Ascorbic acid solution for IV and IM administration 50 mg/ml or 100 mg/ml

pharmachologic effect

Ascorbic acid (vitamin C) is not formed in the human body, but comes only from food. Pharmacological effects: in quantities significantly exceeding the daily requirement (90 mg), it has almost no effect, with the exception of the rapid elimination of symptoms of hypo- and vitamin deficiency (scurvy). Physiological functions: is a cofactor in some hydroxylation and amidation reactions - transfers electrons to enzymes, providing them with a reducing equivalent.

Participates in the hydroxylation reactions of proline and lysine residues of procollagen with the formation of hydroxyproline and hydroxylysine (post-translational modification of collagen), the oxidation of lysine side chains in proteins with the formation of hydroxytrimethyllysine (in the process of kartinite synthesis), the oxidation of folic acid to folinic acid, the metabolism of drugs in liver microsomes and hydroxylation dopamine to form norepinephrine.

Increases the activity of amidating enzymes involved in the processing of oxytocin, antidiuretic hormone and cholecystokinin. Participates in steroidogenesis in the adrenal glands. The main role in tissues is participation in the synthesis of collagen, proteoglycans and other organic components of the intercellular substance of teeth, bones and capillary endothelium.

Compatibility of B vitamins in injections

B vitamins are antagonists, therefore, if you are prescribed drugs separately, and not in a complex, ready-made drug, they should be injected every other day. Otherwise, their effectiveness is lost. It is for this reason that B vitamins cannot be mixed in one syringe. Complex solutions work a little differently. Currently, pharmaceutical companies have learned to produce complex preparations of B vitamins, which contain special stabilizing substances that prevent the antagonists in the ampoule from being destroyed.

Pharmacokinetics

Communication with plasma proteins - 25%. The normal concentration of ascorbic acid in plasma is approximately 10 - 20 μg/ml. Easily penetrates into leukocytes, platelets, and then into all tissues; the highest concentration is achieved in the glandular organs, leukocytes, liver and lens of the eye; penetrates the placenta. The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and plasma. In deficiency states, leukocyte concentrations decline later and more slowly and are considered a better measure of deficiency than plasma concentrations.

Metabolized primarily in the liver into deoxyascorbic acid and further into oxaloacetic acid and ascorbate-2-sulfate.

It is excreted by the kidneys, through the intestines, with sweat, breast milk unchanged and in the form of metabolites. When high doses are prescribed, the rate of elimination increases sharply. Smoking and drinking ethanol accelerate the destruction of ascorbic acid (conversion into inactive metabolites), sharply reducing reserves in the body. Excreted during hemodialysis.

Indications for use

Treatment of hypo- and vitamin C deficiency (if it is necessary to quickly replenish vitamin C and the impossibility of oral administration). Used for medicinal purposes in all clinical situations associated with the need for additional administration of ascorbic acid, including: parenteral nutrition, diseases of the gastrointestinal tract (persistent diarrhea, resection of the small intestine, peptic ulcer, gastrectomy), Addison's disease.

In laboratory practice: for marking red blood cells (together with sodium chromate Cr51).

Contraindications

Hypersensitivity, with long-term use in large doses (more than 500 mg) - diabetes mellitus, hyperoxaluria, nephrolithiasis, hemochromatosis, thalassemia, glucose-6-phosphate dehydrogenase deficiency.

Carefully

Sideroblastic anemia, urolithiasis.

Use during pregnancy and lactation

During pregnancy and lactation, they are used only if the expected benefit to the mother outweighs the potential risk to the fetus and child. The minimum daily requirement for ascorbic acid in the II-III trimesters of pregnancy is about 60 mg. It should be borne in mind that the fetus can adapt to high doses of ascorbic acid taken by a pregnant woman, and then the newborn may develop ricochet scurvy syndrome. With long-term use of large doses, inhibition of the function of the pancreatic insular apparatus is possible, so it must be regularly monitored during treatment. In patients with high iron levels in the body, ascorbic acid should be used in minimal doses. Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (the content of glucose, bilirubin in the blood and urine, the activity of “liver” transaminases and lactate dehydrogenase).

Impact on the ability to drive vehicles and operate machinery

During the treatment period, care must be taken when driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Reviews

11/02/2018 Clinic with a normal nurse. I was given intramuscular injections. No blood, no vein problems.

T.H.

01/26/2018 The plasma therapy procedure helped a lot. The hip joint did not give rest either day or night. It was painful to walk, sit, and stand up. After five sessions I feel almost healthy. Special thanks to Dr. Usenko N.S.

Bestuzhev

Read also:  Sumamox 100 mg/5 ml 20 ml (4 doses) granules for preparation. suspensions (azithromycin)

09/04/2017 Many thanks to Dr. Shogenov R.K. The plasma therapy procedure put me on my feet, my back pain went away. I wish you health and prosperity.

Zaitseva

Read all reviews

Directions for use and doses

Intravenous, intramuscular (slow), adults from 100 to 500 mg (2 - 10 ml of 50 mg/ml solution or 1 - 5 ml of 100 mg/ml solution) per day, for the treatment of scurvy - up to 1000 mg per day.

Children from 100 to 300 mg (2 - 6 ml of 50 mg/ml solution or 1 - 3 ml of 100 mg/ml solution) per day, for the treatment of scurvy - up to 500 mg (10 ml of 50 mg/ml solution or 5 ml of 100 mg/ml solution mg/ml) per day.

To mark red blood cells (together with sodium chromate Cr51), 100 mg of ascorbic acid is injected into a vial with sodium chromate Cr51.

Side effect

From the central nervous system: with rapid intravenous administration - dizziness, feeling of fatigue; with long-term use of large doses (more than 1 g) - headache, increased excitability of the central nervous system, insomnia.

From the urinary system: moderate pollakiuria (when using a dose of more than 600 mg/day), with long-term use of large doses - hyperoxaluria, nephrolithiasis (from calcium oxalate), damage to the glomerular apparatus of the kidneys.

From the cardiovascular system: with long-term use of large doses - a decrease in capillary permeability (possible deterioration of tissue trophism, increased blood pressure, hypercoagulation, development of microangiopathies).

Allergic reactions: allergic reactions up to the development of anaphylactic shock.

Laboratory indicators: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia, glycosuria.

Local reactions: pain at the site of intramuscular injection.

Other: with long-term use of large doses (more than 1 g) - inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glycosuria), with intravenous administration - threat of miscarriage (due to estrogenemia), hemolysis of red blood cells.

Overdose

Symptoms: nephrolithiasis, insomnia, irritability, hypoglycemia.

Treatment: symptomatic, forced diuresis.

What vitamins help with osteochondrosis?

One of the contributing factors in the appearance and progression of osteochondrosis is an unbalanced diet and improperly dosed physical activity. And if degenerative changes are already visible on an MRI of the spine or make themselves felt by back pain, a feeling of numbness or tingling in the extremities, a neurologist can prescribe vitamin therapy for you - injection or drip administration of B vitamins. A regimen of vitamin injections is developed individually depending on your needs , complaints and health status of each patient. So, to maintain muscles and muscle corset, injections of vitamin B6 are given. This vitamin is also needed for the normal functioning of the nervous system, so when there is compression of the nerve roots, it is advisable to use drugs containing pyridoxine. Vitamin B1 injections have a positive effect on the functioning of the entire central and peripheral nervous system. Especially injections of this vitamin are beneficial for improving the functioning of the nerves responsible for nutritional processes in tissues. A neurologist will prescribe a course of vitamin B12 injections for the prevention and treatment of demyelination (the process of destruction of nerve cells and damage to the nerve sheath). In addition to B vitamins, vitamin D is sometimes prescribed for degenerative changes in the spine. Vitamin D or calciferol is a vitamin that determines the ratio of calcium and phosphorus in the body. The positive effects of vitamin D are still being studied. Thus, D-vitamin therapy is even used to prevent the development of cerebral atherosclerosis and slow down the aging of the body. The form of taking this vitamin is through the mouth (orally). These vitamins are produced in oil and water solutions. Thus, by undergoing inexpensive complex treatment with vitamins for osteochondrosis, the patient can reduce or completely eliminate symptoms such as:

• numbness in the limbs;
• tingling or nagging pain in the arms and legs.

Interaction with other drugs

Pharmaceutically incompatible with aminophylline, bleomycin, cefazolin, cefapirin, chlordiazepoxide, estrogens, dextrans, doxapram, erythromycin, methicillin, nafcillin, benzylpenicillin, warfarin.

Increases the concentration of benzylpenicillin and tetracyclines in the blood; at a dose of 1 g/day increases the bioavailability of ethinyl estradiol (including that included in oral contraceptives). Reduces the effectiveness of heparin and indirect anticoagulants.

When used simultaneously with acetylsalicylic acid, the urinary excretion of ascorbic acid increases and the excretion of acetylsalicylic acid decreases.

Increases the risk of developing crystalluria during treatment with salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), and reduces the concentration of oral contraceptives in the blood. Increases the overall clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.

Quinoline drugs, calcium supplements, salicylates, and glucocorticosteroids deplete ascorbic acid reserves when used for a long time.

When used simultaneously, it reduces the chronotropic effect of isoprenaline.

With long-term use or use in high doses, it may interfere with the interaction of disulfiram and ethanol. In high doses, it increases the excretion of mexiletine by the kidneys. Barbiturates and primidone increase the excretion of ascorbic acid in the urine.

Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

Where to get injections of B vitamins in St. Petersburg?

MRI and ultrasound center RIORIT

Area:

Kalininsky

Metro:

metro station Grazhdansky Prospekt, metro station Devyatkino, metro station Prospekt Prosveshcheniya

Address:

St. Petersburg, Kalininsky district, st. Rustaveli, 66 lit. G

Telephone:

Equipment:

Siemens, open type

Schedule:

Around the clock

Vitamin B deficiency

Vitamin B9 (folic acid) is a water-soluble vitamin. It is especially necessary for women during pregnancy for the development of the fetus. A normal amount of this vitamin reduces the possibility of intrauterine defects.

read more

Vitamin B deficiency

Vitamin B1 (thiamine) is a water-soluble vitamin, one of the most famous of the entire B group. Vitamin B1 deficiency is quite common because it is heavily consumed by the body. This is an essential vitamin that is involved in energy metabolism. It normalizes the activity of the central nervous, cardiovascular and endocrine systems.

read more

Vitamin B deficiency

Vitamin B6 (pyridoxine) is a water-soluble vitamin. In pharmacies it is often sold in the form of ampoules with a solution. The fact is that this vitamin, like vitamins B1, B12, C, can be isolated and made into a solution. It is worth noting that this vitamin is not synthesized by the body; it comes only from the outside.

read more