Tablets, dragees and IV Ascorbic acid: instructions for use, price, overdose. Is it possible for pregnant women

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Medicines

Compound

The composition of the dragee includes ascorbic acid, starch syrup, sugar, talc, light mineral oil, yellow wax, dye E104 (quinoline yellow), orange flavor.
Composition of r/ra for IV and IM administration: ascorbic acid (0.05 g/ml or 0.1 g/ml), sodium bicarbonate and sulfite, water saturated with carbon dioxide for injection.

The tablets contain ascorbic acid, dextrose, sugar, potato starch, additive E470 (calcium stearate), flavoring (strawberry/raspberry/cranberry/wild berries).

Chewable tablets contain ascorbic acid, refined sugar, magnesium stearate, aspartame , microcrystalline cellulose, orange flavor, hypromellose, sunset yellow E110 or beta-carotene.

Release form

Dragees, packaged in 50, 100 or 200 pcs. in bottles made of polymer materials/glass jars or 10 pieces in blister packs, 5 packs in a cardboard box.
R/R for intravenous and intramuscular administration of 5 and 10% in ampoules of 1, 2 and 5 ml, 10 ampoules in a cardboard box.
Lyophilisate for the preparation of solution for intravenous and intramuscular administration. Dosage 0.05 g. The drug is available in ampoules, 5 ampoules in a cardboard pack complete with solvent (water for 2 ml).
Powder for the preparation of oral solution for oral administration. Dosage 1 and 2.5 g; sold in paper bags laminated with PE.
Tablets, packaged in 50 pcs. in glass jars.
Chewable tablets in package No. 30.

Pharmacodynamics and pharmacokinetics

The drug has the activity of vitamin C. It has a metabolic effect, regulates oxidation-reduction reactions and hydrogen transport in a large number of biochemical reactions, improves the use of glucose in the citrate cycle, accelerates tissue regeneration, takes part in the formation of H4-folate, collagen and steroid hormones .

Maintains normal permeability of capillary walls and the colloidal state of the extracellular matrix. Activates proteases, participates in the metabolism of cholesterol , pigments and aromatic amino acids, promotes the deposition of glycogen in the liver.

Due to the activation of liver cytochromes, it increases its protein-forming and detoxification activity, as well as the synthesis of prothrombin . Restores the endocrine function of the thyroid gland and the exocrine function of the pancreas , stimulates the secretion of bile .

Regulates immunological reactivity (activates the production of interferon , antibodies, components of the C3 complement system), promotes phagocytosis and strengthens the immune system .

It has an antiallergic effect and relieves inflammatory processes. Inhibits the production of mediators of anaphylaxis and inflammation (including prostaglandins ), inhibits the release of histamine and accelerates its degradation.

Since vitamin C is not produced in the human body, an insufficient amount of it in food provokes hypo- and vitamin C deficiency .

The daily norm for men is 0.07-0.1 g, for women - 0.08 g. During pregnancy, the need increases to 0.1 g, during lactation - up to 0.12 g. Children and adolescents, depending on age, should take from 0.03 to 0.07 g of vitamin C.

Absorbed in the small intestine: when taking less than 0.2 g, about 2/3 of the dose taken is absorbed; with increasing dose, absorption decreases to 50-20%.

The concentration of ascorbic acid when taken orally reaches a maximum after 4 hours.

The substance easily penetrates platelets and leukocytes , and subsequently into all tissues; deposited in the adrenal cortex, posterior lobe of the pituitary gland , intestinal walls, muscle tissue, brain, ovaries, interstitial cells of the seminal glands, ocular epithelium, spleen, liver, kidneys, lungs, pancreas and thyroid glands, heart.

Biotransformed mainly in the liver.

Ascorbate and its metabolites ( diketogulonic and oxaloacetic acids ) are excreted in urine and intestinal contents, and are also excreted in breast milk and sweat gland secretions.

Buy Ascorbic acid FST etc. 50 mg No. 200 in pharmacies

Trade name:

Ascorbic acid

International nonproprietary name:

ascorbic acid

Dosage form:

dragee

Composition per tablet

Active substance:

Ascorbic acid (vitamin C) - 50.0 mg.

Excipients:

sucrose - 177.5 mg, starch syrup - 7.2 mg, wheat flour - 15.0 mg, sunflower oil - 0.05 mg, beeswax - 0.04 mg, talc - 0.14 mg, orange flavor - 0.02 mg, quinoline yellow dye - 0.05 mg.

Description

Dragee is yellow to greenish-yellow in color and has a regular spherical shape. The surface of the dragee should be even, smooth, and uniform in color.

Pharmacotherapeutic group:

Vitamin

Pharmacological properties

Pharmacodynamics

Ascorbic acid (vitamin C) is not formed in the human body, but comes only from food.

It is a cofactor in some hydroxylation and amidation reactions - it transfers electrons to enzymes, providing them with a reducing equivalent. Participates in the reactions of hydroxylation of proline and lysine residues of procollagen with the formation of hydroxyproline and hydroxylysine (post-translational modification of collagen), oxidation of lysine side chains in proteins with the formation of hydroxytrimethyllysine (in the process of carnitine synthesis), oxidation of folic acid to folinic acid, drug metabolism agents in liver microsomes and hydroxylation of dopamine with the formation of norepinephrine.

Increases the activity of amidating enzymes involved in the processing of oxytocin, antidiuretic hormone and cholecystokinin. Participates in steroidogenesis in the adrenal glands. Restores ferric ions to ferrous ions in the intestine, promoting its absorption.

The main role in tissues is participation in the synthesis of collagen, proteoglycans and other organic components of the intercellular substance of teeth, bones and capillary endothelium.

In low doses (150-250 mg/day orally) it improves the complexing function of deferoxamine in chronic intoxication with iron preparations, which leads to increased excretion of the latter.

Ascorbic acid is actively involved in many redox reactions and has a nonspecific general stimulating effect on the body.

Increases the body's adaptive abilities and its resistance to infections; promotes regeneration processes.

Pharmacokinetics

Absorption

Absorbed in the gastrointestinal tract (GIT) (mainly in the jejunum). With an increase in dose to 200 mg, up to 140 mg (70%) is absorbed; with a further increase in dose, absorption decreases (50-20%). The time to reach maximum concentration (TCmax) after oral administration is 4 hours. Gastrointestinal diseases (peptic ulcer of the stomach and duodenum, constipation or diarrhea, helminthic infestation, giardiasis), consumption of fresh fruit and vegetable juices, alkaline drinking reduce the absorption of ascorbic acid in the intestine. .

Distribution

The normal plasma ascorbic acid concentration is approximately

10-20 mcg/ml, body reserves are about 1.5 g when taking daily recommended doses and 2.5 g when taking 200 mg/day. Communication with plasma proteins - 25%.

Easily penetrates into leukocytes, platelets, and then into all tissues; the highest concentration is achieved in the glandular organs, leukocytes, liver and lens of the eye; penetrates the placenta. The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and plasma. In deficiency states, the concentration in leukocytes decreases later and more slowly and is considered a better criterion for assessing deficiency than plasma concentration.

Metabolism

Metabolized primarily in the liver into deoxyascorbic acid and further into oxaloacetic acid and ascorbate-2-sulfate.

Removal

It is excreted by the kidneys, through the intestines, with sweat, with breast milk unchanged and in the form of metabolites.

When high doses are used, the rate of elimination increases sharply. Smoking and ethanol consumption accelerate the destruction of ascorbic acid (conversion into inactive metabolites), sharply reducing reserves in the body. Excreted during hemodialysis.

Indications for use

Treatment and prevention of hypo- and avitaminosis of vitamin C and related conditions.

Contraindications

Hypersensitivity to ascorbic acid and/or any excipient in the composition of the drug, thrombophlebitis, tendency to thrombosis, diabetes mellitus, sucrose/fructose intolerance, sucrase/isomaltase deficiency, glucose-galactose malabsorption syndrome.

If you have one of the diseases/conditions or risk factors listed above, you should consult your doctor before using the drug.

Carefully

Sideroblastic anemia, sickle cell anemia, urolithiasis, renal failure, progressive malignant diseases, polycythemia, leukemia, oxalosis. Thalassemia, hemochromatosis, hyperoxaluria, glucose-6-phosphate dehydrogenase deficiency.

If you have one of the diseases/conditions or risk factors listed above, you should consult your doctor before using the drug.

Use during pregnancy and breastfeeding

Pregnancy

The minimum daily requirement for ascorbic acid in the II-III trimesters of pregnancy is about 60 mg. It should be borne in mind that the fetus can adapt to high doses of ascorbic acid taken by a pregnant woman, and then the newborn may develop a “withdrawal” syndrome.

During pregnancy, the dose of ascorbic acid should not exceed 300 mg per day.

Breastfeeding period

Ascorbic acid passes into breast milk. The minimum daily requirement during breastfeeding is 80 mg. A maternal diet containing adequate amounts of ascorbic acid is sufficient to prevent vitamin C deficiency in the infant.

Directions for use and doses

The drug is taken orally after meals.

For prevention: adults 0.05-0.1 g (1-2 tablets) per day, children from 5 years old 0.05 g

(1 tablet) per day.

For treatment: adults 0.05-0.1 g (1-2 tablets) 3-5 times a day, children from 5 years old 0.05-0.1 g (1-2 tablets) 2-3 times a day day.

During pregnancy and breastfeeding, 0.3 g (6 tablets) per day for

10-15 days, then 0.1 g (2 tablets) per day.

Use the drug only according to the indications, method of administration and in the doses indicated in the instructions.

Side effect

If any side effects occur, you should stop taking the drug and consult a doctor.

Nervous system disorders: headache, fatigue

Gastrointestinal disorders: irritation of the mucous membrane of the gastrointestinal tract (GIT); depression of the pancreatic insular apparatus (hyperglycemia, glycosuria).

Vascular disorders: thrombosis

Immune system disorders: skin rash, hyperemia.

Laboratory and instrumental data: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.

If you experience any undesirable reactions indicated in the instructions or they get worse, or you notice any other undesirable reactions not listed in the instructions, inform your doctor.

Overdose

Symptoms: diarrhea, nausea, irritation of the gastrointestinal mucosa, flatulence, spastic abdominal pain, frequent urination, nephrolithiasis, insomnia, irritability, hypoglycemia.

Treatment: symptomatic, forced diuresis.

In case of overdose, consult a doctor.

Interaction with other drugs

Absorption of ascorbic acid is reduced with simultaneous use of oral contraceptives, acetylsalicylic acid, consumption of fresh fruit and vegetable juices, and alkaline drinks.

Ascorbic acid, when taken orally, increases the absorption of penicillin and iron, reduces the effectiveness of heparin and indirect anticoagulants, and increases the risk of developing crystalluria when treated with salicylates.

When used simultaneously, it reduces the chronotropic effect of isoprenaline.

With long-term use or use in large doses, it may interfere with the interaction of disulfiram and ethanol.

Barbiturates and primidone increase the excretion of ascorbic acid in the urine.

Reduces the therapeutic effect of antipsychotic drugs (phenothiazine derivatives), tubular reabsorption of amphetamine and tricyclic antidepressants.

If you are using the above or other medications (including over-the-counter medications), consult your doctor before using Ascorbic Acid.

special instructions

Due to the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor kidney function and blood pressure.

With long-term use of large doses, inhibition of the function of the pancreatic insular apparatus is possible, so it must be regularly monitored during treatment.

In patients with high iron levels in the body, ascorbic acid should be used in minimal doses.

The use of ascorbic acid in patients with rapidly proliferating and intensely metastasizing tumors can aggravate the process.

Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (plasma concentrations of glucose, bilirubin, transaminase activity, lactate dehydrogenase).

Impact on the ability to drive vehicles and machinery

The use of the drug does not affect the ability to drive vehicles and machinery.

Release form

Dragee, 50 mg. 200 tablets in polymer jars. The jars are sealed with screw-on lids. Each polymer jar, together with instructions for use, is placed in a pack of cardboard, or 32 polymer jars, together with the corresponding number of instructions for use, are placed in shrink film.

Storage conditions

In a place protected from light, at a temperature not exceeding 25 ° C. Keep out of the reach of children.

Best before date

1 year 6 months.

Do not use after the expiration date stated on the package.

Vacation conditions

Available without a prescription.

Indications for use

The use of the drug is advisable for:

hypovitaminosis C;
capillarotoxicosis;
hemorrhagic diathesis;
hemorrhagic stroke;
infectious diseases;
bleeding (including nasal, uterine, pulmonary);
idiopathic mehemoglobinemia;
liver pathologies (including chronic hepatitis , Botkin's disease , cirrhosis );
acute radiation sickness;
complications of infusion-transfusion therapy;
diseases of the digestive tract (including enteritis , colitis , peptic ulcer , achylia );
Addison's disease ( hypocorticism );
cholecystitis;
parasitic diseases caused by helminths
difficult-to-heal wounds, burns, fractures, ulcers;
mental and physical overload;
pregnancy;
lactation;
conditions that are accompanied by excessive deposition of hemosiderin ;
erythro- and melasma ;
psoriasis;
chronic widespread dermatosis.

The antioxidant properties of ascorbic acid are used in the treatment of bronchial asthma , atherosclerosis , infectious and alcoholic delirium, diffuse connective tissue lesions (SLE, rheumatoid arthritis , scleroderma ), overdose of anticoagulants, intoxication with barbiturates, sulfonamides, benzene, aniline, methyl alcohol, anesthesin, carbon monoxide, dichloroethane, disulfiram, hydrocyanic acid, potassium permanganate, phenols, thallium, arsenic, quinine , aconite.

Taking the drug is also indicated during the recovery period after illnesses and surgical interventions.

Intravenous and intramuscular Ascorbic acid in ampoules is administered in situations where it is necessary to quickly compensate for vitamin C , as well as in situations where oral administration is impossible.

In particular, parenteral administration is required for Addison's disease , a number of gastrointestinal diseases (in conditions after resection of a section of the small intestine and gastrectomy , persistent diarrhea , peptic ulcer ).

Contraindications

Absolute contraindications:

hypersensitivity;
venous diseases complicated by thrombosis and .

Conditions in which Ascorbic acid is prescribed with caution:

diabetes;
fructose intolerance;
kidney pathologies (in particular, urolithiasis - when using more than 1 g per day);
hemochromatosis;
leukemia;
thalassemia;
progressive tumor diseases ;
sideroblastic and sickle cell anemia ;
polycythemia;
deficiency of the cytosolic enzyme G6PD.

In pediatrics, the restriction on the use of Ascorbic acid tablets is the age of up to 4 years. Tablets are prescribed from the age of six. Chewable tablets are not used in pediatric practice.

Side effects

From the heart, vascular and hematopoietic systems: neutrophilic leukocytosis , thrombocytosis , erythropenia , hyperprothrombinemia .

From the sensory organs and nervous system: weakness and dizziness (with too rapid administration of ascorbic acid intravenously).

From the digestive tract: when taken orally - diarrhea (when taking more than 1 g/day), irritation of the mucous membrane of the digestive canal, accompanied by nausea, diarrhea , vomiting, erosion of tooth enamel (with frequent use of chewing tablets or dissolving pills/tablets).

Metabolic disorders: disruption of metabolic processes, inhibition of glycogen , excessive formation of adrenergic steroids , water and Na retention, hypokalemia .

From the urogenital tract: increased diuresis , formation of oxalate stones (especially with long-term intake of more than 1 g per day), damage to the glomerular apparatus of the kidneys .

When injected into a muscle, pain at the injection site may occur; injection into a vein may be accompanied by a feeling of heat.

The substance is a strong allergen and can provoke hypersensitivity reactions even in cases where the person does not exceed the recommended daily dose.

Symptoms of an allergy to ascorbic acid manifest themselves in the form of skin hyperemia and the appearance of a skin rash.

Overdose and side effects

If you significantly exceed the dosage of ascorbic acid, its effectiveness will not increase.
On the contrary, it can aggravate some problems of the body, or create new ones.

In addition, excessive consumption of vitamin C increases the feeling of hunger and appetite, and accordingly increases cravings for unhealthy and high-calorie foods.

Abuse of ascorbic acid can lead to disorders from:

CNS - headaches, fatigue, malaise, increased excitability and sleep disturbances
Digestive system - nausea, vomiting, stomach cramps, stool upset, irritation of the gastrointestinal mucosa
Endocrine system - disruption of the pancreas - hyperglycemia, glycosuria
Urinary system - formation of stones in the bladder, excess of oxalic acid (hyperoxalaturia)
Cardiovascular system - increased blood pressure, thrombosis, development of microangiopathy, myocardial dystrophy

In addition, an overdose can cause various allergic reactions , including anaphylactic shock (extremely rare), and affect laboratory parameters - erythropenia, hypokalemia, hypoprothrombinemia, thrombocytosis, neutrophilic leukocytosis.

Other side effects are a feeling of heat, hypovitaminosis, fluid retention with sodium salts, disruption of the metabolic processes of copper and zinc.

Important! If any adverse symptoms appear and an overdose is suspected, you should stop taking the drug and consult a doctor for advice.

Hypervitaminosis

A significant overdose (more than 1000 mg/day) is manifested by the following symptoms :

Diarrhea;
Heartburn;
Difficulty urinating;
Red coloration of urine;
Hemolysis (destruction of red blood cells) - in people with glucose-6-phosphate dehydrogenase deficiency.

Overdose is treated systematically.

Instructions for use of Ascorbic acid

How to take oral forms of Ascorbic acid?

Dragees and tablets are recommended to be taken after meals. Chewable tablets should be chewed and washed down with a small amount of drinking water before swallowing.

Ascorbic acid powder is used to make drinks. To do this, 1 g of the product (about ⅓ teaspoon) is diluted in a liter of water or juice.

For preventive purposes, adults are advised to take from 0.05 to 0.1 g/day, the daily dose for a child varies from 0.025 to 0.075 g. Pregnant and lactating women should take 0.3 g/day in the first 10-15 days day, then the dose is reduced to 0.1 g/day.

For therapeutic purposes, adults, depending on the indications, are prescribed to take from 0.15 to 0.5 g/day. (dosage depends on indications). The daily dose is divided into 3-5 doses. For children, the daily dose is from 0.1 to 0.3 g. It should be divided into 2-3 doses. The duration of the course is 14 days.

The therapeutic dose of Ascorbic acid in the form of chewable tablets is 0.25 g/day. Treatment lasts from 10 to 15 days. For influenza , severe colds, vitamin deficiency and infectious diseases, the daily dose is increased by 2-4 times. Taking vitamin C in a higher dose is allowed for 7 to 10 days.

Instructions for Ascorbic acid in ampoules

IV ascorbic acid is administered in a stream or drip. The dose is selected individually depending on the nature and severity of the disease. For patients over 12 years of age, it varies from 0.05 to 0.15 g. In case of poisoning, the dosage can be increased to 3 g.

For children under 12 years of age, a single dose is 5-7 mg/kg.

The duration of treatment is determined by the nature of the pathological process and the effectiveness of therapy.

The highest single dose for an adult is 0.2 g, the daily dose is 1 g. For children, the dosage is selected depending on age. As a rule, the daily dose is:

up to six months - 0.03 g;
6-12 months - 0.035 g;
12 months-3 years - 0.04 g;
4-10 years - 0.045 g;
11-12 years old - 0.05 g.

The highest daily dose for a child under 12 years of age is 0.1 g.

The solution is injected in a stream over 1-3 minutes. The drug is administered dropwise slowly by intravenous infusion, having previously dissolved a single dose in 50-100 ml of 0.9% NaCl solution. The rate of administration is 30-40 drops per minute.

Intramuscular Ascorbic acid is injected deep into the muscle.

Ascorbic acid with glucose

Ascorbic acid with glucose is prescribed for the prevention and treatment of infectious diseases in weakened patients.

The prophylactic dose for an adult is 0.5-1 tablets/day, the therapeutic dose is from 1.5 to 5 tablets/day. For children over 5-6 years old, the prophylactic dose is 0.5 tablets/day. therapeutic - 1-3 tablets/day.

Glucose with ascorbic acid is prescribed intravenously for the prevention of secondary infection, pulmonary edema , renal and hepatic failure and a number of other pathologies. The benefits of this remedy are also enormous for pregnant women who suffer from severe toxicosis and need additional support for the body. In each specific case, the dose is selected individually.

Reviews indicate that many people (especially people on a diet) use ascorbic acid tablets with glucose instead of prohibited sweets, believing that they are less harmful. The calorie content of glucose is 340 kcal, and one tablet contains 877 mg. That is, 1 tablet is approximately 30 kcal.

However, using the drug instead of sweets and regularly exceeding the daily requirement of vitamin C is fraught with serious stomach problems.

Ascorbic acid tablets

Ascorbic acid

Registration number: LS-000912.

Trade name: ASCORBIC ACID

International nonproprietary name: Ascorbic acid.

Dosage form: pills.

Compound:

Composition for one dragee:

Active components:

0.05 g ascorbic acid

Excipients: sugar, starch syrup, sunflower oil, wax, talc, aromatic essence, quinoline yellow dye E-104.

Description

The dragee is greenish-yellow or yellow in color, spherical in shape, uniform in color.

Pharmacotherapeutic group

Vitamin.

CodeATKH A11 G A01

Pharmacological properties

Ascorbic acid is actively involved in many redox reactions and has a nonspecific general stimulating effect on the body. Increases the body's adaptive abilities and its resistance to infections; promotes regeneration processes.

Indications for use

Prevention and treatment of hypo- and vitamin C deficiency.

As an aid: hemorrhagic diathesis, nasal, uterine, pulmonary bleeding; overdose of anticoagulants; diseases of the gastrointestinal tract accompanied by impaired absorption of vitamin C; slowly healing wounds.

Increased physical and mental stress, pregnancy and breastfeeding, recovery period after serious long-term illnesses.

Contraindications

Hypersensitivity to the components of the drug, thrombophlebitis, tendency to thrombosis, diabetes mellitus.

Carefully:

Hyperoxalaturia, renal failure, hemochromatosis, thalassemia, polycythemia, leukemia, sideroblastic anemia, glucose-6-phosphate dehydrogenase deficiency, sickle cell anemia, progressive malignant diseases, pregnancy.

Directions for use and doses

The drug is taken orally after meals.

For prevention: adults 0.05-0.1 g (1-2 tablets) per day, children over 5 years old 0.05 g (1 tablet) per day.

For treatment: adults 0.05-0.1 g (1-2 tablets) 3-5 times a day, children from 5 years old 0.05-0.1 g (1-2 tablets) 2-3 times a day day.

During pregnancy and breastfeeding, 0.3 g (6 tablets) per day for 10-15 days, then 0.1 g (2 tablets per day) per day.

Side effect

From the central nervous system (CNS): headache, feeling of fatigue, with prolonged use of large doses - increased excitability of the central nervous system, sleep disturbances.

From the digestive system: irritation of the gastrointestinal mucosa, nausea, vomiting, diarrhea, stomach cramps.

From the endocrine system: inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glycosuria).

From the urinary system: when used in high doses, hyperoxalaturia and the formation of urinary stones from calcium oxalate.

From the cardiovascular system: thrombosis, when used in high doses - increased blood pressure, development of microangiopathies, myocardial dystrophy.

Allergic reactions: skin rash, rarely - anaphylactic shock.

Laboratory indicators: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.

Other: hypervitaminosis, feeling of heat, with prolonged use of large doses - sodium (Na+) and fluid retention, metabolic disorders of zinc (Zn2+), copper (Cu2+).

Overdose

When taking more than 1 g per day, heartburn, diarrhea, difficulty urinating or red urine, and hemolysis (in patients with glucose-6-phosphate dehydrogenase deficiency) are possible.

If any side effects occur, you should stop taking the drug and consult a doctor.

Interaction with other drugs

Increases the concentration of benzylpenicillin and tetracyclines in the blood; at a dose of 1 g/day increases the bioavailability of ethinyl estradiol. Improves the absorption of iron preparations in the intestines (converts ferric iron to divalent iron); may increase iron excretion when used concomitantly with deferoxamine. Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drinks reduce absorption and absorption. When used simultaneously with ASA, the urinary excretion of ascorbic acid increases and the excretion of ASA decreases. ASA reduces the absorption of ascorbic acid by approximately 30%. Increases the risk of developing crystalluria during treatment with salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), and reduces the concentration of oral contraceptives in the blood. Increases the overall clearance of ethanol, which, in turn, reduces the concentration of ascorbic acid in the body. Quinoline drugs (fluoroquinolones, etc.), calcium chloride, salicylates, and glucocorticosteroids with long-term use deplete ascorbic acid reserves. When used simultaneously, it reduces the chronotropic effect of isoprenaline. Long-term use or use in high doses may interfere with the disulfiram-ethanol interaction. In high doses, it increases the renal excretion of mexiletine. Barbiturates and primidone increase the excretion of ascorbic acid in the urine. Reduces the therapeutic effect of antipsychotics (phenothiazine derivatives), tubular reabsorption of amphetamine and tricyclic antidepressants.

special instructions

Due to the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor adrenal function and blood pressure.

With long-term use of large doses, inhibition of the function of the pancreatic insular apparatus is possible, so it must be regularly monitored during treatment.

In patients with high iron levels in the body, ascorbic acid should be used in minimal doses.

Prescribing ascorbic acid to patients with rapidly proliferating and intensively metastasizing tumors can aggravate the process. Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (blood glucose, bilirubin, transaminase activity, LDH).

Use during pregnancy and breastfeeding

The minimum daily requirement for ascorbic acid in the II-III trimesters of pregnancy is about 60 mg. The minimum daily requirement during breastfeeding is 80 mg. A mother's diet containing adequate amounts of ascorbic acid is sufficient to prevent vitamin C deficiency in an infant (it is recommended that a nursing mother not exceed the maximum daily requirement for ascorbic acid).

Release form

Dragee 0.05 g.

200 pieces in glass jars or polymer jars. 10 pieces per blister pack.

Each jar or 5 blister packs along with instructions for medical use are placed in a pack.

It is allowed to place 150 cans or blister packs together with an equal number of instructions in cardboard boxes.

Conditions for dispensing from pharmacies

Over the counter.

Storage conditions:

In a dry place, protected from light, at a temperature not exceeding 25°C.

Best before date:

2 years. Do not use after the expiration date.

Units:

pack

Overdose

An overdose of Ascorbic acid develops with prolonged use of doses exceeding 1 gram per day. Its signs are:

headache;
nausea;
insomnia;
increased excitability of the central nervous system;
ulceration of the mucous membrane of the digestive canal;
vomit;
diarrhea;
inhibition of the functional activity of the pancreas insular apparatus;
nephrolithiasis;
oxalosis;
hyperacid gastritis;
moderate pollakiuria;
damage to the glomerular (glomerular) apparatus of the kidneys;
decreased permeability of capillary walls.

In some cases, blood pressure and blood clotting increase, tissue trophism worsens, and microangiopathies .

Intravenous administration of high doses of vitamin C can provoke erythrocytolysis and abortion.

The lethal dose of vitamin C is 20-30 grams.

Interaction

Ascorbic acid (A.A.) increases the plasma concentration of salicylates , ethinyl estradiol , tetracycline antibiotics , benzylpenicillin ; reduces - oral contraceptives

Absorption and assimilation of A.K. is disrupted by gastrointestinal pathologies ( diarrhea/constipation , peptic ulcer , gastritis , giardiasis , helminthic infestation ), taking the drug with alkaline drinks, as well as with fresh juices from fruits and vegetables, in combination with oral contraceptives and acetylsalicylic acid .

A.k. increases the activity of norepinephrine , reduces the effectiveness of heparin and coumarin anticoagulants , improves the absorption of iron preparations in the intestinal tract.

In combination with deferoxamine, it can provoke an increase in tissue toxicity of iron (including cardiotoxicity ) and lead to the development of heart failure .

Increases the total plasmatic clearance of ethyl alcohol. Affects the effectiveness of disulfiram .

Vitamin C reserves are depleted with long-term use of calcium chloride, quinoline , salicylates , and corticosteroids .

Solution A.K. interacts with most medications when mixed in one syringe.

special instructions

Wikipedia states that vitamin C (L-ascorbic acid) is an organic compound related to glucose. Its benefits for the human body are enormous - the vitamin functions as a coenzyme for a number of metabolic processes, an antioxidant and a reducing agent.

Structural formula of ascorbic acid:

According to the International Pharmacopoeia, the substance has the form of an almost white or white crystalline powder with a sour taste. Easily soluble in water, soluble in ethanol (approximately 750 g/l) TS, practically insoluble in other organic solvents, the powder is practically insoluble. Belongs to the category of antiscorbutic drugs.

Vitamin C in solution is quickly destroyed by exposure to air; Even in a light-protected place, it gradually collapses in a humid atmosphere. The rate of destruction increases with increasing temperature.

Ascorbic acid is present in all tissues of higher plants and animals. Man, unlike most animals, in the process of evolution, due to mutation, has lost the ability to independently synthesize vitamin C , and receives it exclusively from food.

OKPD code for ascorbic acid ( vitamin C ) is 24.41.51.180. For the food industry, the substance is obtained in accordance with GOST 4815-76.

Quantitative determination of a substance

Methods for quantitative determination of A.c. based on its pronounced restorative properties.

The simplest, objective and accurate method is the determination method based on the ability of A.K. reduce ferric ions into ferrous ions.

The amount of Fe2+ ions formed is equimolar to the amount of A.c. in the analyzed sample (the minimum amount of A.C. in the sample is 10 nmol) and is determined by the color reaction with potassium iron sulfide.

What is ascorbic acid needed for?

The substance is involved in the processes of biotransformation of other vitamins , the formation of collagen , as well as the formation and exchange adrenaline and norepinephrine adrenal medulla , supplies hydrogen for the formation of nuclear DNA, reduces the body's need for B vitamins , increases the body's immunobiological resistance, affects the activity of leukocytes ; improving the absorption of Fe, thereby enhancing the synthesis of hemoglobin and the maturation of red blood cells , neutralizes toxins released by pathogenic microflora, accelerates the healing of wounds and postoperative sutures and the healing of fractures.

Ascorbic acid in urine is an important indicator of the health of the body. A small amount of vitamin C in urine may indicate problems with internal organs or the development of a tumor process. Elevated concentrations of ascorbic acid may indicate an unbalanced diet and the likelihood of kidney stones.

The daily rate of excretion of vitamin C in urine is 0.03 g. When diagnosing this indicator, we can conclude that a person receives a sufficient amount of ascorbic acid, and his body works optimally.

How many calories are in ascorbic acid?

100 grams of product contains 0.1 g of fat, 0.1 g of protein and 95.78 g of carbohydrates. This amount of carbohydrates allows you to compensate for more than a third (namely 35%*) of your daily requirement for them.

*The average nutritional value of products from different sources is given. Data may vary depending on the origin of the product. The value is given for a diet that involves consuming 2 thousand kcal per day.

Calorie content of 100 grams of product is 970 kJ or 231.73 kcal.

Why is ascorbic acid useful in cosmetology?

In cosmetology, ascorbic acid is used in preparations that slow down aging, restore protective functions and accelerate healing.

The easiest way to use vitamin C for hair is to add powder (crushed tablet) or solution to a single serving of shampoo or hair mask. Ascorbic acid should be added to care products immediately before use.

Such simple procedures can restore hair structure, prevent hair loss, and make hair soft and shiny.

For the face, ascorbic acid is most often used in powder. Before the procedure, the powder (or crushed tablets) is mixed with mineral water to form a thick paste. The product is applied to the face for 20 minutes and then washed off.

Daily rubbing with a solution of ascorbic acid diluted with mineral water in a 1:1 ratio is also beneficial for the face. You can also add the solution/powder to homemade masks.

How is ascorbic acid beneficial for athletes?

Vitamin C is a stimulator of muscle mass anabolism, which makes its use in bodybuilding appropriate. In addition, scientists were able to prove that by suppressing the process of peroxidation and cortisol , it also has an anti-catabolic effect . Thus, taking vitamin C before exercise will protect your muscles and slow down protein breakdown.

Upon completion of a course of anabolic steroids, ascorbic acid is taken as a component of PCT (post-cycle therapy).

Ascorbic acid to induce menstruation

High doses of vitamin C prevent the entry of progesterone into the uterus, so ascorbic acid is often taken when menstruation is late.

However, doctors do not advise abusing this method. Firstly, repeated use of ascorbic acid can cause problems with the gastrointestinal tract. Secondly, taking pills can make it difficult to diagnose the causes of menstrual irregularities and further treatment.

Precautionary measures

Too rapid intravenous administration of ascorbic acid solution should be avoided. If long-term use of the drug is necessary, monitoring of blood pressure, renal function, and glucose levels is necessary.

Ascorbic acid alters laboratory test results.

Ascorbic acid brings not only benefits, but also harm

A high-quality medication containing ascorbic acid is considered safe for health. However, it should be used in moderation; an overdose is fraught with side effects.

People who have ulcers, gastritis or other stomach problems need to be especially careful. In large quantities, vitamin C causes diarrhea, stomach and bladder upset, abdominal pain, and sometimes even cramps.

Also, long-term and excessive use of this element is fraught with the formation of kidney stones, if there is a predisposition. Like other drugs, ascorbic acid can cause allergic reactions. In this case, you should stop taking it and consult a doctor.

Whether ascorbic acid will bring benefit or harm depends on the correct use of it and the individual characteristics of the body.

For weight loss

Ascorbic acid does not reduce the amount of subcutaneous fat and cannot eliminate the consequences of an unbalanced diet and inactive lifestyle, so using it as an independent means for losing weight is not advisable.

However, vitamin C is by no means an unnecessary addition to the diet of those losing weight, because it helps strengthen the immune system, improve overall well-being in chronic diseases and more quickly restore muscles after physical activity.

Can it be used for weight loss?

Vitamin C is without a doubt essential in the fight against excess weight; But ascorbic acid by itself is not able to cope with the problem of obesity; an integrated approach to eliminating the problem is needed - nutrition, training and vitamins.

Ascorbic acid actively helps restore the body's internal resources after physical training or illness.

In order to get the maximum benefit from a vitamin, you need to figure out when and how to take it correctly.

If you take ascorbic acid before meals , it will help slightly reduce your appetite.

If you take a vitamin after a meal , on the contrary, your appetite increases and a strong feeling of hunger awakens - this can lead to a violation of your diet or eating regimen.

Reference! Many cafes in fitness centers offer various vitamin cocktails with ascorbic acid. Undoubtedly, there will be benefits from them, but if you abuse such cocktails, the sugar they contain can adversely affect the process of losing weight.

Can pregnant women take ascorbic acid?

The minimum requirement for ascorbic acid during pregnancy is approximately 0.06 g/day. (in the 2nd and 3rd trimesters). It is important to consider that the fetus can adapt to increased doses of vitamin C . The consequence of this may be withdrawal syndrome in the newborn.

In accordance with the FDA classification, injectable forms of ascorbic acid belong to group C on the scale of possible risks to the fetus. The administration of the solution can be prescribed to a pregnant woman only if absolutely necessary.

The use of high doses intravenous vitamin C

The minimum requirement during breastfeeding is 0.08 g/day. Theoretically, there are certain risks for the child when a nursing woman uses too high doses of vitamin C.

Ascorbic acid: benefits

Ascorbic acid is beneficial for the following negative manifestations:

insomnia, poor sleep with nightmares;
bleeding gums and loose teeth;
pain in the lower extremities;
prolonged wound healing;
pale skin;
general weakness and weakness
frequent colds;
low-grade fever.

Ascorbic acid is useful in the body's fight against various infections and viruses. It helps with inflamed lymph nodes, strengthens the walls of blood vessels, helps cleanse the blood and eliminate free radicals.

Vitamin C helps the body fight dermatological and allergic problems, improves skin condition, promotes its rejuvenation, hair becomes more well-groomed, and glands produce hormones like a clockwork mechanism. Acid improves the absorption of iron, blood clotting, and also normalizes metabolism, promoting the formation of lipids, proteins and the breakdown of fats.

Reviews about Ascorbic acid

It is impossible to find negative reviews about ascorbic acid. Ascorbic acid is a tasty and healthy medicine that helps alleviate the symptoms of the acute period of infectious diseases and improve the body’s condition in chronic pathologies. It is used as an independent remedy or in combination with other vitamins or with glucose .

Everyone probably knows about the benefits of vitamin C. However, reviews about it also mention little-known properties of ascorbic acid, for example, its ability to induce menstruation. Some women claim that it was thanks to taking ascorbic acid that they were able to regulate their cycle without the use of hormones.

The scheme for using Ascorbic acid to normalize menstruation is simple: count 10 days from the last day of menstrual bleeding and take 1 gram of vitamin C daily from 11 to 20.

What is ascorbic acid

Ascorbic acid is an organic compound with the formula C6H8O6.
It is necessary for the normal functioning of all systems and organs of the body, therefore it must be present in the human diet every day.

The vitamin also has antioxidant, regenerative and metabolic effects.

Visually, ascorbic acid looks like a white crystalline powder with a sour taste.

This powder dissolves well in water and alcohol.

Ascorbic acid is found in sufficient quantities in most vegetables and fruits.

The main effect of ascorbic acid is anti-oxidation - it suppresses the activity of free radicals, which leads to proper reduction, oxidation and metabolic processes in the body.

Ascorbic acid is a kind of protector of cell membranes from various damages.

Functions

Vitamin C has a beneficial effect on the entire body:

Stimulates the immune system and protective functions of the body;
It has a preventive effect against infectious diseases, and also successfully helps to overcome existing infections;
Strengthens immunity to allergic manifestations and inflammatory processes;
Destroys toxic and harmful substances present in the blood;
Improves the process of hemoglobin formation;
Removes “bad” cholesterol, leaving “good”;
Improves the quality of blood clotting;
Enhances absorption of iron by the small intestine;
Normalizes the formation and production of bile;
Neutralizes the effect of toxic substances on the liver;
Plays an important role in the connection of hormones;
Activates the excretory activity of the pancreas;
Improves the functioning and performance of the thyroid gland.

Ascorbic acid price, where to buy

The average price of Ascorbic acid in 2 ml ampoules (package No. 10) is 39 rubles/20 UAH. The price of tablets varies depending on the concentration of the active substance and the number of tablets/dragés in the package. You can buy 0.025 g tablets (package No. 10) in Ukrainian pharmacies for 3 UAH, in Russian pharmacies for 7 rubles.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Ascorbic acid, etc. 50 mg 200 pcs JSC Ufimsky Vitam.Z-D
26 rub. order
Ascorbic acid with glucose tablets 100 mg 40 pcs JSC Ufimsky Vitam.z-d
41 rub. order
Ascorbic acid with sugar, orange flavor 25 mg 10 pcs (dietary supplement)Askoprom LLC RU
7 RUR order
Ascorbic acid tablets 50 mg 200 pcsAltaivitamins JSC
30 rub. order
Ascorbic acid-Marbiofarm with wild berry flavor 25mg tab No. 10JSC Marbiofarm
8 rubles order

Pharmacy Dialogue

Ascorbic acid (other No. 200) FS-UfaVita
26 RUR order
Ascorbic acid (Vitamin C) (amp. 5% 2ml No. 10) Biosynthesis OJSC
38 rub. order
Ascorbic acid powder 2.5gEcotex
4 RUR order
Ascorbic acid (por. 2.5 g (dietary supplement)) Meligen FP ZAO
7 RUR order
Ascorbic acid (table No. 10 with glucose) Ecotex
6 rubles order

Pharmacy24

Ascorbic acid 0.05g No. 50 dragee PAT "Kiev Vitamin Plant", Kiev, Ukraine
6 UAH. order
Ascorbic acid 0.025g N10 mint tablets PAT "Kiev Vitamin Plant", Kiev, Ukraine
5 UAH order
Ascorbic acid 50 mg N50 chewable tablets PAT "Lubnifarm", Ukraine
8 UAH order
Ascorbic acid glucose 0.1g No. 10 tablets PAT "Kiev Vitamin Plant", Kiev, Ukraine
4 UAH order
Ascorbic acid lemon 0.025 g No. 10 tablets PAT "Kiev Vitamin Plant", Kiev, Ukraine
5 UAH order

PaniPharmacy

Ascorbic acid solution d/in.50 mg/ml amp.2ml No. 10 Ukraine, Lekhim-Kharkov JSC
19 UAH order
Ascorbic acid solution d/in.100 mg/ml amp.2ml No. 10 Ukraine, Lekhim-Kharkov JSC
25 UAH order

Calorie content

The calorie content of modern ascorbic acid tablets and dragees is provided by glucose or sugar , which are almost always contained in the drug.

How many calories are in 1 tablet

For example, consider ascorbic acid “Sesana”. A plastic jar contains 200 dragees, small round yellow balls.

The weight of one dragee is 0.25 g. The packaging states that the calorie content of the drug is 283 kcal/100 g, respectively, the calorie content of 1 pill will be 0.7 kcal .

Ascorbic acid tablets with glucose

The calorie content of ascorbic acid with glucose, which is sold in rolled packs of 10 large tablets, is usually approximately 380 kcal/100g.

The mass of one such tablet is 3 grams, respectively, its calorie content will be 11.4 kcal .

Energy value of 1 pack of tablets

One pack of ascorbic acid with glucose consists of 10 tablets, rolled into a candy shape. The weight of such a pack is 30 g, and the calorie content is 380 kcal/100 g.

Accordingly, such a package will contain approximately 114 kcal .