Keravort, 5%, cream for external use, 0.25 g, 12 pcs.
The cream is applied only to the affected areas.
Avoid contact of the cream with the mucous membranes and contact of the cream with the eyes. If the cream gets into your eyes, it is recommended to rinse them with water.
Keravort cream is used before bedtime.
Using an excess amount of cream or longer contact of the cream with the skin may cause a severe local reaction.
Do not reuse cream from a previously opened sachet.
Before and after applying the cream, you should wash your hands with warm water and soap.
Uncircumcised men who are treating genital warts located under the foreskin should wash the affected area daily by retracting the foreskin. It is recommended to immediately stop treatment if early signs of phimosis are detected.
If a local reaction to the drug causes serious discomfort for the patient or an infection occurs in the area where the cream is applied, it is allowed to take a break in treatment for several days. In case of infection, necessary measures are taken.
Keravort cream can cause exacerbation of inflammatory skin diseases.
It is not recommended to use Keravort cream until the skin has healed after other types of medical or surgical treatment.
You should not start treatment with Keravort cream on areas with open ulcers or wounds until they have healed.
The fillers methyl parahydroxybenzoate, propyl parahydroxybenzoate, cetyl alcohol and stearyl alcohol may cause an allergic reaction. If a hypersensitivity reaction is detected, it is recommended to discontinue therapy.
It is not recommended to use an occlusive dressing during treatment with Keravort.
Use of imiquimod in doses higher than recommended may result in an increased risk of severe local reactions.
During the period of use of Keravort cream, exposure to sunlight (including sunlight lamps) should be avoided or minimized, as there is a risk of sunburn.
Since imiquimod does not have a direct antiviral and cytotoxic effect, after therapy, new condylomas of the genital and perianal areas may appear.
Based on current knowledge, treatment of urethral, intravaginal, cervical, rectal or intraanal genital warts with Keravort cream is not recommended.
Keravort cream should be washed off the skin before sexual intercourse.
Keravort cream may reduce the effect of condoms or vaginal diaphragms, so it is not recommended to use these contraceptives while using Keravort cream. An alternative method of contraception should be chosen.
In patients with immunodeficiency, it is not recommended to reuse Keravort cream.
Impact on the ability to drive vehicles and operate machinery.
Studies of the effect of the drug on the ability to drive a car and operate machinery have not been conducted.
Keravort
The cream is applied only to the affected areas.
Avoid getting the cream on mucous membranes.
Avoid contact of the cream with your eyes. If the cream gets into your eyes, it is recommended to rinse them with water.
The drug is used before bedtime. Using an excess amount of cream or longer contact of the cream with the skin may cause a severe local reaction.
Do not reuse cream from a previously opened sachet!
Before and after applying the cream, you should wash your hands with warm water and soap. Uncircumcised men who are treating genital warts located under the foreskin should wash the affected area daily by retracting the foreskin. It is recommended to immediately stop treatment if early signs of phimosis are detected.
If a local reaction to the drug causes serious discomfort for the patient, or an infection occurs in the area where the cream is applied, it is allowed to take a break in treatment for several days. In case of infection, necessary measures are taken.
The drug may cause exacerbation of inflammatory skin diseases.
It is not recommended to use the drug until the skin has healed after other types of medical or surgical treatment.
You should not start treatment with the drug on areas with open ulcers or wounds until they have healed.
The fillers methyl parahydroxybenzoate, propyl parahydroxybenzoate, cetyl alcohol and stearyl alcohol may cause an allergic reaction.
If a hypersensitivity reaction is detected, it is recommended to discontinue therapy.
It is not recommended to apply an occlusive dressing to the site of application of the drug.
Use of imiquimod in doses higher than recommended may result in an increased risk of severe local reactions.
During the period of use of the drug, exposure to sunlight (including sunlight lamps) should be avoided or minimized as much as possible, due to the risk of sunburn.
Since imiquimod does not have a direct antiviral and cytotoxic effect, after therapy, new condylomas of the genital and perianal areas may appear.
Based on current knowledge, treatment of urethral, intravaginal, cervical, rectal or intraanal genital warts is not recommended.
The cream should be washed off the skin before sexual intercourse.
The drug may reduce the effect of condoms or vaginal diaphragms, so it is not recommended to use these contraceptives while using it. An alternative method of contraception should be chosen.
In patients with immunodeficiency, it is not recommended to reuse the cream.
Studies of the effect of the drug on the ability to drive a car and operate machinery have not been conducted.
Keravort cream for external use 5% sachets 25g No. 12
A country
India
Country of manufacture may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.
Active substance
Imiquimod
Compound
25 g packet
Imiquimod 5 g per 100 g.
Excipients: isostearic acid (Emersol 874) - 25 g, cetyl alcohol (Speziol C15 Pharma) - 2.2 g, stearyl alcohol (Speziol C18 Pharma) - 3.1 g, myristyl alcohol (Speziol C14) - 7 g, soft white paraffin - 3 g, polysorbate 60 (Tween 60) - 3.4 g, sorbitan monostearate (Motane 60 PHA) - 0.6 g, methyl parahydroxybenzoate - 0.2 g, propyl parahydroxybenzoate - 0.02 g, glycerol - 2 g, xanthan gum (Xantural 75) - 0.5 g, benzyl alcohol — 2 g, purified water — up to 100 g. Cream for external use, white or almost white, homogeneous, soft.
pharmachologic effect
Immunomodulatory drug for external use. Imiquimod, the active ingredient of the drug Keravort, is a compound that modifies the immune response. Imiquimod does not have a direct antiviral effect; its action is due to the induction of interferon alpha (IFN?) and other cytokines.
Indications for use
Treatment of external genital warts localized on the external genitalia or in the perianal area in adults.
Mode of application
Externally. The cream is applied in a thin layer to the previously cleaned surface of the affected areas of the skin and gently rubbed in until completely absorbed. The cream should be applied only to the affected area, avoiding contact with internal surfaces. Keravort cream should be applied 3 times a week before bedtime and left on the skin for 6-10 hours, during which time you should not shower or bathe. Do not apply a bandage to the area where the cream is applied. After the specified time, the cream should be washed off with warm water and soap. Treatment should be continued until visible genital or perianal warts disappear, but not more than 16 weeks. The cream is packaged in disposable sachets containing the required amount of cream for application to the affected skin area of 20 cm2. If the patient forgot to apply the cream as scheduled, apply the missed dose as soon as he remembers, then follow the usual schedule. The cream should not be used more than once a day. Excessive amounts of cream should not be used.
Side effect
The incidence of side effects is determined as follows: very often (>1/10); often (1/100); uncommon (1/1000); rare (1/10,000); very rare (Local skin reactions: - very often - itching and pain at the site of application of the cream; - often - infection, erythema, erosion, excoriation/flaking and swelling; - infrequently - itching, dermatitis, folliculitis, erythematous rash, eczema, urticaria ; - rarely - induration, ulceration, formation of scabs and the appearance of blisters, local hypopigmentation and hyperpigmentation. From the digestive system: infrequently - pain in the anus, lesions of the rectum. From the genitourinary system: infrequently - fungal and bacterial infection, herpes simplex, vaginitis, vulvitis, painful intercourse, pain in the penis, vagina, atrophic vaginitis. If local side effects occur, the cream should be removed by washing it with soap and water. Treatment can be resumed after the skin reaction has stopped.
Contraindications
- hypersensitivity to imiquimod or other components of the cream;
- children under 18 years of age (due to lack of data). Use during pregnancy and breastfeeding Use during pregnancy is possible according to strict indications, if the expected benefit to the mother outweighs the potential risk to the fetus. If it is necessary to use the drug during lactation, breastfeeding should be discontinued.
Overdose
Overdose is unlikely due to the low absorption of the drug. If a 200 mg dose of imiquimod, equivalent to the contents of approximately 16 sachets, is accidentally ingested, nausea, vomiting, headache, myalgia and fever may occur. The most clinically serious side effect of multiple oral doses of 200 mg is a decrease in blood pressure. In case of overdose, the patient should immediately consult a doctor for symptomatic therapy.
special instructions
The cream is applied only to the affected areas. Avoid contact of cream with mucous membranes. Avoid contact of the cream with the eyes. If the cream gets into your eyes, it is recommended to rinse them with water. Keravort cream is used before bedtime. Using an excess amount of cream or longer contact of the cream with the skin may cause a severe local reaction. Do not reuse cream from a previously opened sachet! Before and after applying the cream, you should wash your hands with warm water and soap. Uncircumcised men who are treating genital warts located under the foreskin should wash the affected area daily by retracting the foreskin. It is recommended to immediately stop treatment if early signs of phimosis are detected. If a local reaction to the drug causes serious discomfort for the patient, or an infection occurs in the area where the cream is applied, it is allowed to take a break in treatment for several days. In case of infection, necessary measures are taken. Keravort cream can cause exacerbations of inflammatory skin diseases. It is not recommended to use Keravort cream until the skin has healed after other types of medical or surgical treatment. You should not start treatment with Keravort cream on areas with open ulcers or wounds until they have healed. The fillers methyl parahydroxybenzoate, propyl parahydroxybenzoate, cetyl alcohol and stearyl alcohol may cause an allergic reaction. If a hypersensitivity reaction is detected, it is recommended to discontinue therapy. It is not recommended to use an occlusive dressing during treatment with Keravort. Use of imiquimod in doses higher than recommended may result in an increased risk of severe local reactions. During the period of use of Keravort cream, exposure to sunlight (including sunlight lamps) should be avoided or minimized, as there is a risk of sunburn. Because Imiquimod does not have a direct antiviral and cytotoxic effect; after therapy, new condylomas of the genital and perianal areas may appear. Based on current knowledge, treatment of urethral, intravaginal, cervical, rectal or intraanal genital warts with Keravort cream is not recommended. Keravort cream should be washed off the skin before sexual intercourse. Keravort cream may reduce the effect of condoms or vaginal diaphragms, so it is not recommended to use these contraceptives while using Keravort cream. An alternative method of contraception should be chosen. In patients with immunodeficiency, it is not recommended to reuse Keravort cream. Effect on the ability to drive vehicles and operate machinery. Studies of the effect of the drug on the ability to drive a car and operate machinery have not been conducted.
Dispensing conditions in pharmacies
On prescription
Keravort instructions for use
Externally. Keravort cream should be used before bedtime. Before using the cream, you must wash the affected areas of the skin with soap and allow them to dry. The cream is applied to the affected areas and gently rubbed into the skin. The cream should remain on the skin for 6-10 hours. You should avoid getting water on the affected area; you should postpone showering and other water treatments for 8 hours. After the specified time, the cream should be washed off with warm water and soap. One sachet of cream is enough to apply to a 20 cm2 area of skin. Do not reuse cream from a previously opened sachet! Before and after applying the cream, you should wash your hands with warm water and soap. When treating genital/perianal warts, the cream should be used after sexual intercourse.
Genital and perianal warts (genital warts) in adults.
Keravort cream should be applied three times a week (for example, on Monday, Wednesday and Friday or Tuesday, Thursday and Saturday) before bed and left on the skin for 6-10 hours. The cream is applied in a thin layer and rubbed into the clean surface of the areas affected by condylomas until completely absorbed.
Limited superficial basal cell carcinoma in adults.
Apply Keravort cream in a row 5 days a week for 6 weeks (for example, from Monday to Friday) before bed and leave on the skin for approximately 8 hours.
The response of the treated tumor to the cream should be assessed 12 weeks after the end of treatment. If the treated tumor does not respond sufficiently, another treatment must be used.
If a local skin reaction to the cream causes increased discomfort to the patient or if the treated surface becomes infected, it is necessary to interrupt treatment for several days.
Actinic keratosis in adults.
Treatment is prescribed and monitored by a doctor. Keravort cream should be applied 3 times a week (for example, on Monday, Wednesday and Friday or Tuesday, Thursday and Saturday) before bed for 4 weeks and left on the skin for 8 hours. A sufficient amount of cream is applied to the entire affected surface. The presence of actinic keratoses should be assessed 4 weeks after stopping treatment. If any symptoms remain, treatment should be continued for another four weeks. The maximum recommended dose is one sachet. The maximum recommended treatment is 8 weeks.
If a local acute inflammatory reaction is observed or if infection of the treated surface occurs, treatment should be suspended. In the latter case, appropriate measures must be taken. Each treatment period should not exceed 4 weeks due to missed doses or rest periods.
If the lesions do not respond sufficiently to treatment at follow-up 4 to 8 weeks after the second treatment period, another treatment must be applied.
If a dose is missed, the patient should apply the cream as soon as he remembers, then continue treatment as usual. However, you should remember that the cream can be applied no more than once a day.
