Composition and release form
The medicine is dispensed in the following forms:
- The tablets are round, light white or cream in color, with minor inclusions possible. Packaged in cardboard packaging with 1-2 blisters, each containing 10 pieces.
- Syrup - presented as a liquid base with the taste of thyme. Available in 50, 100 and 125 ml volumes. Sold in a glass bottle and secondary cardboard packaging with attached instructions for use.
Active ingredients, regardless of type: ambroxol hydrochloride, sodium glycyrrhizinate. Also dry thermopsis extract and sodium bicarbonate in tablets; liquid thyme extract in syrup.
Auxiliary components: starch, cellulose, talc, nipazole, pure water, sorbitol, stearic acid.
Dosage forms and composition
The drug is produced in two forms for oral administration:
- tablets: yellowish in color with visible small inclusions, flat-cylindrical, have a separating score, packaged in foil plates of 10 pieces, the package contains 1 or 2 blisters;
- liquid elixir with thyme: light brown syrup with a characteristic balsamic aroma, in glass bottles with screw caps from 50 to 200 ml, cardboard packaging equipped with a measuring spoon.
Codelac Broncho is a combination drug. It contains several active substances:
- ambroxol: 200 mg in tablets and 100 mg in syrup;
- extracted thermopsis: 100 mg;
- sodium glycyrrhizinate: 300 mg;
- in tablets - sodium bicarbonate: 200 mg;
- in syrup - extracted thyme: 500 mg.
Auxiliary compounds of tablets: starch, MCC, stearic acid, talc and others. The elixir also contains sorbitol, distilled water, napazole and nipagin. When storing in liquid medicine, slight sedimentation may occur. This does not affect the therapeutic properties.
pharmachologic effect
The medicine is intended to treat cough symptoms of any origin. It has a pronounced expectorant and mucolytic effect, and a weak anti-inflammatory effect.
Thanks to the main substances in the composition, the drug promotes the dilution of bronchial secretions and its good discharge.
Due to glycyrrate, there is a decrease in the inflammatory process, the fight against viral agents, and antioxidant properties.
Thermopsis extract stimulates expectoration of sputum, normalizing the secretion in the bronchopulmonary system due to some irritation of the gastric mucosa.
Sodium bicarbonate has an alkaline effect, reduces the viscosity of mucus and stimulates the motility of the epithelial tissue of the bronchopulmonary apparatus.
Thyme plant extract contains a number of essential oils, which contributes to an expectorant, anti-inflammatory and antispasmodic effect.
The pharmacological activity of the drug is aimed at suppressing dry cough, wheezing in the lungs and respiratory failure. In addition, Codelac Broncho reduces the time of intoxication and helps to quickly relieve a runny nose.
Codelac Broncho elixir with thyme 100ml
A country
Russia
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.
Active substance
Ambroxol + Sodium glycyrrhizinate + Creeping thyme herb extract
Compound
Active ingredients: codeine phosphate hemihydrate - 4.5 mg, dry thermopsis extract - 10 mg, liquid thyme extract - 1000 mg, dry licorice extract - 165 mg.
pharmachologic effect
Cough remedy, contains components of plant origin. Combined drug. Codeine reduces the excitability of the cough center, reducing the intensity of the cough. In recommended therapeutic doses, it does not cause depression of the respiratory and cough centers, does not disrupt the function of the ciliated epithelium and does not reduce bronchial secretion. Thermopsis herb has an expectorant effect, manifested in increasing the secretory function of the bronchial glands, increasing the activity of the ciliated epithelium and accelerating the excretion of secretions, increasing the tone of smooth muscles bronchi due to the central vagotropic effect. Licorice root has an expectorant, anti-inflammatory and antispasmodic effect. Contains glycyrrhizin, which has an antiviral effect, and also potentiates the effect of endogenous glucocorticosteroids, providing anti-inflammatory and antiallergic effects. Due to its pronounced anti-inflammatory activity, glycyrrhizin contributes to the most rapid relief of the infectious and inflammatory process in the respiratory tract. Thyme herb extract contains a mixture of essential oils that have expectorant, anti-inflammatory and bactericidal effects due to increased activity of the ciliated epithelium of the mucous membranes of the upper respiratory tract, increasing the amount of mucosal secretion membranes of the bronchi, diluting sputum, accelerating its evacuation and loosening inflammatory plaques. In addition, thyme has weak antispasmodic and reparative properties.
Indications for use
Symptomatic treatment of dry cough of any etiology in bronchopulmonary diseases.
Mode of application
Inside, during meals, with a small amount of water. Adults and children over 12 years old - 10 ml 4 times a day. Children from 2 to 6 years old - 2.5 ml 3 times a day, from 6 to 12 years old - 5 ml 3 times a day.
Interaction
Combined use with antitussive drugs leads to difficulty in sputum discharge.
Side effect
Allergic reactions, weakness, headache, diarrhea, dry mouth and respiratory tract, exanthema, rhinorrhea, constipation, dysuria. With long-term use in high doses - gastralgia, nausea, vomiting.
Contraindications
Hypersensitivity, pregnancy, lactation, children under 2 years of age. With caution: liver and/or kidney failure, gastric and duodenal ulcers, bronchial asthma.
Overdose
Symptoms: nausea, vomiting, diarrhea, dyspepsia. Treatment: symptomatic, gastric lavage is advisable in the first 1-2 hours after taking the drug.
special instructions
Do not combine with antitussives. Patients with diabetes can use the drug, taking into account the sorbitol content in the amount of 0.18 XE per 5 ml of elixir.
Contraindications
The following conditions are absolute contraindications to taking Codelac Broncho:
- Carrying a child and breastfeeding.
- Allergic reaction to the components of the drug.
- Children's age - syrup up to 2 years and tablets up to 12 years.
Use the medicine with caution in case of an attack of bronchial asthma, ulcerative lesions of the gastrointestinal tract and disorders of the liver and kidneys.
When to take Codelac Broncho
The drug is taken when signs of respiratory inflammation or symptoms of exacerbation of chronic conditions develop. It is recommended to start the course of treatment from the first minutes of discomfort: sore throat, hoarseness and coughing.
General indications:
- accumulation of sputum in acute and chronic forms of bronchitis;
- chronic pulmonary obstruction;
- bronchiectasis;
- viral or bacterial pneumonia;
- signs of ARVI, accompanied by cough.
Side effects
If the course of therapy is not followed, side effects may occur in the form of:
- Headache and dizziness.
- Weakness and fatigue.
- Rhinorrhea.
- Dryness of the mucous surface of the respiratory tract.
- Dyspeptic manifestations - nausea followed by vomiting, dry mouth, pain in the epigastrium, abnormal stool.
Skin rashes and problems with urination are less common.
What kind of cough do Codelac Broncho tablets and elixir help with?
The effect of both dosage forms of the drug is similar. These are mucolytics with a moderate anti-inflammatory effect. Designed to liquefy mucous secretions, improve the passage of accumulated clots from the bronchi and lungs. Increases cough productivity and helps cleanse the respiratory system.
Ambroxol in combination with thermopsis extract reduces the viscosity of mucus, stimulating its elimination. Sodium bicarbonate improves the motility of bronchioles and epithelial villi on the walls of the bronchi. Glycyrrhizinate has an antimicrobial effect and neutralizes the damaging effects of oxidation products. Thyme complements the activity of other components of the elixir, helps to expectorate mucus more easily, helps relieve microspasms and makes breathing easier.
Positive dynamics are usually observed from the second day of therapy. The effect of the medicine increases gradually: the cough becomes less intrusive, the mucus leaves in a larger volume, and relief comes faster.
Codelac Broncho, tablets, 20 pcs.
Manufacturer
Pharmstandard-Leksredstva, Russia
Compound
Active ingredients:
ambroxol hydrochloride (ambroxol) – 20.0 mg,
sodium glycyrrhizinate (trisodium salt of glycyrrhizic acid) – 30.0 mg,
Thermopsis lanceolata herb extract – 10.0 mg,
sodium bicarbonate – 200.0 mg.
Excipients:
potato starch – 84.30 mg, microcrystalline cellulose – 150.10 mg, povidone (polyvinylpyrrolidone, povidone K25) – 26.40 mg, talc – 13.00 mg, stearic acid – 5.20 mg, sodium carboxymethyl starch (sodium starch glycolate ) – 11.00 mg.
pharmachologic effect
Pharmacotherapeutic group: expectorant combined drug
ATX Code: [R05CA10]
Pharmacological properties
Pharmacodynamics
A combined drug for the treatment of cough, it has a mucolytic and expectorant effect, and also has anti-inflammatory activity. The action of Codelac® Broncho is due to the pharmacological properties of its components:
Ambroxol has a secretomotor, secretolytic and expectorant effect, normalizes the disturbed ratio of serous and mucous components of sputum, and increases the secretion of surfactant in the alveoli. Reduces the viscosity of sputum and promotes its removal.
On average, when taken orally, the effect of ambroxol occurs within 30 minutes, the duration of action is 6-12 hours, depending on the dose taken.
Glycyrrhat (glycyrrhizic acid and its salts) has anti-inflammatory and antiviral effects. It has a cytoprotective effect due to its antioxidant and membrane-stabilizing activity. Potentiates the effect of endogenous glucocorticosteroids, providing anti-inflammatory and antiallergic effects. Due to its pronounced anti-inflammatory activity, it helps reduce the inflammatory process in the respiratory tract.
Thermopsis extract has an expectorant effect, having a moderate irritant effect on the receptors of the gastric mucosa, and reflexively increases the secretion of the bronchial glands.
Sodium bicarbonate shifts the pH of bronchial mucus to the alkaline side, reduces the viscosity of sputum, and stimulates the motor function of the ciliated epithelium and bronchioles.
Pharmacokinetics
Ambroxol.
Suction. Ambroxol is characterized by rapid and almost complete absorption from the gastrointestinal tract. Bioavailability is 70-80%. The maximum concentration in blood plasma after oral administration is achieved within 1-3 hours. Plasma protein binding is 80-90%.
Distribution. The transition of ambroxol from the blood to tissues when taken orally occurs quickly. The highest concentrations of the active component of the drug are observed in the lungs. Penetrates the blood-brain barrier, placental barrier, and is excreted in breast milk.
Metabolism. Approximately 30% of an ingested dose undergoes a first pass effect through the liver. Studies on human liver microsomes have shown that CYP3A4 is the predominant isoenzyme responsible for the metabolism of ambroxol. The remainder of ambroxol is metabolized in the liver to inactive metabolites.
Excretion. The half-life (T ½) of ambroxol is about 10 hours. Excreted by the kidneys: 90% in the form of metabolites, 10% unchanged.
Pharmacokinetics in special groups of patients. No clinically significant effect of age and gender on the pharmacokinetics of ambroxol was found, so there is no basis for dose adjustment based on these characteristics.
The clearance of ambroxol in patients with severe liver failure is reduced by 20-40%.
In severe renal failure, T ½ of ambroxol metabolites increases.
Sodium glycyrrhizinate (trisodium salt of glycyrrhizic acid).
After oral administration, in the intestine, under the influence of the enzyme β-glucuronidase, produced by bacteria of normal microflora, an active metabolite is formed from glycyrrhizic acid - β-glycyrrhetic acid, which is absorbed into the systemic circulation. In the blood, β-glycyrrhetic acid binds to albumin and is almost completely transported to the liver. The excretion of β-glycyrrhetic acid occurs predominantly in bile, with residual amounts in urine.
Thermopsis lanceolata herb extract.
The components of the extract are well absorbed in the gastrointestinal tract. The maximum effect occurs 30-60 minutes after oral administration and lasts for 2-6 hours. They are excreted from the body by the kidneys, mucous membrane of the respiratory tract and bronchial glands.
Sodium bicarbonate.
Well absorbed from the gastrointestinal tract. The maximum effect occurs 30-60 minutes after oral administration and lasts for 2-6 hours. They are excreted from the body by the kidneys, mucous membrane of the respiratory tract and bronchial glands.
Indications
Diseases of the respiratory tract with difficulty in sputum discharge: acute and chronic bronchitis, pneumonia, chronic obstructive pulmonary disease (COPD), bronchiectasis.
Use during pregnancy and breastfeeding
The use of the drug during pregnancy is contraindicated. If it is necessary to use the drug during lactation, breastfeeding should be discontinued.
Contraindications
Hypersensitivity to the components of the drug, pregnancy, breastfeeding, children under 12 years of age.
Carefully
For liver and/or kidney failure, gastric and duodenal ulcers, bronchial asthma.
Side effects
Allergic reactions.
Rarely - weakness, headache, diarrhea, dry mouth and respiratory tract, exanthema, rhinorrhea, constipation, dysuria. With long-term use in high doses - gastralgia, nausea, vomiting.
Interaction
Combined use with antitussive drugs leads to difficulty in sputum discharge while reducing cough.
The drug increases the penetration of antibiotics into the bronchial secretions.
How to take, course of administration and dosage
Inside, during meals.
Adults and children over 12 years old: 1 tablet 3 times a day.
It is not recommended to use without medical prescription for more than 4-5 days.
Overdose
Symptoms: nausea, vomiting, diarrhea, dyspepsia.
Treatment is symptomatic; gastric lavage is advisable in the first 1-2 hours after taking the drug.
Special instructions
Do not combine with antitussives.
Release form
Pills
Storage conditions
In a dry place, protected from light, at a temperature not exceeding 25 °C
Best before date
2 years
Active substance
Ambroxol, Sodium bicarbonate, Sodium glycyrrhizinate, Thermopsis extract
Dosage form
pills
Barcode and weight
Barcode: 4601669006967, 2962586248680 Weight: 0.022 kg
Side effects
During treatment, the following are rarely possible:
- the appearance of physical weakness, dizziness;
- dryness, unpleasant taste in the mouth, loss of appetite;
- abdominal cramps, stool upset, constipation;
- irritation of the mucous membrane of the nasopharynx, trachea;
- the appearance of a runny nose.
After taking large doses, intoxication may occur. Possible vomiting, severe abdominal pain, diarrhea. In such cases, it is necessary to lavage the stomach and take enterosorbents.
