Instructions for use of Berocca® Plus film-coated tablets

Composition of Berocca Plus

The composition of 1 effervescent tablet of the Berocca Plus multivitamin complex includes 500 mg of ascorbic acid (vitamin C), 15 mg of thiamine (vitamin B1), 15 mg of riboflavin (vitamin B2), 23 mg of pantothenic acid (vitamin B5), 10 mg of pyridoxine hydrochloride (vitamin B6), 40 mg folic acid (vitamin B9), 10 mg cyanocobalamin (vitamin B12), 50 mg nicotinamide (vitamin B3), 15 mg biotin (vitamin B8), 100 mg calcium , 100 mg magnesium and 10 mg zinc .
The main composition of vitamins is supplemented with anhydrous citric acid, sodium bicarbonate, anhydrous sodium carbonate, sodium chloride, acesulfame potassium, aspartame, mannitol , polysorbate 60, betacarotene (E160a), beetroot red dye (E162) and orange flavoring.

Berocca Plus effervescent tablets 30 pcs. in Smolensk

Latin name

Berocca plus

Release form

Effervescent tablets

Package

30 pcs.

Description

Effervescent tablets, flat-cylindrical, from pale orange to light orange, interspersed with darker and lighter colors; dissolve in water with the release of bubbles, forming a solution with the smell of orange.

pharmachologic effect

A combined drug, the pharmacological action of which is determined by the vitamins and microelements included in its composition. B vitamins are involved in many metabolic reactions, incl. synthesis of neurotransmitters. Vitamin C (ascorbic acid) is a biological antioxidant and plays an important role in the inactivation of free radicals, increases the absorption of iron in the small intestine, and affects the metabolism of folic acid and the function of leukocytes. Stimulates the formation of connective tissue, bone tissue, normalizes capillary permeability. Calcium takes part in many physiological processes, the functioning of enzyme systems, and the transmission of nerve impulses in combination with magnesium and vitamin B6. Magnesium is involved in various reactions, including protein synthesis, fatty acid metabolism, and sugar oxidation. Zinc as a catalyst activates more than 200 enzymes and is a component of many proteins, hormones, neuropeptides, hormonal receptors, and is also directly involved in the synthesis of coenzymes derived from pyridoxine. Water-soluble vitamins do not accumulate in the body, therefore, in conditions accompanied by an increased need for vitamins and minerals, the amount of vitamins supplied from food may be insufficient.

Indications

Deficiency or conditions accompanied by an increased need for B vitamins, vitamin C and zinc. The drug is used for conditions accompanied by a deficiency or increased need for vitamins: with increased physical activity; during periods of prolonged nervous tension and stress; with adequate and unbalanced nutrition (diet); in older people; for chronic alcoholism; nicotine addiction (in smokers); when using oral contraceptives in women.

Directions for use and doses

Inside. Film-coated tablets are washed down with water. Effervescent tablets are pre-dissolved in a glass of water. Adults and children over 15 years old - 1 tablet per day. The recommended course duration is 30 days. Repeated courses on the recommendation of a doctor.

Compound

1 effervescent tablet contains: Active substances: Vitamin B1 (thiamine) 15 mg, Vitamin B2 (riboflavin) 15 mg, Vitamin B6 (pyridoxine hydrochloride) 10 mg, Vitamin B12 (cyanocobalamin) 0.01 mg, Vitamin B3 (nicotinamide) 50 mg , Vitamin B5 (pantothenic acid) 23 mg, Vitamin B8 (biotin) 0.15 mg, Vitamin B9 (folic acid) 0.4 mg, Vitamin C (ascorbic acid) 500 mg, Calcium 100 mg, Magnesium 100 mg, Zinc 10 mg . Excipients: anhydrous citric acid, sodium bicarbonate, anhydrous sodium carbonate, sodium chloride, acesulfame potassium, aspartame, mannitol, polysorbate 60, beta-carotene (E160a), beetroot red dye (E162), orange flavor.

Contraindications

Hypersensitivity to the components of the drug. Hypercalcemia. Hypermagnesemia. Urolithiasis (nephrolithiasis, urolithiasis). Hemochromatosis. Hyperoxaluria. Renal dysfunction. Glucose-6-phosphate dehydrogenase deficiency. Children under 15 years of age. With caution: with atrophic gastritis, diseases of the intestines, pancreas, vitamin B12 malabsorption syndrome or congenital deficiency of the internal factor of Castle.

Use during pregnancy and breastfeeding

When using the drug Berocca Plus in the recommended dosage, there is no evidence of a negative effect of the drug on the course of pregnancy or the health of the child. However, during pregnancy the drug should be taken strictly for medical reasons. The vitamins and minerals contained in Berocca Plus pass into breast milk. There is no data on the safety of the drug when used during lactation.

special instructions

Vitamin C may interfere with urine glucose test results even though it does not affect blood sugar levels. Vitamin C should be stopped several days before such tests. Urine may turn yellow, which has no clinical significance and is explained by the presence of riboflavin in the drug. The drug does not contain fat-soluble vitamins. One tablet of the drug contains the maximum daily dose of vitamin B6 (pyridoxine), so you should not exceed the recommended dose of the drug. One tablet contains 12.5% ​​of the recommended daily intake of calcium and 33.3% of the recommended daily intake of magnesium. However, for the treatment of calcium and magnesium deficiency, taking Berocca* Plus alone is not sufficient. One tablet contains 272 mg of sodium, so patients on a low-salt diet are advised to take Berocca Plus in the form of film-coated tablets. Information for patients with diabetes mellitus One tablet of the drug contains 276 mg of mannitol, which corresponds to 0.028 bread units (BU), and an energy value of 0.66 kcal, so the drug can be taken by patients with diabetes mellitus. Patients taking other medications should consult their doctor before taking Berocca* Plus. Impact on the ability to drive vehicles and other mechanisms that require increased concentration. No effect.

Side effects

Allergic reactions: in very rare cases in very rare cases ( Digestive system: in less than 5% of patients, mild transient gastrointestinal disorders are possible. Blood and hematopoietic system: in patients with glucose-6-phosphate dehydrogenase deficiency, ascorbic acid can cause hemolytic anemia .

Drug interactions

Pyridoxine in doses greater than 5 mg may counteract the effects of levodopa in patients with parkinsonism. However, such antagonism is not observed when levodopa is used in combination with a decarboxylase inhibitor (eg, benserazide, cardbidopa). Thiosemicarbazone and 5-fluorouracil neutralize the effect of thiamine. Antacids inhibit thiamine resorption. Neomycin, aminosalicylic acid and histamine H2 receptor blockers reduce the absorption of cyanocobalamin. Acetylsalicylic acid reduces the absorption of ascorbic acid by approximately one third. Oral contraceptives can reduce the serum levels of cyanocobalamin, folic acid, pyridoxine, and ascorbic acid. Some patients taking deferoxamine and ascorbic acid 500 mg daily may experience transient left ventricular dysfunction.

Storage conditions

Store at a temperature not exceeding 25 C, in tightly closed packaging. Keep out of the reach of children.

Release form

Berocca Plus multivitamin complex is available in the form of effervescent tablets, which have a flat cylindrical shape and a pale orange color with splashes. When dissolved in water, the tablets emit bubbles and form an orange solution with an orange smell.

Effervescent tablets can be packed in 10 or 15 pieces in aluminum and polypropylene cylinders. In turn, the cylinders are placed 1, 2 or 3 pieces in cardboard packs. Each package must contain instructions for using Berocca Plus.

pharmachologic effect

Vitamins Berocca Plus is a combined preparation, therefore its pharmacological action is determined by the vitamins and microelements included in its composition. B vitamins take an active part in such an important metabolic process as the synthesis of neurotransmitters.

Vitamin C (ascorbic acid) is a biological antioxidant that plays a key role in the process of inactivating free radicals, and also significantly increases iron absorption in the small intestine and affects the functions of leukocytes and folic acid . Ascorbic acid also promotes the formation of bone and connective tissue and the normalization of capillary permeability.

Calcium is involved in almost all not only physiological processes, but also enzyme systems. Calcium, along with magnesium and vitamin B6, an important role in the transmission of nerve impulses.

Magnesium influences protein synthesis and promotes fatty acid metabolism and sugar oxidation.

Zinc acts as a catalyst in the activation of about 300 enzymes. Zinc is a component of many proteins, some hormones, as well as neuropeptides and hormone receptors. But the main function of zinc is still the synthesis of vitamin B6 derivatives (coenzymes).

The drug Berocca Plus contains the entire complex of active ingredients that must be taken in therapeutic doses for conditions that are accompanied by an increase in the need for vitamins. Particular attention to this multivitamin complex should be paid to people who have been exposed to increased physical activity or have been in a state of severe nervous tension for a long period of time.

It is also recommended to take this drug for people who are on restrictive diets , since their nutrition is inadequate or unbalanced. Vitamins have proven themselves well among older people, as well as among those undergoing treatment for chronic alcoholism and nicotine addiction. Women who regularly take oral contraceptives should also pay attention to these effervescent tablets.

Mechanism of action

Berocca Plus is intended to replenish the deficiency of ascorbic acid and B vitamins, to eliminate the symptoms of hypovitaminosis and prevent their development. The main antioxidants included in the drug regulate the activity of free radicals and prevent them from damaging healthy tissues.

• Ascorbic acid strengthens the vascular system, participates in metabolic processes, absorption of nutrients, reduces inflammatory reactions, helps increase immunity, physical strength during intense exercise and nervous tension.
• B vitamins ensure the normal functioning of the central and autonomic nervous system, participate in the synthesis of neurotransmitters, the synthesis of nerve fibers, muscle tissue and mucous membranes, regulate the absorption of fats and proteins, and reduce the risk of cancer.
• Calcium, zinc and magnesium are involved in the processes of basal metabolism, responsible for the production of enzymes and hormones, the synthesis of connective and bone tissue.

These vitamins and minerals do not accumulate in the body, but are consumed continuously, so the supply of these substances from the outside is constantly required. Berocca Plus is an optimally formulated drug, one tablet of which contains a daily dose of ascorbic acid, pyridoxine and a large number of other important elements. This is an excellent additional source of compounds necessary for the body in conditions of poor nutrition, increased nervous and physical stress, and during seasonal diseases.

Contraindications

It is not recommended to take Berocca Plus:

• with hypercalcemia ;
• with hypermagnesemia ;
• for urolithiasis (nephrolithiasis, urolithiasis );
• with hemochromatosis ;
• for hyperoxaluria ;
• in case of impaired renal function ;
• with deficiency of glucose-6-phosphate dehydrogenase ;
• in children under 15 years of age;
• with hypersensitivity to the components of the drug.

Patients with diseases such as atrophic gastritis , vitamin B12 malabsorption syndrome, congenital deficiency of intrinsic factor Castle . It is also recommended that patients who suffer from diseases of the intestines and pancreas not take this drug.

How to take the drug: instructions

For one course of prevention and replenishment of vitamin deficiency, 30 Berocca Plus tablets are required. They should be taken simultaneously with food, preferably in the morning. Coated pills should be swallowed whole, without chewing, with water or drinks. Effervescent tablets must first be diluted in 100–150 ml of liquid and the resulting drug must be consumed all at once. The daily dose of the complex is 1 tablet.

It is not recommended to exceed the specified amount, since excess water-soluble vitamins are eliminated from the body without being stored in reserve. For the most complete absorption of the components of the complex, additional intake of fat-soluble vitamins is recommended: retinol, tocopherol, D3.

Side effects

When taking the Berocca Plus multivitamin complex, patients may experience discomfort:

From the digestive system: from mild transient gastrointestinal disorders .

Allergic reactions: from urticaria , rash, laryngeal edema .

From the hematopoietic system: from hemolytic anemia (in people with glucose-6-phosphate dehydrogenase deficiency).

Indications for use

Conditions for which it is recommended to use the Berocca Plus vitamin complex:

• chronic alcoholism;
• drug and nicotine addiction;
• lack of B vitamins and ascorbic acid, provoked by long-term use of medications, an unbalanced diet, restrictive diets, and serious illnesses;
• period of preparation for exams, intense nervous stress, sports;
• in complex therapy: chronic diseases of the central nervous system, endocrine pathologies, intoxications, hormonal disorders, cosmetic problems;
• periods of active growth;
• elderly age.

The attending physician may recommend taking the complex to solve these and other problems alone or in combination with other drugs.

Overdose

To date, there have been no cases of overdose with Berocca Plus.

In case of overdose, patients may experience discomfort from gastrointestinal disorders ( diarrhea and discomfort in the stomach). Please note that if vitamin B6 is taken in excess, the patient may experience symptoms of neuropathy .

As a treatment, the patient is recommended to completely stop taking the drug and be sure to consult a doctor for symptomatic therapy.

Interaction

When taking pyridoxine (Vitamin B6) in a dose of more than 5 mg, the process of neutralizing the effect of levodopa may begin in patients who suffer from an illness such as parkinsonism .

Substances such as thiosemicarbazone and 5-fluorouracil neutralize vitamin B1 .

It is also better to avoid using antacid medications, as they inhibit the process of resorption of vitamin B1 .

A decrease in the absorption of vitamin B12 can be caused by substances such as neomycin and aminosalicylic acid .

Concomitant use of histamine H2 receptor blockers causes the same effect.

A significant decrease in serum levels of vitamin B12, folic and ascorbic acid , as well as pyridoxine can be caused by regular use of oral contraceptives .

The absorption of ascorbic acid may decrease by approximately 100% when taking acetylsalicylic acid and Berocca Plus together.

deferoxamine and vitamin C daily not take this drug , as this combination can negatively affect the condition of the left ventricle.

Instructions for use of Berocca® Plus film-coated tablets

Registration number:

LS-001921

Trade name of the drug

Berocca® Plus.

Group name

Multivitamins + Minerals.

Dosage form

film-coated tablets.

Compound

1 film-coated tablet contains

Active ingredients:

Excipients:

Shell:

Description

Oblong, biconvex, film-coated tablets, pale orange to grayish-orange in color.

Pharmacotherapeutic group

Multivitamins + Minerals.

ATS code:

A11AA04

Pharmacological properties

A combined drug, the pharmacological effect of which is determined by the complex of vitamins and microelements included in its composition. B vitamins are involved in many metabolic reactions, including the synthesis of neurotransmitters. Vitamin C (ascorbic acid) is a biological antioxidant and plays an important role in the inactivation of free radicals, increases the absorption of iron in the small intestine, and affects the metabolism of folic acid and the function of leukocytes. Stimulates the formation of connective tissue, bone tissue, normalizes capillary permeability. Calcium takes part in many physiological processes, enzyme systems and nerve impulse transmission in combination with magnesium and vitamin B6. Magnesium is involved in various reactions, including protein synthesis, fatty acid metabolism, and sugar oxidation. Zinc as a catalyst activates more than 200 enzymes and is a component of many proteins, hormones, neuropeptides, hormonal receptors, and is also directly involved in the synthesis of coenzymes derived from vitamin B6. Water-soluble vitamins do not accumulate in the body, therefore, in conditions accompanied by an increased need for vitamins and minerals, the amount of vitamins supplied from food may be insufficient.

Indications for use

Deficiency or conditions accompanied by an increased need for B vitamins, vitamin C and zinc. The content of vitamins in Berocca® Plus is selected for therapeutic purposes and is used for conditions accompanied by a deficiency or increased need for vitamins (increased physical activity, during periods of prolonged nervous strain and stress); with inadequate and unbalanced nutrition (restrictive diets); with chronic alcoholism.

Contraindications

Hypersensitivity to the components of the drug, hypercalcemia, hypermagnesemia, urolithiasis (nephrolithiasis, urolithiasis), hemochromatosis, hyperoxaluria, renal dysfunction, glucose-6-phosphate dehydrogenase deficiency, children under 15 years of age.

Carefully

For atrophic gastritis, diseases of the intestines, pancreas, vitamin B12 malabsorption syndrome or congenital deficiency of internal Castle factor.

Directions for use and doses

The drug is taken orally with water. Adults and children over 15 years of age : 1 tablet per day. Do not exceed the recommended daily dose of the drug. The recommended course duration is 30 days. Repeated courses on the recommendation of a doctor.

Side effect

Allergic reactions: possible urticaria, rash, laryngeal swelling, anaphylactic shock. Digestive system: mild transient gastrointestinal disorders are possible. Blood and hematopoietic system: In patients with glucose-6 phosphate dehydrogenase deficiency, ascorbic acid can cause hemolytic anemia. Nervous system: possible headache, dizziness, insomnia, excitability.

Overdose

Symptoms of overdose may include gastrointestinal distress such as diarrhea and stomach discomfort. Excessive intake of vitamin B6 (more than 20 tablets per day over several months) can lead to symptoms of neuropathy. In case of overdose, stop taking the drug and consult a doctor.

Use during pregnancy and lactation

Berocca® Plus is not intended for use in pregnant or breastfeeding women. Vitamins and minerals at doses used in dietary supplements are generally considered safe for use during pregnancy and lactation. However, Berocca® Plus should be used during pregnancy only as directed by your doctor. The vitamins and minerals contained in Berocca® Plus pass into breast milk. There is no data on the safety of the drug when used during lactation.

Interaction with other drugs

Vitamin B6 (pyridoxine), in doses greater than 5 mg, may counteract the effects of levodopa in patients with parkinsonism. However, such antagonism is not observed when levodopa is used in combination with a decarboxylase inhibitor (eg, benserazide, carbidopa). Thiosemicarbazone and 5-fluorouracil neutralize the effect of vitamin B1. Antacids inhibit the resorption of vitamin B1. Neomycin, aminosalicylic acid and H2 blockers reduce the absorption of vitamin B12. Oral contraceptives may reduce serum levels of vitamin B12, folic acid, pyridoxine, and ascorbic acid. Some patients taking deferoxamine and vitamin C 500 mg daily may experience transient left ventricular dysfunction.

special instructions

Vitamin C may interfere with urine glucose test results even though it does not affect blood sugar levels. Vitamin C should be stopped several days before such tests. Urine may turn bright yellow, which has no clinical significance and is explained by the presence of riboflavin in the drug. The drug does not contain fat-soluble vitamins. One tablet of the drug contains the maximum daily dose of vitamin B6 (pyridoxine), so you should not exceed the recommended dose of the drug. One tablet contains 12.5% ​​of the recommended daily intake of calcium and 33.3% of the recommended daily intake of magnesium. However, for the treatment of calcium and magnesium deficiency, taking Berocca® Plus alone is not sufficient. Information for patients with diabetes. One tablet of the drug contains 25 mg of mannitol, 94 mg of lactose monohydrate and 13.44 mg of dextrose, which corresponds to 0.02 bread unit (XE) and an energy value of 0.143 kcal, so the drug can be taken by patients with diabetes. Patients taking other medications should consult their doctor before taking Berocca® Plus.

Impact on the ability to drive a car or move machinery

Does not have or has an insignificant effect on the ability to drive a car or drive machinery.

Release form

Film-coated tablets. 10 or 20 film-coated tablets in a PVC/PE/PVDC/A1 blister. 3, 6 or 10 blisters (10 tablets each) or 3, 5 blisters (20 tablets each) along with instructions for use in a cardboard box with first opening control.

Storage conditions

At a temperature not higher than 25 °C. Keep out of the reach of children.

Best before date

3 years. Do not use after expiration date.

Conditions for dispensing from pharmacies

Over the counter.

Manufacturer

Registration certificate holder: JSC Bayer, Russia Manufactured by: Delpharm Gaillard, 33, rue d'Industry, 74240 Gaillard, France

Organization receiving consumer complaints: JSC "BAIER", Russia

107113, Moscow, st. 3rd Rybinskaya, 18, building 2 Tel. Fax www.bayer.ru

This version of the instructions is valid from 03/29/2021.

Analogs

Level 4 ATX code matches:
Vitacap

Glutamevit

Bio-Max

Menopace

Lavita

Wellman

Teravit

Gerovital

Kaltsinova

Pregnakea

Oligovit

Multi-Tabs Intensive

Multi-Tabs Junior

Multi-Tabs Perinatal

Multi-Tabs Teen

Multi-Tabs Classic

Multi-Tabs Baby

Special Dragee Merz

Pregnavite

Complivit Trimester

The main analogues of the drug are Duovit and Supradin , but analogues of Berocca Plus such as Menopace and Revalid .

Reviews of Berocca Plus

The average rating of Berocca Plus on the forums is 4.3 on a 5-point scale.

The advantages of this vitamin complex include forum visitors:

• effectiveness during physical and mental stress;
• helps to endure strict diets easier;
• Available in effervescent form.

Forum visitors consider the following to be the disadvantages of the drug:

• high price;
• low efficiency.

Having analyzed reviews of Berocca vitamins, it is worth noting that most often Berocca Plus vitamins are compared with Supradin , but there is no clear answer to the question “ Supradin or Berocca: which is better?” as of today no. However, doctors more often prescribe Supradin .

There is no information about the drug Berocca Plus on Wikipedia.