Compound
The composition of Troxerutin, produced in the form of capsules, includes 300 mg of Troxerutin and excipients: lactose monohydrate, colloidal silicon dioxide, Macrogol 6000, Magnesium stearate .
To make the capsule, the following are used: titanium dioxide (Titanium dioxide), gelatin (Gelatin), dyes (quinoline yellow - 0.75%, sunset yellow - 0.0059%).
Gel composition: troxerutin (Troxerutin) at a concentration of 20 mg/gram, methyl parahydroxybenzoate (E218; Methyl parahydroxybenzoate), carbomer (Carbomer), triethanolamine (Triethanolamine), disodium edetate (Edetate disodium), purified water (Aqua purificata).
Pharmacodynamics and pharmacokinetics
The product increases the tone of the walls of venous vessels and reduces their distensibility, thereby eliminating stagnation of venous blood and preventing the development of edema , reduces the intensity of the inflammatory process, and has membrane-stabilizing and capillary-protective effects .
Troxerutin takes an active part in redox processes of lipid peroxidation and hyaluronidase , as well as the oxidation of epinephrine ( Adrenaline ) and ascorbic acid .
The drug is characterized by P-vitamin activity, stimulates the processes of elimination of metabolic products from tissues, does not have an embryotoxic effect, does not cause mutations or disturbances in fetal development.
After oral administration, it is well absorbed from the digestive tract. The plasma concentration of the substance reaches its peak values 2-8 hours after taking the capsule. The second peak occurs approximately 30 hours later.
Troxerutin is almost completely eliminated from the body within 24 hours after administration, with about 75-80% of the substance being excreted by the liver, the remaining 20-25% by the kidneys .
When applied topically, the substance is not absorbed into the systemic circulation; however, the drug penetrates well into adjacent tissues through the skin.
Pharmacology
The medicine helps relax the smooth muscles of internal organs. After taking it, there is an improvement in the tone of the walls of blood vessels, they become less distensible, as a result of which blood stagnation disappears, the likelihood of edema decreases, and the severity of inflammatory processes decreases.
Capsules for oral administration are easily excreted from the stomach. The maximum concentration of the active element occurs 3-7 hours after administration. The second peak occurs approximately 28 hours later. The drug leaves the body completely within a day. Most of it is excreted by the liver, and a small part is excreted by the kidneys.
When the gel is applied locally, the constituent elements do not leak into the blood, but they still penetrate into the tissue adjacent to the skin.
Indications for use: what is Troxerutin prescribed for?
The use of Troxerutin tablets and gel is advisable:
- when accompanied by trophic skin lesions , static heaviness in the legs, leg ulcers, chronic venous insufficiency ;
- for varicose veins (including during pregnancy);
- for postthrombophlebitic syndrome ;
- for peri- and thrombophlebitis ;
- for hemorrhoids ;
- with hemorrhagic diathesis , which are characterized by increased permeability of capillary walls;
- for post-traumatic hematomas and tissue swelling ;
- with Henoch-Schönlein disease ( hemorrhagic capillary toxicosis ; including influenza , measles or scarlet fever );
- for diabetic retino- and microangiopathy ;
- with vascular effects that developed during radiation therapy.
As a prophylactic agent, the medicine can be used after vein surgery.
Troxerutin
Dosage form: gel for external use.
Composition per 100 g:
active ingredient: troxerutin (in terms of 100% substance) – 2.00 g;
excipients: carbomer 940 - 0.6 g, disodium edetate - 0.050 g, benzalkonium chloride - 0.0575 g, sodium hydroxide 30% - 0.700 g, purified water - up to 100 g.
Description: homogeneous transparent gel from yellow to light brown or yellow-green.
Pharmacotherapeutic group: venotonic and venoprotective agent.
ATX code: C05CA04.
pharmachologic effect
Pharmacodynamics. Troxerutin is a flavonoid (derivative of rutin), has P-vitamin activity: it has venotonic, venoprotective, decongestant, anti-inflammatory, anticoagulant and antioxidant effects. Its pharmacodynamic properties are associated with the participation of troxerutin in redox processes and inhibition of hyaluronidase. By inhibiting hyaluronidase, troxerutin stabilizes hyaluronic acid in cell membranes and reduces the permeability and fragility of capillaries, increasing their tone. It has antioxidant activity, which prevents the oxidation of ascorbic acid, adrenaline and lipids. Prevents damage to the basement membrane of endothelial cells when exposed to various factors. Troxerutin reduces exudative inflammation in the vascular wall, limiting the adhesion of platelets to its surface. As a result of treatment with troxerutin, the feeling of heaviness in the legs disappears, tissue swelling decreases, and trophism improves.
Pharmacokinetics. When the gel is applied to the affected area, the active substance quickly penetrates the epidermis, after 30 minutes it is found in the dermis, and after 2-5 hours in the subcutaneous fatty tissue.
Indications for use:
Varicose veins, chronic venous insufficiency, accompanied by swelling, pain, a feeling of heaviness in the legs, thrombophlebitis, periphlebitis, varicose dermatitis, pain and swelling after injuries (bruises, ligament damage).
Contraindications:
Hypersensitivity to the drug. Violation of the integrity of the skin. Children under 18 years of age (no experience of use).
with caution in chronic renal failure (long-term use).
Use during pregnancy and breastfeeding.
Pregnancy.
In preclinical studies, teratogenicity and fetotoxicity of drugs containing troxerutin were not noted. In the first trimester of pregnancy, the use of the drug Troxerutin is contraindicated due to the lack of experience in clinical use. In the second and third trimesters of pregnancy, the use of the drug Troxerutin is possible only if the expected benefit to the mother outweighs the potential risk to the child.
Breastfeeding period
There are no data on the penetration of troxerutin into breast milk. The drug Troxerutin should not be used during breastfeeding.
Directions for use and dosage:
Outwardly! A column of gel 4-5 cm long is applied in a thin layer to the affected areas and lightly rubbed in 3-4 times a day until completely absorbed. The daily dose should not exceed 20 cm of gel. If necessary, the gel can be applied under bandages or elastic stockings. The duration of treatment is no more than 10 days.
If the symptoms of the disease worsen or do not go away after 6-7 days of daily use of the drug, you should consult a doctor who will prescribe further treatment and determine the duration of the course of therapy.
Side effect:
In rare cases, allergic skin reactions are observed - urticaria, eczema, dermatitis. These symptoms disappear quickly after stopping treatment.
Overdose:
Cases of overdose with the recommended method of use of the drug are not known. If the drug is accidentally swallowed, a burning sensation in the mouth, salivation, nausea, and vomiting may occur. In this case, lavage of the oral cavity and stomach is indicated, and, if necessary, symptomatic treatment.
In case of contact with eyes, mucous membranes and open wounds, local irritation is observed - lacrimation, hyperemia, burning, pain. The gel is washed off with a large amount of distilled water or isotonic sodium chloride solution until the complete disappearance or significant reduction in the severity of these symptoms.
Interaction with drugs:
No information available.
Special instructions:
The gel is applied only to an undamaged surface.
Avoid contact with open wounds, eyes and mucous membranes!
In conditions characterized by increased vascular permeability (including scarlet fever, influenza, measles, allergic reactions), the gel is used in combination with ascorbic acid to enhance its effect.
Features of the action of the drug when first taken or when discontinued:
No information available.
Information about the possible effect of a medicinal product for medical use on the ability to drive vehicles and machinery:
Does not affect the ability to drive vehicles or operate moving machinery.
Storage conditions:
Store in a place protected from light at a temperature not exceeding 25°C. Keep out of the reach of children.
Shelf life: 2 years.
Do not use the drug after the expiration date indicated on the package.
Release form:
Gel for external use 2%.
20, 25, 30, 40, 50, 60, 70, 80, 100 g in orange glass jars with a triangular rim and a lid that is tensioned with a sealing element.
20, 25, 30, 40, 50, 60, 70, 80, 100 g in polymer jars complete with lids or in polyethylene terephthalate jars with closures.
Labels made of label or writing paper, or a self-adhesive label, are glued onto jars and cardboard boxes.
20, 25, 30, 40, 50, 60, 70, 80, 100 g in aluminum tubes, coated with BF-2 varnish, with caps made of high-density polyethylene or in polymer tubes with polyethylene screw caps.
Each jar and tube, along with instructions for use, is placed in a cardboard pack.
Vacation conditions:
Available without a prescription.
Contraindications
Contraindications for use are:
- hypersensitivity components of the drug;
- chronic gastritis in the acute phase;
- stomach ulcer;
- duodenal ulcer;
- age up to 15 years;
- first trimester of pregnancy ;
- breast-feeding.
The drug is prescribed with caution in case of insufficiency of renal function (if long-term use is necessary).
Instructions for use of Troxerutin
Troxerutin capsules: instructions for use
Troxerutin tablets are taken with meals, swallowed whole. In accordance with the standard treatment regimen, 0.9 grams of troxerutin per day is prescribed orally (one tablet three times a day). If the medicine is used as a maintenance agent, it should be taken one capsule twice a day.
The full course of treatment lasts from 3 to 4 weeks. The advisability of longer-term use is determined individually by the attending physician.
Instructions for drugs from different manufacturers may differ slightly.
So, for example, Troxerutin Zentiva are taken according to the scheme described above, and Troxerutin Vramed in the initial stages of treatment are taken one 2 or 3 times a day, after which they switch to maintenance treatment, which involves taking one capsule per day.
Treatment with Troxerutin-MIC begins with intravenous or intramuscular administration of 0.5 grams of troxerutin in the form of an injection solution. The procedures are repeated every other day, and it is recommended to give at least 5 injections of the drug.
After this, they switch to oral dosage forms. The starting dose is 0.6-0.9 grams per day, the maintenance dose is 0.3 grams per day. The course of treatment is from 2 to 4 weeks, unless there are other indications.
Gel Troxerutin: instructions for use
Troxerutin ointment is a product for external use. It should be applied twice a day (in the morning and evening), in a thin layer, evenly distributed on the skin of the painful area from the distal (most distant) to the proximal (closest) part of it and lightly massaging until completely absorbed.
The dose is determined by the area of the damaged surface, but should not exceed 1-2 grams (this corresponds to approximately 3-4 cm of gel). After applying the medication, an occlusive dressing can be applied to the affected area of skin.
Unlike capsules, the treatment regimen using gels from different manufacturers is no different, that is, the instructions for using Troxerutin Vramed are identical to the instructions, for example, Troxerutin Vetprom .
How to take Troxerutin gel
The drug in the form of a gel is intended for local application. It should be applied to the problem area 2 times a day (morning and evening). The ointment should be distributed in a thin layer over the entire damaged area, without affecting healthy skin. You need to rub the product in with smooth massaging movements until the gel is completely absorbed.
The permissible dose depends on the size of the problem skin, but should not be more than 2 g. When the ointment is applied, a bandage should be applied to the surface of the skin.
The drug in the form of an ointment, regardless of the manufacturer, has a similar treatment regimen.
Analogs
Level 4 ATX code matches:
Rutin
Venosmin
Indovazin
Venoruton
Troxevasin Neo
Troxevasin
Detralex
Ginkor Gel
Ginkor fort
Vasocket
Anavenol
Askorutin
Antistax
Venarus
Synonyms: Troxevasin , Troxerutin Vramed , Troxerutin Zentiva , Troxerutin-MIK , Troxerutin Vetprom , Troxevenol .
Analogues of the drug by mechanism of action: Antistax , Askovertin , Askorutin , Vazoket, Venarus , Venolek , Venoruton , Ginkor , Detralex , Diosmin , Rutin , Phlebodia 600 , Phlebofa , Yuglanex .
Reviews about Troxerutin
It is quite difficult to find negative reviews about Troxerutin gel. Given its low price (the medicine is a 100% analogue of the much more expensive drug Troxevasin ), the drug is described as very effective.
However, as most patients rightly note, to achieve maximum effect, it is better to use it in the early stages of the disease.
To the question “Troxerutin - what is it?” Most people with early manifestations of varicose veins answer that the ointment for them is a real salvation from spider veins, fatigue and soreness of the legs, as well as from bruises and bumps.
One of the indications for the use of the drug is the presence of hemorrhoids (a common problem that is especially often encountered by pregnant women and women who have recently given birth).
For hemorrhoids, treatment involves the use of Troxerutin in the form of compresses, and many are satisfied with the results achieved. Although, for the sake of objectivity, it should be said that this method does not help everyone (here, probably, everything depends on the severity of the pathology).
Analyzing the reviews left by patients about Troxerutin capsules and gel for external use, we can conclude that both dosage forms are often powerless for severe lesions: they do not help eliminate large nodes on the venous vessels, but probably prevent the process from worsening.
As for the reviews of doctors about tablets and ointments, almost all experts note the need for their use in combination. In more advanced situations, therapy begins with the prescription of troxerutin drugs in the form of an injection solution.
The key to successful treatment, according to doctors, is the regularity and timeliness of medication use. Moreover, it is optimal to start using the product when the first signs of the development of a pathological process appear.
Patients note that the most pronounced result was achieved in cases where the use of the drug was supplemented by swimming, pouring cold water on the feet, and using products based on essential oils (for example, cypress oil), Ascorutin .
It should be remembered that the composition is not suitable for relieving swelling of the legs, which is associated with kidney dysfunction , liver and heart diseases . Before using the drug and using accompanying therapeutic measures, you should definitely consult your doctor.
special instructions
The drug in one of its forms can be used as part of a complex treatment. In case of vein thrombosis, parallel use of appropriate medications is allowed.
Shelf life: capsules – 5 years, gel – 2 years from the date of production.
Store in a dark place. Storage temperature for gel is 10-15 degrees, for capsules - 17-25 degrees.
Sold in any pharmacy without a doctor's prescription.
Manufacturers assure that the drug is absolutely harmless. It is prescribed to people who are overweight, as well as to the fair sex who wear high-heeled shoes. The medicine is recommended for people whose work requires constant standing.
To achieve maximum effect, you need to use gel and capsules from the same manufacturer. In the absence of contraindications, it is best to use Troxerutin together with ascorbic acid for a more pronounced effect.
Troxerutin price
The price of Troxerutin gel starts from 30 rubles, the price of Troxerutin capsules starts from 100 rubles.
In Ukrainian pharmacies the price of Troxerutin tablets is from 59 UAH, the price of Troxerutin ointment is from 11 UAH.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Troxerutin Vramed gel 2% 40gSopharma AD
82 RUR order - Troxerutin DS gel 2% tube 40gVetProm AD
89 rub. order
- Neohalen gel-balm for feet Venaktiv Troxerutin with refrigeration. effect Health without overpayment" 125 ml LLC "KorolevPharm"
86 rub. order
- Neohalen gel-balm for feet VenActive. Leech extract. Troxerutin Health without overpayment 125ml KorolevPharm LLC
77 RUR order
- Gel-balm for feet “Shark oil with troxerutin” 125ml LLC KorolevPharm
82 RUR order
Pharmacy Dialogue
- Troxerutin (caps. 300 mg No. 50) Synthesis OJSC
RUB 399 order
- Horse chestnut and troxerutin gel-balm (natura medica for feet tube 85 ml)Twins Tech
97 RUR order
- Troxerutin capsules 300 mg No. 30Zentiva
RUB 215 order
- Troxerutin gel (tube 2% 40g)Green oak grove
39 RUR order
- Troxerutin (caps. 300 mg No. 50) Ozone LLC
RUB 345 order
show more
Pharmacy24
- Troxerutin 300 mg No. 30 capsules PAT "Khimpharmzavod" Chervona Zirka", Kharkov, Ukraine
63 UAH. order - Troxerutin 300 mg No. 60 capsules PAT "Khimpharmzavod" Chervona Zirka", Kharkov, Ukraine
115 UAH order
- Troxerutin 20 mg/g 35 g gel PAT "Khimpharmzavod" Chervona Zirka", Kharkov, Ukraine
26 UAH order
- Troxerutin-Darnitsa 2% 30 g gel PrAT” Pharmaceutical company “Darnitsa”, Ukraine
35 UAH order
PaniPharmacy
- TROXERUTIN gel Troxerutin gel 35g Ukraine, Red Star OJSC
31 UAH order
- TROXERUTIN gel Troxerutin gel 2% 30g Ukraine, Darnitsa ChAO
27 UAH order
show more
