Nosological classification (ICD-10)
- B99 Other infectious diseases
- D65-D69 Bleeding disorders, purpura and other hemorrhagic conditions
- D84.9 Immunodeficiency, unspecified
- E27.4 Other and unspecified adrenal insufficiency
- E54 Ascorbic acid [vitamin C] deficiency
- E63 Physical and mental overload
- N93 Other abnormal bleeding from the uterus and vagina
- O25 Malnutrition in pregnancy
- R04.0 Nosebleed
- R04.8.0* Pulmonary hemorrhage
- R58 Bleeding, not elsewhere classified
- T14.1 Open wound of unspecified body area
- T14.2 Fracture in an unspecified area of the body
- Z29.1 Preventive immunotherapy
Ascorbic acid - powder
Ascorbic acid Registration number: LS-002248 dated 11/10/2006
Trade name: Ascorbic acid
International nonproprietary name (INN): Ascorbic acid Dosage form: powder for oral administration 1000 mg
Ingredients: Ascorbic acid – 1 g
Description: White crystalline powder, odorless.
Pharmacotherapeutic group: Vitamin.
ATX code : A 11 GA 01
Pharmacological properties: Vitamin preparation, has a metabolic effect, is not formed in the human body, but comes only with food. Participates in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, and in the synthesis of steroid hormones; increases the body's resistance to infections, reduces vascular permeability, reduces the need for vitamins B1, B2, A, E, folic acid, pantothenic acid. Has pronounced antioxidant properties. Regulates hydrogen transport in many biochemical reactions, improves the use of glucose in the tricarboxylic acid cycle, participates in the formation of tetrahydrofolic acid and tissue regeneration, the synthesis of steroid hormones, collagen, procollagen. Maintains the colloidal state of the intercellular substance and normal capillary permeability (inhibits hyaluronidase). Activates proteolytic enzymes, participates in the metabolism of aromatic amino acids, pigments and cholesterol, promotes the accumulation of glycogen in the liver. Due to the activation of respiratory enzymes in the liver, it enhances its detoxification and protein-forming functions, increases the synthesis of prothrombin. Improves bile secretion, restores exocrine function of the pancreas and endocrine function of the thyroid gland.
Indications for use
Prevention and treatment of hypo- and vitamin C deficiency.
As an aid: hemorrhagic diathesis, nasal, uterine, pulmonary and other bleeding, including those caused by radiation sickness; overdose of anticoagulants, diseases of the gastrointestinal tract accompanied by impaired absorption of vitamin C; injuries.
Conditions accompanied by an increased need for vitamin C: increased physical and mental stress, pregnancy and breastfeeding, recovery period after long-term illnesses.
Contraindications:
Hypersensitivity to the components of the drug, thrombophlebitis, tendency to thrombosis, diabetes mellitus.
Carefully:
Hyperoxaluria, renal failure, hemochromatosis, thalassemia, polycythemia, leukemia, sideroblastic anemia, glucose-6-phosphate dehydrogenase deficiency, sickle cell anemia, progressive malignant diseases, pregnancy, oxalosis, kidney stones.
Use during pregnancy and breastfeeding
The minimum daily requirement for ascorbic acid in the second and third trimesters of pregnancy is about 60 mg.
The minimum daily requirement during breastfeeding is 80 mg. A maternal diet containing adequate amounts of ascorbic acid is sufficient to prevent vitamin C deficiency in the infant.
During pregnancy and breastfeeding, the recommended dosage of ascorbic acid should not be exceeded.
Directions for use and doses
Inside, after eating. The powder is used to prepare drinks - 1 g (the contents of one sachet sachet) of ascorbic acid powder - per 1 liter of water. The solution is taken freshly prepared, in accordance with the dosages suggested below.
For dosing, it is recommended to use a medical measuring cup.
For prevention: adults 50 mg - 100 mg (50 ml - 100 ml) per day, children over 5 years old 50 mg (50 ml) per day.
For treatment: adults 50 mg - 100 mg (50 ml - 100 ml) 3 - 5 times a day, children from 5 years old 50 mg (50 ml) -100 mg (100 ml) 2 - 3 times a day.
During pregnancy and breastfeeding, 300 mg (300 ml) per day for 10 - 15 days, then 100 mg (100 ml) per day.
For adults, the maximum single dose is 200 mg, daily dose is 1 g; for children – 50 – 100 mg/day.
Note: Medical measuring cup is not included.
Side effects
From the central nervous system (CNS): headache, feeling of fatigue, with prolonged use of large doses - increased excitability of the central nervous system, sleep disturbances.
From the digestive system: irritation of the gastrointestinal mucosa, nausea, vomiting, diarrhea, stomach cramps.
From the endocrine system: inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glycosuria).
From the urinary system: when used in high doses, hyperoxaluria and the formation of urinary stones from calcium oxalate.
From the cardiovascular system: thrombosis, when used in high doses - increased blood pressure, development of microangiopathies, myocardial dystrophy.
Allergic reactions: skin rash, rarely - anaphylactic shock. Laboratory indicators: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.
Other: hypervitaminosis, feeling of heat, with prolonged use of large doses - sodium and fluid retention, impaired zinc and copper metabolism. If any side effects occur, you should stop taking the drug and consult a doctor.
Overdose
When taking more than 1 g per day, heartburn, diarrhea, difficulty urinating and/or red coloration of urine, hemolysis (in patients with glucose-6-phosphate dehydrogenase deficiency) are possible.
If symptoms of overdose appear, consult a doctor.
Interaction with other drugs
Increases the concentration of benzylpenicillin and tetracyclines in the blood; at a dose of 1 g/day increases the bioavailability of ethinyl estradiol. Improves the absorption of iron preparations in the intestines (converts ferric iron to divalent iron); may increase iron excretion when used concomitantly with deferoxamine.
Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drinks reduce absorption and absorption. When used simultaneously with ASA, the urinary excretion of ascorbic acid increases and the excretion of ASA decreases. ASA reduces the absorption of ascorbic acid by approximately 30%. Increases the risk of developing crystalluria during treatment with salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), and reduces the concentration of oral contraceptives in the blood. Increases the overall clearance of ethanol, which, in turn, reduces the concentration of ascorbic acid in the body. Quinoline drugs (fluoroquinolones, etc.), calcium chloride, salicylates, and glucocorticosteroids with long-term use deplete ascorbic acid reserves. When used simultaneously, it reduces the chronotropic effect of isoprenaline. Long-term use or use in high doses may interfere with the disulfiram-ethanol interaction. In high doses, it increases the renal excretion of mexiletine. Barbiturates and primidone increase the excretion of ascorbic acid in the urine.
Reduces the therapeutic effect of antipsychotics (phenothiazine derivatives), tubular reabsorption of amphetamine and tricyclic antidepressants.
Reduces the effectiveness of heparin and indirect anticoagulants.
special instructions
Due to the stimulating effect of ascorbic acid on the synthesis of glucocorticosteroid hormones, it is necessary to monitor kidney function and blood pressure. With long-term use of large doses, inhibition of the function of the pancreatic insular apparatus is possible, so it must be regularly monitored during treatment. In patients with high iron levels in the body, ascorbic acid should be used in minimal doses. Prescribing ascorbic acid to patients with rapidly proliferating and intensively metastasizing tumors can aggravate the process. Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (blood glucose, bilirubin, transaminase activity, LDH).
Release form
Powder for solution for oral administration 1 g.
1 g in heat-sealable bags made of combined film material or packaging paper with a polymer coating.
3 or 5 packages along with instructions for use are placed in boxed cardboard packs.
It is allowed to place packages with an equal number of instructions in a group package.
The text of the instructions for use may be placed on the pack.
Conditions for dispensing from pharmacies: Without a doctor's prescription.
Storage conditions:
In a dry place, protected from light, at a temperature not exceeding 25°C
Best before date:
3 years. Do not use after expiration date.
Units:
pack
Ascorbic acid
Ascorbic acid
Registration number: P N000375/01
Trade name of the drug: Ascorbic acid
International nonproprietary name: Ascorbic acid.
Dosage form:
Pills.
Composition of the drug:
Active components:
ascorbic acid - 25 mg or 50 mg or 75 mg.
Excipients: dextrose (glucose), sugar, stearic acid, potato starch, food flavoring.
Description: White tablets, flat-cylindrical in shape with a chamfer.
Pharmacotherapeutic group:
Vitamin.
ATX code: [ A 11 GA 01].
Pharmacological properties
Ascorbic acid plays an important role in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, and helps increase the body's resistance. Ascorbic acid (vitamin C) is not formed in the human body, but comes only from food. With a balanced and nutritious diet, a person does not experience a deficiency in vitamin C.
Indications for use
Prevention and treatment of hypo- and avitaminosis of vitamin C. With the body’s increased need for vitamin C during periods of active growth in children, pregnancy, breastfeeding, with increased physical and mental stress, overwork, stressful conditions, during the period of recovery after long and serious illnesses.
Contraindications
Hypersensitivity to the components of the drug. Large doses should not be prescribed to patients with increased blood clotting, thrombophlebitis and a tendency to thrombosis, as well as diabetes mellitus and conditions accompanied by high blood sugar.
With caution: glucose-6-phosphate dehydrogenase deficiency, hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, oxalosis, kidney stones.
Directions for use and doses
The drug is taken orally after meals.
For preventive purposes the following is prescribed:
Adults - 50-100 mg/day; children 25 mg/day. During pregnancy and lactation
300 mg/day. for 10-15 days, then 100 mg/day.
For therapeutic purposes the following is prescribed:
Adults - 50-100 mg/day 3-5 times a day; children 50-100 mg 2-3 times a day.
The duration of treatment depends on the nature and course of the disease and is determined by the doctor.
Side effect
Allergic reactions to the components of the drug are possible.
From the digestive system: when taken orally - irritation of the mucous membrane of the gastrointestinal tract. Changes in laboratory parameters: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.
Interaction with other drugs
Ascorbic acid increases the absorption of drugs from the penicillin group and iron.
special instructions
Due to the stimulating effect of ascorbic acid on the formation of glucocorticosteroid hormones, it is necessary to monitor adrenal function and blood pressure. With long-term use of large doses, the function of the insular apparatus of the pancreas may be suppressed, therefore, during the treatment process, it is necessary to regularly monitor the functional ability of the pancreas.
Release form
Tablets 25, 50, 75 mg.
10 tablets are packed in waxed paper and a label made of label or writing paper is pasted on.
The instructions for use are printed on the front and back of the label. 300 packages are placed in cardboard boxes.
10 tablets are packaged in waxed paper labels with waxed paper gaskets. 300 packages with an equal number of instructions for use are placed in cardboard boxes.
Release from pharmacies
Over the counter.
Storage conditions:
In a dry place, protected from light, at a temperature not exceeding 30°C.
Best before date:
2 years. Do not use the drug after the expiration date.
Units:
pack
