Ketorolac tablets and injections: instructions for use, price, what the drug is used for

Release form

Ketorolac tablets are white-coated, biconvex. 10 such tablets in contour packaging; 1,2, 5 or 10 packs in a paper pack. 10 such tablets in a polymer jar; one such jar in a pack of paper. 25 of these tablets in contour packaging; 2 or 4 packs in a paper pack.
Ketorolac (i.v., i.m.) in ampoules contains a transparent solution of white-yellow color. 1 or 2 ml of this solution in an ampoule; 5 ampoules in contour packaging, 1 or 2 such packages in a cardboard box. 1 or 2 ml of this solution in an ampoule; 10 such ampoules in a cardboard box.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

It has a strong analgesic effect, moderate antipyretic and anti-inflammatory effect.

They are associated with indiscriminate inhibition of the enzyme cyclooxygenase of the first and second types in peripheral tissues, resulting in inhibition of the synthesis of prostaglandins - mediators of pain, inflammation and thermoregulation.

The drug has no effect on opioid receptors, does not cause addiction, does not depress breathing, and does not have a sedative or anxiolytic effect.

The strength of the analgesic effect is comparable to morphine and superior to other drugs in its group.

After oral administration, the analgesic effect is recorded after one hour, the greatest effect – after one to two hours. After an intramuscular injection, the onset of the analgesic effect is recorded after 30 minutes, the greatest effect – after one to two hours.

Pharmacokinetics

When taken internally and when administered by injection, it is actively absorbed from the intestines and tissues. The maximum concentration in the blood is recorded after 40-50 minutes, both after oral administration and after intramuscular injection. Eating does not affect absorption. Plasma protein binding is about 99%.

The half-life is approximately 6 hours. 90% of the dose is excreted by the kidneys, in its original form - 60%; the remaining amount is excreted through the digestive tract.

What are the side effects of ketorolac?

You should seek immediate medical attention if you experience symptoms of a severe allergic reaction:

skin allergic manifestations (urticaria, itching, soreness of the skin, peeling of the skin, blisters, purple rash);
fever;
a sore throat;
burning in the eyes;
swelling of the face and larynx.

Be careful!

If, after taking ketorolac, you notice a number of symptoms such as:

chest pain spreading to your jaw or shoulder;
sudden numbness or weakness on one side of the body;
slurred speech;
feeling of shortness of breath.

This may indicate a heart attack or stroke. In this case, you need to urgently seek emergency help.

Common side symptoms when using ketorolac may include:

headache and/or dizziness;
drowsiness;
nausea, digestive disorders (diarrhea or constipation);
swelling or swelling of soft tissues.

This is a non-exhaustive list of side effects that may occur when using ketorolac. For more detailed information, consult your doctor and carefully read the instructions for this medication.

Indications for use

Moderate to severe pain syndrome :

toothache;
pain of traumatic etiology;
pain in the postoperative and postpartum period;
pain due to cancer ;
dislocations , sprains ;
arthralgia , neuralgia , myalgia , radiculitis ;
rheumatic diseases.

Used for symptomatic therapy, relief of inflammation and pain at the time of use, does not affect the development of the disease.

Consequences of an overdose of ketorolac

Symptoms of ketorolac overdose:

shortness of breath, even with slight exertion;
the first sign of any skin rash, no matter how mild;
bloody or tarry stools, coughing up blood, or vomit that looks like coffee grounds (this may indicate stomach bleeding);
liver disorders that are accompanied by characteristic symptoms (pain in the upper abdomen, nausea, loss of appetite, clay-colored stools, yellowing of the skin and eyeballs, feeling tired, itchy skin);
symptoms of anemia (anemia) (pale skin, feeling dizzy or short of breath, rapid heartbeat, problems concentrating);
kidney problems (little or no urination, painful or difficult urination, swelling of the legs or ankles, feeling tired or short of breath).

If you take too much ketorolac and experience any of the above symptoms, seek emergency medical help immediately.

Contraindications

Combination (complete or incomplete) of bronchial asthma , intolerance to aspirin (or other drugs in this group) and recurrent polyposis of the paranasal sinuses and nose .
Hypersensitivity.
Hypovolemia.
Intolerance pyrazolone drugs .
Exacerbation of erosive and ulcerative diseases of the gastrointestinal tract.
Hypocoagulation , high risk of bleeding.
Severe kidney or liver damage , liver disease.
Condition after coronary artery bypass surgery .
Hyperkalemia.
3rd trimester of pregnancy, childbirth and lactation.
Inflammatory intestinal lesions.
Age less than 16 years.

Use with caution for: bronchial asthma , alcoholism , chronic heart failure, cholecystitis , postoperative period, arterial hypertension , edema syndrome, kidney damage, active hepatitis, cholestasis, systemic lupus erythematosus, sepsis, coronary heart disease, dyslipidemia , cerebrovascular diseases, peripheral damage arteries, diabetes mellitus, ulcerative lesions of the digestive tract in the past, H. pylori infection, prolonged use of other non-steroidal anti-inflammatory drugs , old age, 1st and 2nd trimesters of pregnancy.

What you need to know before you start taking ketorolac

Note!

If Ketorolac is used incorrectly and over a long period of time, a heart attack or stroke can occur, which can be fatal, even if you have no history of heart disease.

You should not take this drug if you have had heart surgery or are about to undergo heart surgery.

Ketorolac may also cause stomach or intestinal bleeding, which can be fatal. This condition is especially dangerous for older people.

You should not use ketorolac if you have an intolerance to any of its ingredients or an allergic reaction to it, or if you have:

active or recent stomach ulcer, stomach bleeding, or intestinal bleeding;
bleeding or bleeding disorder;
closed head injury or bleeding in the brain;
bleeding from recent surgery;
severe kidney disease or dehydration;
history of asthma or severe allergic reaction after taking aspirin or other NSAIDs;
upcoming surgery (especially bypass surgery);
last trimester of pregnancy;
lactation period.

Some medications may cause unwanted or dangerous effects when used with ketorolac. Your doctor may need to change your treatment plan if you are taking any of the following drugs:

pentoxifylline (a drug that improves blood microcirculation - angioprotector);
probenecid (an anti-gout medicine);
other drugs from the NSAID group.

To make sure ketorolac is safe for you, tell your doctor if you have ever had:

heart disease, high blood pressure, high cholesterol, diabetes;
if you have bad habits (abuse of tobacco products or alcohol-containing drinks);
heart attack, stroke, or blood clots (blood clots);
stomach ulcers or bleeding;
inflammatory bowel disease, ulcerative colitis, or Crohn's disease;
liver disease;
kidney disease (or if you are on dialysis);
bronchial asthma;
fluid retention in the body.

Using ketorolac during the last 3 months of pregnancy may harm the unborn baby. Ketorolac may also increase the risk of uterine bleeding, so it should not be used during pregnancy.

Ketorolac passes into breast milk and may harm a nursing baby. Therefore, it is not recommended to use this drug during breastfeeding.

Side effects

Reactions from the circulatory system: changes in pressure, bradycardia , rapid heartbeat , fainting.
Reactions from the digestive system: abdominal pain, diarrhea, flatulence, nausea, constipation , vomiting, thirst , gastritis, stomatitis , erosive and ulcerative changes in the digestive tract, liver damage.
Reactions from the nervous system: paresthesia , anxiety, sleep disturbances , drowsiness , depression , visual disturbances, dizziness , movement disorders.
Reactions from the respiratory system: attacks of suffocation.
Reactions from the genitourinary system: oliguria , increased urination, polyuria, proteinuria, hematuria, azotemia, acute renal failure .
Reactions from the hematopoietic system: nosebleeds, anemia , eosinophilia, thrombocytopenia.
Metabolic reactions: edema , hypokalemia , increased creatinine or urea in the blood, hyponatremia.
Allergic reactions: hemorrhagic rash, Stevens-Johnson syndrome , urticaria , Quincke's edema , Lyell's syndrome , anaphylactic shock, bronchospasm, myalgia .
Other reactions: fever .
Local reactions: pain in the injection area.

Side effects and overdose of ketorolac

It is not recommended to use ketorolac if you have a history of conditions such as:

recent or active gastric bleeding;
head injury;
stomach and duodenal ulcers;
severe kidney disease;
heart problems;
bleeding or blood clotting disorder;
history of severe allergic reaction to aspirin or NSAIDs;
if you are scheduled for surgery;
if you are late in pregnancy or breastfeeding.

Common side effects of ketorolac include:

headache and/or dizziness;
feeling drowsy;
digestive disorders (constipation or diarrhea);
bloating due to increased gas production (flatulence);
ulcerative lesions of the oral mucosa;
increased sweating.

Some side effects of ketorolac can be serious, which may indicate an overdose of this medication:

high body temperature;
the appearance of blisters on the skin;
unexplained weight gain;
shortness of breath or difficulty breathing;
swelling of the abdomen, ankles, feet, or legs;
yellowing of the skin or eyes;
excessive fatigue;
unusual bleeding or bruising on the body;
lack of energy;
nausea;
loss of appetite;
pain in the upper right corner of the abdomen;
flu symptoms;
pale skin;
fast heartbeat (tachycardia);
cloudy, discolored, or bloody urine;
backache;
difficulty or painful urination.

If you experience any of the symptoms mentioned above, you should definitely seek medical help.

Instructions for use of Ketorolac (Method and dosage)

Ketorolac tablets instructions for use recommend using them orally. Single dose - 10 mg. The next time you use it, you can take 10 mg up to four times a day; the highest daily dose should not be more than 40 mg. The duration of treatment is up to 5 days.

Ketorolac injections instructions for use recommend that when administered intramuscularly, stick to a single dose of up to 30 mg once every 4-6 hours. The highest dose is 90 mg (three ampoules) per day. The longest duration of use of the drug is up to 2 days.

How to take ketorolac?

To eliminate severe pain of various etiologies, ketorolac is usually administered first as an injection, and then it is taken as an oral (by mouth) medication. Injectable ketorolac can be administered either intramuscularly (into a muscle) or intravenously (into a vein through a drip). Parenteral use should be carried out on an outpatient basis (in a medical facility).

It is necessary to follow all doctor's instructions and carefully study the instructions for the medication. Do not take ketorolac in larger quantities or for longer than recommended. Use the lowest dose that is effective in treating your condition.

Note!

Ketorolac should not be used for more than 5 days, including injections and tablets. Long-term use of this medication may damage the kidneys or cause bleeding.

Store at room temperature away from moisture, heat and light. When not in use, keep the bottle tightly closed.

Interaction

Use with other drugs from the same group (OKPD - non-steroidal anti-inflammatory drugs ), glucocorticosteroids, corticotropin, ethanol, calcium supplements increases the risk of ulceration of the gastrointestinal tract and bleeding from the stomach and intestines.

Co-administration with heparin , coumarin derivatives, thrombolytics ( Streptokinase, Alteplase ), cephalosporins, antiplatelet agents, valproic acid and aspirin increases the risk of bleeding.

Ketorolac weakens the effect of diuretic and antihypertensive drugs.

Use together with methotrexate increases hepato- and nephrotoxicity .

Ketorolac enhances the effect of narcotic analgesics.

Myelotoxic drugs enhance the hematotoxic effect of the drug.

Ketorolac solution d/iv and intramuscular injection 30 mg/ml 1 ml No. 10

Compound

Active substance: ketorolac trometamol (ketorolac tromethamine) - 30 mg. Excipients: ethanol 95% (in terms of 100% substance) - 100 mg, sodium chloride - 4.35 mg, hydrochloric acid solution 1M or sodium hydroxide solution 1M - to pH 6.9-7.9, water for injection - up to 1 ml.

Pharmacokinetics

When taken orally, ketorolac is well absorbed from the gastrointestinal tract. Bioavailability is 80-100%. Cmax in blood plasma is 0.7-1.1 mcg/ml and is achieved 40 minutes after taking the drug on an empty stomach at a dose of 10 mg. Food rich in fat reduces the Cmax of the drug in the blood and delays its achievement by 1 hour.

With intramuscular administration, absorption is complete and rapid. After intramuscular administration of the drug at a dose of 30 mg, Cmax in blood plasma is 1.74-3.1 mcg/ml, at a dose of 60 mg - 3.23-5.77 mcg/ml. Tmax is respectively 15-73 min and 30-60 min.

After an intravenous infusion of the drug at a dose of 15 mg, Cmax is 1.96-2.98 mcg/ml, at a dose of 30 mg - 3.69-5.61 mcg/ml.

Plasma protein binding - 99%. With hypoalbuminemia, the amount of free substance in the blood increases.

Vd is 0.15-0.33 l/kg.

The time to reach Css when taken orally is 24 hours when used 4 times a day (above subtherapeutic). Css after oral administration at a dose of 10 mg is 0.39-0.79 mcg/ml.

Css with parenteral administration is achieved after 24 hours when used 4 times a day (above subtherapeutic) and with IM administration at a dose of 15 mg is 0.65-1.13 mcg/ml, with IM administration at a dose of 30 mg - 1.29-2.47 mcg /ml; with an intravenous infusion at a dose of 15 mg - 0.79-1.39 mcg/ml, with an intravenous infusion at a dose of 30 mg - 1.68-2.76 mcg/ml.

Poorly passes through the BBB, penetrates the placental barrier (10%).

Excreted in breast milk: when the mother takes 10 mg of ketorolac orally, Cmax in breast milk is achieved 2 hours after taking the first dose and is 7.3 ng/ml, 2 hours after taking the second dose of ketorolac (when using the drug 4 times a day) Cmax is 7.9 ng/ml.

When administered parenterally, it is excreted in breast milk in small quantities.

More than 50% of the administered dose is metabolized in the liver with the formation of pharmacologically inactive metabolites. The main metabolites are glucuronides and p-hydroxyketorolac.

Excreted in urine - 91% (40% in the form of metabolites), in feces - 6%. Not excreted by hemodialysis.

After oral administration, T1/2 in patients with normal renal function is 2.4-9 hours (average 5.3 hours).

After intramuscular administration of 30 mg T1/2 - 3.5-9.2 hours, after intravenous administration of 30 mg T1/2 - 4-7.9 hours.

The total clearance with intramuscular injection of 30 mg is 0.023 l/kg/h, with intravenous infusion of 30 mg - 0.03 l/kg/h.

In patients with renal failure, the Vd of the drug may increase by 2 times, and the Vd of its R-enantiomer by 20%. With a plasma creatinine concentration of 19-50 mg/l with intramuscular administration of 30 mg of the drug, the total clearance is 0.015 l/kg/h.

In patients with impaired renal function with a plasma creatinine concentration of 19-50 mg/l (168-442 µmol/l), T1/2 is 10.3-10.8 hours, with more severe renal failure - more than 13.6 hours.

Liver function has no effect on T1/2.

In elderly patients, the total clearance when administered intramuscularly at a dose of 30 mg is 0.019 l/kg/h. T1/2 lengthens in elderly patients and shortens in young ones.

Indications for use

Pain syndrome of severe and moderate severity: injuries, toothache, pain in the postoperative period, cancer, myalgia, arthralgia, neuralgia, radiculitis, dislocations, sprains, rheumatic diseases.

Intended for symptomatic therapy, reducing pain and inflammation at the time of use, does not affect the progression of the disease.

Contraindications

Hypersensitivity to ketorolac or to other components of the drug, complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses, intolerance to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (including a history), urticaria, rhinitis caused by taking non-steroidal anti-inflammatory drugs medications (history), dehydration.

Intolerance to pyrazolone-type drugs, hypovolemia (regardless of the cause), bleeding or a high risk of its development, condition after coronary artery bypass surgery, confirmed hyperkalemia, inflammatory bowel diseases.

Erosive and ulcerative lesions of the gastrointestinal tract in the acute stage, peptic ulcers, hypocoagulation (including hemophilia).

Severe liver and/or renal failure (creatinine clearance less than 30 ml/min).

Hemorrhagic stroke (confirmed or suspected), hemorrhagic diathesis, hematopoiesis disorder, intracranial hemorrhage or suspicion of it.

Concomitant use with probenecid, pentoxifylline, acetylsalicylic acid and other NSAIDs (including cyclooxygenase-2 inhibitors), lithium salts, anticoagulants, including warfarin and heparin is not recommended.

Pregnancy, childbirth and breastfeeding.

Children under 16 years of age (safety and effectiveness of use have not been established).

The drug is not used for pain relief before and during surgery due to the high risk of bleeding, as well as for the treatment of chronic pain.

Directions for use and doses

Intravenously, intramuscularly.

Injected deep into the muscle, slowly (or intravenously in a stream) for at least 15 seconds in the minimum effective doses, in a minimally short course.

Single doses for a single intramuscular or intravenous administration:

adults under 65 years of age and children over 16 years of age - 10-30 mg, depending on the severity of the pain syndrome;
adults over 65 years of age or with impaired renal function - 10-15 mg.

Doses for repeated parenteral administration:

intramuscularly

adults under 65 years of age and children over 16 years of age are given 10-60 mg (0.3-2 ml) for the first injection, then 10-30 mg (0.3-1 ml) every 6 hours (usually 30 mg ( 1 ml) every 6 hours);
adults over 65 years of age or with impaired renal function - 10-15 mg (0.3-0.5 ml) every 4-6 hours.

intravenously

adults under 65 years of age and children over 16 years of age are injected with 10-30 mg (0.3-1 ml), then 10-30 mg (0.3-1 ml) every 6 hours, with continuous infusion using an infusion pump the initial dose is 30 mg (1 ml), and then the infusion rate is 5 mg/h;
adults over 65 years of age or with impaired renal function are given a bolus of 10-15 mg (0.3-0.5 ml) every 6 hours.

The maximum daily dose for adults under 65 years of age and children over 16 years of age should not exceed 90 mg (3 ml), and for adults over 65 years of age or with impaired renal function - 60 mg (2 ml) for both intramuscular and intravenous routes of administration .

Continuous intravenous infusion should not last more than 24 hours.

The maximum duration of treatment should not exceed 2 days.

When switching from parenteral administration of the drug to oral administration, the total daily dose of both dosage forms on the day of transfer should not exceed 90 mg for adults under 65 years of age and children over 16 years of age and 60 mg for adults over 65 years of age or with impaired renal function. In this case, the dose of the drug in tablets on the day of transition should not exceed 30 mg.

Storage conditions

In a place protected from light, at a temperature not exceeding 25 ° C. Do not freeze.

Keep out of the reach of children.

Best before date

3 years. Do not use after expiration date.

special instructions

When used together with other NSAIDs, fluid retention, cardiac decompensation, and arterial hypertension may occur.
To reduce the risk of developing NSAID gastropathy, antacids, misoprostol, and omeprazole are prescribed.
The effect on platelet aggregation lasts for 24-48 hours.
Hypovolemia increases the risk of developing adverse reactions from the kidneys.
If necessary, can be prescribed in combination with opioid analgesics.
Do not use simultaneously with paracetamol for more than 5 days.
In patients with blood coagulation disorders, it is used only with constant monitoring of the platelet count, especially in the postoperative period, which requires careful monitoring of hemostasis.

Description

NSAIDs with a pronounced analgesic effect.

Dosage form

Solution for intravenous and intramuscular administration in the form of a clear, light yellow liquid.

Use in children

Contraindication: children and adolescents under 16 years of age (efficacy and safety have not been established).

Pharmacodynamics

NSAIDs have a pronounced analgesic (pain-relieving) effect, and also have anti-inflammatory and moderate antipyretic effects.

The mechanism of action is associated with non-selective inhibition of the activity of the enzymes COX-1 and COX-2, mainly in peripheral tissues, resulting in inhibition of the biosynthesis of prostaglandins - modulators of pain sensitivity, inflammation and thermoregulation. Ketorolac is a racemic mixture of R(+) and S(-)-enantiomers, with the analgesic (pain-relieving) effect due to the S(-)-enantiomer.

Ketorolac does not affect opioid receptors, does not depress respiration, does not cause drug dependence, and does not have a sedative or anxiolytic effect.

The strength of the analgesic (pain-relieving) effect is comparable to morphine and significantly superior to other NSAIDs.

After oral administration, the onset of analgesic (pain-relieving) effect is observed after 1 hour, the maximum effect is achieved after 2-3 hours.

After intramuscular administration, the onset of analgesic (pain-relieving) effect is noted after 0.5 hours, the maximum effect is achieved after 1-2 hours.

Side effects

From the digestive system: often (especially in elderly patients over 65 years of age with a history of erosive and ulcerative lesions of the gastrointestinal tract) - gastralgia, diarrhea; less often - stomatitis, flatulence, constipation, vomiting, feeling of fullness in the stomach; rarely - loss of appetite, nausea, erosive and ulcerative lesions of the gastrointestinal tract (including with perforation and/or bleeding - abdominal pain, spasm or burning in the epigastric region, melena, vomiting with blood or coffee grounds, nausea, heartburn), cholestatic jaundice, hepatitis, hepatomegaly, acute pancreatitis.

From the urinary system: rarely - acute renal failure, lower back pain, hematuria, azotemia, hemolytic-uremic syndrome (hemolytic anemia, renal failure, thrombocytopenia, purpura), frequent urination, increased or decreased urine volume, nephritis, edema of renal origin.

From the nervous system: often - headache, dizziness, drowsiness; rarely - aseptic meningitis (including fever, severe headache, convulsions, stiffness of the neck and/or back muscles), hyperactivity (including mood changes, anxiety), hallucinations, depression, psychosis.

From the cardiovascular system: less often - increased blood pressure; rarely - fainting.

From the respiratory system: rarely - bronchospasm, dyspnea, rhinitis, pulmonary edema, laryngeal edema (including shortness of breath, difficulty breathing).

From the senses: rarely - hearing loss, ringing in the ears, visual impairment (including blurred visual perception).

From the hematopoietic system: rarely - anemia, eosinophilia, leukopenia.

From the blood coagulation system: rarely - bleeding from a postoperative wound, nosebleeds, rectal bleeding.

From the skin: less often - skin rash (including maculopapular), purpura; rarely - exfoliative dermatitis (including fever with or without chills, redness, thickening or flaking of the skin, swelling and/or tenderness of the tonsils), urticaria, Stevens-Johnson syndrome, Lyell's syndrome.

Allergic reactions: rarely - anaphylaxis or anaphylactoid reactions (including discoloration of the facial skin, skin rash, urticaria, itching of the skin, tachypnea or dyspnea, swelling of the eyelids, periorbital edema, shortness of breath, difficulty breathing, heaviness in the chest, wheezing ).

Local reactions: less often - burning or pain at the injection site.

Other: often - swelling (including of the face, legs, ankles, fingers, feet), weight gain; less often - increased sweating; rarely - swelling of the tongue, fever.

Use during pregnancy and breastfeeding

The use of the drug is contraindicated during pregnancy, during childbirth and during breastfeeding.

Interaction

The simultaneous use of ketorolac with acetylsalicylic acid or other NSAIDs, calcium preparations, corticosteroids, ethanol, corticotropin can lead to the formation of gastrointestinal ulcers and the development of gastrointestinal bleeding.
Co-administration with paracetamol increases nephrotoxicity, and with methotrexate - hepato- and nephrotoxicity.
Co-administration of ketorolac and methotrexate is possible only when using low doses of the latter (monitor the concentration of methotrexate in the blood plasma).
With the use of ketorolac, the clearance of methotrexate and lithium may decrease and the toxicity of these substances may increase.
Co-administration with indirect anticoagulants, heparin, thrombolytics, antiplatelet agents, cefoperazone, cefotetan and pentoxifylline increases the risk of bleeding.
Reduces the effect of antihypertensive and diuretic drugs (the synthesis of prostaglandins in the kidneys decreases).
When used simultaneously with opioid analgesics, the doses of the latter can be significantly reduced, because their effect is enhanced.
When used simultaneously, it enhances the hypoglycemic effect of insulin and oral hypoglycemic drugs (dose recalculation is necessary).
Co-administration with valproic acid causes disruption of platelet aggregation.
Increases the plasma concentration of verapamil and nifedipine.
When prescribed with other nephrotoxic drugs (including gold preparations), the risk of developing nephrotoxicity increases.
Probenecid and drugs that block tubular secretion reduce the clearance of ketorolac and increase its concentration in the blood plasma.
Myelotoxic drugs increase the manifestations of hematotoxicity of the drug.
Pharmaceutically incompatible with tramadol solution and lithium preparations.

Overdose

Symptoms: abdominal pain, nausea, vomiting, erosive and ulcerative lesions of the gastrointestinal tract, impaired renal function, metabolic acidosis.

Treatment: there is no specific antidote; gastric lavage, administration of adsorbents (activated carbon) and symptomatic therapy (maintaining vital body functions) are recommended. Ketorolac is not sufficiently eliminated by dialysis.

Impact on the ability to drive vehicles and operate machinery

Since a significant proportion of patients using ketorolac develop side effects from the central nervous system (drowsiness, dizziness, headache), it is recommended to avoid performing work that requires increased attention and quick reaction (driving vehicles, working with machinery).

special instructions

Before prescribing the drug, it is necessary to find out about the presence of a previous allergy to other non-steroidal anti-inflammatory drugs .

Hypovolemia increases the risk of developing kidney toxicity.

If necessary, Ketorolac can be prescribed with narcotic analgesics . The drug should not be used for premedication or to maintain anesthesia.

Do not use the product simultaneously with paracetamol for more than 5 days.

To reduce the risk of developing gastropathy , misoprostol, antacids, and omeprazole are prescribed simultaneously .

To reduce the risk of side effects, the lowest effective dose should be used for the shortest possible course.

During treatment with the drug, you must be careful when driving.

What you need to know about ketorolac

Ketorolac should be used strictly as prescribed by a doctor and in compliance with all rules of administration as prescribed by a specialist.

Even if this page contains comprehensive information on your question, you should always consult with your doctor to make sure that the information received is actually applicable to your specific individual case.

Sources

Ketorolac / Drugs.com (English)

Ketorolac / State register of medicinal products (ukr.)

Medmarket Pharmacy24 provides comprehensive and reliable information on issues of medicine, health and well-being, however, diagnosis and choice of treatment methods can only be made by your attending physician! Self-medication may be unsafe for your health. Medmarket Apteka24 is not responsible for possible negative consequences resulting from the use by users of apteka24.ua of the information posted on the site.

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In Russia, the price of Ketorolac No. 10 ampoules is 99-101 rubles, the price of Ketorolac No. 20 tablets is approximately 18 rubles. In Ukraine, ampoules of drug No. 10 cost 54-75 hryvnia, tablets No. 10 cost 9-25 hryvnia.

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