Amoxiclav powder for solution for injection 1g+200mg fl 5 pcs

Composition of Amoxiclav

• Amoxiclav 250 mg/125 mg tablets contain the active ingredients amoxicillin (trihydrate form) and clavulanic acid (potassium salt form). The tablets also contain auxiliary components: MCC sodium croscarmellose.
• Amoxiclav 2X 625 mg and 1000 mg tablets contain the active ingredients amoxicillin and clavulanic acid, as well as additional components: anhydrous colloidal silicon dioxide, flavorings, aspartame , yellow iron oxide, talc, hydrogenated castor oil, silicated MCC.
• Amoxiclav Quiktab 500 mg and 875 mg tablets contain the active ingredients amoxicillin and clavulanic acid, as well as additional components: anhydrous colloidal silicon dioxide, flavorings, aspartame, yellow iron oxide, talc, hydrogenated castor oil, silicated MCC.
• The powder from which the Amoxiclav suspension is prepared also contains amoxicillin and clavulanic acid, and also contains sodium citrate, MCC, sodium benzoate, mannitol, and sodium saccharin as inactive components.
• The powder for preparing Amoxiclav IV infusion contains amoxicillin and clavulanic acid.

Amoxiclav: composition

Amoxiclav is a successful combination of clavulanic acid and amoxicillin. Each formulation of the drug may use various additional components, including:

• aspartame;
• hydrogenated oil;
• flavorings;
• talc;
• silica;
• iron oxide.

Amoxiclav can be taken orally or used intravenously. Most often, tablets are prescribed for treatment of various bacterial infections, since the vast majority of diseases are transmitted by patients at home.

The dosage of tablets can be different: from 250 mg to 875 mg amoxicillin + 125 mg clavulanic acid in each dose of antibiotic.

Release form

The drug is produced in the form of tablets:

• Amoxiclav 250 mg/125 mg – film-coated tablets, package contains 15 pieces.
• Amoxiclav 2X (500 mg/125 mg; 875 mg/125 mg) - coated tablets; the package may contain 10 or 14 pieces.
• Amoxiclav Quiktab (500 mg/125 mg; 875 mg/125 mg) is available in the form of dispersed tablets, 10 such tablets per package.

The product is also produced in the form of a powder from which a suspension is made; the bottle contains powder for preparing 100 ml of the product.

A powder is also produced, from which a solution is made, which is administered intravenously. The bottle contains 600 mg of the product (amoxicillin 500 mg, clavulanic acid 100 mg), 1.2 g bottles are also available (amoxicillin 1000 mg, clavulanic acid 200 mg), the package contains 5 bottles.

pharmachologic effect

The abstract provides information that the antibiotic Amoxiclav (INN Amoksiklav) is a broad-spectrum agent. Group of antibiotics: broad-spectrum penicillins. The medicine contains amoxicillin (semi-synthetic penicillin) and clavulanic acid (β-lactamase inhibitor). The presence of clavulanic acid in the composition of the drug ensures the resistance of amoxicillin to the action of β-lactamases produced by microorganisms.

The structure of clavulanic acid is similar to beta-lactam antibiotics, this substance also has an antibacterial effect. Amoxiclav is active against strains that demonstrate sensitivity to Amoxicillin. These are a number of gram-positive bacteria, aerobic gram-negative bacteria, gram-positive and gram-negative anaerobes.

Description of the antibiotic Amoxiclav

The substance belongs to the group of penicillins. A wide spectrum of action makes it possible to achieve positive dynamics in the treatment of many diseases of bacterial etiology. When it enters the body, Amoxiclav destroys the cell wall of the bacterium, and it dies. Efficacy was noted against a wide group of enterobacteria, Haemophilus influenzae, staphylococcus, streptococcus, enterococcus, listeria, clostridia, and salmonella. In addition, this medicine can treat infections caused by most resistant strains of bacteria.

Clavulonic acid, in turn, protects amoxicillin from the influence of beta-lactamases of microorganisms.

After absorption from the gastrointestinal tract, the active components are quickly distributed into the bloodstream. Food does not interfere with absorption. However, in order to reduce the risk of possible negative reactions from the digestive system, it is still not recommended to take the medicine on an empty stomach.

Pharmacokinetics and pharmacodynamics

As the Vidal drug reference book informs, after oral administration, both substances are actively absorbed from the gastrointestinal tract; the absorption of the components is not affected by food intake, so it does not matter how you take it - before or after meals. The highest concentration in the blood is observed one hour after the drug was taken. Both active ingredients of the drug are distributed in fluids and tissues. Amoxicillin also enters the liver, synovial fluid, prostate, tonsils, gall bladder, muscle tissue, saliva, and bronchial secretions.

If the membranes of the brain are not inflamed, both active substances do not penetrate through the BBB. At the same time, the active components penetrate the placental barrier and traces of them are detected in breast milk. They bind to blood proteins to a small extent.

In the body, amoxicillin undergoes partial metabolism , clavulanic acid is intensively metabolized. It is excreted from the body through the kidneys; small particles of active substances are excreted by the intestines and lungs. The half-life of amoxicillin and clavulanic acid is 1-1.5 hours.

Amoxiclav powder for solution for injection 1g+200mg fl 5 pcs

Pharmacological group:

Antibiotic - semi-synthetic penicillin + beta-lactamase inhibitor.
Pharmacodynamics:
Mechanism of action

Amoxicillin is a semisynthetic broad-spectrum antibiotic that is active against many gram-positive and gram-negative microorganisms. Amoxicillin inhibits one or more enzymes (often called penicillin binding proteins, PBPs) in the biosynthetic pathway of bacterial peptidoglycan, which is an integral structural component of the bacterial cell wall. Inhibition of peptidoglycan synthesis leads to weakening of the cell wall, which is usually followed by cell lysis and death. At the same time, amoxicillin is susceptible to destruction by beta-lactamases, and therefore the spectrum of activity of amoxicillin does not extend to microorganisms that produce this enzyme.

Clavulanic acid is a beta-lactamase inhibitor, structurally related to penicillins, and has the ability to inactivate a wide range of beta-lactamases found in microorganisms resistant to penicillins and cephalosporins. Clavulanic acid is sufficiently effective against plasmid beta-lactamases, which most often cause bacterial resistance, and is not effective against type I chromosomal beta-lactamases, which are not inhibited by clavulanic acid.

The presence of clavulanic acid in the drug protects amoxicillin from destruction by enzymes - beta-lactamases, which expands the antibacterial spectrum of amoxicillin.

Below is the activity of the combination of amoxicillin and clavulanic acid in vitro.

Bacteria usually susceptible to the combination of amoxicillin and clavulanic acid

Gram-positive aerobes: Bacillus anthracis, Enterococcus faecalis, Listeria monocytogenes, Nocardia asteroides, Streptococcus pyogenes1,2, Streptococcus agalactiae1,2, other beta-hemolytic steptococci1,2, Staphylococcus aureus (methicillin-sensitive)1, Staphylococcus saprophyticus (methicillin-sensitive), coagulase-negative staphylococci (sensitive to methicillin).

Gram-negative aerobes: Bordetella pertussis, Haemophilus influenzae1, Helicobacter pylori, Moraxella catarrhalis1, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholerae.

Other: Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum.

Gram-positive anaerobes: species of the genus Clostridium, Peptococcus niger, Peptostreptococcus magnus, Peptostreptococcus micros, species of the genus Peptostreptococcus.

Gram-negative anaerobes: Bacteroides fragilis, species of the genus Bacteroides, species of the genus Capnocytophaga, Eikenella corrodens, Fusobacterium nucleatum, species of the genus Fusobacterium, species of the genus Porphyromonas, species of the genus Prevotella.

Bacteria for which acquired resistance to the combination of amoxicillin and clavulanic acid is likely

Gram-negative aerobes: Escherichia сoli1, Klebsiella oxytoca, Klebsiella pneumoniae, species of the genus Klebsiella, Proteus mirabilis, Proteus vulgaris, species of the genus Proteus, species of the genus Salmonella, species of the genus Shigella.

Gram-positive aerobes: species of the genus Corynebacterium, Enterococcus faecium, Streptococcus pneumoniae1,2, streptococci of the Viridans group.

Bacteria that are naturally resistant to the combination of amoxicillin and clavulanic acid

Gram-negative aerobes: species of the genus Acinetobacter, Citrobacter freundii, species of the genus Enterobacter, Hafnia alvei, Legionella pneumophila, Morganella morganii, species of the genus Providencia, species of the genus Pseudomonas, species of the genus Serratia, Stenotrophomonas maltophilia, Yersinia enterocolitica.

Other: Chlamydia pneumoniae, Chlamydia psittaci, species of the genus Chlamydia, Coxiella burnetii, species of the genus Mycoplasma. 1-for these bacteria, the clinical effectiveness of the combination of amoxicillin with clavulanic acid has been demonstrated in clinical studies. 2-strains of these types of bacteria do not produce beta-lactamases. Sensitivity during amoxicillin monotherapy suggests similar sensitivity to the combination of amoxicillin and clavulanic acid.

Pharmacokinetics:

Suction

Below are the results of a pharmacokinetic study of intravenous bolus administration of amoxicillin and clavulanic acid to healthy volunteers at a dosage of 500 mg + 100 mg (0.6 g) or 1000 mg + 200 mg (1.2 g) over 30 minutes. average value of pharmacokinetic parameters

Mean (±SD) pharmacokinetic parameters

Active ingredients Single dose (mg) Cmax (µg/ml) T1/2 (h) AUC (h*mg/l) Urinary excretion, % 0-6 h

Amoxicillin 500 32.2 1.07 25.5 66.5 1000 105.4 0.9 76.3 77.4 Clavulanic acid 100 10.5 1.12 9.2 46.0 200 28.5 0.9 27 .9 63.8 Cmax - maximum concentration in blood plasma; AUC - area under the concentration-time curve; T1/2 - half-life.

Distribution

With intravenous administration of a combination of amoxicillin and clavulanic acid, therapeutic concentrations of amoxicillin and clavulanic acid are found in various tissues and interstitial fluid (in the gallbladder, abdominal tissue, skin, adipose and muscle tissue, synovial and peritoneal fluids, bile, purulent discharge).

Amoxicillin and clavulanic acid have a weak degree of binding to plasma proteins. Studies have shown that about 13-20% of each component of Amoxiclav® is bound to blood plasma proteins.

In animal studies, no accumulation of the components of the drug Amoxiclav® was found in any organ.

Amoxicillin, like most penicillins, passes into breast milk. Trace amounts of clavulanic acid may also be found in breast milk. With the exception of the possibility of diarrhea or oral candidiasis, there are no other known negative effects of amoxicillin and clavulanic acid on the health of breastfed infants. Animal reproductive studies have shown that amoxicillin and clavulanic acid cross the placental barrier. However, no negative effects on the fetus were detected.

Metabolism 10-25% of the initial dose of amoxicillin is excreted by the kidneys in the form of an inactive metabolite (penicillic acid). Clavulanic acid is extensively metabolized to 2,5-dihydro-4-(2-hydroxyethyl)-5-oxo-1H-pyrrole-3-carboxylic acid and 1-amino-4-hydroxybutan-2-one and is excreted by the kidneys. through the gastrointestinal tract (GIT), as well as with exhaled air in the form of carbon dioxide.

Removal

Like other penicillins, amoxicillin is eliminated primarily by the kidneys, while clavulanic acid is eliminated through both renal and extrarenal mechanisms. Approximately 60-70% of amoxicillin and 40-65% of clavulanic acid are excreted unchanged by the kidneys in the first 6 hours after a single bolus injection of Amoxiclav® at a dosage of 500 mg + 100 mg or 1000 mg + 200 mg.

Co-administration of probenecid slows the excretion of amoxicillin but does not slow the renal excretion of clavulanic acid.

The pharmacokinetics of amoxicillin/clavulanic acid does not depend on the gender of the patient.

Patients with impaired renal function

The total clearance of amoxicillin/clavulanic acid decreases in proportion to the decrease in renal function. The decrease in clearance is more pronounced for amoxicillin than for clavulanic acid, because Most amoxicillin is excreted by the kidneys. Doses of the drug for renal failure should be selected taking into account the undesirability of amoxicillin accumulation while maintaining normal levels of clavulanic acid.

Patients with liver dysfunction

In patients with impaired liver function, the drug is used with caution; continuous monitoring of liver function is necessary.

Both components are removed by hemodialysis and minor amounts by peritoneal dialysis.

Indications for use of Amoxiclav

Amoxiclav is prescribed for infectious and inflammatory diseases that develop due to the influence of microorganisms sensitive to this medicine. The following indications for the use of this drug are determined:

• infections of the ENT organs, as well as infectious diseases of the upper respiratory tract ( otitis media , retropharyngeal abscess, sinusitis , pharyngitis , tonsillitis );
• urinary tract infections ( cystitis , prostatitis , etc.);
• infectious diseases of the lower respiratory tract (pneumonia, acute and chronic bronchitis
• gynecological diseases of an infectious nature;
• connective and bone tissue infections;
• infectious diseases of soft tissues, skin (including consequences of bites);
• biliary tract infections (cholangitis, cholecystitis );
• odontogenic infections.

What else Amoxiclav helps with, you should ask a specialist during an individual consultation.

Indications for use of Amoxiclav

The use of the drug is so widespread that some doctors starting their therapeutic practice prescribe it at every opportunity. In the situation with diseases of the otolaryngology organs, this is:

• otitis, including purulent;
• tonsillitis;
• sinusitis;
• pharyngolaryngitis.

When the urinary system is affected, Amoxiclav can also be prescribed. These diseases include chronic cystitis, prostatitis, and urethritis.

Diseases of the respiratory system are rarely treated without amoxicillin. For bronchitis of bacterial etiology and pneumonia, this particular drug is used. In addition, the antibiotic has shown its effectiveness against:

• infections affecting bones and connective tissue;
• soft tissue diseases caused by bacterial infection;
• cholecystitis;
• diseases of the pelvic organs.

Some types of surgery require the patient to take a course of antibiotics to prevent superinfection.

Contraindications

When determining why tablets and other forms of the drug help, you should also take into account existing contraindications:

• Infectious mononucleosis;
• previous liver disease or cholestatic jaundice when taking clavulanic acid or Amoxicillin;
• lymphocytic leukemia;
• high sensitivity to antibiotic drugs from the group of cephalosporins, penicillins, as well as other beta-lactam antibiotics;
• high sensitivity to the active components of the drug.

It is prescribed with caution to people suffering from liver failure and people with severe kidney disease.

Side effects

When taking this antibiotic, patients may experience the following side effects:

• Digestive system: loss of appetite, vomiting, nausea, diarrhea ; in rare cases, abdominal pain and liver dysfunction may occur; isolated manifestations - hepatitis, jaundice, pseudomembranous colitis.
• Hematopoietic system: in rare cases - reversible leukopenia , thrombocytopenia ; in very rare cases - eosinophilia , pancytopenia .
• Allergic manifestations: itching , erythematous rash, urticaria ; in rare cases - anaphylactic shock , exudative erythema, edema , allergic vasculitis; isolated manifestations - Stevens-Johnson syndrome, pustulosis, exfoliative dermatitis.
• Functions of the nervous system: dizziness , headache ; in rare cases - convulsions, anxiety, hyperactivity, insomnia .
• Urinary system: crystalluria , interstitial nephritis .
• In rare cases, superinfection may occur.

It is noted that such treatment, as a rule, does not provoke significant side effects.

Instructions for use of Amoxiclav (Method and dosage of Amoxiclav for adults)

Medicine in tablets is not prescribed to children under 12 years of age. When prescribing the drug, it should be taken into account that the permissible dose per day of clavulanic acid is 600 mg (adults) and 10 mg per 1 kg of weight (child). The permissible daily dose of amoxicillin is 6 g for an adult and 45 mg per 1 kg of weight for a child.

The agent for parenteral administration is prepared by dissolving the contents of the vial in water for injection. To dissolve 600 mg of the product, you need 10 mol of water, to dissolve 1.2 g of the product - 20 ml of water. The solution should be administered slowly over 3-4 minutes. The intravenous infusion should continue for 30-40 minutes. The solution must not be frozen.

Before anesthesia, to prevent purulent complications, 1.2 g of drugs should be administered intravenously. If there is a risk of complications, the drug is administered intravenously or taken orally in the period after surgery. The duration of the appointment is determined by the doctor.

Amoxiclav tablets, instructions for use

As a rule, adults and children (who weigh more than 40 kg) receive 1 tablet every eight hours. (375 mg), provided the infection is mild or moderate. Another acceptable treatment regimen in this case is to take 1 tablet every 12 hours. (500 mg+125 mg). For severe infectious diseases, as well as for infectious diseases of the respiratory tract, taking 1 tablet every eight hours is recommended. (500 mg+125 mg) or taken every 12 hours 1 tablet. (875 mg+125 mg). Depending on the disease, you need to take an antibiotic from five to fourteen days, but the doctor must individually prescribe a treatment regimen.

Patients with odontogenic infections should take 1 tablet every 8 hours. (250 mg + 125 mg) or once 12 hours, 1 tablet. (500 mg + 125 mg) for five days.

People suffering from moderate renal failure are advised to take 1 tablet. (500 mg + 125 mg) every twelve hours. Severe renal failure is a reason to increase the interval between doses to 24 hours.

Amoxiclav suspension, instructions for use

The patient's childhood involves calculating the dose taking into account the child's weight. Before preparing the syrup, shake the bottle well. In two doses you need to add 86 ml of water to the bottle, each time you need to shake its contents well. Please note that the measuring spoon contains 5 ml of product. Prescribed in a dose depending on the age and weight of the child.

Instructions for use Amoxiclav for children

Children from birth to three months are prescribed the drug at the rate of 30 mg per 1 kg of weight (dose per day), this dose should be divided equally and administered at equal intervals. From the age of three months, Amoxiclav is prescribed at a dose of 25 mg per 1 kg of weight, which is similarly divided equally into two administrations. For infectious diseases of moderate severity, the dose is prescribed at the rate of 20 mg per 1 kg of weight, divided into three administrations. For severe infectious diseases, the dose is prescribed at the rate of 45 mg per 1 kg of weight, divided into two doses per day.

Instructions for use Amoxiclav Quiktab

Before taking, the tablet must be dissolved in 100 ml of water (the amount of water may be more). Before taking, you need to stir the contents well. You can also chew the tablet; it is better to take the drug before meals. Adults and children after reaching 12 years of age should take 1 tablet per day. 625 mg 2-3 times a day. For severe infectious diseases, 1 tablet is prescribed. 1000 mg 2 times a day. Treatment should not last more than 2 weeks.

Sometimes a doctor may prescribe analogues of the drug, for example, Flemoclav Solutab , etc.

Amoxiclav for sore throat

The drug Amoxiclav for angina for an adult is prescribed 1 tablet. 325 mg once every 8 hours. Another treatment regimen involves taking 1 tablet once every 12 hours. A doctor may prescribe a higher dose of an antibiotic if the disease in an adult is severe. Treatment of sore throat in children involves the use of a suspension. As a rule, 1 spoon is prescribed (a dosage spoon is 5 ml). The frequency of administration is determined by the doctor, whose recommendations are important to follow. How to take Amoxiclav for children with sore throat depends on the severity of the disease.

Dosage of Amoxiclav for sinusitis

Whether Amoxiclav helps with sinusitis depends on the causes and characteristics of the course of the disease. The dosage is determined by the otolaryngologist. It is recommended to take 500 mg tablets three times a day. How many days to take the medicine depends on the severity of the disease. But after the symptoms disappear, you need to take the drug for two more days.

Amoksiklav®

Inside.

Daily dosages of suspensions are 125 mg+31.25 mg/5 ml and 250 mg+62.5 mg/5 ml

(to facilitate correct dosing, each package of suspensions 125 mg + 31.25 mg/5 ml and 250 mg + 62.5 mg/5 ml includes a dosing spoon with a capacity of 5 ml or a graduated dosage pipette).

Newborns and children up to 3 months

prescribed 30 mg/kg (amoxicillin)/day, divided into 2 doses (every 12 hours);
children over 3 months
- from 20 mg (for amoxicillin)/kg/day for
mild and moderate
infections to 40 mg/kg (for amoxicillin)/day for
severe infections and respiratory tract infections
, divided into 3 doses (every 8 h).

Recommended doses of suspensions depending on the child’s body weight and the severity of the infection.

Daily doses of suspension 400 mg + 57 mg/5 ml

are calculated per 1 kg of body weight depending on the severity of the infection and amount to 25-45 mg/kg body weight/day (in terms of amoxicillin), divided into 2 doses.

To facilitate correct dosing, a dosage pipette is inserted into each package of the 400 mg + 57 mg/5 ml suspension, graduated simultaneously into 1, 2, 3, 4, 5 ml and into 4 equal parts.

Recommended doses of the suspension depending on the child’s body weight and the severity of the infection.

Exact daily doses are calculated based on the child's body weight, not his age.

The maximum daily dose of amoxicillin is for adults

6 g, for
children
- 45 mg/kg body weight.

The maximum daily dose of clavulanic acid (in the form of potassium salt) is for adults

600 mg, for
children
- 10 mg/kg body weight.

In patients with severe renal failure (creatinine clearance less than 10 ml/min)

the dose should be adequately reduced or the interval between two doses should be increased (for anuria up to 48 hours or more).

The course of treatment is 5-14 days. The duration of treatment is determined by the attending physician. Treatment should not continue for more than 14 days without repeated medical examination.

Rules for preparing the suspension

Powder for preparing a suspension 125 mg + 31.25 mg/5 ml: shake the bottle vigorously, add 86 ml of water (to the mark) in two doses, shaking well each time until the powder is completely dissolved.

Powder for preparing a suspension of 250 mg + 62.5 mg/5 ml: shake the bottle vigorously, add 85 ml of water (to the mark) in two doses, shaking well each time until the powder is completely dissolved.

Powder for preparing a suspension 400 mg + 57 mg/5 ml: shake the bottle vigorously, add water in the amount indicated on the label and given in the table (up to the mark) in two doses, shaking well each time until the powder is completely dissolved.

The bottle should be shaken vigorously before use.

Overdose

To avoid overdose, the prescribed dosage for children and the dosage of Amoxiclav for adults must be strictly observed. It is recommended to carefully study the instructions or watch a video on how to dilute the suspension.

Wikipedia indicates that an overdose of the drug may result in a number of unpleasant symptoms, but there is no data on life-threatening conditions for the patient. , abdominal pain , vomiting , diarrhea may occur . In severe cases, seizures may occur.

If the drug has been taken recently, gastric lavage is performed, activated charcoal . The patient must be monitored by a doctor. In this case, hemodialysis .

Interaction

When taking the drug simultaneously with some drugs, undesirable manifestations may occur, which is why tablets, syrup and intravenous administration of the drug should not be used in parallel with a number of drugs.

The simultaneous use of the drug with Glucosamine , antacids, aminoglycosides, and laxatives slows down the absorption of Amoxiclav; when taken simultaneously with Ascorbic acid , the absorption accelerates.

With simultaneous treatment with Phenylbutazone , diuretics, NSAIDs, Allopurinol and other drugs that block tubular secretion, the concentration of amoxicillin increases.

If anticoagulants and Amoxiclav are taken simultaneously, the prothrombin time increases. Therefore, drugs in such a combination must be prescribed with caution.

Amoxiclav increases the toxicity of Methotrexate when taken simultaneously.

When taking Amoxiclav and Allopurinol , the likelihood of exanthema increases.

You should not take Disulfiram and Amoxiclav at the same time.

Antagonists when taken together are amoxicillin and Rifampicin . The drugs mutually weaken the antibacterial effect.

You should not take Amoxiclav and bacteriostatic antibiotics (tetracyclines, macrolides), as well as sulfonamides at the same time, as these drugs can reduce the effectiveness of Amoxiclav.

Probenecid increases the concentration of amoxicillin and slows down its elimination.

When using Amoxiclav, the effectiveness of oral contraceptives may decrease.

special instructions

Since most people with lymphocytic leukemia and infectious mononucleosis who received Ampicillin subsequently noted the appearance of an erythematous rash, such people are not recommended to take ampicillin antibiotics.

It is prescribed with caution to people with a tendency to allergies .

If a course of treatment with the drug is prescribed for adults or children, it is important to monitor the functions of the kidneys, liver, and the process of hematopoiesis.

People who have impaired renal function need a dose adjustment of the drug or an increase in the interval between taking the drug.

It is optimal to take the product during meals to reduce the likelihood of side effects from the digestive system.

Patients undergoing treatment with Amoxiclav may experience a false positive reaction when determining glucose levels in urine when using Felling's solution or Benedict's reagent .

There is no data on the negative impact of Amoxiclav on the ability to drive vehicles and work with precision machinery.

Patients who are interested in whether Amoxiclav is an antibiotic or not should keep in mind that the product is an antibacterial drug.

It is recommended to drink plenty of water and other liquids during the course of treatment with the drug.

If Amoxiclav is prescribed, the patient's childhood age must be taken into account when prescribing the medication form and dosage.

Instructions for use AMOXIKLAV® (AMOKSIKLAV) for injection

Before prescribing the drug, a detailed history should be obtained regarding previous hypersensitivity reactions to penicillins, cephalosporins or other β-lactam antibiotics.

Serious (in some cases fatal) hypersensitivity reactions (anaphylactic reactions) to penicillins have been described. The risk of such reactions is highest in patients with a history of hypersensitivity reactions to penicillins. If an allergic reaction occurs, it is necessary to stop treatment with Amoxiclav and begin alternative therapy. For severe hypersensitivity reactions, the patient should be given epinephrine (adrenaline) immediately. Oxygen therapy, intravenous administration of corticosteroids, and airway management, including intubation, may also be required.

Amoxiclav® should not be prescribed if infectious mononucleosis is suspected, since amoxicillin can cause a skin rash in patients with this disease, which makes diagnosing the disease difficult.

It is not recommended to prescribe Amoxiclav® if there is a high risk that the suspected pathogens have reduced susceptibility or are resistant to beta-lactam antibiotics (for example, penicillin-resistant Streptococcus pneumoniae). Seizures may occur in patients with impaired renal function or in patients receiving high doses.

Special caution is required if it is necessary to use the drug Amoxiclav® in patients with severe allergic diseases, bronchial asthma, with diarrhea and/or vomiting.

Amoxiclav® should be prescribed with caution to patients with impaired liver function. Drug-induced liver failure has been reported predominantly in men and elderly patients and may be associated with long-term therapy. Liver dysfunction has been very rarely reported in children. In all groups of patients, symptoms usually begin during or shortly after treatment, but in some cases become apparent only several weeks after treatment has stopped. Symptoms are usually reversible. Liver failure can be severe and, in extremely rare cases, fatal. It is almost always observed in patients with a serious underlying disease or who are concomitantly taking medications that can have undesirable effects on the liver.

During long-term therapy with Amoxiclav, it is recommended to periodically evaluate renal, liver and hematopoietic function. In patients receiving amoxicillin, an increase in prothrombin time is occasionally observed, therefore, with the simultaneous use of Amoxiclav and anticoagulants, it is necessary to regularly monitor the relevant indicators. With this combination, dose adjustment of oral anticoagulants may be required to achieve the desired level of coagulation.

Long-term treatment with Amoxiclav sometimes leads to excessive growth of insensitive microflora.

The appearance of febrile generalized erythema associated with a pustule at the beginning of treatment may be a symptom of acute generalized exanthemal pustulosis. This reaction requires discontinuation of treatment with Amoxiclav and is a contraindication for any subsequent prescriptions of amoxicillin.

In general, amoxicillin is well tolerated and has the low toxicity characteristic of all penicillins.

Antibiotic-induced colitis occurs with almost all antibacterial drugs and can range in severity from mild to life-threatening. Therefore, it is important to recognize this diagnosis in patients with diarrhea during or after taking any antibiotic. In case of colitis caused by an antibiotic, Amoxiclav should be stopped immediately, a doctor should be consulted, and appropriate therapy should be started. Antiperistaltic drugs are contraindicated in this situation.

In patients with reduced diuresis, crystalluria very rarely occurs, mainly during parenteral therapy. During administration of high doses of amoxicillin, it is recommended to take sufficient fluids and maintain adequate diuresis to reduce the likelihood of amoxicillin crystal formation. In patients with a catheter installed in the bladder, it is necessary to regularly monitor its patency.

The presence of clavulanic acid in Amoxiclav may cause nonspecific binding of IgG and albumin to red blood cell membranes, which may lead to false-positive Coombs test results.

When taking Amoxiclav orally, amoxicillin is detected in the urine. High concentrations of amoxicillin give a false-positive reaction to urine glucose when using Benedict's reagent or Fehling's solution. It is recommended to use enzymatic reactions with glucose oxidase.

Cases of positive enzyme immunoassay (ELISA) results for Aspergillus have been observed in patients receiving the drug, who were subsequently determined to be free of Aspergillus infections. Cross-reactions with non-Aspergillus polysaccharides and polyfuranoses have been observed in the Aspergillus ELISA test. Positive test results in patients receiving Amoxiclav® should be interpreted with caution and confirmed by other diagnostic methods.

Amoxiclav® 1000 mg/200 mg powder for injection solution contains 1 mmol of potassium (39 mg). This should be considered in patients with impaired renal function or in patients on a controlled potassium diet.

Amoxiclav® 500 mg/100 mg powder for injection solution contains less than 1 mmol of potassium (less than 39 mg), i.e. contains virtually no potassium.

Amoxiclav® 1000 mg/200 mg powder for injection solution contains approximately 2.7 mmol sodium (63 mg). This should be considered in patients on a sodium-controlled diet.

Amoxiclav® 500 mg/100 mg powder for injection solution contains approximately 1.4 mmol sodium (31.5 mg). This should be considered in patients on a sodium-controlled diet.

Impact on the ability to drive vehicles and operate machinery

Undesirable effects may develop (for example, allergic reactions, dizziness, convulsions), potentially affecting the performance of these functions.

Analogues of Amoxiclav

Level 4 ATX code matches:
Arlet

Ecoclave

Panclave

Oxamp-Sodium

Oxamp

Amoxicillin + Clavulanic acid

Augmentin

Ampisid

Amoxil K 625

Flemoklav Solutab

Sultasin

There are a number of analogues of this drug. The price of analogues depends, first of all, on the manufacturer of the drug. There are analogues on sale that are cheaper than Amoxiclav. For patients interested in what can replace this antibiotic, experts offer a large list of medications. These are Moxiclav , Co-Amoxiclav , Augmentin , Clavocin , Flemoclav , Medoclav , Baktoklav , Ranclave , Amoviklav , etc. However, any substitute should only be prescribed by a doctor. You can choose a cheaper analogue in tablets, for example, Augmentin. You can also choose a Russian analogue, for example, Amoxicillin .

Flemoklav Solutab and Amoxiclav - the difference between the drugs

The active components of the drugs are similar. The difference between drugs is in the dosage of the active components in the release forms of these drugs. Both drugs fall into approximately the same price category.

Which is better: Amoxiclav or Augmentin?

What is the composition of Amoxiclav and Augmentin , what is the difference between these drugs? Both of these products contain similar active ingredients, that is, in fact they are the same thing. Accordingly, the pharmacological action of the drugs is almost identical, as are the side effects. Only the manufacturers of these drugs differ.

Which is better: Sumamed or Amoxiclav?

Sumamed contains azithromycin, which is a broad-spectrum antibiotic. Before prescribing any of the drugs, it is important to check the sensitivity of the microflora to their action.

Which is better: Flemoxin Solutab or Amoxiclav?

Flemoxin contains only amoxicillin. Accordingly, its spectrum of influence is smaller than that of the drug Amoxiclav, which also contains clavulonic acid .

Reviews about Amoxiclav

In the process of discussing the drug Amoxiclav, reviews from doctors and patients are predominantly positive. It is noted that the antibiotic is effective in the treatment of respiratory tract diseases, and it is suitable for both adults and children. Reviews mention the effectiveness of the product for sinusitis, otitis media, and genital tract infections. As a rule, adult patients take 875 mg + 125 mg tablets; if the dosage is correct, relief occurs quickly. Reviews note that after a course of antibiotic treatment, it is advisable to take drugs that restore normal microflora .

Reviews of the Amoxiclav suspension are also positive. Parents write that it is convenient to give the product to children, as it has a pleasant taste and is normally perceived by children.

Directions for use and doses

Doses are given as amoxicillin/clavulanic acid content unless the dose of the individual component is indicated.

When choosing a dose of a drug to treat a specific infection, you must consider:

• expected pathogens and their expected sensitivity to antibacterial substances (see section “Peculiarities of application”);
• severity and location of infection;
• the patient's age, weight, and renal function status, as described below.

If necessary, alternative forms of Amoxiclav ® can be used (for example, with higher doses of amoxicillin and/or a different ratio of amoxicillin and clavulanic acid).

These dosage forms of Amoxiclav ® can be used in a daily dose of up to 3000 mg of amoxicillin and 600 mg of clavulanic acid. If it is necessary to use a higher dose of amoxicillin, a drug with a different amoxicillin/clavulanic acid ratio should be prescribed to avoid ultra-high daily doses of clavulanic acid.

The duration of treatment is determined by the doctor individually. Some infections (such as osteomyelitis) require long-term treatment. The duration of treatment should not exceed 14 days without assessing the results of use and the clinical picture (see Section “Peculiarities of use”).

Dosage for adults and children weighing ≥ 40 kg

Standard dose is 1000 mg/200 mg every 8:00.

Prevention of complications during surgical interventions.

For operations lasting less than 1 hour, the recommended dose is from 1000 mg / 200 mg to 2000 mg / 200 mg during induction of anesthesia (a dose of 2000 mg / 200 mg can be achieved using the appropriate intravenous form of the drug).

For operations lasting more than 1 hour, the recommended dose ranges from 1000 mg / 200 mg to 2000 mg / 200 mg when injecting anesthesia, a dose of 1000 mg / 200 mg can be administered 3 times within 24 hours.

If there are clinical signs of infection during surgery, a course of treatment with intravenous or oral administration of the drug should be prescribed in the postoperative period.

Dosage for children weighing <40 kg.

Children over 3 months: 25 mg/5 mg/kg every 8:00.

Children under 3 months of age or weighing less than 4 kg: 25 mg/5 mg/kg body weight every 12:00.

Features of drug administration.

Amoxiclav ® is administered by intravenous injection (stream) or by periodic infusion (drip). The drug cannot be administered intramuscularly.

For children under 3 months of age, Amoxiclav ® is prescribed only as an intravenous infusion.

Treatment can begin with the administration of Amoxiclav ® and continue with oral forms.

Preparation of solution for intravenous injection.

500 mg / 100 mg dissolve the contents of the vial in 10 ml of water for injection (final volume - 10.5 ml)

1000 mg / 200 mg dissolve the contents of the vial in 20 ml of water for injection (final volume - 20.9 ml).

Reconstituted solutions have a yellowish (pale straw) color. Use only clear solutions. The solution should be used within 20 minutes after recovery, inject the drug slowly over 3-4 minutes directly into a vein or through a catheter, drip-wise.

Preparation of solution for intravenous infusion

Reconstituted as shown above, the solution of 500 mg / 100 mg is then added without delay to 50 ml of infusion fluid or the solution of 1000 mg / 200 mg - up to 100 ml of infusion fluid (it is better to use a mini-container or burette). The infusion should be carried out over 30-40 minutes.

The solution for infusion is chemically and physically stable for 2-3 hours at a temperature of 25°C or 8:00 at a temperature of 5°C. From a microbiological point of view, it is better to administer the prepared solution immediately.

Various solvents can be used for intravenous infusions. A satisfactory concentration of the antibiotic is maintained at 5°C and at room temperature (25°C) in the recommended volumes specified in the instructions.

Amoxiclav price, where to buy

• The price of Amoxiclav tablets 250 mg + 125 mg is on average 250 rubles for 15 pieces. You can buy the antibiotic Amoxiclav 500 mg + 125 mg at a price of 350 – 400 rubles for 15 pcs. How much 875 mg + 125 mg tablets cost depends on the place of sale. On average, their cost is 400 - 500 rubles for 14 pieces.
• Price Amoxiclav Kviktab 625 mg – from 350 rubles for 14 pcs.
• The price of Amoxiclav suspension for children is 300 rubles (100 ml).
• The price of Amoxiclav 1000 mg in Ukraine (Kyiv, Kharkov, etc.) is from 300 hryvnia for 14 pieces.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Amoxiclav powder for suspension.
  for internal approx. 400mg+57mg/5ml 17.5gLek dd RUB 193 order
• Amoxiclav tablets p.p.o. 500mg+125mg 15 pcs. Lek dd

  RUB 213 order

• Amoxiclav powder for suspension. for internal approx. 250mg+62.5mg/5ml 20 doses 25gLek dd

  RUB 273 order

• Amoxiclav Quiktab dispersible tablets 250mg+62.5mg 20 pcs. Lek dd

  RUB 259 order

• Amoxiclav powder for suspension. for internal approx. 400mg+57mg/5ml 35gLek dd

  RUB 286 order

Pharmacy Dialogue

• Amoxiclav tablets 875mg+125mg No. 14Lek

  RUB 297 order

• Amoxiclav Quiktab (dispersible tablet 625 mg No. 14)Lek

  RUB 179 order

• Amoxiclav Quiktab (dispersible tablet 1000 mg No. 14)Lek

  452 rub. order

• Amoxiclav powder for suspension 125mg+31.25mg/5ml 100mlLek

  115 rub. order

• Amoxiclav powder for suspension 400mg+57mg/5ml 140ml(35g)Lek

  RUB 278 order

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Pharmacy24

• Amoxiclav 125 mg/31.25 mg 5 ml 100 ml powder for oral suspension Lek pharmaceutical company d.d., Slovenia
  131 UAH. order
• Amoxiclav 500mg/100mg No. 5 powder for the preparation of solution for injection Sandoz GmbH, Austria

  379 UAH. order

• Amoxiclav Quiktab 875mg/125mg N14 tablets Lek pharmaceutical company d.d. Slovenia / Sandoz Ilac Sanay ve Tikaret A.S., Turecchina

  164 UAH order

• Amoxiclav 2x 875 mg / 125 mg No. 14 tablets Lek pharmaceutical company d.d., Slovenia

  189 UAH order

• Amoxiclav 2S 400 mg/57 mg 5 ml 17.5 70 ml powder for oral suspension Lek pharmaceutical company d.d., Slovenia

  115 UAH order

PaniPharmacy

• Amoxiclav 2 tablets Amoxiclav 2 film-coated tablets 875/125 mg No. 14 Slovenia, Lek

  217 UAH. order

• Amoxiclav Quiktab tablets Amoxiclav Quiktab dispersible tablets 500mg/125mg No. 10 Slovenia, Lek

  87 UAH order

• Amoxiclav bottle Amoxiclav lyophilized powder for injection 1.2g No. 5 Slovenia, Lek

  454 UAH. order

• Amoxiclav liquid Amoxiclav powder for suspension 250mg/62.5mg (312.5mg)/5ml 100ml Slovenia, Lek

  167 UAH order

• Amoxiclav liquid Amoxiclav powder for suspension 125mg/31.25mg (156.25mg)/5ml 100ml Slovenia, Lek

  131 UAH order

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