Acipol Active (dietary supplement) suspension for oral administration 10ml N10

Acipol Active: instructions for use

Solvent water, sweetener fructose, inulin, lactobacilli Lactobacillus rhamnosus ATCC 53103, bifidobacterium Bifidobacterium longum CECT 7894, filler maltodextrin, acidity regulator citric acid (E 330), natural pear flavor, zinc citrate, preservative potassium sorbate (E 202), preservative sodium benzoate (E 211), anti-caking agent silicon dioxide (E 551), emulsifier magnesium stearate (E 470).

Content of active ingredients

* — TR CU 022/2011 “Food products regarding their labeling”, ** — “Unified sanitary-epidemiological and hygienic requirements for goods subject to sanitary-epidemiological supervision (control)” of the EurAsEC Customs Union

Nutritional and energy value

Nutritional and energy value of 1 bottle (1 serving): fats less than 0.01 g, proteins less than 0.01 g, carbohydrates - 3.34 g, including sugars - less than 2.3 g; energy value – 13.38 kcal / 56.02 kJ.

What is Acipol® Active suspension:

1. This is a complex composition with EFFECTIVE
   components - living probiotic bacteria necessary for the functioning of the body, which enhance and complement each other’s action.
2. This is a MAXIMUM CONCENTRATION
   - 10 billion beneficial live bacteria in one bottle, which can provide maximum effectiveness for various disorders of the gastrointestinal tract in adults.
3. This is CONVENIENCE
   of reception. Only 1 time per day. You can take it with you (on vacation, to work, on the road).
4. This is TECHNOLOGICAL
   production - thanks to the unique “LONG LIFE CUP” technology of preserving the strength of living beneficial bacteria that are part of the complex (in the cap), the activity of the product is ensured throughout the entire shelf life.
5. This is high QUALITY
   in accordance with the GMP standard - a guarantee of the viability of bacteria until the end of the shelf life. Made in Spain.
6. The microflora of the human intestine is a very important factor that determines the functioning of the entire organism.
   Qualitative and quantitative changes in the state of intestinal microflora, or its IMBALANCE

   (changes in the ratio of microorganisms - representatives of normal microflora and pathogenic bacteria) are a common cause of disruption of the digestive process, the functioning of the immune system, and atopic reactions. The balance of normal intestinal microflora is an important factor in the body's immune defense.

   Disturbance of microbial balance in the intestine is otherwise called intestinal dysbiosis. There can be many reasons that disrupt the balance of intestinal microflora and lead to dysbiosis: stress, unbalanced poor nutrition, poor diet, diseases of the gastrointestinal tract, and insufficient consumption of prebiotics (dietary fiber and polysaccharides). Also, the development of dysbiosis syndrome is possible during travel, with changes in climatic conditions and diet.

   Acipol® Active suspension is an innovative product of complex composition and action, containing:

   • Probiotic Lactobacillus rhamnosus

   Probiotic Bifidobacterium longum

7. Prebiotic inulin
8. Mineral zinc.

The action of Acipol® Active is due to the properties of the active components included in the composition, which enhance and complement each other’s action (according to scientific data):

1. Lactobacillus (Lactobacillus rhamnosus)

   According to the results of clinical studies of the use of Lactobacillus, it was shown:

   • reducing the risk of developing microflora imbalance, including after taking drugs and agents that cause unfavorable changes in the qualitative or quantitative composition of the microbiocenosis of the gastrointestinal tract; against the background of stress and errors in diet;

   reduction in the frequency of colds;

2. increase in nonspecific resistance of the body.

What are the benefits of Lactobacillus (Lactobacillus rhamnosus)?

• produce metabolites that selectively suppress the growth of pathogenic microflora;
• have an immunomodulatory effect.

INTERESTING:

one study showed a significant reduction in body weight and fat mass when taking Lactobacillus rhamnosus and a prebiotic.

Lactobacilli promote the formation of lactic acid, and the acidic environment created in this way has a beneficial effect on the development of bifidobacteria, which are also present in the Acipol® Active suspension;

What are the benefits of Bifidobacterium longum?

The presence of a sufficient amount of bifidobacteria in the intestine and the normal state (BALANCE) of the intestinal microflora contributes to the synthesis of vitamins in the intestine, better absorption of food components and optimization of metabolic processes in the body.

A deficiency of bifidobacteria in the intestine can lead to gastrointestinal dysfunction.

Bifidobacteria support normal processes of parietal digestion in the intestine.

It is the complexes containing lactobacilli and bifidobacteria (including Lactobacillus rhamnosus and Bifidobacterium longum), according to a number of studies, that are characterized by good tolerability, a favorable safety profile, and the ability to reduce the risk of developing functional disorders of the gastrointestinal tract. An important property of the probiotics Lactobacillus rhamnosus and Bifidobacterium longum is their ability to attach to the intestinal epithelium, thereby ensuring and strengthening its barrier functions, as well as supporting immunity.

Application area

Acipol® Active suspension is recommended as a biologically active food supplement - an additional source of probiotic microorganisms (lactobacteria and bifidobacteria), zinc, and inulin.

The ingredients of Acipol® Active comprehensively help restore the balance of intestinal microflora, strengthen the immune system, and accelerate the body’s adaptation processes.

The complex can be used on the recommendation of a doctor in cases of imbalance in the intestinal microflora associated with the use of drugs that suppress one’s own normal microflora (including antibiotics), with a change in climate, usual diet, manifestations of atopic reactions, and during seasonal surges of colds.

Recommendations for use

Inside, during meals. Adults: 1 bottle 1 time per day with meals. Duration of treatment – ​​1 month.

Before use, it is necessary to combine/mix the filler in the bottle and the concentrate of active substances contained in the cap, according to the visual instructions:

1. press firmly on the dispenser cap;
2. wait until the contents of the dispenser cap enter the bottle;
3. shake the bottle thoroughly;
4. open the lid and drink the suspension;
5. If desired, the prepared suspension can be mixed with drinks at room temperature (water, fruit juice, yogurt, etc.). Do not mix with hot milk or other hot liquids!

Use the suspension immediately after preparation. The prepared suspension cannot be stored.

Contraindications

Individual intolerance to components. It is recommended to consult a doctor before use.

Storage conditions

Store in original, unopened packaging out of the reach of children at a temperature not exceeding 25 °C. Do not freeze.

Release form

A bottle with a liquid filler and a concentrate of the active substance for preparing a suspension. Bottles with a volume of 10 ml. 1, 5, 10 bottles per package.

Sales to the public through pharmacy chains and specialized stores, departments of retail chains.

Best before date

2 years from the date of manufacture.

Certificate of state registration

No. RU.77.9988.003.E.002607.06.17 dated 06/08/2017

Manufacturer

Erbozeta, SpA, Strada delle Seriole 41/43 ZI Gualdicciolo 47894, Chiesanuova, Republic of San Marino, for AB-Biotics, SA, Spain

Importer

Pharmstandard LLC, 123317, Russia, Moscow, st. Testovskaya, house 10..

Organization that receives complaints from consumers

PJSC "OTCIPHARM", 123317, Russia, Moscow, st. Testovskaya, house 10.. otcpharm.ru

Instructions, PDF version
Where to buy

Drops Acipol Baby

> References

Advantages

*

- Associated with an imbalance of intestinal microflora (see leaflet).

Symptoms

**

— Atopy is one of the most common types of dermatosis, the manifestation of which is inflammation of the skin associated with an allergic reaction

Composition and effects

1

— Elazab N. et al. Probiotic Administration in Early Life, Atopy, and Asthma: A Meta-analysis of Clinical Trials. PEDIATRICS Volume 132, Number 3, September 2013

2

— Elazab N. et al. Probiotic Administration in Early Life, Atopy, and Asthma: A Meta-analysis of Clinical Trials. PEDIATRICS Volume 132, Number 3, September 2013; Kalliomaki M, Salminen S, Arvilommi H, Kero P, Koskinen P, Isolauri E. Probiotics in primary prevention of atopic disease: a randomized placebo-controlled trial. Lancet 2001; 357:1076-9.

3

-Synbiotic in the management of infantile colic: a randomized controlled trial. Kianifar H1, Ahanchian H, Grover Z, Jafari S et al. J Paediatr Child Health. 2014 Oct;50(10):801-5. doi: 10.1111/jpc.12640. Epub 2014 Jun 24.

4

-L Lactobacillus GG in the prevention of antibiotic associated diarrhea in children Jon A. Vanderhoof, MD, David B. Whitney. THE JOURNAL OF PEDIATRICS VANDERHOOF ET AL VOLUME 135, NUMBER 5.

5

-Lactobacillus rhamnosus GG Supplementation for Preventing Respiratory Infections in Children: A Meta-analysis of Randomized, Placebo-controlled Trials. SHAN LIU, PENGWEI HU. INDIAN PEDIATRICS. VOLUME 50, APRIL 16, 2013; Elazab N. et al. Probiotic Administration in Early Life, Atopy, and Asthma: A Meta-analysis of Clinical Trials. PEDIATRICS Volume 132, Number 3, September 2013

Situations of use

Disorders of the intestinal microflora in a baby

1.

Kato, K et al. Changes in the composition of intestinal bifidobacteria species associated with age // Nast. Microbiol. . – 2022. – T. 74. – No. 8. – pp. 987-995

2.

Avershina E. et al. Continuity and correlation of the network of bifidobacteria in a large unselected cohort of mothers and their children // Applied and environmental microbiology. – 2013. – T. 79. – No. 2. – pp. 497-507.

3.

Martin R. et al. Early life events, including the method and type of feeding, relationship and gender, which shape the developing intestinal microbiota // Public Library of Science One - 2016. - Vol. 11. - No. 6. – P. e0158498.

4.

Dubois N.E., Gregory K.E. Characteristics of the intestinal microbiota in intestinal colic: results based on an integrative review of the literature. Biological Research for Nurses. - 2016. - T. 18. - No. 3. - pp. 307-315.

5.

Zakharova I. N. et al. Infantile intestinal colic: a modern view of the problem // Cons. Med. Pediatrics. – 2014. – No. 4. – pp. 46-53.

6.

Milani S et al. The first microbial colonizers of the human intestine: composition, activity and consequences for the health of the intestinal microbiota of infants // Review of Microbiology and Molecular Biology. – 2022. – T. 81. – No. 4. – P. e00036-17.

7.

Koppen IJN et al. Pediatric Rome IV criteria: What's new? // Expert review of gestroenterology and hepatology. – 2017. – T. 11. – No. 3. – pp. 193-201.

8.

Belaiche M. et al. Multiple functional gastrointestinal disorders are common in formula-fed infants and reduce their quality of life / Acta Paediatrica. – 2022. – T. 107. – No. 7. – pp. 1276-1282.

Acipol, capsules, 30 pcs.

Manufacturer

Lecco, Russia

Compound

Active ingredients:
at least 107 live acidophilic lactobacilli and kefir grain polysaccharide - 0.4 mg.

Indications

Dysbacteriosis and conditions leading to its development:

• acute intestinal infections (dysentery, salmonellosis, rotavirus gastroenteritis, etc.);
• chronic colitis, enterocolitis of infectious and non-infectious origin;
• long-term antibacterial therapy.

Dysbacteriosis and weight loss associated with:

• active antibiotic therapy for purulent-septic diseases in infants;
• chronic, protracted, recurrent pathologies of the respiratory system (bronchitis, pneumonia, including Pneumocystis);
• atopic dermatitis and other allergic manifestations.

Prevention of dysbacteriosis.

• Increasing the overall resistance of the body.

Recommendations for use

Capsules are taken orally, without chewing, washed down with boiled water.

The size of the daily dose and duration of treatment for patients is determined by the doctor depending on the age, severity and duration of the disease and the severity of dysbacteriosis.

Children from 3 months to 3 years old should take Acipol® with food, 1 capsule 2-3 times a day, after opening the capsule and dissolving its contents in milk or boiled water.

For other age groups and adults, Acipol® is prescribed 1 capsule 3-4 times a day, 30 minutes before meals.

For acute intestinal infections, the drug is prescribed for 5-8 days.

Longer courses are prescribed for the treatment of children with weight loss caused by the chronic course of diseases accompanied by dysbacteriosis.

For prophylactic purposes, Acipol® is prescribed 1 capsule 1 time per day for 10-15 days.

Repeated courses are carried out no earlier than 1 month after the end of the previous treatment.

Contraindications

Hypersensitivity to the components of the drug.

Side effects

Not installed.

Purpose

Prevention and treatment of diseases of the gastrointestinal tract in children from 3 months of age and adults; in combination with traditional treatment.

Description

The drug is a mixture of microbial mass, lyophilized in a cultivation medium, of living antagonistically active acidophilic lactobacilli and heat-inactivated kefir grains containing a water-soluble polysaccharide, crushed, packaged in capsules.

1 capsule contains at least 107 live acidophilic lactobacilli and kefir grain polysaccharide - 0.4 mg.

The contents of the capsules are dry biomass from light cream to cream color with a sour milk smell. The therapeutic effect of Acipol® is determined by the live acidophilic lactobacilli and kefir grain polysaccharide it contains. According to the mechanism of action, Acipol® is a multifactorial therapeutic agent, has antagonistic activity against pathogenic and opportunistic microorganisms, has a corrective effect on the intestinal microflora, and increases the immunological reactivity of the body.

Special instructions

Not suitable for use:

• a drug whose internal packaging has been damaged (cracked cans, blister packs);
• the drug is unlabeled or unclearly labeled;
• a drug with altered physical properties (the shape of the capsule is disrupted), in the presence of foreign inclusions;
• an expired drug.

Release form

Capsules

Storage conditions

Storage and transportation in accordance with SP 3.3.2.1248-03 at a temperature not exceeding 10°C.

Best before date

2 years.

Active substance

Lactobacillus acidophilus, kefir grains

Dosage form

capsules

Purpose

For adults

Indications

Bronchitis, Dysbacteriosis, Dermatitis, After a course of antibiotic therapy, Flatulence, Pneumonia, Colitis, Intestinal infections

Barcode and weight

Barcode: 60367 1002258, 603671002258, 4603671002258, - Weight: 0.026 kg