 drops 3 times a day for 3 days; 8–10 drops 3 times a day for the next 3 months without interruption. Maintenance therapy after the main course of treatment should be carried out for 2–4 months, 10 drops 2 times a day. When treating viral hepatitis B, C, the following dosage regimen is recommended: from 1 to 3 days - 3 drops 3 times a day; from 4 to 6 days - 5 drops 3 times a day; from day 7 - 10 drops 3 times a day. Duration of therapy is at least 4–6 months. To treat herpetic lesions of the skin and mucous membranes, apply lotions with the drug to the affected area 3-5 times a day. To prepare lotions with Proteflazid, you need to dilute 1.5 ml (36–38 drops) of the drug in 10 ml of isotonic sodium chloride solution. For primary and recurrent genital herpes, vaginal tampons with Proteflazide solution are used. To prepare the solution, dilute 3.0 ml (72–75 drops) of the drug in 20 ml of 0.9% sodium chloride solution and insert a gauze swab moistened with the prepared solution into the vagina. These procedures must be carried out 2 times a day. If a burning sensation occurs in the vagina, you need to double the amount of solvent. Treatment should be continued until signs of damage to the skin or mucous membrane disappear. The duration of the course of therapy is up to 14 days.

Proteflazid's analogs

Analogs of this drug in terms of its effect on the body are the following drugs: Herpes simplex , Arbidol , Detoxopirol , Ingavirin , Imustat , Armenicum , Ferrovir , Kagocel , Panavir , Flavoside , Yodantipirin . Any analogue of this medicine can be used instead of Proteflazide only after consulting a doctor.

Reviews about Proteflazide

There are numerous positive reviews from doctors and patients about the effectiveness of this remedy in the treatment of infectious diseases. In particular, parents note that the drops used for children had a pronounced antiviral effect.

The drug is also effective as an immunomodulator : reviews of Proteflazide often say that after a course of such treatment the patient began to get sick much less often.

There is a pronounced positive effect of Proteflazide in the treatment of herpetic infections , a decrease in the frequency of relapses after such treatment. Negative impressions of the medicine include its unpleasant taste, as well as its high price.

Proteflazid price, where to buy

In Ukraine you can buy this drug at any pharmacy. The price of Proteflazide in Kharkov, Odessa, Donetsk and other cities ranges from 200 to 230 hryvnia per 30 ml bottle.

You can buy Proteflazid in Moscow for an average of 2,000 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine

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