Sesame tablets: instructions for use, analogues, reviews

pharmachologic effect

The abstract indicates that Phezam is a combined agent that provides nootropic, antihypoxic and vasodilating effects. There is a mutual potentiation of a decrease in cerebral vascular resistance, improving blood flow in these vessels.

As Wikipedia informs, the therapeutic effect and its mechanism are determined by the main active substances that are part of the drug Phezam. The main effect observed after taking the medicine is improvement of blood circulation in the brain and metabolic processes in nerve fibers and brain cells.

The substance piracetam has a nootropic effect, activating brain activity and positively affecting metabolism in the body. Under the influence of the substance, the rate of consumption of glucose, which is the main nutrient for the brain, increases. Thus, under the influence of piracetam, more active nutrition of cells occurs, which leads to the production of more energy and activation of brain function. Piracetam helps increase the speed of impulse transmission between neurons. As a result, memory increases, concentration improves, which leads to increased intellectual function.

Piracetam also helps improve blood flow in those areas of the brain where there are damaged vessels, and ischemia , that is, oxygen starvation. Since microcirculation improves, ischemic zones that arise due to lack of oxygen disappear, and the entire volume of neurons participates in brain function.

In addition, there is an indirect effect of this component, which helps to activate blood flow. It is ensured by inhibiting the process of platelet adhesion, which essentially prevents the formation of blood clots. The piracetam component not only activates blood flow, but also improves its properties. Thus, blood circulates more actively through microvessels.

hypoxia increases . Piracetam improves the integrative function of the brain, activates intellectual work, facilitates the process of assimilation of new material, and ensures restoration and support of brain functions in older people.

The substance cinnarizine has a pronounced effect directly on the blood vessels of the brain, dilating them. Also, under the influence of this substance, the tone of smooth muscles decreases, their response to active substances that constrict blood vessels decreases. Due to the fact that the substance dilates blood vessels, blood flow is activated, and more oxygen and nutrients enter the brain. Due to improved blood flow, the resistance of brain tissue to oxygen deficiency also increases. Moreover, despite the vasodilating effect, cinnarizine does not affect blood pressure and intracranial pressure .

The presence of these two components in Phezam simultaneously ensures a mutual enhancement of the effects of the active components. Consequently, the severity of the effect of the drug is more pronounced compared to taking these components separately.

When taking Phezam, there is a predominance of the sedative effect of cinnarizine, from which the medicine does not lead to the manifestation of psychomotor agitation, as happens when taking piracetam.

Mechanism of action of Piracetam

The use of Sesame tablets (remember, their correct name is Phezam) as a nootropic drug abroad, for example, in the USA, is not practiced, since its effectiveness in control groups of patients has not been proven. However, in Russia this drug is used widely and successfully. Two of its main components “work” in it. Each plays its role, but together they complement and optimize each other's action.

Most of the capsule contains Piracetam. In our country it is used in psychiatry, neurology, and drug addiction practice. “Piracetam” easily penetrates into the blood, and with it into any organs, and is excreted from the body by the kidneys. It activates the process of glucose utilization, improves metabolic processes, enhances the synthesis of nuclear RNA in the brain, and stabilizes blood flow. In addition, Piracetam improves the nutrition of brain cells, as a result of which they begin to function more actively. Another important role is to reduce platelet aggregation, and therefore reduce thrombus formation, which also leads to improved circulation in blood vessels and its clear delivery to all cells.

Pharmacokinetics and pharmacodynamics

After the patient has taken Phezam tablets orally, the active substances are completely absorbed from the gastrointestinal tract. The highest concentration of piracetam in plasma is observed after 2-6 hours, cinnarizine - after 1-4 hours. The bioavailability level of piracetam is 100%.

Piracetam does not bind to plasma proteins, cinnarizine binds 91%. Penetrates the BBB, is detected in all tissues and organs, and passes through the placental barrier. Its selective accumulation in the cerebral cortex is noted.

The substance piracetam is not metabolized, the metabolism of cinnarizine occurs in the liver.

The half-life of piracetam is 4-5 hours from the blood, 8.5 hours from the cerebrospinal fluid. Mainly excreted through the kidneys. The half-life of cinnarizine is 4 hours. Metabolites are excreted mostly in urine and also in feces. In people with renal failure, the half-life of piracetam is increased.

Indications for use of Phezam

Before using the medicine Phezam, you should definitely take into account the indications for use. The drug is prescribed in the following cases:

• with insufficiency of blood flow in the brain (in the case of vascular atherosclerosis , during the recovery period after an ischemic or hemorrhagic stroke , with encephalopathy of various origins, after a TBI);
• in case of intoxication;
• in diseases of the central nervous system, in which there is a decrease in intellectual-mnestic functions, that is, deterioration of attention, memory, mood;
• with psychoorganic syndrome, in which signs of asthenia and adynamia ;
• consequences of traumatic brain injury;
• labyrinthopathy (tinnitus, dizziness, nausea and vomiting);
• asthenic syndrome associated with psychogenic origin;
• Meniere's syndrome;
• for the purpose of preventing migraine , kinetosis ;
• in the complex therapy of children who have a psychoorganic syndrome, which has led to low learning ability.

Analogs

On the pharmaceutical market you can buy analogues of Sesame tablets. Among them there are 2 groups of funds.

1. Medicines whose chemical composition also includes piracetam and cinnarizine. This:

• "Omaron";
• "Pyracesin";
• "NooCam."

2. Medicines that have identical therapeutic effects with Sesame (Phesam). There are a lot of such drugs. Here are just a few of them:

• "Acefen";
• "Vincetin";
• "Bravinton";
• "Vinpotropil";
• "Memotropil";
• "Idebenone";
• "Carnicetine";
• "Gopantam";
• "Glycine";
• "Noben";
• “Pantogam” (available in syrup, suitable for treating children);
• "Pyriditol";
• "Tiocetam";
• "Celestab";
• "Ceraxon";
• "Escotropile."

Contraindications

Phezam should not be taken in the following cases:

• in severe forms of renal and liver failure;
• during periods of increased psychomotor agitation;
• with Huntington's chorea ;
• during pregnancy and breastfeeding;
• when the patient is under 5 years of age;
• with high sensitivity to the components of the product.

The medicine is prescribed with caution to those patients who have been diagnosed with Parkinson's disease , hemostasis disorders, impaired liver or kidney function, and severe bleeding .

What is the drug "Sesame"?

I would like to warn you right away that you will not find such a name in Russian. In pharmacies you can purchase the drug SEZAM produced in China. Mostly women are interested in it, since this product is a test cassette to determine whether there is a pregnancy or not, and in just 7 days.

The material for research is urine. There are no tablets inside the package. “Sesame” is a kit that includes a pipette, a container for collecting urine and a super-sensitive scale that can show that fetal development has begun even before the menstrual cycle is delayed. The action of the scale indicator is based on sensitivity to the hormone human chorionic gonadotropin. It is produced by the future placenta of a woman's fertilized egg. In small quantities, this hormone appears in the urine already on the 5th day, but more often on the 7th day after conception has occurred. Using the Sesame test is very simple - you just need to use a pipette to place a couple of drops of your urine in a special window on the scale.

Side effects of Phezam

The following side effects are possible during treatment:

• Nervous system: nervousness, feeling of drowsiness, hyperkinesia. In rare cases - headaches, dizziness , insomnia , ataxia , agitation, anxiety.
• Allergic manifestations: in rare cases - skin rash, dermatitis , swelling, itching, photosensitivity.
• Digestive system: severe salivation, nausea, vomiting, abdominal pain, diarrhea .
• Other manifestations: increased libido.

Side effects

Sometimes even in people who have no contraindications, the use of Sesame tablets can cause unpleasant reactions. Reviews from patients indicate the following sensations after taking the drug:

• drowsiness (therefore the drug is contraindicated for vehicle drivers);
• dizziness;
• impaired balance and coordination of movements;
• headache.

In some patients, taking Sesame caused the opposite conditions:

• increased excitability;
• insomnia;
• anxiety;
• nervousness;
• hallucinations.

All these adverse reactions are observed from the central nervous system. In addition, there may be allergic manifestations after taking this medication, such as:

• itchy skin;
• rashes;
• swelling.

There are also side effects from the gastrointestinal tract in those taking Sesame. This:

• diarrhea;
• abdominal pain;
• dry mucous membranes in the mouth;
• nausea (sometimes it comes to vomiting).

If any of the above reactions occur, you should stop taking the capsules. This medicine also has a pleasant side effect, which is increased sexual activity.

Phezam tablets, instructions for use (Method and dosage)

The instructions for use of Phezam, which are provided in the annotation for the drug, indicate that the medicine should be taken 1-2 capsules three times a day for one to three months. The duration of treatment depends on the severity of the disease. The drug is usually taken in courses - 2-3 courses annually.

Children over 5 years old are advised to take 1-2 capsules 1-2 times a day. Capsules are used for one and a half to three months. Capsules should be taken by swallowing them whole, without violating the integrity of the capsule. The tablet should be taken with half a glass of non-hot water.

Many users ask about capsules and how to take them - before or after meals. The instructions say that there is no particular difference in whether to take the product before or after meals. But it is optimal to drink capsules 20-30 minutes after eating. It is advisable to take the medicine at the same time every day.

Doctors warn that you cannot take the medicine for longer than 3 months - a break is necessary between courses.

Use in pediatrics

The instructions for use of Sesame tablets indicate that this drug is prescribed for children over 5 years of age, but in special cases it is permissible to prescribe it to children aged only 1 year. Indications for taking Sesame in children are the same as in adults. In addition, for this category of patients the drug is used in the following cases:

• neurological pathology in a mild form (restlessness, poor memory, difficulties at school with memorizing material, poems, texts, poor concentration);
• inability to clearly express one’s thoughts or formulate an answer;
• when there is a lag in intellectual development, as one of the components of a comprehensive teaching methodology;
• autism;
• past infectious diseases;
• restlessness, tearfulness, anxiety;
• headache;
• Down syndrome;
• hysteria, mood instability;
• frequent night awakenings.

Interaction

Not all medications can be taken with Phezam tablets at the same time, so the interaction of this medication with other medications should be taken into account.

When taking medications simultaneously with Phezam that depress the action of the central nervous system, ethanol , tricyclic antidepressants , their sedative effect may increase.

When taking Phezam, the effect of nootropic and antihypertensive drugs is potentiated.

Vasodilator medications enhance the effect of Phezam.

Due to the presence of cinnarizine in the drug, the activity of hypertensive drugs .

When taking Phezam simultaneously, there is an increase in the activity of thyroid hormones , which can lead to tremor and anxiety.

Due to the antihistamine effect, cinnarizine can mask the manifestation of positive reactions in relation to factors of skin reactivity during skin tests. To avoid this effect, you must stop using the medication 4 days before such tests.

Phezam may enhance the effect of oral anticoagulants .

Can I take medicine with alcohol?

The drug to improve cerebral circulation cannot be combined in any way with alcohol. There are many reasons for this. It is worth knowing what consequences a person can expect if he violates the rules for taking Phezam.

Consequences of combination with ethanol

In order to understand what you can expect when mixing medicine and alcohol, the mechanism of action of alcohol on the body in combination with most medications, including Phezam, is explained below:

1. Any alcohol has a destructive effect on the brain. Over time, the cerebral cortex is destroyed and the person becomes weak-minded. Brain cells (neurons) die without the possibility of subsequent recovery. As a result, it turns out that what Phezam treats, we destroy with our own hands by drinking alcohol. Thus, the therapeutic effect is not achieved.
2. Fezam has a mild sedative effect. With the simultaneous intake of alcohol, this effect is enhanced significantly. In addition, no one can predict in advance how the nervous system will behave under such conditions. For some, taking medication with ethanol will have an inhibitory effect, for others it will have a stimulating effect on the nervous system.
3. Phezam is aimed at dilating the blood vessels of the brain, while alcohol, on the contrary, narrows them, which leads to significant dissonance in the body. Blood pressure can either rise to extreme levels or drop significantly. There is a risk of developing hemorrhagic stroke.
4. Both alcohol and medications put a certain amount of stress on the liver. When several toxic substances enter the body at once, this load increases significantly. If the liver has previously been negatively affected, it may not be able to withstand it and the person will experience acute liver failure.
5. There is also a risk of developing allergies and side effects.

special instructions

If Fezam is prescribed to patients with impaired liver function, liver enzyme levels should be monitored.

The medicine activates the functions of thyroid hormones, which is why patients undergoing treatment may experience anxiety and tremors .

Since cinnarizine can cause drowsiness, during treatment you should drive carefully and work with precise and dangerous machinery.

When treating elderly people, it is necessary to regularly monitor kidney function indicators and, if necessary, adjust the dose.

Active components are able to penetrate the filter membranes of hemodialysis .

The medication should be avoided in case of porphyria .

When taking Phezam, a false positive result may occur during doping control in athletes, also due to the presence of iodine-containing dyes in the capsule shell. A false positive result may occur in the radioiodine test .

Since piracetam reduces platelet aggregation, it should be prescribed with caution when hemostasis is impaired in patients, as well as in conditions accompanied by hemorrhages. You should not take the medicine during complex surgical operations, with severe bleeding and a history of hemorrhagic strokes

Phezam can provoke irritation in the epigastric region; when used after meals, a decrease in the severity of gastric irritation may be observed, for which purpose the medicine should be used with caution in patients suffering from gastrointestinal diseases.

lactose as an auxiliary component .

Phezam's analogs

Level 4 ATX code matches:
Bravinton

Acefen

Carnicetine

Pyracesin

Nooclerin

Semax

Piracetam

Olatropil

Vinpocetine

Cerebrocurin

Cavinton Forte

Calcium hopantenate

Glutamic acid

Cephabol

Olanzapine

Cerebrolysate

Pramistar

Sidnocarb

Vinpotropil

Glycine Ozone

Phezam and its analogues should be prescribed by a doctor after an accurate diagnosis. Active components similar to those contained in the drug Fezam are included in the following drugs: Combitropil , Piracezin , Omaron , NooKam . The price of analogues depends on the manufacturer of the drug and its packaging.

Medicines also have a similar pharmacological effect on the patient’s body: Acefen , Vinpocetine , Demanol , Memotropil , Combitropil , Pantogam , Pyriditol , Cellex , Encephabol , etc.

Omaron or Fezam - which is better?

Omaron drug and has the same indications for use, contraindications and causes similar side effects. At the same time, the price of the drug Omaron is lower compared to Fezam.

Chemical composition

Tablets "Sesame" (or "Phesame") are a complex therapeutic drug. It consists of two main components:

1. The drug "Piracetam" (contains 400 mg in each capsule of "Phesam").
2. The drug "Cinnarizine" (contains 25 mg per capsule).

In addition, the drug contains excipients:

• magnesium stearate;
• lactose;
• colloidal silicon dioxide.

The capsule shell includes gelatin (98%) and titanium dioxide (2%). It is white in color, smooth in texture and very dense.

Reviews of Fezam

Most often, reviews about Phezam on forums are positive, they talk about improving the condition of patients when taking this medicine. Users write that after taking it, memory normalizes, attention and performance improve. Also, under the influence of the medicine, stress and anxiety .

Similar positive reviews appear when capsules are used for children.

On forums where the drug Phezam is discussed, reviews from doctors are also often positive. However, there are also negative comments that the drug causes drowsiness, as well as the lack of positive effects during treatment.

Reviews

Many people, due to their occupation or for health reasons, take Sesame tablets. Reviews about the drug are mixed. Most respondents name its advantages:

• low price;
• availability;
• effectiveness for headaches, psychological fatigue, decreased mental performance, memory impairment.

The disadvantages of the drug, according to patients, are its side effects:

• irresistible drowsiness or, conversely, difficulty falling asleep;
• hallucinations;
• the effect is visible only for a while (usually at the beginning of the course of treatment);
• The capsules are too large, making them difficult to swallow.

Phezam price, where to buy

The price of Phezam capsules in Moscow is on average 270 rubles for 60 pieces. You can buy them at any pharmacy with a doctor's prescription.

The price of Phezam in Ukraine (Kyiv, Kharkov, etc.) is from 200 UAH. per pack 60 capsules.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Phezam capsules 400mg+25mg 60 pcs.Balkanpharma/Zdravle HFZ
  RUB 291 order

Pharmacy Dialogue

• Phezam (caps. No. 60) ZiO-Zdorovye CJSC

  RUB 310 order

• Phezam (cap. No. 60)Zdravlje

  RUB 319 order

show more

Pharmacy24

• Phezam No. 60 capsules Pharmaceutical and Chemical Industry, Zdravle AT, Serbia
  199 UAH.order

PaniPharmacy

• Phezam capsule Phezam capsules No. 60 Bulgaria, Balkanpharma-Dupnitza

  223 UAH order

show more

What is the drug Phezam?

This is exactly the product that people want to buy when they ask for Sesame tablets in pharmacies to improve memory, insomnia, headaches and other similar conditions. It is mainly of interest to people engaged in mental work, students about to take exams, and older citizens who have developed symptoms of impaired brain activity. This drug is produced in Bulgaria at the Balkanfarma - Dupnitsa enterprise, as well as in a branch in Serbia. It goes on sale in the form of capsules, 10 pieces in a blister (plate) and 6 blisters in a package, that is, 60 capsules in 1 pack.

Phezam is a nootropic drug that provides neurometabolic stimulation of brain functions. It is sold with or without a prescription in any pharmacy in Russia. The price varies from 170 to 260 rubles per 1 package. The difference in cost does not affect the quality and depends on transport, purchasing and other expenses of the seller.