pharmachologic effect
The active ingredient of the drug is an amino acid, which is produced in the human body and helps regulate metabolism and normalizes the processes of protective inhibition in the central nervous system. Under its influence, the level of psycho-emotional stress in the body decreases, performance increases, and the severity of conflict and aggressiveness decreases. Taking the medicine, the patient notes normalization of falling asleep and improved mood. The substance reduces the severity of vegetative-vascular disorders, in particular during menopause . The condition of general cerebral disorders in people after a stroke or TBI improves. The product also reduces the toxic effects of alcohol on the body.
Vitamin B1 helps normalize the nervous system, stimulates mental performance and thinking processes.
Vitamin B6 normalizes brain functioning and helps overcome irritability and fatigue.
Vitamin B12 accelerates the processes of renewal of the structure of nervous tissue, improves attention and memory. This substance takes part in the production of acetylcholine, that is, a neurotransmitter that determines the processes of learning, memory, etc.
Achieved effect
The medicine underwent clinical trials, during which its effectiveness was proven.
According to the instructions, Glycine helps:
- reduce psycho-emotional stress, conflict, aggressiveness, increase social adaptation;
- improve mood;
- make it easier to fall asleep;
- increase mental performance;
- reduce vegetative-vascular disorders;
- reduce the severity of brain disorders in traumatic brain injury and ischemic stroke;
- reduce the toxic effects of drugs and alcohol.
Indications for use
Glycine Forte Evalar is used as a dietary supplement, providing an additional source of glycine for the body. It is recommended to take tablets during periods of severe stress, to overcome the symptoms of neuroses , vegetative-vascular dystonia , and severe excitability. Also indicated for use is the condition after TBI, stroke, various forms of encephalopathies . Used to treat adolescents with deviant behavior.
Glycine and metabolism
The main source of energy in the body is glucose. This process occurs in the mitochondria of each cell using the Krebs cycle. How does glycine work in this case? It influences the activity of all reactions occurring in the Krebs cycle. And if the body lacks oxygen, thanks to glycine it will be used as efficiently as possible. That is, the cells will be able to perform their functions even under hypoxic conditions.
A lack of glycine in the body is observed quite rarely. However, the problems arising from its shortage are very serious. First of all, metabolic processes occurring especially in the cerebral cortex are affected. For all its cells to function normally, a lot of energy is needed, that is, a large number of ATP molecules.
Nervous tissue synthesizes this amino acid in the required quantities, but under increased stress, for example under stress, its production increases several times. How does glycine work in the body under stress? At such moments, an additional dose of this amino acid will not hurt at all, since protective inhibition processes are activated and cellular respiration is simultaneously activated. Thus, glycine helps neurons work better under stress.
How else does glycine affect the body? With the participation of this amino acid, glutathione is synthesized, which is a powerful endogenous antioxidant. Therefore, the drug Glycine is often prescribed if there is a risk of damage to body cells by free radicals.
Glycine is also involved in the synthesis of many compounds:
- the non-protein, iron-containing part of hemoglobin, called hemes;
- conjugated bile acids;
- lipids;
- creatinine;
- coenzymes NAD and FAD;
- peptides.
And yet, one of the main properties of glycine, due to which it is widely used in medicine, is the connection of this amino acid with glycine receptors located both in the brain and in the spinal cord. Glycine reduces the production of amino acids, which have an exciting effect on the body, and at the same time stimulates the synthesis of GABA - gamma-aminobutyric acid, which is the main neurotransmitter of central inhibition in the nervous system. Thus, it becomes obvious that the benefits of glycine for the body are very great.
special instructions
Before using this remedy, the patient should consult a specialist.
With prolonged use of Glycine Forte Evalar, the patient does not develop dependence on the drug, since it contains components that are natural to the body.
People with a tendency to arterial hypotension should take smaller doses of Glycine Forte and at the same time control blood pressure levels. If your blood pressure drops to a lower level than normal, you should stop taking the tablets.
Glycine forte 500 mg lozenges 60 pcs. evalar
pharmachologic effect
Metabolic agent.
Composition and release form Glycine forte 500 mg lozenges 60 pcs. evalar
1 cheek tablet contains:
- active substance glycine - 500 mg;
- excipients: aspartame, croscarmellose sodium, copovidone, magnesium stearate, sorbitol.
Buccal tablets 500 mg. 10 or 30 tablets in a blister pack made of polyvinyl chloride film and printed varnished aluminum foil.
1, 2, 3, 5, 6, 9, 10 blister packs of 10 tablets or 1, 2, 3 blister packs of 30 tablets, together with instructions for use, are placed in a cardboard pack.
Characteristic
The life of a modern person is dynamic, eventful and, moreover, filled with mental and emotional stress. Work, study, preparation for exams, an upcoming conference, an important meeting - this is not the entire list of reasons that cause nervous tension and mental fatigue.
Normally, in a person, the influence of the parasympathetic nervous system (calm) predominates, but with prolonged nervous stress, the balance is disturbed and the sympathetic nervous system (activity) becomes more active. As a result, the increased activity that a person needs to solve specific problems becomes a predominant state of overexcitation, which is difficult to manage. At the same time, concentration decreases, a feeling of anxiety appears, and it becomes increasingly difficult to find a way out of a difficult situation. Mental stress, inability to sleep and relax lead to exhaustion of the nervous system. It is difficult to cope with a problem of this level on your own. Glycine is widely used throughout the world to solve these problems - as a non-drug that helps reduce stress and mental strain, and in significant quantities.
produces Glycine forte Evalar, similar to foreign ones - with a high glycine content, which has a positive effect on the activity of the nervous system: helps to equalize the processes of excitation and inhibition in the cerebral cortex, increase mental performance, reduce increased irritability, and normalize sleep.
For the first time, the effect of glycine is enhanced by the maximum dosage of vitamins B1, B6, B12 in the same ratio as they exist in nature. B vitamins have a beneficial effect on the nervous system and help counteract stress.
The combination of glycine and B vitamins in one tablet is necessary for our brain during increased mental and psycho-emotional stress.
Glycine forte Evalar tablets are easy to use and easily dissolve, which helps to achieve the effect more quickly - reducing nervous tension and increasing mental performance.
"Glycine forte Evalar" does not form dependence upon long-term use, since it contains active components natural to the body.
Directions for use and doses
Sublingual or buccal 250 mg (in tablets or in powder form after crushing the tablets).
For children, adolescents and adults with psycho-emotional stress, decreased memory, attention, mental performance, mental retardation, and deviant forms of behavior, glycine is prescribed ½ tablet 2-3 times a day for 14-30 days.
For functional and organic lesions of the nervous system, accompanied by increased excitability, emotional lability and sleep disturbances, children under 3 years of age are prescribed ¼ tablet 2-3 times a day for 7-14 days, then ¼ tablet 1 time per day for 7-10 days. Daily dose - 100-150 mg, course dose - 2-2.6 g.
Children over 3 years of age and adults are prescribed ½ tablet 2-3 times a day, the course of treatment is 7-14 days, it can be increased to 30 days, if necessary, the course is repeated after 30 days.
For sleep disorders, ¼-½ tablets are prescribed 20 minutes before bedtime or immediately before bedtime (depending on age).
For ischemic cerebral stroke: during the first 3-6 hours from the onset of stroke, 1 g (4 tablets) is prescribed buccally or sublingually with 1 teaspoon of water, then for 1-5 days, 1 g / day (4 tablets), then over the next 30 days, ½-1 tablet 3 times a day.
In narcology - ½ tablet 2-3 times a day for 14-30 days. If necessary, courses are repeated 4-6 times a year.
Pharmacodynamics
A non-essential amino acid, a central inhibitory neurotransmitter. Improves metabolic processes in brain tissue, has an antidepressant and sedative effect. It has glycine- and GABA-ergic, alpha1-adrenergic blocking, antioxidant and antitoxic effects; regulates the activity of glutamate (NMDA) receptors, thereby reducing psycho-emotional stress, aggressiveness and conflict; improves social adaptation and mood; makes it easier to fall asleep and normalizes sleep; increases mental performance; reduces the severity of vegetative-vascular disorders (including during menopause) and cerebral disorders in ischemic stroke and traumatic brain injury, the toxic effect of ethanol on the central nervous system.
Pharmacokinetics
Easily penetrates into most biological fluids and body tissues, including the brain, and does not accumulate. It is quickly destroyed in the liver by glycine oxidase to water and carbon dioxide.
Indications for use Glycine forte 500 mg lozenges 60 pcs. evalar
Stressful conditions (including psycho-emotional stress), decreased mental performance, deviant forms of behavior in children and adolescents, various functional and organic diseases of the nervous system, accompanied by increased excitability, emotional instability, decreased mental performance and sleep disturbances: neuroses, neurosis-like conditions, consequences of neuroinfections and traumatic brain injury, perinatal and other forms of encephalopathies (including alcoholic origin).
Ischemic stroke.
In narcology - as medicines that increase mental performance and reduce psycho-emotional stress during the period of remission in cases of encephalopathy, organic lesions of the central and peripheral nervous system.
Contraindications
Hypersensitivity.
With caution: arterial hypotension.
Effect on the body
- increases mental performance and resistance to stress;
- reduces nervous and mental tension;
- improves sleep.
special instructions
In patients with a tendency to arterial hypotension, the prescription is made in smaller doses and with blood pressure under control; when it decreases below the usual level, the intake is stopped.
Side effects Glycine forte 500 mg lozenges 60 pcs. evalar
Allergic reactions.
Drug interactions
Reduces the severity of side effects of antipsychotic drugs (neuroleptics), anxiolytics, antidepressants, hypnotics and anticonvulsants.
Reviews of Glycine Forte Evalar
In most cases, patients leave positive reviews about Glycine Forte online, noting its positive effect on the nervous system, as well as on the human body in general. There are many reviews from students that these tablets help to activate mental abilities and cope with mental stress more effectively. Some reviews note that the drug is more effective than regular Glycine. Reviews from doctors about this medicine are also mostly positive.
All about the dosage form
Unfortunately, not all people carefully study the instructions for the drug when purchasing medications. But in vain. Even when products have the same active substance, their indications and method of use can be very different. And a clear example of this is the drug Glycine, which is produced by the company BIOTICS. The peculiarity of the amino acid is that it is poorly absorbed by the digestive system. If you take the drug by swallowing it with water, it will not have any effect. Glycine, which is produced by the BIOTICS company, is significantly different from other products. It's all about microencapsulation technology, which was developed and patented by the company (the RF patent number is indicated on each package).
GLYCINE FORTE (tablets)
th little, the recording for them is very dense and goes on for several months in advance.
After consulting with a pharmacist at one of the local pharmacies, I decided to buy inexpensive “Glycine Forte” cheek tablets. The cost of one package containing 30 tablets was about 60 rubles.
The packaging of the drug is small, typical for tablets in blisters. Decorated in green tones.
The tablets are located in blister packs (3 pieces), access to them is easy, everything is simple and convenient.
After opening, we see tablets of a uniform white color, round in shape with a cross-shaped line (weighing 250 mg). Another convenient provision from the manufacturer, which makes it easier to divide the tablet into the desired dose.
The drug, as expected, comes with instructions for use. In it we can familiarize ourselves with the composition of these tablets.
The active substance of the drug is glycine, its pharmacological action and indications are described in great detail. Having become familiar with the scope of its purpose, it became clear that this drug should solve some of my health problems.
Let's pay attention to such excipients as aspartame and sorbitol (sweeteners).
They add sweetness to the drug and make taking the medicine more pleasant. Croscarmellose sodium is necessary to improve the dissolution of the drug in the body; copovidone is a substance with a detoxifying effect; Magnesium sterate is used as a filler and is harmless.
The constituent ingredients are relatively safe components.
The medication can be administered in two ways:
1) sublingually - by placing the tablet under the tongue;
2) buccal - the location of the tablet between the upper lip and gum (or in the oral cavity, behind the cheek).
Dosing recommendations are prescribed for both adults and children, and dosage is indicated for certain diseases.
Adults are prescribed 1/2 tablet 2-3 times for 7-14 days, with the possibility of increasing to a month with increased excitability and sleep disturbances. I stopped at 1/2 tablet 1-2 times a day.
The therapeutic effect occurred already on the 3-4th day, the manifestations of a nervous tic in the upper eyelid of the eye decreased, and mental performance noticeably improved.
At the same time, sleep returned to normal, but falling asleep at first became even more difficult. I don't know if this is due to the medication or if other factors are causing it. After some time, falling asleep returned to normal.
Ultimately, taking this drug for two weeks helped me cope with neuroses and improve sleep.
There were no side effects in the form of allergic rashes; I found taking the lozenges very pleasant (their sweetness seemed optimal to me, not cloying).
The shelf life of the drug is 2 years. Can be stored under normal conditions (at a temperature not exceeding 25 C).
In my house the air temperature is borderline acceptable, so I prefer to store medicines in the refrigerator.
“(Russia) determined that the drug could be dispensed only by doctor’s prescription—with a prescription, but they freely sold it to me without providing it.
This medicine has many analogues and is quite common. I believe that there will be no problems with purchasing such a medicine.
To calm my soul, I sometimes check the purchased medications using the “Your Pharmacist” application installed on my smartphone. Checking the barcode and series showed that the tablets were genuine.
As a conclusion, I want to say that I am satisfied with my purchase, the therapeutic effect was obtained without side effects, which indicates the effectiveness of this medicine. Despite the positive dynamics, I will definitely contact a specialist when the appointed day of the appointment arrives.
I cannot recommend “Glycine Forte”, since the prescription of medications must be made by the attending physician. I can only, based on my personal experience of using it, rate these tablets, in my case, a high rating!
Thank you for your attention!
