Instructions for use CEFTRIAXONE

Pharmacodynamics and pharmacokinetics

What is Ceftriaxone?

According to Wikipedia, ceftriaxone is an antibiotic whose bactericidal effect is due to its ability to disrupt the synthesis of peptidoglycan in bacterial cell walls.

Pharmacodynamics

A universal antibacterial agent, the mechanism of action of which is determined by the ability to suppress the synthesis of the bacterial cell wall. The drug exhibits greater resistance to most β-lactamases of gram(+) and gram(-) microorganisms.

Active regarding:

• Gram(+) aerobes - St. aureus (including penicillinase-producing strains) and Epidermidis, Streptococcus (pneumoniae, pyogenes, viridans group);
• Gram(-) aerobes - Enterobacter aerogenes and cloacae, Acinetobacter calcoaceticus, Haemophilus influenzae (including penicillinase-producing strains) and parainfluenzae, Borrelia burgdorferi, Klebsiella spp. (including pneumoniae), Escherichia coli, Moraxella catarrhalis and diplococci of the genus Neisseria (including penicillinase-producing strains), Morganella morganii, Proteus vulgaris and Proteus mirabilis, Neisseria meningitidis, Serratia spp., some strains of Pseudomonas aeruginosa;
• anaerobes - Clostridium spp. (exception: Clostridium difficile), Bacteroides fragilis, Peptostreptococcus spp..

In vitro (clinical significance remains unknown) activity is observed against strains of the following bacteria: Citrobacter diversus and freundii, Salmonella spp. (including against Salmonella typhi), Providencia spp. (including in relation to Providencia rettgeri), Shigella spp.; Bacteroides bivius, Streptococcus agalactiae, Bacteroides melaninogenicus.

Methicillin -resistant Staphylococcus, many strains of Enterococcus (including Str. faecalis) and group D Streptococcus are resistant to cephalosporin antibiotics (including ceftriaxone).

Pharmacokinetics

• bioavailability - 100%;
• T Cmax when Ceftriaxone is administered intravenously - at the end of the infusion, when administered intramuscularly - 2-3 hours;
• connection with plasma proteins - from 83 to 96%;
• T1/2 with intramuscular administration - from 5.8 to 8.7 hours, with intravenous administration - from 4.3 to 15.7 hours (depending on the disease, the patient’s age and the condition of his kidneys).

In adults, the concentration of ceftriaxone in the cerebrospinal fluid when administered 50 mg/kg after 2-24 hours is many times higher than the MIC (minimum inhibitory concentration) for the most common pathogens of meningococcal infection . The drug penetrates well into the cerebrospinal fluid during inflammation of the meninges.

Ceftriaxone is excreted unchanged:

• kidneys - by 33-67% (in newborn babies this figure is 70%);
• with bile into the intestines (where the drug is inactivated) - by 40-50%.

Hemodialysis is ineffective.

Indications for use of Ceftriaxone

The annotation states that the indications for the use of Ceftriaxone are infections caused by bacteria sensitive to the drug. Intravenous infusions and injections of medications are prescribed to treat:

• infections of the abdominal cavity (including empyema of the gallbladder , angiocholitis , peritonitis ), ENT organs and respiratory tract ( empyema of the pleura , pneumonia , bronchitis , lung abscess , etc.), bone and joint tissue, soft tissues and skin, urogenital tract (including pyelonephritis , pyelitis , prostatitis , cystitis , epididymitis );
• epiglottitis;
• infected burns/wounds;
• infectious lesions of the maxillofacial area;
• bacterial septicemia;
• sepsis;
• bacterial endocarditis;
• bacterial meningitis;
• syphilis;
• chancroid;
• tick-borne borreliosis (Lyme disease);
• uncomplicated gonorrhea (including in cases where the disease is caused by microorganisms that secrete penicillinase);
• salmonellosis/salmonella carriage;
• typhoid fever.

The drug is also used for perioperative prophylaxis and for the treatment of immunocompromised patients.

What is Ceftriaxone used for for syphilis?

Although Penicillin is the drug of choice of syphilis , its effectiveness may be limited in some cases.

The use of cephalosporin antibiotics is resorted to as a backup option in case of intolerance to drugs of the penicillin group.

The valuable properties of the drug are:

• the presence in its composition of chemical substances that have the ability to suppress the formation of cell membranes and mucopeptide synthesis in the walls of bacterial cells;
• the ability to quickly penetrate organs, fluids and tissues of the body and, in particular, into the cerebrospinal fluid, which in patients with syphilis undergoes many specific changes;
• Possibility of use for the treatment of pregnant women.

The medicine is most effective in cases where the causative agent of the disease is Treponema pallidum, since the distinctive feature of Ceftriaxone is its high treponemocidal activity. The positive effect is especially pronounced with intramuscular administration of the drug.

Treatment of syphilis with the use of the drug gives good results not only in the early stages of the disease, but also in advanced cases: with neurosyphilis , as well as with secondary and latent syphilis.

Since T1/2 of Ceftriaxone is approximately 8 hours, the drug can be used equally successfully in both inpatient and outpatient treatment regimens. It is enough to administer the drug to the patient once a day.

For preventive treatment, the drug is administered over 5 days, for primary syphilis - a 10-day course, early latent and secondary syphilis are treated within 3 weeks.

For non-advanced forms of neurosyphilis, the patient is administered a single dose of 1-2 g of Ceftriaxone for 20 days; in the later stages of the disease, the drug is administered at a dose of 1 g/day. for 3 weeks, after which an interval of 14 days is maintained and treatment with a similar dosage is carried out for 10 days.

For acute generalized meningitis and syphilitic meningoencephalitis, the dose is increased to 5 g/day.

Ceftriaxone injections: why is the drug prescribed for angina in adults and children?

Despite the fact that the antibiotic is effective for various lesions of the nasopharynx (including sore throat and sinusitis ), it is, as a rule, rarely used as a drug of choice, especially in pediatrics.

For angina, the medicine can be administered through a dropper into a vein or in the form of regular injections into the muscle. However, in the vast majority of cases, the patient is prescribed intramuscular injections. The solution is prepared immediately before use. The finished mixture remains stable at room temperature for 6 hours after preparation.

For children with angina, Ceftriaxone is prescribed in exceptional cases when acute angina is complicated by severe suppuration and inflammation.

The appropriate dosage is determined by the attending physician.

During pregnancy, the drug is prescribed in cases where penicillin antibiotics are not effective. Although the medicine crosses the placental barrier, it does not have a significant effect on the health and development of the fetus.

Treatment of sinusitis with Ceftriaxone

For sinusitis, antibacterial agents are first-line drugs. Completely penetrating the blood, Ceftriaxone is retained at the site of inflammation in the required concentrations.

As a rule, the medicine is prescribed in combination with mucolytics , vasoconstrictors , etc.

How to inject the drug for sinusitis? Typically, the patient is prescribed Ceftriaxone to be injected into the muscle twice a day, 0.5-1 g. Before injection, the powder is mixed with Lidocaine (it is preferable to use a one percent solution) or d/i water.

Treatment lasts at least 1 week.

When is it prescribed to inject Ceftriaxone intramuscularly?

Intramuscular administration of Ceftriaxone is the most popular route of administration of this antibiotic and is prescribed for moderate to severe infections.

Indications for injections:

• blood poisoning - sepsis;
• inflammation of the membranes of the brain - meningitis;
• infections inside the abdominal cavity and pelvis - peritonitis, suppuration of the gallbladder and ducts (cholecystitis, cholangitis), endometritis, adnexitis, prostatitis;
• inflammatory process in bones and joints, soft tissues, skin - osteomyelitis, purulent arthritis, abscess (abscess), phlegmon (suppuration of soft tissues), carbuncle;
• bacterial meningitis;
• infectious inflammation of the kidneys and urinary tract – pyelitis, pyelonephritis, urethritis;
• diseases of the ENT organs - sore throat, otitis, sinusitis with the risk of complications;
• infected wounds and burns;
• inflammation of the respiratory tract - pneumonia, suppuration in the pleura, pleurisy, bronchiectasis, lung abscess;
• specific infections - syphilis, gonorrhea, tick-borne borreliosis (Lyme disease), salmonellosis, typhoid fever;
• infectious lesions in the maxillofacial area;
• prevention of suppuration during operations on the biliary, urinary tract, digestive organs and gynecology.

We recommend reading the article about how many days to inject Ceftriaxone. From it you will learn for which diseases and for how many days Ceftriaxone should be injected into children and adults, how to dilute the drug, and the interval between injections. And here is more information about how to dilute Ceftriaxone with Lidocaine.

Contraindications

Ceftriaxone is not prescribed in case of known hypersensitivity to cephalosporin antibiotics or auxiliary components of the drug.

Relative contraindications:

• the neonatal period if the child has hyperbilirubinemia ;
• prematurity;
• renal/liver failure;
• enteritis , UC or colitis associated with the use of antibacterial agents;
• pregnancy;
• lactation.

Side effects of Ceftriaxone

Side effects of the drug appear as:

• hypersensitivity reactions: eosinophilia , fever, itching, urticaria edema , skin rash, multiforme (in some cases malignant) exudative erythema , serum sickness , anaphylactic shock , chills;
• headache and dizziness;
• oliguria;
• dysfunction of the digestive organs: nausea, vomiting, flatulence , taste disturbance, stomatitis , diarrhea , glossitis , formation of sludge in the gallbladder and pseudocholelithiasis , pseudomembranous enterocolitis , dysbacteriosis , candidomycosis and other superinfections;
• hematopoiesis disorders: anemia (including hemolytic ), lymphopenia , leukopenia, neutropenia, thrombocytopenia, granulocytopenia , thrombocytosis and leukocytosis , hematuria , basophilia , nosebleeds).

If the medicine is administered intravenously, inflammation of the venous wall, as well as pain along the vein, is possible. The injection of the drug into the muscle is accompanied by pain at the injection site.

Ceftriaxone (injections and IV infusion) may also affect laboratory parameters. The patient's prothrombin time decreases (or increases), the activity of alkaline phosphatase and liver transaminases increases, as well as the concentration of urea, hypercreatininemia , hyperbilirubinemia , and glycosuria .

Reviews of the side effects of Ceftriaxone allow us to conclude that with intramuscular administration of the drug, almost 100% of patients complain of severe pain from the injection, some report muscle pain, dizziness, chills, weakness, itching and rash.

The injections are easiest to tolerate if you dilute the powder with an anesthetic. In this case, it is necessary to do a test both for the drug itself and for the painkiller.

Is it always possible to dilute Ceftriaxone with Lidocaine?

Ceftriaxone can be diluted with Lidocaine only for injection into the muscle. Injections into a vein are made with water, and when using droppers, saline solution or 5% glucose is allowed as a solvent.

If you accidentally administer a mixture of antibiotic and painkiller intravenously, there is a risk of:

• disturbances in the conduction of the heart muscle, up to complete blockade (the nutrition of vital organs is disrupted);
• slowing down the rhythm of contractions (the brain and myocardium do not receive the required volume of blood);
• a drop or sharp increase in blood pressure;
• fainting, vascular collapse.

Saline solution 5% glucose solution
In patients with lidocaine intolerance, cardiac and liver failure, it is best to use water for injection for dissolution. If at the same time unbearable pain occurs, then they change the method of administration - they put in droppers or give injections into a vein. When none of these options are suitable, the doctor may replace Ceftriaxone with another drug with a broad antibacterial effect.

Instructions for use of Ceftriaxone (Method and dosage)

How to dilute Ceftriaxone for injection?

The manufacturer's instructions, as well as the Vidal reference book, indicate that the drug can be injected into a vein or into a muscle.

Dosage for adults and children over 12 years of age: 1-2 g/day. The antibiotic is administered once or once every 12 hours at half the dose.

In particularly serious cases, as well as if the infection is caused by a pathogen moderately sensitive to Ceftriaxone, the dose is increased to 4 g/day.

For gonorrhea , a single injection of 250 mg of the drug into the muscle is recommended.

For preventive purposes, before an infected or suspected infected operation, depending on the degree of danger of infectious complications, the patient should be administered a single dose of 1-2 g of Ceftriaxone 0.5-1.5 hours before surgery.

For children in the first 2 weeks of life, the medicine is administered 1 time per day. The dose is calculated using the formula 20-50 mg/kg/day. The highest dose is 50 mg/kg (which is due to the underdevelopment of the enzyme system).

The optimal dosage for children under 12 years of age (including infants) is also selected depending on weight. The daily dose varies from 20 to 75 mg/kg. For children weighing more than 50 kg, Ceftriaxone is prescribed in the same dose as for adults.

Doses greater than 50 mg/kg should be administered as an intravenous infusion over at least 30 minutes.

For bacterial meningitis, treatment begins with a single dose of 100 mg/kg/day. The highest dose is 4 g. As soon as the pathogen is isolated and its sensitivity to the drug is determined, the dose is reduced.

Reviews about the drug (in particular, about its use in children) allow us to conclude that the drug is very effective and affordable, but its significant drawback is severe pain at the injection site. As for side effects, according to the patients themselves, there are no more of them than with any other antibiotic.

How many days to inject the drug?

The duration of treatment depends on what pathogenic microflora causes the disease, as well as on the characteristics of the clinical picture. If the causative agent is Gram (-) diplococci of the genus Neisseria, the best results can be achieved in 4 days, if enterobacteria are sensitive to the drug - in 10-14 days.

Ceftriaxone injections, instructions for use. How to dilute the drug?

Lidocaine solution (1 or 2%) or water for injection (d/i).

When using water d/i, it should be taken into account that intramuscular injections of the drug are very painful, so if the solvent is water, there will be discomfort both during the injection and for some time after it.

Water for diluting the powder is usually taken in cases where the use of Lidocaine is impossible due to the patient being allergic to it.

The best option is a one percent solution of Lidocaine. It is better to use water as an adjuvant when diluting the drug with Lidocaine 2%.

Is it possible to dilute Novocaine with Ceftriaxone?

Novocaine , when used to dilute the drug, reduces the activity of the antibiotic, while at the same time increasing the likelihood of the patient developing anaphylactic shock .

Based on the reviews of the patients themselves, they note that Lidocaine is better than Novocaine in relieving pain when Ceftriaxone is administered.

In addition, the use of a non-freshly prepared solution of Ceftriaxone with Novocaine increases pain during injection (the solution remains stable for 6 hours after preparation).

How to dilute Ceftriaxone with Novocaine?

If Novocain is used as a solvent, it is taken in a volume of 5 ml per 1 g of the drug. If you take a smaller amount of Novocaine, the powder may not completely dissolve, and the syringe needle will become clogged with lumps of medicine.

Dilution with Lidocaine 1%

For injection into the muscle, 0.5 g of the drug is dissolved in 2 ml of a one percent solution of Lidocaine (the contents of one ampoule); For 1 g of the drug take 3.6 ml of solvent.

The dosage of 0.25 g is diluted in the same way as 0.5 g, that is, with the contents of 1 ampoule of 1% Lidocaine. After this, the finished solution is drawn into different syringes, half the volume in each.

The medicine is injected deep into the gluteal muscle (no more than 1 g in each buttock).

The drug diluted with Lidocaine is not intended for intravenous administration. It is allowed to be injected strictly into the muscle.

How to dilute Ceftriaxone injections with Lidocaine 2%?

To dilute 1 g of the drug, take 1.8 ml of water and two percent Lidocaine. To dilute 0.5 g of the drug, also mix 1.8 ml of Lidocaine with 1.8 ml of water, but only half of the resulting solution (1.8 ml) is used for dissolution. To dilute 0.25 g of the drug, take 0.9 ml of a solvent prepared in a similar way.

How to dilute Ceftriaxone for intramuscular administration in children?

This method of intramuscular injection is practically not used in pediatric practice, since Ceftriaxone with Novocaine can cause severe anaphylactic shock in a child, and in combination with Lidocaine, it can contribute to the occurrence of convulsions and disruption of the heart.

For this reason, the optimal solvent when using the drug in children is ordinary water. The impossibility of using painkillers in childhood requires an even slower and more careful administration of the medicine in order to reduce pain during the injection.

Dilution for intravenous administration

For intravenous administration, 1 g of the drug is dissolved in 10 ml of distilled water (sterile). The drug is administered slowly over 2-4 minutes.

Dilution for intravenous infusion

When carrying out infusion therapy, the drug is administered for at least half an hour. To prepare a solution, 2 g of powder is diluted in 40 ml of a Ca-free solution: dextrose (5 or 10%), NaCl (0.9%), fructose (5%).

Additionally

Ceftriaxone is intended exclusively for parenteral administration: manufacturers do not produce tablets and suspensions due to the fact that the antibiotic, when in contact with body tissues, is highly active and severely irritates them.

Doses for animals

The dosage for cats and dogs is selected taking into account the body weight of the animal. As a rule, it is 30-50 mg/kg.

If a 0.5 g bottle is used, 1 ml of two percent Lidocaine and 1 ml of water d/i (or 2 ml of Lidocaine 1%) should be added to it. After vigorously shaking the medicine until the lumps are completely dissolved, it is drawn into a syringe and injected into the muscle or under the skin of the sick animal.

The dosage for a cat (Ceftriaxone 0.5 g is usually used for small animals - cats, kittens, etc.), if the doctor prescribed 40 mg of Ceftriaxone per 1 kg of weight, is 0.16 ml/kg.

For dogs (and other large animals), take bottles of 1 g. The solvent is taken in a volume of 4 ml (2 ml Lidocaine 2% + 2 ml water for injection). For a dog weighing 10 kg, if the dose is 40 mg/kg, you need to administer 1.6 ml of the prepared solution.

If it is necessary to administer Ceftriaxone intravenously through a catheter, sterile distilled water is used for dilution.

Which is better - intramuscular or intravenous?

For Ceftriaxone, intravenous injections are better than intramuscular injections for severe infections. Moreover, both routes of administration have high antibacterial effectiveness, but differ in pharmacokinetic properties, that is, in the rate of entry into the blood and elimination (see table).

It is better to inject an antibiotic into a vein in such cases:

• high doses are needed (from 2 to 4 g per day);
• there is intolerance to lidocaine (painkiller);
• Treatment is carried out on a newborn or a child under 3 years of age.

Recipe

To purchase Ceftriaxone, you need a prescription from a doctor; it is prescribed according to this example:

Rp.: Ceftriaxoni 1.0

1. td no. 7
2. Dilute the contents of the bottle with 4 ml of 1% Lidocaine and administer intramuscularly once a day for 7 days.

Contraindications to antibiotics

Ceftriaxone is contraindicated in case of intolerance or allergy to any drug from the group of cephalosporins, penicillins, carbapenems. This antibiotic cannot be administered intramuscularly in case of allergic reactions to lidocaine or a ban on its use (epilepsy, heart rhythm disturbances - blockade, bradycardia, weakness of the sinus node).

There are special restrictions for newborns:

• premature;
• the need to introduce calcium salts;
• increased level of bilirubin in the blood, jaundice;
• low protein levels;
• a shift in blood pH to the acidic side (acidosis).

Side effects

Ceftriaxone is a non-toxic drug, but its use is always carried out under the supervision of a physician due to the risk of adverse reactions:

• digestive system - diarrhea, intestinal dysbiosis, nausea and vomiting, abdominal pain, loss of appetite and unpleasant taste in the mouth;
• biliary tract - precipitation of salts, increased bilirubin and liver enzyme activity, drug-induced hepatitis, jaundice;
• blood - increased eosinophils (a sign of allergy), decreased leukocytes (responsible for immunity), platelets (increased bleeding), anemia;
• nervous system – dizziness, headache, convulsions;
• kidneys and urinary tract - deterioration of renal function, decreased urine output, salt deposition in the kidneys;
• immunity - allergic reactions, including the rapid increase in swelling of the face and neck, urticaria, anaphylactic shock, rashes; due to decreased immunity, the development of thrush or a second infection is possible;
• respiratory tract - bronchospasm with paroxysmal cough;
• local reactions – pain upon insertion, hardening.

If any unusual symptoms appear during treatment, you should consult a doctor.

Interaction

In one volume, it is pharmaceutically incompatible with other antimicrobial agents.

By suppressing intestinal microflora, it prevents the formation of vitamin K . For this reason, the use of the drug in combination with drugs that reduce platelet aggregation (sulfinpyrazone, NSAIDs) may provoke bleeding.

The same feature of Ceftriaxone enhances the effect of anticoagulants when used together.

In combination with loop diuretics, the risk of nephrotoxicity increases.

special instructions

The drug is used in a hospital setting. In patients who are on hemodialysis, as well as with simultaneous severe hepatic and renal failure, plasma concentrations of Ceftriaxone should be kept under control.

With long-term treatment, regular monitoring of the peripheral blood picture and indicators characterizing the function of the kidneys and liver is required.

Sometimes (rarely) an ultrasound of the gallbladder may show shadows that indicate the presence of sediment. The darkening disappears after stopping the course of treatment.

vitamin K in addition to Ceftriaxone .

If there is an imbalance of water and electrolytes, as well as arterial hypertension , the level of sodium in the blood plasma should be monitored. If the treatment is long-term, the patient is advised to undergo a general blood test.

Like other cephalosporins, the drug has the ability to displace bilirubin , and therefore it is used with caution in newborns with hyperbilirubinemia (and, in particular, in premature infants).

The drug does not affect the speed of neuromuscular conduction.

How to dilute 2 lidocaine to 1 percent

Lidocaine is used to dilute the antibiotic Ceftriaxone at a concentration of 1%, but such a percentage of the solution is rarely available in pharmacies, so you can dilute 2% to 1%; for this, take 2 ml of water for injection for 2 ml of 2% Lidocaine.

The instructions for the drug indicate that the volume of the solvent should be 3.5 ml, and if you dilute a 2% solution, you will end up with 4 ml. This difference (0.5 ml) does not affect the treatment process in any way. A slightly larger volume is even better, since Ceftriaxone is quite difficult to dissolve.

Lidocaine Water for injections

Is it possible to inject without Lidocaine?

Ceftriaxone can be injected without Lidocaine in the following cases:

• intolerance (allergy);
• contraindications to painkillers: liver disease, circulatory failure, heart block, old age, pregnancy, lactation;
• intravenous injections and drips (Lidocaine is prohibited as it can cause heart rhythm disturbances).

For dilution then only water for injection is used in an amount of 4 ml (2 ampoules). Antibiotic injections into the buttock without pain relief are very painful.

Ceftriaxone analogues, what can replace the drug?

Level 4 ATC code matches:
Cephosin

Lendatsin

Medakson

Loprax

Cefixime

Lorakson

Sulperazon

Cefoperazone

Rocephin

Tsedex

Fortum

Ceftazidime

Cefotaxime

Cefix

Ceforal Solutab

Pantsef

Claforan

Cefodox

Suprax Solutab

Analogues of Ceftriaxone in injections:

• Ceftriaxone-LEKSVM (Kabi, Jodas, KMP, Promed, Vial, Elfa)
• Ceftriabol
• Tsefson
• Cefaxon
• Torotsef
• Hizon
• Cephogram
• Medakson
• Lorakson
• Ifitsef

Analogues in tablets:

• Pantsef
• Suprax Solutab
• Ceforal Solutab
• Cefpotec
• Spectraceph

Ceftriaxone or Cefazolin - which is better?

Both drugs belong to the cephalosporin group, but Ceftriaxone is a third-generation antibiotic, and Cefazolin is a first-generation drug.

An important feature of first generation cephalosporin antibiotics is that they are not effective against listeria and enterococci, have a narrow spectrum of action and a low level of activity against gram(-) bacteria.

Cefazolin is used mainly in surgery for perioperative prophylaxis, as well as for the treatment of soft tissue and skin infections.

Its prescription for the treatment of infections of the genitourinary system and respiratory tract cannot be considered as justified, which is associated with a narrow spectrum of antimicrobial activity and high resistance to it among potential pathogens.

Which is better: Ceftriaxone or Cefotaxime?

Cefotaxime and Ceftriaxone are the basic antimicrobial agents of the third generation cephalosporin group. The drugs are almost identical in their bactericidal properties.

Ceftriaxone during pregnancy and breastfeeding

The drug is contraindicated in the first trimester of pregnancy. If it is necessary to prescribe to a nursing woman, the child should be switched to formula.

Reviews of Ceftriaxone during pregnancy confirm that the drug is indeed a very powerful and very effective antibacterial agent that can not only cure the underlying disease, but also prevent the development of its complications.

Considering that the drug (like other antibiotics) has side effects, it is prescribed only in cases where potential complications of the disease could be more harmful than the use of the drug (in particular, for infections of the urogenital tract, to which pregnant women are very susceptible).

In what cases is hypertonic sodium chloride solution used?

A hypertonic solution is a concentrated sodium chloride solution that contains more salts than an isotonic solution. It is used for several indications. A hypertonic solution has a direct effect on the fluids in the body. It draws water out of cells. Therefore, it is prescribed to patients with cerebral edema. In addition, the solution helps increase blood pressure during blood loss.

It is often used to treat wounds - salt is a natural antiseptic. Patients with arthritis make compresses that relieve pain, reduce inflammation and swelling. For diseases of the oral cavity, it is recommended to rinse with a hypertonic solution, and for sinusitis, rinse the nose with it.

Reviews of Ceftriaxone

Ceftriaxone is a potent antibiotic (reviews from doctors confirm this fact), which helps cure the disease in a short time and with a minimum number of side effects. It is allowed to be used for children and during pregnancy (exception - 1st trimester).

According to the patients themselves, the main disadvantage of the drug is that the injections are very painful.

In reviews of Ceftriaxone injections for children, to facilitate the procedure, mothers (on the advice of the attending physician) are recommended to use Emla , which is a local anesthetic. It is applied in about half an hour to the intended injection site.

Ceftriaxone price, where to buy

How much does an antibiotic cost in Russian pharmacies? The price of Ceftriaxone injections varies depending on which company produces it, as well as the number of ampoules in each package and the concentration of the active substance in the vial.

The price of Ceftriaxone in Russian pharmacies is from 30 rubles per bottle.

The price of Ceftriaxone in Ukraine is from 15 UAH. per bottle of 1 g. At the same time, there is no significant difference between prices in the capital's pharmacies and pharmacies in other cities (Kharkov, Dnepropetrovsk, Lvov).

It is impossible to buy Ceftriaxone tablets. The drug is intended exclusively for parenteral administration.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Ceftriaxone por.
  ready sol. intravenous and intramuscular injection. fl. 1 g 50 pcs. PJSC Kraspharma 1179 rub. order
• Ceftriaxone powder for injection solution 1g bottle JSC Pharmaceutical company LEKKO

  42 RUR order

• Ceftriaxone powder for injection solution for IV and IM injection. 1gJSC "Rapharma"

  45 rub. order

• Ceftriaxone powder prig solution for intravenous and intramuscular administration. 1gPAO Biosintez

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• Ceftriaxone por. d/prig solution for IV and IM insertion. fl. 1g (individual pack)Deco Company LLC

  40 rub. order

Pharmacy Dialogue

• Ceftriaxone (vial 1g IM, IV) Belmedpreparaty

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• Ceftriaxone (vial 1g intravenous i.m. individual pack) Lecco JSC

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• Ceftriaxone (vial 1g i.v. i.m. individual pack) Ruzpharma LLC

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• Ceftriaxone (vial 1g i.m., i.v.) Biosynthesis OJSC

  RUB 882 order

• Ceftriaxone 1g IV IM ind. upbzmp

  41 rub. order

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Pharmacy24

• Ceftriaxone 1 g N10 powder PAT "Kievmedpreparat", Ukraine
  151 UAH.order
• Ceftriaxone-BHFZ 500 mg No. 1 powder PAT NVC "Borshchagivsky chemical-pharmaceutical plant", Kiev, Ukraine

  11 UAH order

• Ceftriaxone-Darnitsa 0.5 g N5 lyophilisate for the preparation of solution for injection PrAT" Pharmaceutical company "Darnitsa", Ukraine

  58 UAH order

• Ceftriaxone-Darnitsa 1 g No. 5 solution PrAT” Pharmaceutical company “Darnitsa”, Ukraine

  72 UAH order

• Ceftriaxone 1.0 g No. 1 powder AT Lekhim-Kharkiv, Ukraine

  13 UAH order

PaniPharmacy

• Ceftriaxone bottle Ceftriaxone sodium salt powder for injection 1g Ukraine, Kievmedpreparat OJSC

  169 UAH order

• CEFTRIAXONE bottle Ceftriaxone powder for injection 1g No. 5 Ukraine, Lekhim-Kharkov JSC

  74 UAH order

• Ceftriaxone bottle Ceftriaxone sodium salt powder for injection 0.5g Ukraine, Kievmedpreparat OJSC

  110 UAH order

• Ceftriaxone bottle Ceftriaxone powder for injection 1g bottles No. 40 Ukraine, Darnitsa ChAO

  681 UAH order

• CEFTRIAXONE bottle Ceftriaxone powder for injection 1g Ukraine, Lekhim-Kharkov JSC

  15 UAH order

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Where to store lidocaine for dilution

Lidocaine ampoules for dilution of 1% or 2% concentration are stored in a place protected from light at room temperature (from 15 to 25 degrees). Exactly the same conditions are needed for vials of Ceftriaxone and water for injection.

We recommend reading the article about the combined use of Azithromycin and Ceftriaxone. From it you will learn about which antibiotic is stronger, the compatibility of drugs, and for what diseases they can be combined. And here is more information about the rules for using Ciprofloxacin and Ceftriaxone.

Ceftriaxone should be diluted with a 1% lidocaine solution or diluted with a 2% solution of water for injection. This helps reduce the pain of injections in the buttock. For intravenous administration, only water or saline solution and glucose are used.