Pharmacological properties of the drug Cevicap
Ascorbic acid (vitamin C). Vitamin C has strong restorative properties. Ascorbic acid affects immunological reactions, detoxification processes, the conversion of folic acid into its active form - folinic acid, affects the metabolism of cholesterol, promotes the absorption of iron, and also suppresses peroxidation processes. Ascorbic acid takes part in the biosynthesis of connective tissue components (collagen, elastin and proteoglycans), due to which it participates in maintaining the intracellular structure of all body tissues. Ascorbic acid (vitamin C) is a water-soluble vitamin that is not synthesized in the human body. During infectious and inflammatory diseases, the concentration of vitamin C in leukocytes decreases sharply, and for the normal functioning of the body's immune system, sufficient saturation of tissues with ascorbic acid is important (the concentration of ascorbic acid in the blood plasma decreases due to an increase in its uptake by leukocytes). Vitamin C deficiency in the body leads to the development of hypo- and avitaminosis C, manifested by increased irritability, tachypnea, dyspepsia, anorexia, gingivitis, impaired dentin formation, low-grade fever, anemia, sluggish healing of wounds and fractures, Meller-Barlow disease (radiological changes in tubular bones, hyperostosis and pain in the area of the epiphyses), scurvy.
pharmachologic effect
Vitamin C. Ascorbic acid is necessary for the formation of intracellular collagen and is required to strengthen the structure of teeth, bones and capillary walls. Participates in redox reactions, tyrosine metabolism, conversion of folic acid into folinic acid, carbohydrate metabolism, lipid and protein synthesis, iron metabolism, cellular respiration processes, activates the synthesis of steroid hormones. Reduces the need for vitamins B1, B2, A, E, folic acid, pantothenic acid, helps increase the body's resistance to infections; improves iron absorption, promoting its deposition in a reduced form. Has antioxidant properties.
When used intravaginally, ascorbic acid reduces the pH of the vagina, inhibiting the growth of bacteria and helps restore and maintain normal pH and vaginal flora (Lactobacillus acidophilus, Lactobacillus gasseri).
Use of the drug Cevicap
Orally during or after meals, for preventive purposes - 1 time per day, for therapeutic purposes - 3 times per day. For infants, it is recommended to dilute the drops with water, tea, juice or add to food. 1 drop contains 5 mg of vitamin C. For prevention: children under 1 year of age: 5–8 drops (25–40 mg) per day; children aged 2–11 years: 10 drops (50 mg) per day; children aged 12–17 years: 15–20 drops (75–100 mg) per day. Therapeutic doses are 2–5 times higher than prophylactic doses (depending on the indications). Doses and duration of treatment are determined by the doctor individually.
Indications for use
For systemic use: prevention and treatment of hypo- and vitamin C deficiency; ensuring the body's increased need for vitamin C during growth, pregnancy, lactation, heavy loads, overwork, and during convalescence after long-term serious illnesses; in winter, with an increased risk of developing infectious diseases.
For intravaginal use: chronic or recurrent vaginitis (bacterial vaginosis, nonspecific vaginitis) caused by anaerobic flora (due to altered vaginal pH); in order to normalize the disturbed vaginal microflora.
Side effects of the drug Cevicap
The drug is well tolerated in recommended doses. With long-term use of the drug in high doses, side effects may occur. From the urinary system: crystalluria, formation of urate and/or oxalate stones in the kidneys. From the endocrine system: in case of glucose-6-phosphate dehydrogenase deficiency, the use of vitamin C can cause hemolysis, hyperglycemia, and glycosuria. From the gastrointestinal tract: dyspeptic disorders (heartburn, vomiting). From the cardiovascular system : hypertension (arterial hypertension), myocardial dystrophy. From the blood system: thrombocytosis, hyperprothrombinemia, anemia, neutrophilic leukocytosis. From the side of the central nervous system: excitement. Metabolic disorders: metabolic disorders of zinc and copper. Long-term use of ascorbic acid in high doses can lead to addiction.
Special instructions for the use of Cevicap
Do not exceed the recommended dose. Do not mix with preparations containing iron and copper, as ascorbic acid has a restorative effect. It is recommended to use ascorbic acid in a dose of no more than 100 mg/day for patients with urolithiasis, hyperoxaluria or a predisposition to the formation of kidney stones (especially oxalate or uric acid), as well as with excess iron in the body (hemochromatosis, sickle cell anemia, thalassemia, intoxication with iron preparations), as well as in patients with renal failure, with metabolic disorders of oxalic and ascorbic acids. Ascorbic acid, used in high doses, can affect the results of laboratory tests that are carried out using redox methods (for example, conducting the Gregersen reaction, determining the concentration of glucose and creatinine in blood plasma and urine). Prescribe with caution to patients with diabetes. During pregnancy and breastfeeding. The drug can be used during pregnancy. The daily requirement for ascorbic acid during pregnancy is 80 mg. However, the use of ascorbic acid in high doses during pregnancy leads to the development of symptoms of its deficiency in the newborn due to the induction of metabolic processes. The drug can be used during breastfeeding. The daily requirement for ascorbic acid during breastfeeding is 100 mg. The concentration of ascorbic acid in mother's milk is 30–55 μg/ml. High doses of vitamin C should be avoided during breastfeeding due to the risk of overdose in a breastfed baby. Does not affect reaction speed when driving vehicles or operating other mechanisms. Children. Cevicap is a solution of vitamin C in the form of drops, specially designed for use in children.
Cevicap 100 mg/ml 30 ml drops for oral administration
Instructions for use of the medicinal product for consumers (insert summary) Cevicap Trade name Cevicap International nonproprietary name Ascorbic acid Dosage form Drops for oral administration 100 mg/ml Composition 1 ml contains the active substance - ascorbic acid (vitamin C) 100 mg excipients: disodium edetate 0.5 mg, anhydrous glycerin, purified water up to 1 ml. Description Transparent, light yellow or yellow liquid with a sweet and sour taste. Pharmacological properties Due to its strong restorative properties, vitamin C is involved in many metabolic exchanges that take place in the human body. Ascorbic acid is capable of transporting electrolytes and enzymes. Ascorbic acid affects the immune system, detoxification processes, the conversion of folic acid into its active form - folinic acid, cholesterol metabolism, iron absorption, and also prevents peroxidation processes. Taking part in the biosynthesis of collagen, elastin and proteoglycans, ascorbic acid also participates in the formation of connective tissue, due to which it integrates and maintains the intracellular structure of all body tissues. Collagen, which makes up 30-40% of the body's proteins, is the main building component of connective tissue. It is part of the skin, endothelium of blood vessels, ligaments, tendons, bones, teeth, cornea, as well as the intercellular substance that binds cells. Affects the healing process of wounds, diaper rash, bone fractures. Ascorbic acid - vitamin C - is a water-soluble vitamin that is not synthesized in the human body. Ascorbic acid is very sensitive to the action of many factors and is subject to breakdown under the influence of light, high temperature and oxygen contained in the air. Optimal saturation of tissues with ascorbic acid is essential for the proper functioning of the body’s defense system. Due to the increased uptake of ascorbic acid by leukocytes, its concentration in the blood decreases. The use of vitamin C already at the first symptoms of a cold causes a significant increase in its concentration in the blood, from where it is captured in the tissues by phagocyte cells. It has been proven that the use of vitamin C reduces and softens the course of colds by an average of 23%. Lack of ascorbic acid leads to the formation of scurvy. Symptoms of vitamin C deficiency: increased irritability, tachypnea, dyspepsia, loss of appetite causing a characteristic position of the legs, swelling and subperiosteal hemorrhage, inflammatory changes in the gums, abnormal dentin structure, radiological changes in long bones, painful hyperostosis in the epiphyseal region (Möller-Barlow disease) . In this case, a low-grade fever, anemia, and delayed healing of wounds and fractures are observed. Symptoms stop after using vitamin C. Indications for use Cevicap - a solution of vitamin C in the form of drops is specially designed for children - it makes it possible to take small, children's doses of ascorbic acid. · In complex therapy: — infectious diseases with elevated temperature, as well as viral recurrent infections of the upper respiratory tract — in inflammatory conditions · Conditions of increased need for vitamin C — convalescence — reduced immunity — sports or intense physical exercise § For the preventive purpose of hypovitaminosis C in case: - artificial feeding of children - malnutrition - anorexia - malabsorption (for diseases of the gastrointestinal tract). Method of administration and dosage: Oral. Drops can be given in one or more doses, preferably with meals. For infants, it is recommended to dissolve the drops in water, tea, juice or add to food. One drop contains 5 mg of vitamin C. Preventive doses: - infants and children of the 1st year of life: 5-8 drops (approx. 25-40 mg) per day; - children from 2 to 11 years: 10 drops (approx. 50 mg) per day; - adolescents from 12 to 17 years: 15 – 20 drops (approx. 75-100 mg) per day. Therapeutic doses are 2-5 times higher than prophylactic doses (depending on the indications). Side effects The drug used in recommended doses is well tolerated. With long-term use of large doses, the following may appear: - increased excretion of oxalic acid in the urine, crystallization of urates and citrates, which increases the risk of kidney stones in the urinary system - in persons with deficiency of glucose - 6 - phosphate dehydrogenase can cause hemolysis - hyperglycemia, glycosuria - dyspeptic disorders (regurgitation, vomiting) - hemorrhages. - long-term use of high doses of ascorbic acid can lead to addiction. Contraindications Hypersensitivity to ascorbic acid and/or other components of the drug. Drug interactions Iron. Ascorbic acid increases the absorption of non-heme iron from the digestive tract by 2-4 times, especially in individuals with a low supply of iron in tissues. Deferroxamine. In patients with excess iron in the body, the use of deferroxamine in combination with ascorbic acid in the initial phase of detoxification or treatment may increase iron toxicity. Acetylsalicylic acid. Large doses of acetylsalicylic acid reduce the bioavailability of ascorbic acid. Vitamin E. Both vitamins exhibit a synergistic antioxidant effect. Ascorbic acid reactivates tocopherol, preventing its inactivation both in vitro and in vivo. Co-trimoxazole. Large doses of ascorbic acid may increase the risk of crystalluria of the sulfomide component of co-trimoxazole. Medicines of an acidic and alkaline nature. Large doses of ascorbic acid (2 g/day or more) acidify the urine, which can affect the reduced excretion of acidic drugs in the urine, and therefore enhance their effect (eg nitrofuratonin, salicylates), as well as weaken the effect of alkaline drugs ( etc. antidepressant drugs, phenothiazine derivatives) due to their accelerated exclusion. Special instructions Do not mix with preparations containing iron and copper due to its reducing properties. It is recommended to take ascorbic acid in a dose of no more than 100 mg per day for patients with kidney stones, hyperoxaluria or a tendency to form kidney stones (especially oxalate or uric acid), as well as with excess iron in the body, i.e. patients with hemochromatosis, sickle cell anemia, thalassemia and iron poisoning, persons with pre-existing hyperoxaluria or a predisposition to its formation, as well as in patients with recurrent kidney stones or renal failure accompanied by a metabolic defect in the conversion of oxalic and ascorbic acids. Ascorbic acid, consumed in large doses, can distort the results of laboratory tests performed by oxide-reduction methods (for example, testing for the presence of blood hidden in the stool, determining the concentration of glucose and creatinine in the blood and urine). Pregnancy and lactation The drug can be used during pregnancy. The recommended daily intake of vitamin C for pregnant women (including dietary intake) is 80 mg. The use of large doses of vitamin C by pregnant women leads to the manifestation of symptoms of its deficiency in the newborn due to the induction of metabolic processes under the influence of large doses of vitamin C. The drug can be used during breastfeeding. The recommended daily intake of vitamin C for breastfeeding women (including dietary intake) is 100 mg. The content of ascorbic acid in mother's milk is 30-55 mg/l, which is sufficient for a breastfed infant (Goodman & Gilman's 1996). Large doses of vitamin C should be avoided due to the risk of overdose of this compound in infants. Effect on the ability to drive vehicles and operate mechanical equipment. No effect. Overdose There are no data on overdose. The use of high doses of vitamin C (more than 1000 mg = 200 drops per day) can lead to an overdose with increased side effects. Treatment is symptomatic. Release form Drops for oral administration 100 mg/ml. 10 ml or 30 ml in dark glass bottles with a dropper inside and a screw cap with a guarantee ring. 1 bottle with instructions for use in a cardboard box. Storage conditions Store in a carefully closed bottle at a temperature of 15°C to 25°C. Protect from light. Keep out of the reach of children! Shelf life: 2 years Do not use after the expiration date indicated on the package. Conditions for dispensing from pharmacies Without a prescription Manufacturer MEDANA PHARMA TERPOL GROUP Joint Stock Company 98-200 Sieradz, st. Warcka 3, POLAND
Drug interactions Cevicap
Iron. Ascorbic acid increases the rate of absorption of non-heme iron in the gastrointestinal tract by 2–4 times, especially in individuals with iron deficiency. Deferoxamine. In patients with excess iron in the body, the use of deferoxamine in combination with ascorbic acid at a dose of 150–250 mg/day increases its excretion; the use of higher doses does not contribute to additional excretion of iron compounds. Acetylsalicylic acid. Acetylsalicylic acid in high doses reduces the bioavailability of ascorbic acid. Vitamin E. Vitamins E and C are synergistic in terms of antioxidant action. Ascorbic acid has an antioxidant effect in the presence of α-tocopherol both in vitro and in vivo. Co-trimoxazole. When used simultaneously with ascorbic acid, the risk of crystalluria increases. The use of ascorbic acid in high doses (≥2 g/day) leads to a decrease in urine pH, which can affect the reduction in the urinary elimination of drugs with an acidic reaction, and therefore enhances their effect (nitrofurantoin, salicylates), and also weaken the effect of drugs with an alkaline reaction (antidepressants, phenothiazine derivatives) due to the acceleration of their elimination.
Directions for use and doses
The method of administration and dosage regimen of a particular drug depend on its release form and other factors. The optimal dosage regimen is determined by the doctor. The compliance of the dosage form of a particular drug with the indications for use and dosage regimen should be strictly observed.
Used orally, intramuscularly, intravaginally, intravaginally.
For the prevention of deficiency conditions - 25-75 mg/day, for treatment 250 mg/day or more in divided doses.
For intravaginal use, ascorbic acid preparations are used in appropriate dosage forms.
