Diclofenac-Acri ointment for external use 1% 30g
Compound
Active substance: diclofenac sodium - 1 g. Excipients: dimethyl sulfoxide (dimexide), macrogol (polyethylene oxide 1500), macrogol (polyethylene oxide 400), propylene glycol, succinic acid.
Pharmacokinetics
When applied, systemic absorption is no more than 6%. When applied to the area of the affected joint, the concentration in the synovial fluid is higher than in the plasma.
Indications for use
- Post-traumatic inflammation of soft tissues and joints, for example, as a result of sprains, strains and bruises.
- Rheumatic diseases of soft tissues (tenosynovitis, bursitis, damage to periarticular tissues).
- Pain and swelling associated with diseases of muscles and joints (osteoarthrosis, radiculitis, lumbago, sciatica, muscle pain of rheumatic and non-rheumatic origin).
Contraindications
Hypersensitivity to diclofenac or other components of the drug, to acetylsalicylic acid or other NSAIDs, anamnestic data on an attack of bronchial obstruction, rhinitis;
urticaria after taking acetylsalicylic acid or other NSAIDs, pregnancy (III trimester), lactation period, children (up to 6 years), violation of the integrity of the skin. Carefully:
Hepatic porphyria (exacerbation), erosive and ulcerative lesions of the gastrointestinal tract, severe dysfunction of the liver and kidneys, chronic heart failure, old age, bronchial asthma, pregnancy (I and II trimester).
Directions for use and doses
Externally.
For adults and children over 12 years of age, the drug is applied in a thin layer over the area of inflammation 3-4 times a day and lightly rubbed in. The required amount of the drug depends on the size of the painful area. A single dose of the drug is 2-4 g (in volume comparable to the size of a large cherry).
For children from 6 to 12 years of age, use no more than 2 times a day, a single dose of the drug is up to 2 g.
After applying the drug, hands must be washed.
The duration of treatment depends on the indications and the observed effect. After 2 weeks of using the drug, you should consult your doctor.
Storage conditions
At a temperature not higher than 15°C.
Short-term storage of the drug is allowed at a temperature not exceeding 25°C for 2 days. Keep out of the reach of children.
Best before date
4 years. Do not use after expiration date.
special instructions
- The ointment should be applied only to intact skin, avoiding contact with open wounds.
- After application, do not apply an occlusive dressing.
- The drug should not come into contact with the eyes and mucous membranes.
- When using the drug together with other dosage forms of diclofenac, the maximum daily dose should be taken into account.
- When applied to large surface areas of the skin for a long time, the risk of developing systemic side effects characteristic of NSAIDs increases.
Description
NSAIDs for external use.
Use in children
The use of the drug is contraindicated in children under 6 years of age.
Pharmacodynamics
The active component diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) with pronounced analgesic and anti-inflammatory properties.
Indiscriminately inhibiting cyclooxygenase types 1 and 2, it disrupts the metabolism of arachidonic acid and the synthesis of prostaglandins, which are the main link in the development of inflammation.
Diclofenac-Akrikhin is used to eliminate pain and reduce swelling associated with the inflammatory process. When applied topically, it causes a weakening or disappearance of joint pain at rest and during movement. Reduces morning stiffness and swelling of joints, helps increase range of motion.
Side effects
Local reactions: eczema, photosensitivity, contact dermatitis (itching, redness, swelling of the treated skin area; papules, vesicles, peeling).
Systemic reactions: generalized skin rash, allergic reactions (urticaria, angioedema, bronchospastic reactions).
Use during pregnancy and breastfeeding
The drug should not be used in the third trimester of pregnancy.
There is no experience with the use of the drug during lactation.
Use in the first and second trimesters is possible only after consultation with a doctor.
Interaction
The drug may enhance the effect of drugs that cause photosensitivity. Clinically significant interactions with other drugs have not been described.
Overdose
The extremely low systemic absorption of the active components of the drug when used externally makes overdose almost impossible.
Impact on the ability to drive vehicles and operate machinery
Does not affect.
Buy Diclofenac retard-Akrikhin film-coated tablets 100 mg No. 20 in pharmacies
Active ingredients Diclofenac
Pharmacological action Diclofenac is a non-steroidal anti-inflammatory drug (NSAID). It has anti-inflammatory, analgesic and antipyretic effects. Inhibits the COX enzyme in the arachidonic acid metabolic cascade and disrupts the biosynthesis of prostaglandins. When applied externally, it has an anti-inflammatory and analgesic effect. Reduces and relieves pain at the site of application of the ointment (including pain in the joints at rest and during movement), reduces morning stiffness and swelling of the joints. Helps increase range of motion.
Indications Inflammatory and inflammation-activated degenerative forms of rheumatism: - chronic polyarthritis; — ankylosing spondylitis (ankylosing spondylitis); - arthrosis; — spondyloarthrosis; - neuritis and neuralgia, such as cervical syndrome, lumbago (lumbago), sciatica; - acute attacks of gout. Rheumatic lesions of soft tissues. Painful swelling or inflammation after injury or surgery. Non-rheumatic inflammatory pain conditions.
Contraindications - pathological changes in the blood picture of unknown origin; - peptic ulcer of the stomach and duodenum; — destructive and inflammatory bowel diseases in the acute phase; - pregnancy; - lactation period (breastfeeding should be avoided); - childhood and adolescence up to 12 years (i.m. administration, supp.); - children under 6 years of age (tablets, ointment); - hypersensitivity to acetylsalicylic acid or other NSAIDs (including the “aspirin triad”); - hypersensitivity to diclofenac and other components of the drug; - inflammation of the rectum - proctitis (suppositories)
Taking the drug Diclofenac is possible only under the strict supervision of a physician after a careful assessment of the benefit/risk ratio in the following conditions: congenital disorder of hematopoiesis (induced porphyria); systemic lupus erythematosus and other systemic connective tissue diseases; the presence of complaints about the function of the gastrointestinal tract, or if a gastric or duodenal ulcer is suspected, as well as erosive and ulcerative lesions (ulcerative colitis, Crohn's disease); in patients with pre-existing kidney disease and/or severe liver dysfunction; with severe arterial hypertension and/or heart failure; in elderly patients; immediately immediately after surgery.
With great caution and only under the direct supervision of a physician, Diclofenac can be used in patients with bronchial asthma, allergic rhinitis, polyps of the nasal mucosa, as well as in chronic obstructive respiratory diseases and chronic respiratory tract infections due to the risk of an asthma attack, Quincke's edema or hives.
Special instructions Use the drug with caution simultaneously with other NSAIDs. Effect on the ability to drive a car and operate machinery Due to the fact that when using the drug in high doses, side effects such as dizziness and fatigue may develop, in some cases the ability to drive a car or other moving objects is impaired. These phenomena are enhanced by simultaneous intake of alcohol.
Composition: 1 tablet contains diclofenac sodium 100 mg; excipients: ludipress, hydroxypropyl methylcellulose, magnesium stearate, aerosil, stearic acid, polyethylene glycol, glycerin, titanium dioxide, iron oxide.
Directions for use and dosage: Orally, without chewing, before, during or after meals, with a small amount of water. Adults - 100 mg 1 time per day. For dysmenorrhea and migraine attacks - up to 200 mg/day. When taking 100 mg of retard, if it is necessary to increase the daily dose to 150 mg/day, you can additionally take 1 regular tablet (50 mg). The maximum daily dose is 150 mg.
Side effects Side effects depend on individual sensitivity, the dose used and the duration of treatment. From the digestive system: nausea, vomiting, epigastric pain, anorexia, flatulence, constipation, gastritis up to erosive with bleeding, increased transaminase activity, drug-induced hepatitis, pancreatitis. From the urinary system: interstitial nephritis. From the side of the central nervous system: headache, dizziness, disorientation, agitation, insomnia, irritability, fatigue, aseptic meningitis. From the respiratory system: bronchospasm. From the hematopoietic system: anemia, thrombocytopenia, leukopenia, agranulocytosis. Dermatological reactions: exanthema, erythema, eczema, hyperemia, erythroderma, photosensitivity. Allergic reactions: erythema multiforme, Lyell's syndrome, Stevens-Johnson syndrome, anaphylactic reactions, including shock. Other: fluid retention in the body, edema, increased blood pressure.
Drug interactions When using the drug Diclofenac simultaneously with digoxin, phenytoin or lithium preparations, it is possible to increase the plasma concentrations of these drugs; with diuretics and antihypertensive drugs - the effect of these drugs may be reduced; with potassium-sparing diuretics - hyperkalemia may develop; with acetisalicylic acid - a decrease in the concentration of diclofenac in the blood plasma and an increased risk of side effects. Diclofenac may enhance the toxic effect of cyclosporine on the kidneys. Diclofenc can cause hypo- or hyperglycemia, therefore, when used simultaneously with hypoglycemic agents, monitoring of blood glucose concentrations is required. When using methotrexate within 24 hours before or after taking Diclofenac, the concentration of methotrexate may increase and its toxic effect may increase. When used simultaneously with anticoagulants, regular monitoring of blood clotting parameters is necessary.
Overdose Symptoms: dizziness, headache, hyperventilation, clouding of consciousness, vomiting, bleeding from the gastrointestinal tract, diarrhea, tinnitus, convulsions, in case of significant overdose - acute renal failure, hepatotoxic effect. Treatment: gastric lavage, taking activated charcoal. Symptomatic therapy is aimed at eliminating increased blood pressure, impaired renal function, seizures, gastrointestinal irritation, and respiratory depression. Forced diuresis and hemodialysis are ineffective (due to the significant connection with proteins and intensive metabolism).
Storage conditions Store in a dry place, protected from light, at a temperature not exceeding 25 C.
Conditions for dispensing from pharmacies Dispensed with a doctor's prescription
The appearance of the product may differ from the product shown in the photo.
Diclofenac-Akrikhin retard tablets 100 mg No. 20
A country
Russia
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.
Active substance
Diclofenac
Compound
1 tablet contains: diclofenac sodium 100 mg.
Excipients: ludipress LCE (lactose monohydrate - 94.7-98.3%, povidone - 3-4%), hypromellose (hydroxypropyl methylcellulose), microcrystalline cellulose, magnesium stearate, colloidal silicon dioxide (Aerosil 200), stearic acid. Shell composition: hypromellose (hydroxypropyl methylcellulose), macrogol (polyethylene glycol 6000), glycerol (glycerin), talc, titanium dioxide, red iron oxide dye. Extended-release tablets, film-coated, light brown or pinkish-brown in color, round, biconvex. Roughness is allowed. On the fracture it is white with a creamy or yellowish tint.
pharmachologic effect
Nonsteroidal anti-inflammatory drug (NSAID), a derivative of phenylacetic acid. It has anti-inflammatory, analgesic, antipyretic and antiplatelet effects. By indiscriminately inhibiting COX-1 and COX-2, it disrupts the metabolism of arachidonic acid, reduces the amount of prostaglandins in the site of inflammation, and suppresses the exudative and proliferative phases of inflammation. In rheumatic diseases, the anti-inflammatory and analgesic effect of diclofenac helps to significantly reduce the severity of pain, morning stiffness, and swelling of the joints, which improves the condition of the joint. For injuries, in the postoperative period, diclofenac reduces pain and inflammatory swelling.
Indications for use
Inflammatory and degenerative diseases of the musculoskeletal system: - rheumatoid arthritis; - psoriatic arthritis; - juvenile chronic arthritis; - ankylosing spondylitis (ankylosing spondylitis); - gouty arthritis (in case of an acute attack of gout, fast-acting dosage forms are preferred); - rheumatic lesions of soft tissues; — osteoarthritis of peripheral joints and spine, incl. with radicular syndrome; - tendovaginitis, bursitis. The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use, and does not affect the progression of the disease. Pain syndrome of mild or moderate severity: - lumbago, sciatica; - neuralgia; - myalgia; - post-traumatic pain syndrome accompanied by inflammation; - postoperative pain; - headache; - migraine; - toothache; - algodismenorrhea; - adnexitis; - proctitis; As part of complex therapy for infectious and inflammatory diseases of the ENT organs with severe pain: - pharyngitis; - tonsillitis; - otitis media
Side effects
Determination of the frequency of adverse reactions: - often - 1-10%; - sometimes - 0.1-1%; - rarely - 0.01-0.1%; - very rare - less than 0.001%, including isolated cases. From the digestive system: - often - epigastric pain, nausea, vomiting, diarrhea, dyspepsia, flatulence, anorexia, increased aminotransferase activity; - rarely - gastritis, proctitis, bleeding from the gastrointestinal tract (vomiting with blood, melena, diarrhea mixed with blood), gastrointestinal ulcers (with or without bleeding or perforation), hepatitis, jaundice, impaired liver function; - very rarely - stomatitis, glossitis, esophagitis, nonspecific hemorrhagic colitis, exacerbation of ulcerative colitis or Crohn's disease, constipation, pancreatitis, fulminant hepatitis. From the nervous system: - often - headache, dizziness; - rarely - drowsiness; - very rarely - sensory disturbances (including paresthesia), memory disorders, tremor, convulsions, anxiety, cerebrovascular disorders, aseptic meningitis, disorientation, depression, insomnia, nightmares, irritability, mental disorders. From the senses: - often - vertigo; - very rarely - visual impairment (blurred vision, diplopia), hearing impairment, tinnitus, impaired sense of taste. From the urinary system: very rarely - acute renal failure, hematuria, proteinuria, interstitial nephritis, nephrotic syndrome, papillary necrosis. From the hematopoietic organs: very rarely - thrombocytopenia, leukopenia, hemolytic and allastic anemia, agranulocytosis. From the cardiovascular system: very rarely - palpitations, chest pain, increased blood pressure, vasculitis, heart failure, myocardial infarction. From the respiratory system: - rarely - exacerbation of bronchial asthma (including shortness of breath); - very rarely - pneumonitis. From the skin: - often - skin rash; - very rarely - erythema, bullous rashes, exfoliative dermatitis, itching, hair loss, photosensitivity, purpura, incl. allergic. Allergic reactions: - anaphylactic/anaphylactoid reactions, including a pronounced decrease in blood pressure and shock; - rarely - urticaria; - very rarely - erythema multiforme and Stevens-Johnson syndrome, Lyell's syndrome, angioedema (including the face).
Contraindications
- complete or incomplete combination of bronchial asthma, recurrent polyposis of the nasal mucosa and paranasal sinuses and intolerance to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (including a history);
- erosive and ulcerative lesions of the gastric or duodenal mucosa, active gastrointestinal bleeding; - inflammatory bowel diseases (ulcerative colitis, Crohn's disease) in the acute phase; — the period after coronary artery bypass grafting; - decompensated heart failure; — hematopoietic disorders, hemostasis disorders (including hemophilia); - severe liver failure or active liver disease; — severe renal failure (creatinine clearance less than 30 ml/min); - progressive kidney diseases; - confirmed hyperkalemia; — III trimester of pregnancy; - lactation period; - children and adolescents up to 18 years of age; - hereditary lactose intolerance, impaired absorption of glucose-galactose, lactase deficiency; - hypersensitivity to the active substance (including other NSAIDs) or excipients. With caution Anemia, bronchial asthma, cerebrovascular diseases, coronary artery disease, chronic heart failure, arterial hypertension, peripheral arterial disease, edema syndrome, liver and kidney failure (creatinine clearance 30-60 ml/min), dyslipidemia/hyperlipidemia, diabetes mellitus, inflammatory bowel disease , conditions after extensive surgery, inducible porphyria, diverticulitis, systemic connective tissue diseases, anamnestic data on the development of gastrointestinal ulcers, the presence of Helicobacter pylori infection, long-term use of NSAIDs, alcoholism, severe somatic diseases, concomitant use of corticosteroids (for example, prednisolone), anticoagulants (for example, warfarin), antiplatelet agents (for example, acetylsalicylic acid, clopidogrel), selective serotonin reuptake inhibitors (for example, citalopram, fluoxetine, paroxetine, sertraline), smoking, I and II trimesters of pregnancy, old age. Use during pregnancy and breastfeeding The use of the drug in the third trimester of pregnancy and lactation is contraindicated. The drug should be prescribed with caution in the first and second trimesters of pregnancy.
Use in children The use of the drug in children and adolescents under 18 years of age is contraindicated.
Use in elderly patients The drug should be prescribed to elderly patients with caution.
Mode of application
The drug is taken orally, during or after meals. The tablets should be swallowed without chewing and washed down with a small amount of water. Adults are prescribed 100 mg 1 time/day. For algodismenorrhea and migraine attacks - up to 200 mg/day for no more than 1-2 days. When taking 100 mg extended-release tablets, if you need to increase the daily dose to 150 mg/day, you can additionally take 1 regular tablet (50 mg). The maximum daily dose is 150 mg.
special instructions
To quickly achieve the desired therapeutic effect, it is recommended to take the drug 30 minutes before meals. In other cases, take before, during or after meals, without chewing, with a sufficient amount of water. Because of the important role of prostaglandins in maintaining renal blood flow, special caution should be exercised when prescribing to patients with heart or renal failure, as well as when treating the elderly, taking diuretics, and patients who, for any reason, have a decrease in blood volume (for example, after major surgery). If diclofenac is prescribed in such cases, monitoring of renal function is recommended as a precaution. In patients with liver failure (chronic hepatitis, compensated cirrhosis of the liver), the kinetics and metabolism do not differ from similar processes in patients with normal liver function. When carrying out long-term therapy, it is necessary to monitor liver function, peripheral blood patterns, and stool analysis for occult blood. Due to the negative effect on fertility, the drug is not recommended for women wishing to become pregnant. In patients with infertility (including those undergoing examination), it is recommended to discontinue the drug. To reduce the risk of developing adverse events from the gastrointestinal tract, the drug should be used in the minimum effective dose for the shortest possible short course. Patients taking the drug must refrain from drinking alcohol. Impact on the ability to drive vehicles and operate machinery It is necessary to refrain from engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Overdose
Symptoms: vomiting, bleeding from the gastrointestinal tract, epigastric pain, diarrhea, dizziness, tinnitus, convulsions, increased blood pressure, respiratory depression, in case of significant overdose - acute renal failure, hepatotoxic effect. Treatment: - gastric lavage, administration of activated carbon; - carrying out symptomatic therapy aimed at eliminating arterial hypertension, renal dysfunction, seizures, gastrointestinal irritation, respiratory depression. Forced diuresis and hemodialysis are ineffective (due to a significant degree of protein binding and intensive metabolism).
Interaction with other drugs
Diclofenac increases plasma concentrations of digoxin, methotrexate, lithium and cyclosporine. Diclofenac reduces the effect of diuretics. With the simultaneous use of potassium-sparing diuretics, the risk of hyperkalemia increases. With the simultaneous use of anticoagulants and thrombolytic agents (alteplase, streptokinase, urokinase), the risk of bleeding increases (usually from the gastrointestinal tract). Diclofenac reduces the effects of antihypertensive and hypnotic drugs. Diclofenac increases the likelihood of side effects of other NSAIDs and GCS (gastrointestinal bleeding), the toxicity of methotrexate and the nephrotoxicity of cyclosporine. Acetylsalicylic acid reduces the concentration of diclofenac in the blood. Paracetamol increases the risk of developing nephrotoxic effects of diclofenac. Diclofenac reduces the effect of hypoglycemic drugs. Cefamandole, cefaperazone, cefotetan, valproic acid and plicamycin increase the incidence of hypoprothrombinemia. Cyclosporine and gold preparations increase the effect of diclofenac on the synthesis of prostaglandins in the kidneys, which increases nephrotoxicity. Concomitant use with ethanol, colchicine, corticotropin, selective serotonin reuptake inhibitors and St. John's wort preparations increases the risk of bleeding in the gastrointestinal tract. Diclofenac enhances the effect of drugs that cause photosensitivity. Drugs that block tubular secretion increase the plasma concentration of diclofenac, thereby increasing its toxicity. When used simultaneously with diclofenac, antibacterial drugs from the quinolone group increase the risk of developing seizures.
Dispensing conditions in pharmacies
On prescription
