Cough is a reaction of the body aimed at clearing the airways of foreign elements. Thus, a cough, manifested in the appearance of respiratory diseases as a result of the occurrence of infectious and viral diseases, occurs to free the bronchi and lungs from the viscous mucus that forms in them.
ACC is a mucolytic drug, the action of which is aimed at more rapid dilution of mucus and its easier removal. That is why the drug is prescribed for both so-called dry and wet coughs. It should be remembered that any medicine is taken only after consultation with a specialist. Taking ACC on your own can significantly reduce the effectiveness of the drug and cause side effects.
pharmachologic effect
The product has a mucolytic effect. Since the structure of the acetylcysteine molecule contains sulfhydryl groups, this ensures the rupture of disulfide bonds of acidic mucopolysaccharides of sputum, as a result, the viscosity of the mucus decreases.
ACC Long is also active if the patient produces purulent sputum.
Provided that the drug is used for the purpose of prevention, the severity and frequency of exacerbations in people who suffer from cystic fibrosis and chronic bronchitis .
What is the difference?
The drugs differ:
- active substance and composition,
- forms of production,
- some application features.
Active substance
Bromhexine hydrochloride is a derivative of vasicin, a chemical derived from the plant Justice vascularis. It has long been used in the East as an expectorant. Bromhexine in the body is converted into an active metabolite - ambroxol .
ACC contains acetylcysteine , which is a derivative of the amino acid cysteine.
Release forms
The choice of dosage form is based on the patient's age and desired dosage, as well as individual characteristics and preferences.
Bromhexine is available in the form of tablets and dragees, fruit-flavored syrup for children, oral solution and alcohol-based drops.
ACC is available as cold or hot drink powder, effervescent tablets, soluble granules, or syrup.
Pharmacokinetics and pharmacodynamics
Once in the body, it is absorbed quickly. Metabolism occurs in the liver, resulting in the formation of a pharmacologically active metabolite - cysteine , also cystine , diacetylcysteine , mixed disulfides.
When taken orally, the level of bioavailability is 10% (as there is a pronounced first-pass effect). The highest level of concentration in the blood is determined after 1–3 hours. 50% bound to plasma proteins. Excreted from the body through the kidneys. The half-life is approximately 1 hour; if liver function is impaired, the half-life is 8 hours. Penetrates through the placental barrier. There is no evidence of penetration through the BBB.
What kind of cough does ACC help with?
Penetrating inside, acetylcysteine reduces the viscosity of the mucous secretion, promotes the influx of moisture into it, and dilutes the resulting clots. As a result of using the medicine:
- sputum increases in volume and is easier to cough up;
- swelling and inflammation in the respiratory tract decreases;
- thanks to the expectorant action, non-productive cough is relieved;
- the accumulation of exudate in inflamed areas is prevented.
For so-called dry cough caused by irritation of the functional epithelium without sputum production, ACC is not used. A mucolytic drug is intended for wet coughs in order to help the body cleanse itself of accumulated secretions.
After oral administration, the medicine is concentrated in the blood and tissues, starting to work within 1–1.5 s. In the body, the components of ACC are transformed by the liver, and the metabolites are completely eliminated 6–8 hours after administration, not accumulating inside.
Indications for use
ACC Long is used in the following cases:
- for diseases of the respiratory system that are accompanied by the formation of viscous sputum, which is difficult to separate ( acute and chronic bronchitis laryngotracheitis , obstructive bronchitis , bronchiectasis , pneumonia , cystic fibrosis , bronchiolitis , bronchial asthma );
- acute and chronic sinusitis
- otitis media.
Contraindications
ACC Long is contraindicated for use in the following cases:
- during pregnancy and breastfeeding ;
- when the patient is under 14 years of age;
- with high sensitivity to the components of the drug.
The drug is used with caution for stomach and duodenal ulcers during exacerbation, for pulmonary hemorrhage, hemoptysis, varicose veins of the esophagus, bronchial asthma , diseases of the adrenal glands, as well as for liver and kidney failure .
Who is ACC contraindicated for?
In addition to pregnant women and children under 2 years of age, the use of the medicine is prohibited for the following conditions:
- stomach ulcer in the acute stage;
- internal bleeding;
- hypersensitivity to drug substances;
- Effervescent tablets are prohibited for patients with diabetes and children under 6 years of age.
The medicine should be used with caution by patients with varicose veins, hypertension, renal failure, and people with disorders of the adrenal glands and liver. They need to discuss reduced dosage therapy with their doctor and monitor their well-being more closely.
Side effects
The following side effects may occur during treatment:
- nervous system: in rare cases - tinnitus, headaches ;
- digestive system: stomatitis , vomiting , diarrhea , nausea , heartburn ;
- heart and blood vessels: tachycardia , low blood pressure;
- allergies: bronchospasm (in isolated cases - mainly in patients with bronchial hyperreactivity), urticaria , skin rash, itching ;
- other manifestations: bleeding - in isolated cases.
Effervescent tablets ACC Long, instructions for use (Method and dosage)
The drug 600 mg is usually prescribed to patients over 14 years of age. The instructions for use of ACC Long 600 stipulate that the patient should take 1 effervescent tablet per day, this dose corresponds to 600 mg of acetylcysteine.
The tablet is dissolved in 1 glass of water and should be taken immediately after the tablet has dissolved. It is allowed to take the prepared solution for 2 hours in exceptional cases.
If we are talking about colds, then treatment continues for 5-7 days. If it is necessary to treat other diseases that have a longer course, the duration of therapy is determined by the doctor. People with chronic bronchitis are given longer treatment to ensure infection is prevented.
It is recommended to take the drug after meals.
When treating with ACC tablets, it is recommended to take additional fluid to ensure an enhanced mucolytic effect.
What is ACC
The active component of the drug is acetylcysteine. This substance helps to liquefy the mucous secretion, increase its volume and improve its discharge to the outside. ACC is intended for oral use. For this purpose, several pharmaceutical forms are produced:
- soluble effervescent tablets: white, with berry flavor, active substance dosage - 100–600 mg each;
- granulated mixture for hot drinks;
- flavored baby powders with vitamin C: in dark bottles of 30–60 g.
Among the formative additives and drug stabilizers: soda, sugar, lactose.
Interaction
In the case of simultaneous use of acetylcysteine and cough suppressants, due to suppression of the cough reflex, the likelihood of mucus stagnation increases. Therefore, such medications must be combined with caution.
If treatment with acetylcysteine and nitroglycerin , the vasodilatory effect of nitroglycerin may be enhanced.
Acetylcysteine is not compatible pharmaceutically with a number of antibiotics (cephalosporins, penicillins, Erythromycin , Amphotericin B , Tetracycline ) and with proteolytic enzymes.
tetracycline decreases . In this regard, it is necessary to observe an interval between taking these medications of at least 2 hours.
If acetylcysteine comes into contact with rubber or metals, sulfides with a characteristic odor are formed.
Application of bromhexine
Bromhexine - description of the substance and instructions
Advantages
- Suitable for the treatment of not yet formed sputum, promotes the transition from a debilitating dry cough to a productive one if indicated.
- It has a higher bioavailability of the active substance and a prolonged effect.
- Suitable for people of all ages. It has several dosage forms for use in pediatric practice. Prescribed for the treatment of cystic fibrosis and other inflammatory diseases in children even under the age of 2 years (for certain dosage forms).
- Can be used to treat pneumonia and bacterial bronchitis in combination with broad-spectrum antibiotics. Bromhexine helps to increase the concentration of antibacterial drugs in the alveoli and bronchial secretions, which makes it easier to get rid of pathogens.
- In the treatment of lung diseases, it activates the synthesis of surfactant, which supports air exchange in the alveoli and the protective function.
Flaws
- With large doses or impaired respiratory peristalsis, a large amount of sputum may be released, which can lead to congestion and difficulty breathing.
- The simultaneous use of bromhexine with antitussives (codeine) is strictly contraindicated.
- It is prohibited to use it during breastfeeding and is not recommended during pregnancy (especially in the first trimester). It has a number of other contraindications and restrictions.
- Some forms are not used in patients under 12 years of age due to the presence of alcohol in the composition (solutions, drops), and also have additional restrictions specified in the instructions.
special instructions
It is important to use ACC Long with caution to treat patients with bronchial asthma and obstructive bronchitis. In this case, it is necessary to ensure systematic monitoring of bronchial patency.
If side effects occur during therapy, you should stop taking it and consult a specialist.
It is recommended to dissolve the tablets in glass containers to avoid contact with rubber, metal, and easily oxidized materials.
Patients with diabetes should take into account that one tablet corresponds to 0.01 XE.
Analogs
Level 4 ATX code matches:
Mukolik
Abrol
Ambrosan
Bronchorus
ACC 100
ACC 200
ACC
Mukolwan
Lazolvan
Bromhexine 8
Bromhexine 8 Berlin-Chemie
Bromhexine
Bronchobos
Carbocisteine
Erdomed
Pulmozyme
Pectolvan C
Halixol
Ambrobene
Acetylcysteine
Analogs of the drug ACC Long are:
- ACC
- ACC 100
- ACC 200
- ESPA-NAC
- Mucocil Solution Tablets
- N-AC-ratiopharm
- Acetylcysteine
- N-acetylcysteine
- Eifa AC
- Acestine
- Fluimucil
- Mucomist
- Mukobene
- Mukonex
The most optimal drug must be selected individually by a specialist.
ACC Long price, where to buy
The price of 600 mg tablets is from 350 rubles for 10 pieces. Packaging of the drug 20 pcs. can be purchased at a price of 650 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
ZdravCity
- Acc Long tablets spike.
600 mg 20 pcs. Hermes Arzneimittel GmbH/Salutas Pharma, GmbH 450 rub. order - Acc Long tablets spike. 600 mg 10 pcs. Hermes Arzneimittel GmbH/Salutas Pharma, GmbH
RUR 384 order
Pharmacy Dialogue
- ACC long (tab. spike 600 mg No. 10) Hermes
155 rub. order
- ACC long (tab.spike.600mg No.20)Hermes
RUR 431 order
- ACC long (tab. spike 600 mg No. 10) Hermes
RUB 305 order
- ACC long (tab.spike.600mg No.20)Hermes
RUB 692 order
- ACC long (spike tab. 600 mg No. 20) Salutas Pharma GmbH
610 rub. order
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Pharmacy24
- ACC Long 600 mg No. 10 effervescent tablets Salutas Pharma GmbH.,Nimechchina/Hermes Artsnaimittel Gmb.H.Nimechchina
146 UAH.order - ACC Long Lemon 600 mg N6 tablets Salutas Pharma GmbH, Nimechchina
130 UAH order
