Berocca Plus: vitamins for immunity and nervous system

The manufacturer of the drug Berocca Plus is a French pharmaceutical concern. The complex contains essential water-soluble vitamins and several minerals:

• ascorbic acid;
• thiamine;
• riboflavin;
• biotin;
• nicotinamide;
• pantothenic acid;
• pyridoxine;
• folic acid;
• cyanocobalamin;
• calcium;
• zinc;
• magnesium.

Existing forms of Berocca Plus:

• coated tablets: light orange, elongated, convex on both sides, packaged in blisters, cardboard packaging contains 30 pieces;
• effervescent pills with orange flavor: bright orange, with light and dark inclusions, soluble in water and other liquids, sold in 15 pieces per package;
• effervescent tablets with cherry and mango flavor: dissolve in water, have a characteristic fruit and berry aroma and sweetish taste, the package contains from 10 to 30 pieces.

In addition to active substances, the drug contains sodium salts, carbohydrates, dyes, and stabilizing additives. Effervescent tablets also contain flavorings and citric acid.

Mechanism of action

Berocca Plus is intended to replenish the deficiency of ascorbic acid and B vitamins, to eliminate the symptoms of hypovitaminosis and prevent their development. The main antioxidants included in the drug regulate the activity of free radicals and prevent them from damaging healthy tissues.

• Ascorbic acid strengthens the vascular system, participates in metabolic processes, absorption of nutrients, reduces inflammatory reactions, helps increase immunity, physical strength during intense exercise and nervous tension.
• B vitamins ensure the normal functioning of the central and autonomic nervous system, participate in the synthesis of neurotransmitters, the synthesis of nerve fibers, muscle tissue and mucous membranes, regulate the absorption of fats and proteins, and reduce the risk of cancer.
• Calcium, zinc and magnesium are involved in the processes of basal metabolism, responsible for the production of enzymes and hormones, the synthesis of connective and bone tissue.

These vitamins and minerals do not accumulate in the body, but are consumed continuously, so the supply of these substances from the outside is constantly required. Berocca Plus is an optimally formulated drug, one tablet of which contains a daily dose of ascorbic acid, pyridoxine and a large number of other important elements. This is an excellent additional source of compounds necessary for the body in conditions of poor nutrition, increased nervous and physical stress, and during seasonal diseases.

Berocca Plus, brain vitamins, tablets, 30 pcs., Bayer

Active substance:

1 film-coated tablet contains: Thiamine mononitrate (Vitamin B1) 15 mg Riboflavin (Vitamin B2) 15 mg Nicotinamide (Vitamin B3) 50 mg Calcium pantothenate (Vitamin B5) 23 mg Pyridoxine hydrochloride (Vitamin B6) 10 mg Biotin 0, 15 mg Folic acid (Vitamin B9) 0.4 mg Cyanocobalamin (Vitamin B12) 0.01 mg Ascorbic acid (Vitamin C) 500 mg Calcium (in the form of calcium carbonate and calcium pantothenate) 100 mg Magnesium (in the form of magnesium hydroxycarbonate and magnesium oxide lung) 100 mg Zinc (in the form of zinc citrate trihydrate) 10 mg.
Excipients:
Lactose monohydrate, povidone K90, croscarmellose sodium, mannitol, talc, magnesium stearate Shell: opadry brown: polydextrose, hypromellose, titanium dioxide, fractionated coconut oil, iron oxide yellow, iron oxide red, iron oxide black.

Description:

Berocca - B complex of vitamins. Thanks to the most complete complex of B vitamins, Berocca (1) activates the areas of the brain responsible for mental activity (2) and improves (3) concentration; attention; performance.

A course of taking Berocca will allow you to react, think and act faster, and will also increase your resistance to stress (4).

With Berocca vitamins you can become more focused and effective. Berocca. Vitamins for the brain. When efficiency is your goal.

(1). There are contraindications. Before use, consult a specialist;(2). Scholey A., Bauer I., et al. Acute effects of different multivitamin mineral preparations with and without Guaran on mood, cognitive performance and functional brain activation. Nutrients. 2013 Sep 13;5(9):3589-604;(3). Kennedy DO, Veasey RC, et al. Vitamins and psychological functioning: a mobile phone assessment of the effects of a B vitamin complex, vitamin C and minerals on cognitive performance and subjective mood and energy. Hum Psychopharmacol. 2011 Jun-Jul;26(4-5):338-47;(4). Kennedy DO, Veasey R., et al. Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males. Psychopharmacology (Berl). 2010 Jul;211(1):55-68.

Release form:

Film-coated tablets. 10 film-coated tablets in a PVC/PE/PVDC/Al blister. 3 blisters (10 tablets each) along with instructions for use in a cardboard pack.

Indications for use

Conditions for which it is recommended to use the Berocca Plus vitamin complex:

• chronic alcoholism;
• drug and nicotine addiction;
• lack of B vitamins and ascorbic acid, provoked by long-term use of medications, an unbalanced diet, restrictive diets, and serious illnesses;
• period of preparation for exams, intense nervous stress, sports;
• in complex therapy: chronic diseases of the central nervous system, endocrine pathologies, intoxications, hormonal disorders, cosmetic problems;
• periods of active growth;
• elderly age.

The attending physician may recommend taking the complex to solve these and other problems alone or in combination with other drugs.

How to take the drug: instructions

For one course of prevention and replenishment of vitamin deficiency, 30 Berocca Plus tablets are required. They should be taken simultaneously with food, preferably in the morning. Coated pills should be swallowed whole, without chewing, with water or drinks. Effervescent tablets must first be diluted in 100–150 ml of liquid and the resulting drug must be consumed all at once. The daily dose of the complex is 1 tablet.

It is not recommended to exceed the specified amount, since excess water-soluble vitamins are eliminated from the body without being stored in reserve. For the most complete absorption of the components of the complex, additional intake of fat-soluble vitamins is recommended: retinol, tocopherol, D3.

Contraindications and side effects

Berocca Plus is intended for adults. It is not recommended for children under 15 years of age to avoid overdose and intoxication with the components. It is also necessary to refuse therapy:

• during pregnancy, breastfeeding;
• for urolithiasis, kidney inflammation;
• for peptic ulcers and gastritis during exacerbation;
• with intolerance to fructose and citric acid (for effervescent forms);
• for violations of the absorption of vitamins in the intestines.

When using the product, your urine may turn bright yellow. This is a normal reaction to riboflavin. Possible negative consequences of taking it include: dizziness, nausea, epigastric pain, drowsiness, and unpleasant taste in the mouth.

Signs of an allergic reaction: swelling of the mucous membranes, itching, urticaria, conjunctivitis.

Instructions for use of Berocca® Plus film-coated tablets

Registration number:

LS-001921

Trade name of the drug

Berocca® Plus.

Group name

Multivitamins + Minerals.

Dosage form

film-coated tablets.

Compound

1 film-coated tablet contains

Active ingredients:

Excipients:

Shell:

Description

Oblong, biconvex, film-coated tablets, pale orange to grayish-orange in color.

Pharmacotherapeutic group

Multivitamins + Minerals.

ATS code:

A11AA04

Pharmacological properties

A combined drug, the pharmacological effect of which is determined by the complex of vitamins and microelements included in its composition. B vitamins are involved in many metabolic reactions, including the synthesis of neurotransmitters. Vitamin C (ascorbic acid) is a biological antioxidant and plays an important role in the inactivation of free radicals, increases the absorption of iron in the small intestine, and affects the metabolism of folic acid and the function of leukocytes. Stimulates the formation of connective tissue, bone tissue, normalizes capillary permeability. Calcium takes part in many physiological processes, enzyme systems and nerve impulse transmission in combination with magnesium and vitamin B6. Magnesium is involved in various reactions, including protein synthesis, fatty acid metabolism, and sugar oxidation. Zinc as a catalyst activates more than 200 enzymes and is a component of many proteins, hormones, neuropeptides, hormonal receptors, and is also directly involved in the synthesis of coenzymes derived from vitamin B6. Water-soluble vitamins do not accumulate in the body, therefore, in conditions accompanied by an increased need for vitamins and minerals, the amount of vitamins supplied from food may be insufficient.

Indications for use

Deficiency or conditions accompanied by an increased need for B vitamins, vitamin C and zinc. The content of vitamins in Berocca® Plus is selected for therapeutic purposes and is used for conditions accompanied by a deficiency or increased need for vitamins (increased physical activity, during periods of prolonged nervous strain and stress); with inadequate and unbalanced nutrition (restrictive diets); with chronic alcoholism.

Contraindications

Hypersensitivity to the components of the drug, hypercalcemia, hypermagnesemia, urolithiasis (nephrolithiasis, urolithiasis), hemochromatosis, hyperoxaluria, renal dysfunction, glucose-6-phosphate dehydrogenase deficiency, children under 15 years of age.

Carefully

For atrophic gastritis, diseases of the intestines, pancreas, vitamin B12 malabsorption syndrome or congenital deficiency of internal Castle factor.

Directions for use and doses

The drug is taken orally with water. Adults and children over 15 years of age : 1 tablet per day. Do not exceed the recommended daily dose of the drug. The recommended course duration is 30 days. Repeated courses on the recommendation of a doctor.

Side effect

Allergic reactions: possible urticaria, rash, laryngeal swelling, anaphylactic shock. Digestive system: mild transient gastrointestinal disorders are possible. Blood and hematopoietic system: In patients with glucose-6 phosphate dehydrogenase deficiency, ascorbic acid can cause hemolytic anemia. Nervous system: possible headache, dizziness, insomnia, excitability.

Overdose

Symptoms of overdose may include gastrointestinal distress such as diarrhea and stomach discomfort. Excessive intake of vitamin B6 (more than 20 tablets per day over several months) can lead to symptoms of neuropathy. In case of overdose, stop taking the drug and consult a doctor.

Use during pregnancy and lactation

Berocca® Plus is not intended for use in pregnant or breastfeeding women. Vitamins and minerals at doses used in dietary supplements are generally considered safe for use during pregnancy and lactation. However, Berocca® Plus should be used during pregnancy only as directed by your doctor. The vitamins and minerals contained in Berocca® Plus pass into breast milk. There is no data on the safety of the drug when used during lactation.

Interaction with other drugs

Vitamin B6 (pyridoxine), in doses greater than 5 mg, may counteract the effects of levodopa in patients with parkinsonism. However, such antagonism is not observed when levodopa is used in combination with a decarboxylase inhibitor (eg, benserazide, carbidopa). Thiosemicarbazone and 5-fluorouracil neutralize the effect of vitamin B1. Antacids inhibit the resorption of vitamin B1. Neomycin, aminosalicylic acid and H2 blockers reduce the absorption of vitamin B12. Oral contraceptives may reduce serum levels of vitamin B12, folic acid, pyridoxine, and ascorbic acid. Some patients taking deferoxamine and vitamin C 500 mg daily may experience transient left ventricular dysfunction.

special instructions

Vitamin C may interfere with urine glucose test results even though it does not affect blood sugar levels. Vitamin C should be stopped several days before such tests. Urine may turn bright yellow, which has no clinical significance and is explained by the presence of riboflavin in the drug. The drug does not contain fat-soluble vitamins. One tablet of the drug contains the maximum daily dose of vitamin B6 (pyridoxine), so you should not exceed the recommended dose of the drug. One tablet contains 12.5% ​​of the recommended daily intake of calcium and 33.3% of the recommended daily intake of magnesium. However, for the treatment of calcium and magnesium deficiency, taking Berocca® Plus alone is not sufficient. Information for patients with diabetes. One tablet of the drug contains 25 mg of mannitol, 94 mg of lactose monohydrate and 13.44 mg of dextrose, which corresponds to 0.02 bread unit (XE) and an energy value of 0.143 kcal, so the drug can be taken by patients with diabetes. Patients taking other medications should consult their doctor before taking Berocca® Plus.

Impact on the ability to drive a car or move machinery

Does not have or has an insignificant effect on the ability to drive a car or drive machinery.

Release form

Film-coated tablets. 10 or 20 film-coated tablets in a PVC/PE/PVDC/A1 blister. 3, 6 or 10 blisters (10 tablets each) or 3, 5 blisters (20 tablets each) along with instructions for use in a cardboard box with first opening control.

Storage conditions

At a temperature not higher than 25 °C. Keep out of the reach of children.

Best before date

3 years. Do not use after expiration date.

Conditions for dispensing from pharmacies

Over the counter.

Manufacturer

Registration certificate holder: JSC Bayer, Russia Manufactured by: Delpharm Gaillard, 33, rue d'Industry, 74240 Gaillard, France

Organization receiving consumer complaints: JSC "BAIER", Russia

107113, Moscow, st. 3rd Rybinskaya, 18, building 2 Tel. Fax www.bayer.ru

This version of the instructions is valid from 03/29/2021.