Clotrimazole-Akrikhin ointment for external use 1% 20g

• February 2, 2021
• Dermatology
• Evgenia Yushkova

Chemical-pharmaceutical industry dates back to the 30s of the last century. Then the chemical plant literally saved the country from a malaria epidemic. The company organized the mass production of quinine (mepacrine), a synthetic substitute for quinine capable of destroying the cells of the malarial plasmodium. This drug gave the name to the production complex.

Akrikhin today is rightfully considered one of the leading enterprises in the industry among Russian drug manufacturers. It ranks 4th in terms of sales volumes in Russia. Produces effective and affordable medicines. Among the most popular are Akrikhin ointments and creams.

Directions for use and doses

Tablets: orally; adults and children over 2 years old for the treatment of herpetic diseases - 0.2 g 5 times a day for 5 days; for immunodeficiency - a single dose is increased to 0.4 g. For the prevention of herpetic infections in patients with immunodeficiency - 0.2 g 4 times a day. Infections caused by the herpes zoster virus: 0.8 g 5 times a day for 7 days. Patients with impaired renal function need to adjust the dosage regimen: if creatinine Cl is less than 10 ml/min, the daily dose is reduced to 0.4 g in 2 divided doses with an interval between doses of at least 12 hours. In the treatment of infections caused by Varicella zoster and maintenance therapy of patients with a pronounced decrease in immunity and creatinine Cl 10–25 ml/min - 2.4 g/day in 3 divided doses with an interval of 8 hours. In patients with creatinine Cl less than 10 ml/min, the daily dose is reduced to 1.6 g in 2 divided doses with at intervals of 12 hours.

Children under 2 years old - half the adult dose.

Ointment: apply a thin layer to the affected area immediately after the first signs of the disease appear 5 times a day (every 4 hours) for 5–10 days.

Acyclovir-Akrikhin ointment for external use 5% 5g

Compound

Active substance: acyclovir - 5 g; Excipients: propylene glycol, petroleum jelly, petroleum jelly, emulsion wax, macrogol (polyethylene oxide 1500), purified water.

Pharmacokinetics

When used on intact skin: absorption is minimal;
not detected in blood and urine. On affected skin: absorption is moderate; in patients with normal renal function, the concentration in the blood serum is up to 0.28 mcg/ml, in patients with chronic renal failure (CRF) - up to 0.78 mcg/ml. Excreted by the kidneys (up to 9.4% of the daily dose).

Indications for use

• skin infections caused by Herpes simplex virus types 1 and 2;
• genital herpes;
• shingles;
• chicken pox.

Contraindications

Hypersensitivity to acyclovir and other components of the drug.
With caution - pregnancy, lactation, dehydration, renal failure.

Directions for use and doses

Externally. Apply the drug with clean hands or a cotton swab 5 times a day (every 4 hours) in a thin layer to the affected and adjacent areas of the skin. Therapy should be continued until a crust forms on the blisters or until they are completely healed. The duration of therapy is on average 5 days, maximum 10 days. If there is no effect, you should consult a doctor.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25°C. Keep out of the reach of children.

Best before date

3 years. Do not use the drug after the expiration date.

special instructions

To achieve the maximum therapeutic effect, it is necessary to use the drug as early as possible (at the first signs of the disease: burning, itching, tingling, feeling of tension and redness).
The ointment is not recommended to be applied to the mucous membranes of the mouth and eyes, as severe local inflammation may develop. When treating genital herpes, you should avoid sexual intercourse or use condoms, since the use of acyclovir does not prevent transmission of the virus to partners.

Description

Antiviral drug for external use.

Dosage form

Ointment for external use 5% white or almost white; The presence of a characteristic odor is allowed.

Action

The antiviral drug is a synthetic analogue of thymidine nucleoside. In infected cells containing viral thymidine kinase, phosphorylation occurs and is converted to acyclovir monophosphate. Under the influence of acyclovir guanylate cyclase, monophosphate is converted into diphosphate and, under the action of several cellular enzymes, into triphosphate. High selectivity of action and low toxicity to humans are due to the absence of the necessary enzyme for the formation of acyclovir triphosphate in intact cells of the macroorganism.

Acyclovir triphosphate, being integrated into the DNA synthesized by the virus, blocks the reproduction of the virus. The specificity and very high selectivity of action are also due to its predominant accumulation in cells affected by the herpes virus. Highly active against Herpes simplex virus types 1 and 2; the virus that causes chickenpox and herpes zoster (Varicella zoster); Epstein-Barr virus. Moderately active against cytomegaloviruses.

Side effects

From the skin and subcutaneous tissues: hyperemia, dryness, peeling of the skin.

Other: burning, inflammation upon contact with mucous membranes. Allergic dermatitis may develop.

Use during pregnancy and breastfeeding

The use of the drug is indicated only in cases where the expected benefit to the mother outweighs the potential risk to the fetus.

During the treatment period, it is necessary to decide whether to stop breastfeeding.

Interaction

When used externally, no interactions with other drugs were detected.

An enhanced effect is observed with the simultaneous administration of immunostimulants.

Overdose

Data on drug overdose are not provided.

Impact on the ability to drive vehicles and operate machinery

No data.

Adverse reactions

Side effects after using ointments vary from person to person.

Akrikhin Acyclovir ointment can cause a negative response from the body in the form of:

• sensations of dryness, burning;
• the appearance of irritation, inflammation;
• signs of allergic dermatitis.

"Akrikhin Clotrimazole" can lead to the appearance of:

• skin rash;
• itching;
• redness;
• peeling of the skin.

Symptoms such as:

• burning, redness, pigmentation at the site of use;
• local excess hair growth;
• thinning of tissues;
• hormonal imbalances.

The side effects of Sinaflan Akrikhin are due to its use on large areas of the skin and the risk of penetration of the composition into the deep layers of tissue. It could be:

• local reaction in the form of skin rashes, peeling and itching;
• hair loss in certain areas;
• Excessive male pattern hair growth;
• insufficiency of adrenal glands;
• the appearance of steroid ulcers;
• exacerbation of chronic pathologies of infectious nature.

When using Diclofenac Akrikhin, negative symptoms may appear in the form of:

• increased photosensitivity;
• signs of contact dermatitis;
• hives, swelling, peeling.

A negative response from the body to the use of Heparin Akrikhin is rare. However, some patients note the appearance after application:

• redness;
• peeling;
• slight swelling.

If any undesirable signs appear, discomfort after using the drugs, or a change in the usual state, it is recommended to stop using the ointment and consult with your doctor.

Terms of sale and storage

Local drugs from Akrikhin are freely available on pharmacy shelves. You do not need a doctor's prescription to purchase them. However, you should not self-medicate. Even knowing exactly what Akrikhin ointment can help with, you can harm your health by using it without a doctor’s prescription.

It is better to store ointments and creams in dry places, protected from direct sunlight, away from children and pets. Strictly observe the expiration date indicated on the packaging. Do not use after expiration.

Form and composition

Variations of liniments differ in their composition. Common to all ointments is branding. Each box contains a tube of medicine and instructions for using Akrikhin ointment. The only difference in external design is the medicinal form of the Akriderm cream.

"Acyclovir" is a white medicinal mass, homogeneous in composition, having an unobtrusive specific odor. Each tube contains 5 grams of 5% ointment. 100 grams of the product contains 5 grams of the main ingredient - acyclovir - and a number of additional ones (propylene glycol, petroleum jelly and petroleum jelly, emulsion wax, macrogol and water).

Clotrimazole ointment is a soft white mass with a characteristic aroma. The main component - clotrimazole - has a concentration of 1% and a set of auxiliary components (propylene glycol, nipagin, succinic acid, sodium benzoate, emulsion wax, castor oil, methylcellulose, monoglycerides and water).

Akriderm cream has a yellowish tint and a homogeneous composition. The main component of the drug is betamethasone dipropionate. Propyl parahydroxybenzoate, petroleum jelly and petroleum jelly, isopropyl myristate are used as additional ones.

Sinaflan is based on fluocinolone acetonide (0.025 g/100 g of medication). The composition is supplemented with petroleum jelly, lanolin, liquid paraffin and propylene glycol. The soft medicinal mass is packaged in tubes of 10 grams each.

The main active ingredient in the structure of Diclofenac is diclofenac sodium. Dimethyl sulfoxide, macrogol, propylene glycol and succinic acid are used as auxiliary agents. In appearance, it is a white ointment with a slight grayish-yellow tint and pearlescent inclusions. The concentration of the active component is 1%.

Heparin is characterized by a soft, transparent gel. It contains 100,000 units of sodium heparin in terms of dry matter. A slightly yellowish tint and a specific smell are allowed. The composition is easy to apply, it is quickly absorbed and does not leave stains. The main component is supplemented with minor ones, among which methyl parahydroxybenzoate, carbamer, trometamol, ethanol, lavender and neroli oils, and water are found.

Medicinal properties

All medicinal forms have an anti-inflammatory effect. They are used in the treatment of non-infectious pathologies. But in each specific case, you need to know what Akrikhin ointment of one type or another helps with and which one is needed at the moment.

"Akrikhin Acyclovir" is included in the group of antiviral drugs and belongs to the category of synthetic analogues of thymidine nucleoside. The soft composition is able to penetrate inside a cell affected by the herpes virus and stop its reproduction. The ointment acts selectively: it is activated only on infected skin, without affecting healthy tissue and without penetrating into the systemic bloodstream.

"Akrikhin Clotrimazole" has antifungal properties. It is successfully used in the treatment of mycotic lesions of the skin and mucous membranes. The active component of the drug blocks the synthesis of the enzyme ergosterol in the cellular space and stops the growth and development of the fungus. Penetrates into the deep layers of the epidermis, concentrates in the skin without having a systemic effect.

Many people know the problem of dermatitis of various etiologies: the skin becomes rough, peeling, itching, and redness appear. A remedy is required that can eliminate unpleasant symptoms, which is why Akrikhin Akriderm ointment is needed. The therapeutic composition containing active glucocorticosteroids copes with all inflammatory processes of non-infectious origin. Penetrating deep into the skin, the active component inhibits the release of inflammatory mediators, leukocytes, enzymes, and protects cell membranes.

Sinaflan Akrikhin ointment has similar properties. Her arsenal includes anti-inflammatory, decongestant and anti-allergic tools. The components of the ointment can slow down the immune response and reduce the production of inflammatory mediators.

"Diclofenac Akrikhin" belongs to the group of non-hormonal anti-inflammatory drugs. This is a non-steroidal drug with obvious analgesic properties. Penetrating into the tissue, the components accumulate in the synovial fluid, anesthetize and eliminate swelling.

Heparin Akrikhin ointment has an anticoagulant effect. It is indispensable in the treatment of vascular pathologies, soft tissue injuries and osteoarticular apparatus. The active component of the gel helps relieve swelling and eliminate pain. It is able to reduce the rate of platelet aggregation and improve the blood thinning process.

All topical preparations of the Akrikhin brand are in demand by consumers due to their effective action and availability.

Similar drugs:

• Ergoferon () Lozenges
• Groprinosin Oral tablets
• Groprinosin Oral tablets
• Tea tree DN Ointment for external use
• Valtrex Oral tablets
• Zanamivir Powder for inhalation, dosed
• Valacyclovir Oral tablets
• Oseltamivir Capsule
• Anaferon for children (Anaferon filios) Lozenges
• Laripront Lozenges

** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Acyclovir-Acri, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.

Are you interested in the drug Acyclovir-Acri? Do you want to know more detailed information or do you need a doctor's examination? Or do you need an inspection? You can make an appointment with a doctor - the Euro lab is always at your service! The best doctors will examine you, advise you, provide the necessary assistance and make a diagnosis. You can also call a doctor at home . Euro lab clinic is open for you around the clock.

** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Acyclovir-Acri is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!

If you are interested in any other drugs and medications, their descriptions and instructions for use, information about the composition and form of release, indications for use and side effects, methods of use, prices and reviews of drugs, or you have any other questions and suggestions - write to us, we will definitely try to help you.

Varieties of "Akrikhin" in the form of ointment

Pharmacy chains offer consumers several types of Akrikhin brand ointment:

• "Acyclovir".
• "Clotrimazole".
• Akriderm.
• "Sinaflan".
• "Diclofenac".
• "Heparin."

Each variation has its own therapeutic focus and an individual list of indications. Before use, you should consult with a specialist who will explain why Akrikhin ointment is used and which one should be used in each specific case.

Indications for use

Despite the high effectiveness of the drugs and over-the-counter sale in pharmacies, it is worth visiting a doctor before use. He will conduct the necessary research and tell you exactly which Akrikhin ointment is worth buying and for what purpose.

Among the indications for prescribing Acyclovir it is worth highlighting:

• herpes of all types;
• chicken pox;
• cytomegalovirus.

"Clotrimazole Akrikhin" is effective in the following cases:

• mycoses of the foot and nails caused by dermatophytes and fungi of the Candida species;
• complex treatment of fungal infections against the background of a bacterial infection;
• pityriasis versicolor and versicolor versicolor;
• infectious erythrasma.

Good results are observed with this ointment “Akrikhin” for thrush. It is used as part of complex therapy.

For the use of "Akriderm Akrikhin" the following are indicated:

• acute and chronic forms of dermatitis (seborrheic, atopic, contact);
• neurodermatitis;
• eczema;
• psoriasis.

"Sinaflan Akrikhin" is used to eliminate the following problems:

• signs of atopic dermatitis;
• limited neurodermatitis;
• eczema;
• skin itching;
• psoriasis;
• dry dermatitis.

For Diclofenac Akrikhin the following indications can be considered:

• bruises and sprains of soft tissues and joints of the limbs;
• rheumatic processes affecting large and small joints;
• inflammation of the muscular and nervous systems;
• pathological changes in bone tissue, accompanied by swelling and severe pain.

"Heparin Akrikhin" is recommended for use for:

• thrombophlebitis of the veins in the legs of the superficial type;
• damage to soft tissues with hematomas and swelling;
• joint injuries.