Adaklin for wrinkles. Reviews, how to apply the cream, before and after photos, price

From this article you will learn:

• the most effective retinoids for acne,
• list of drugs,
• retinoids for the face against wrinkles.

The article was written by a specialist with higher medical education.

Retinoids are a class of chemical compounds that are structural analogues of vitamin A, exhibiting similar biological activity to it. This is exactly the definition of retinoids given by Dr. Michael Sporn and his colleagues in 1976, when scientists knew only a few naturally occurring retinoids. At the moment this definition is outdated, because a large number of synthetic molecules are now known that are not structurally similar to vitamin A, but at the same time have a retinoid-like effect.

At the moment, retinoids are any chemical compounds of natural or artificial origin that are capable, independently or through metabolic transformation, of binding to retinoid receptors and activating them. We are talking about retinoic acid receptors (RAR) and retinoid X receptors (RXR). The first retinoid to be marketed was trans-retinoic acid, also called tretinoin. And the first commercial preparation for external use based on tretinoin is the drug “Retin-A”.

Compound

The composition of the product is presented in the table:

The active component, adapalene, is a synthetic analogue of vitamin A, which is produced from naphthoic acid. This substance is chemically stable, it has anti-inflammatory and comedolytic effects.

When applied to the skin, adapalene stimulates the production of keratin and eliminates dead skin cells from the surface of the skin.

In what form is it produced?

The product is available in the form of a cream and has an active ingredient concentration of 0.1%.

"Adaklin" is sold in a white cardboard box. On its front side the name of the product is indicated, on the back - the composition, storage conditions and information about the manufacturer. The shelf life of the cream and the batch number are indicated on the side. Inside the package there are instructions for using the product.

The cream itself is in a tin tube with a lid, which is protected by a membrane from opening. The volume of the container is 30 g. The cream has medium thickness and white color, there is practically no smell, the structure of the product is greasy.

The drug is available without a prescription and can be stored for 3 years at temperatures up to +25 °C.

The cost of Adaklin cream is approximately 600 rubles. and depends on the point of sale.

Topical retinoids: preparations

But a topical retinoid alone is not enough in most cases. Monotherapy with adapalene or tretinoin is indicated only for comedonal acne, i.e. for acne. In this case, the patient has only non-inflammatory elements of acne on his face - open and closed comedones (also called black and whiteheads). In this case, monotherapy will be sufficient, and most often dermatologists prescribe drugs with 0.1% adapalene - such as Differin or Klenzit (in the form of a gel or cream).

But if you have acne (in fact, acne is a colloquial expression, and correctly it is a papulopustular form of acne) - topical retinoid therapy alone is not enough. In addition, here it is necessary to clarify that pimples themselves can be either in the form of pustules with pus, or in the form of papules. This is very important because... The treatment regimen should take into account the predominant type of inflammatory elements in the patient. Depending on this, we will use combinations - 1) “adapalene + benzoyl peroxide”, 2) or “adapalene + benzoyl peroxide + antibiotic”.

Combined topical retinoids –

Especially for the treatment of acne (in the form of papules or pustules), there are combination preparations in which the topical retinoid adapalene is combined with antimicrobial components. The latter can be used as a bactericidal component such as benzoyl peroxide or the antibiotic clindamycin. Examples of combined preparations in the form of gels:

• Klenzit-S – contains 0.1% adapalene + 1% clindamycin,
• Effezel – contains 0.1% adapalene + 2.5% benzoyl peroxide.

In addition, in treatment you can use not only combination drugs, but also create a treatment regimen from a combination of several single drugs. For example, a patient is prescribed the drug “Baziron AS” with benzoyl peroxide in the morning + the drug “Differin” with the topical retinoid adapalene in the evening, etc. You can read about international protocols for the treatment of acne and pimples in the following articles (they are taken from the dermatology textbook “Fitzpatrick's Dermatology”):

→ Acne treatment protocols → Acne treatment protocols

Action

"Adaklin" is prescribed to people who suffer from the problem of acne formation. The product also helps fight pimples and acne, after which pustular formations appear on the skin.

“Adaklin” for wrinkles, reviews of which confirm the anti-inflammatory effect of the product, nourishes the skin and restores its damaged areas. Thanks to the action of the active component on the surface of the skin, the proliferation of bacteria is stopped.

This in turn leads to a decrease in sebum production and a decrease in the amount of redness and pore blockages. After applying the product, adapalene softens the top layer of skin, which makes it easier for pus to come out.

Features of using the cream:

• The product is practically not absorbed into the skin, the absorption percentage is 4%. The active substance is excreted from the body with bile;
• When using the cream, dermatologists do not recommend sunbathing, visiting a solarium, or staying outside for a long time on a hot day, since the drug increases the photosensitivity of the skin. If the recommendation is not followed, sunburn may occur;
• at the beginning of treatment, deterioration of the skin condition (itching, redness, peeling) may be observed. In this case, it is necessary to reduce the dosage of the cream or temporarily stop using it. After the symptoms disappear, you can use the cream again, starting with the minimum dosage;
• During treatment, cosmetic products containing ethanol should not be applied to the skin. Alcohol can worsen the effects of adapalene on the skin, leading to excessive drying. It is necessary to replace cosmetics with ethanol with those that will additionally moisturize the skin;
• The simultaneous use of Adaklin cream and salicylic acid is not recommended;
• After applying the cream and before using decorative cosmetics, 8-10 hours should pass. If the interval is not observed, the components of the cosmetics may react with the ingredients of the cream and cause allergy symptoms;
• During treatment, you should avoid using peelings, scrubs and exfoliating cosmetics;
• if the skin has eczema, dermatitis or seborrhea, you must use the cream with caution, avoiding areas with open wounds and damage when applying;
• adapalene does not react with oxygen, so it can be used in combination with benzoyl peroxide and clindamycin;
• the drug does not affect driving.

The cream also exhibits a dermatotropic effect and effectively fights scars remaining on the skin after inflammation and age spots. This is explained by the fact that the product activates the release of free radicals from the skin and the production of collagen, which is the main component of connective tissue, which gives the skin firmness, youthful appearance and elasticity.

Retinoids for acne and acne -

Retinoids are the basis of modern acne therapy (pimples and pimples). They affect almost all links of pathogenesis, which lead to the formation of inflammatory and non-inflammatory elements of acne - such as comedones, pimples (in the form of papules or pustules), or nodules.

The main therapeutic effects of retinoids:

• decreased activity of the sebaceous glands,
• elimination of follicular hyperkeratosis of the epithelium of hair follicles,
• comedolytic action,
• anti-inflammatory effect,
• exfoliating effect (reduces the cohesion of cells of the stratum corneum of the epidermis, promoting their desquamation).

For mild to moderate acne, topical retinoids are prescribed (external agents in the form of a gel or cream containing adapalene or tretinoin). However, in severe cases, the patient is usually prescribed systemic retinoids based on isotretinoin (the drugs Acnecutane and Roaccutane).

Using retinoids: before and after photos

1st and 2nd choice topical retinoids –

Tretinoin was a topical retinoid that was approved for the treatment of acne (pimples and pimples). However, now, in all international acne treatment protocols, not tretinoin is recommended as the first line of therapy, but the retinoid adapalene 0.1%. Firstly, this is due to the fact that patients with adapalene develop side effects much less frequently (for example, dryness and flaking of the skin, redness, itching, burning, feeling of tightness, etc.).

Secondly, there are clinical studies on the comparative effectiveness of tretinoin and adapalene in the treatment of acne. These studies showed that preparations with 0.1% adapalene were more or equal to the effectiveness of tretinoin preparations 0.025%. This is also stated in the most authoritative textbook on dermatology, Fitzpatrick's Dermatology, which is a reference book for most dermatologists around the world.

Preparations with tretinoin can be used to treat acne - only as a 2nd line of therapy, namely in the absence of effect from external agents with adapalene. The fact is that in an extremely small number of patients adapalene may not give the expected effect (24stoma.ru). We have already said above that 0.1% adapalene and 0.025% tretinoin are generally similar in effectiveness, however, it must be admitted that the comedolytic and anti-inflammatory effects of tretinoin are somewhat more pronounced.

The comedolytic effect is that the retinoid will help dissolve the fatty substrate of acne (comedones), which are formed during acne in the lumen of the hair follicles. So, in some patients the comedolytic effect of adapalene for unknown reasons may be insufficient. And in this case, the dermatologist may decide to prescribe the patient alternative retinoids, for example, tretinoin.

Application

Reviews of Adaklin cream when used to prevent the formation of wrinkles prove that the product must be used regularly.

To apply the cream correctly, you must follow the following instructions:

1. The product is applied only externally in the evening. To do this, you need to cleanse your facial skin of cosmetics and impurities using cleansing milk, and then wipe off excess liquid with a napkin. To enhance the effect, you can make a compress with a hot towel to open the pores.
2. Next, you need to open the tube of cream and squeeze a pea-sized portion of the product onto your finger.
3. Then you need to apply the cream to problem areas of the skin and then rub it in, following the massage lines, until the composition is completely absorbed. Do not apply the product to mucous membranes (eyes or lips). If the cream accidentally gets into these areas, they must be thoroughly rinsed with water.
4. The product should be applied once a day and left on the skin for 1 hour.
5. After the allotted time has passed, the unabsorbed cream must be blotted with a napkin or washed off with cool water without using soap.
6. Next, you need to apply a nourishing or moisturizing cream to the skin.

The visual effect is noticeable after 4-10 weeks. after starting to use the cream. The treatment period is prescribed by a dermatologist individually in each case.

To determine whether a person has an allergic reaction to the components of the drug, it is necessary to conduct an allergy test.

To do this, perform the following steps:

1. First you need to apply a thin layer of cream to the inner area of ​​the wrist. It's better to do this at night.
2. After 12 hours, you should visually assess the condition of the skin - whether there is redness, peeling or rash.
3. If the appearance of the skin has not changed, the cream can be used.

Adaclin for wrinkles is used to treat acne.
If during an allergy test, itching, swelling, or obvious redness of the skin occurs, you should wash off the product with water without using soap and take an antihistamine. Also, if an allergic reaction is detected, you should consult a therapist or dermatologist as soon as possible.

Adaklin cream external 0.1% 30 g x1

Dosage form ADACLIN cream for external use. approx. 1 mg/g: tube 30 g reg. No.: LP-001247 dated November 21, 2011 - Active Release form, composition and packaging Cream for external use 1 g adapalene 1 mg

30 g - aluminum tubes (1) - cardboard packs.

Clinical and pharmacological group: Drug for the treatment of acne. Retinoid Pharmacotherapeutic group: Acne rash treatment Pharmacological action Means for external use. Adapalene is a retinoid metabolite, has comedolytic and anti-inflammatory effects, normalizes the processes of keratinization and epidermal differentiation.

The mechanism of action of adapalene is based on interaction with specific γ-receptors of epidermal skin cells. As a result of the action of adapalene, in particular, there is a decrease in the “adhesion” of epithelial cells at the mouth of the pilosebaceous follicle and a decrease in the prerequisites for the formation of microcomedones.

Adapalene has an anti-inflammatory effect in vitro and in vivo, affecting inflammatory factors by inhibiting the migration of leukocytes at the site of inflammation and the metabolism of arachidonic acid.

Pharmacokinetics Absorption of adapalene through the skin is very low (about 4% of the administered dose). Adapalene is excreted from the body mainly through bile.

Indications: Acne. ICD-10 codes ICD-10 code Indication L70 Acne

Dosage regimen Apply externally. Apply evenly to the affected surface 1 time/day before bedtime, avoiding contact with the mucous membranes of the eyes and lips.

The therapeutic effect develops after 4-8 weeks of treatment, persistent improvement occurs after 3 months of treatment.

Side effects Dermatological reactions: skin irritation (treatment should be suspended until the skin irritation disappears or the frequency of use should be reduced). Contraindications for use: Pregnancy, lactation (breastfeeding), hypersensitivity to adapalene.

Use during pregnancy and breastfeeding It is not recommended to use the drug during pregnancy and lactation (breastfeeding). Special instructions Use with caution for dermatitis and eczema.

Direct sunlight should be avoided as skin irritation may occur. Treatment can be continued if exposure to sunlight is kept to a minimum.

The simultaneous use of cosmetics with a drying and irritating effect on the skin (for example, perfumes or ethanol-containing products) is not recommended.

Adapalene applied to the skin in the evening can be combined with acne medications used in the morning.

Drug interactions Since adapalene does not interact with oxygen and is not destroyed by light, simultaneous treatment of acne with drugs such as clindamycin phosphate or benzoyl peroxide is possible.

Side effects

“Adaklin” for wrinkles (reviews of the drug confirm that an allergic reaction occurs extremely rarely) can cause redness of the skin at the site of application of the cream.

In more severe cases, other symptoms may appear:

• itching;
• peeling;
• keratinization of cells;
• swelling of local tissues;
• swelling of the eyelids;
• increased pigmentation;
• the appearance of conjunctivitis;
• the appearance of erythema;
• exacerbation of contact dermatitis.

Despite the fact that adapalene is absorbed into the skin by only 4%, it can accumulate in the liver tissue, causing a toxic reaction. It has also been proven that the drug penetrates the placenta and has a negative effect on the development of the fetus.

If a nursing woman uses the cream, its active substance can be passed on to the baby through breast milk, which leads to toxic shock in the newborn because his immature liver is unable to cope with the dangerous substance.

If Adaklin is used only externally, an overdose of the drug is impossible.

Advantages and disadvantages

“Adaklin” for wrinkles (reviews about the drug are in most cases positive) has the following advantages:

• affordable price;
• can be bought at any pharmacy;
• helps eliminate rashes before the onset of menstruation;
• tightens and smoothes the skin;
• eliminates acne, comedones, pimples;
• accelerates the healing of damaged skin areas;
• normalizes sebum production;
• reduces the depth of wrinkles;
• carefully removes dead cells;
• prevents pore clogging.

It has also been proven that the cream slows down the following age-related skin changes:

• weakening of the clear contour of the face;
• change in skin color;
• the appearance of age spots;
• weakening of the tone of the facial muscles;
• drooping corners of the lips;
• the appearance and deepening of wrinkles at the outer edge of the eyes, called “crow’s feet” and nasolabial folds.

The product has disadvantages in use:

• dries the skin;
• before use it is necessary to carry out an allergy test;
• Caution is required when applied to dry skin as the cream may aggravate the problem.

“Adaklin” for wrinkles quickly leads to renewal of the epithelial layer of the skin, frees pores from dirt, preventing inflammatory processes. Reviews of the drug indicate that its use slows down age-related changes in the skin of the face and reduces the depth of facial folds. The product encourages cells to produce their own elastin and collagen, prolonging the youth of the skin.