Corinfar, 10 mg, extended-release film-coated tablets, 50 pcs.: instructions for use, reviews and analogues, prices in pharmacies. Buy and deliver to the nearest pharmacy or home

Corinfar, 10 mg, extended-release film-coated tablets, 50 pcs.

During the treatment period it is necessary to refrain from taking ethanol.

It is recommended to stop treatment with the drug gradually.

It should be borne in mind that angina pectoris may occur at the beginning of treatment, especially after recent abrupt withdrawal of beta-blockers (the latter should be withdrawn gradually).

The simultaneous administration of beta-blockers must be carried out under conditions of careful medical supervision, as this may cause an excessive decrease in blood pressure, and in some cases, aggravation of symptoms of heart failure.

In case of severe heart failure, the drug is dosed with great caution.

Diagnostic criteria for prescribing the drug for vasospastic angina are: a classic clinical picture, accompanied by an increase in the ST segment, the occurrence of ergonovine-induced angina or coronary artery spasm, detection of coronary spasm during angiography or identification of an angiospastic component without confirmation (for example, with a different voltage threshold or with unstable angina, when data ECGs indicate transient vasospasm).

For patients with severe obstructive cardiomyopathy, there is a risk of increased frequency, severity and duration of angina attacks after taking nifedipine; in this case, discontinuation of the drug is necessary.

In patients with irreversible renal failure who are on hemodialysis, have high blood pressure and a reduced total blood volume, the drug should be used with caution, as a sharp drop in blood pressure is possible. Patients with impaired liver function are closely monitored; if necessary, reduce the dose of the drug and/or use other dosage forms of nifedipine.

If surgery under general anesthesia is necessary, the anesthesiologist must be informed about the patient's treatment with nifedipine.

During in vitro fertilization, in some cases, BMCC cause changes in the head part of the sperm, which can lead to dysfunction of the sperm. In cases in which repeated in vitro fertilization has not been carried out for an unclear reason, the use of BMCC, including nifedipine, can be considered a possible reason for failure.

During treatment, it is possible to obtain a false positive result from the direct Coombs test and laboratory tests for antinuclear antibodies. In the spectrophotometric determination of vanillylmandelic acid in urine, nifedipine may cause a falsely elevated result, however, nifedipine does not affect the results of tests performed using high-performance liquid chromatography.

Caution should be exercised during simultaneous treatment with nifedipine, disopyramide and flecainamide due to a possible increase in inotropic effect.

Impact on the ability to drive a car and other mechanisms

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Corinfar retard 20 mg 30 pcs. extended-release film-coated tablets

pharmachologic effect

Selective blocker of slow calcium channels (SCBC), a derivative of 1,4-dihydropyridine.
Has antianginal and hypotensive effects. Reduces the flow of extracellular Ca2+ into cardiomyocytes and smooth muscle cells of the coronary and peripheral arteries; in high doses inhibits the release of Ca2+ from intracellular stores. In therapeutic doses, it normalizes the transmembrane Ca2+ current, which is disturbed in a number of pathological conditions, primarily in arterial hypertension. Does not affect the tone of the veins. Strengthens coronary blood flow, improves blood supply to ischemic areas of the myocardium without developing the “steal” phenomenon, and activates the functioning of collaterals.

By dilating peripheral arteries, it reduces peripheral vascular resistance, myocardial tone, afterload and myocardial oxygen demand. It has virtually no effect on the sinoatrial node and AV node, and has weak antiarrhythmic activity.

Increases renal blood flow, causes moderate natriuresis.

The negative chrono-, dromo- and inotropic effects are overlapped by reflex activation of the sympathoadrenal system and an increase in heart rate in response to peripheral vasodilation.

The onset of the clinical effect is 20 minutes and its duration is 4-6 hours.

With long-term use (2-3 months), tolerance to the action of the drug develops.

Composition and release form Corinfar retard 20 mg 30 pcs. extended-release film-coated tablets

Tablets - 1 tablet:

Active substance: nifedipine 20 mg.
Excipients: lactose monohydrate - 31.6 mg, potato starch - 31.4 mg, microcrystalline cellulose - 31 mg, povidone K25 - 5.4 mg, magnesium stearate - 0.6 mg.
Film shell composition: hypromellose - 5.188 mg, macrogol 6000 - 0.861 mg, macrogol 35000 - 0.393 mg, quinoline yellow dye (E104) - 0.143 mg, titanium dioxide (E171) - 1.377 mg, talc - 1.038 mg.

30 pcs. - brown glass bottles (1) - cardboard packs.

Description of the dosage form

Extended-release tablets, yellow, round, biconvex, film-coated; at the fracture there is a homogeneous yellow mass.

Characteristic

Selective blocker of “slow” calcium channels, a 1,4-dihydropyridine derivative.

Directions for use and doses

Take orally after eating, without chewing and with a sufficient amount of liquid. The dose of the drug is selected by the doctor individually in accordance with the severity of the disease and the patient’s sensitivity to the drug. For patients with concomitant severe cerebrovascular diseases and in elderly patients, the dose of the drug should be reduced.

Simultaneous food intake delays, but does not reduce, the absorption of nifedipine from the gastrointestinal tract.

Chronic stable and vasospastic angina

The initial dose is 10 mg (1 tablet) 2-3 times a day. If the clinical effect is not sufficiently pronounced, the dose of the drug is gradually increased to 2 tablets. (20 mg) 1-2 times/day. The maximum daily dose is 40 mg (4 tablets/day).

Essential hypertension

The average daily dose is 10 mg (1 tablet) 2-3 times a day.

If the clinical effect is not sufficiently pronounced, it is possible to gradually increase the dose of the drug to 20 mg (2 tablets) 2 times a day. The maximum daily dose is 40 mg (4 tablets/day).

When prescribed twice, the minimum interval between doses of the drug should be at least 4 hours.

The duration of treatment is determined by the attending physician.

Pharmacodynamics

Strengthens coronary blood flow, improves blood supply to ischemic areas of the myocardium without developing the “steal” phenomenon, and activates the functioning of collaterals. By dilating peripheral arteries, it reduces peripheral vascular resistance, myocardial tone, afterload and oxygen demand. It has virtually no effect on the sinoatrial and AV nodes and has weak antiarrhythmic activity. Increases renal blood flow, causes moderate natriuresis. The negative chrono-, dromo- and inotropic effects are overlapped by reflex activation of the sympathoadrenal system and an increase in heart rate in response to peripheral vasodilation. Does not affect the tone of the veins. The onset of the clinical effect is 20 minutes, its duration is 4-6 hours.

Pharmacokinetics

Suction

Absorption is high (more than 90%). Bioavailability - 50-70%. Eating increases bioavailability. Has a “first pass” effect through the liver. The Cmax of nifedipine in blood plasma after a single oral dose of 2 tablets (corresponding to 20 mg of nifedipine) is achieved after 1-3 hours and its value averages 28.3 ng/ml.

Distribution

Binding to blood plasma proteins (albumin) - 95%.

Penetrates through the BBB and placental barrier, excreted in breast milk.

There is no cumulative effect.

Metabolism and excretion

Completely metabolized in the liver.

T1/2 is 2-5 hours. It is excreted by the kidneys in the form of an inactive metabolite (60-80% of the dose taken), 20% with bile.

Pharmacokinetics in special clinical situations

Chronic renal failure, hemodialysis and peritoneal dialysis do not affect pharmacokinetics.

In patients with liver failure, total clearance decreases and T1/2 increases.

Indications for use Corinfar retard 20 mg 30 pcs. extended-release film-coated tablets

Chronic stable angina (angina pectoris);
Prinzmetal's angina (variant angina);
arterial hypertension.

Contraindications

Arterial hypotension (systolic blood pressure below 90 mm Hg);
cardiogenic shock, collapse;
chronic heart failure in the stage of decompensation;
severe aortic stenosis;
unstable angina;
acute myocardial infarction (first 4 weeks);
combined use with rifampicin;
I trimester of pregnancy;
lactation period (breastfeeding);
hypersensitivity to nifedipine and other 1,4-dihydropyridine derivatives or other components of the drug.

With caution: mitral valve stenosis, hypertrophic obstructive cardiomyopathy, severe bradycardia or tachycardia, SSSS, malignant arterial hypertension, hypovolemia, severe cerebrovascular accidents, myocardial infarction with left ventricular failure, gastrointestinal obstruction, renal and hepatic failure, hemodialysis (due to the risk of arterial hypotension), II and III trimesters of pregnancy, childhood and adolescence up to 18 years (efficacy and safety have not been established), simultaneous use of beta-blockers, digoxin.

Application of Corinfar retard 20 mg 30 pcs. extended-release film-coated tablets during pregnancy and lactation

The drug is contraindicated in the first trimester of pregnancy and lactation.

With caution: the drug should be prescribed in the second and third trimesters of pregnancy.

Use in children

With caution: under 18 years of age (efficacy and safety have not been established).

special instructions

During the treatment period it is necessary to refrain from taking ethanol. It is recommended to stop treatment with the drug gradually.

It should be borne in mind that angina pectoris may occur at the beginning of treatment, especially after recent abrupt withdrawal of beta-blockers (the latter should be withdrawn gradually).

In case of severe heart failure, the drug is dosed with great caution.

The diagnostic criteria for prescribing the drug for vasospastic angina are: the classic clinical picture, accompanied by an increase in the ST segment, the occurrence of ergonovine-induced angina or coronary artery spasm, the detection of coronary spasm during angiography or the identification of an angiospastic component without confirmation (for example, with a different voltage threshold or with unstable angina, when ECG data indicate transient vasospasm).

In patients with irreversible renal failure who are on hemodialysis, have high blood pressure and reduced blood volume, the drug should be used with caution, because a sharp drop in blood pressure is possible. Patients with impaired liver function are closely monitored; if necessary, reduce the dose of the drug and/or use other dosage forms of nifedipine.

If surgical intervention under anesthesia is necessary, it is necessary to inform the anesthesiologist about the patient's treatment with nifedipine.

During in vitro fertilization, in some cases, BMCC caused changes in the head part of the sperm, which can lead to dysfunction of the sperm. In cases in which repeated in vitro fertilization has not been carried out for an unclear reason, the use of BMCC, including nifedipine, can be considered a possible reason for failure.

During treatment, it is possible to obtain a false positive result from the direct Coombs test and laboratory tests for antinuclear antibodies.

In the spectophotometric determination of vanillyl-mandelic acid in urine, nifedipine may cause a falsely high result, however, nifedipine does not affect the results of tests carried out using HPLC.

Caution should be exercised during simultaneous treatment with nifedipine, disopyramide and flecainide due to a possible increase in inotropic effect.

Impact on the ability to drive vehicles and operate machinery

During the treatment period, patients must be careful when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Overdose

Symptoms: headache, facial flushing, prolonged pronounced decrease in blood pressure, depression of sinus node function, bradycardia/tachycardia, bradyarrhythmia. In case of severe poisoning - loss of consciousness, coma.

Treatment: symptomatic therapy. In case of severe poisoning (collapse, suppression of the sinus node), the stomach is washed (if necessary, the small intestine), and activated charcoal is prescribed. The antidote is calcium preparations; intravenous administration of 10% calcium chloride or calcium gluconate is indicated, followed by transfer to a long-term infusion. With a pronounced decrease in blood pressure, slow intravenous administration of dopamine, dobutamine, adrenaline or norepinephrine is indicated. It is recommended to monitor glucose levels (insulin release may decrease) and electrolytes in the blood (K+, Ca2+). With the development of heart failure - intravenous administration of strophanthin. For conduction disorders - atropine, isoprenaline or an artificial pacemaker. Hemodialysis is not effective; plasmapheresis is recommended.

Side effects Corinfar retard 20 mg 30 pcs. extended-release film-coated tablets

From the cardiovascular system: tachycardia, palpitations, arrhythmias, peripheral edema (ankles, feet, legs), manifestations of excessive vasodilation (asymptomatic decrease in blood pressure, development or worsening of heart failure, “flushes” of blood to the facial skin, hyperemia of the facial skin, feeling of heat), marked decrease in blood pressure (rare), syncope. In some patients, especially at the beginning of treatment or when the dose is increased, angina attacks and, in isolated cases, myocardial infarction may occur, which requires discontinuation of the drug.

From the nervous system: headache, dizziness, general weakness, increased fatigue, drowsiness. With long-term use of the drug in high doses - paresthesia of the limbs, tremor, extrapyramidal (parkinsonian) disorders (ataxia, “mask-like” face, shuffling gait, tremor of the hands and fingers, difficulty swallowing), depression.

From the digestive system: dyspepsia (nausea, diarrhea or constipation), dry mouth, flatulence, increased appetite; rarely - gum hyperplasia, which completely disappears after discontinuation of the drug; with long-term use - liver dysfunction (intrahepatic cholestasis, increased activity of liver transaminases).

From the musculoskeletal system: arthritis, myalgia, swelling of the joints, cramps of the upper and lower extremities.

Allergic reactions: rarely - skin itching, urticaria, exanthema, autoimmune hepatitis, exfoliative dermatitis, photodermatitis, anaphylactic reactions.

From the hematopoietic system: anemia, leukopenia, thrombocytopenia, thrombocytopenic purpura, agranulocytosis.

From the urinary system: increased daily diuresis, deterioration of renal function (in patients with renal failure).

Other: rarely - visual impairment (including transient blindness at the maximum concentration of nifedipine in the blood plasma), gynecomastia (in elderly patients, completely disappearing after discontinuation of the drug), galactorrhea, hyperglycemia, pulmonary edema, bronchospasm, weight gain.

Drug interactions

With the simultaneous use of other antihypertensive drugs, as well as tricyclic antidepressants, nitrates, cimetidine, inhalational anesthetics, diuretics, the hypotensive effect of nifedipine may be enhanced.

BMCCs may further enhance the negative inotropic effects of antiarrhythmic drugs such as amiodarone and quinidine.

When nifedipine is combined with nitrates, tachycardia increases.

Diltiazem inhibits the metabolism of nifedipine in the body, which may require a reduction in the dose of nifedipine when these drugs are prescribed simultaneously.

Reduces the concentration of quinidine in blood plasma.

Increases the concentration of digoxin and theophylline in the blood plasma.

Rifampicin accelerates the metabolism of nifedipine; co-administration is not recommended.

When administered concomitantly with cephalosporins (for example, cefixime), the concentration of cephalosporins in the blood may increase.

Sympathomimetics, NSAIDs (suppression of prostaglandin synthesis in the kidneys and retention of sodium ions and fluid in the body), estrogens (fluid retention in the body) reduce the hypotensive effect.

Nifedipine can displace drugs with a high degree of binding from protein binding (including indirect anticoagulants - coumarin and indanedione derivatives, anticonvulsants, NSAIDs, quinine, salicylates, sulfinpyrazone), as a result of which their concentrations in the blood plasma may increase.

Nifedipine inhibits the metabolism of prazosin and other alpha-blockers, which may lead to increased hypotensive effects.

If necessary, the dose of vincristine is reduced, because nifedipine inhibits its elimination from the body, which may cause increased side effects.

Lithium preparations may enhance toxic effects (nausea, vomiting, diarrhea, ataxia, tremor, tinnitus).

When procainamide, quinidine and other drugs known to prolong the QT interval are co-administered, the risk of significant prolongation of the QT interval increases.

Grapefruit juice inhibits the metabolism of nifedipine in the body and is therefore contraindicated during treatment with nifedipine.

Nifedipine is metabolized by the CYP3A isoenzyme, and therefore the simultaneous use of drugs that inhibit this system can lead to interaction between this drug and nifedipine: for example, macrolides, antiviral drugs (for example, amprenavir, indinavir, nelfinavir, ritonavir or saquinavir), antifungal drugs of the group azoles (ketoconazole, itraconazole or fluconazole) cause an increase in the concentration of nifedipine in the blood plasma.

Taking into account the experience with the use of nimodipine BMCC, similar interactions with nifedipine cannot be excluded: carbamazepine, phenobarbital can cause a decrease in the concentration of nifedipine in the blood plasma, and valproic acid can cause an increase in the concentration of nifedipine in the blood plasma.

Side effects

Taking Concor may be accompanied by side effects:

From the nervous system: increased fatigue, dizziness, headache, sleep disturbances, depression may be observed (especially at the beginning of therapy), rarely - hallucinations (usually mild and disappear within 1-2 weeks), sometimes - paresthesia.
On the part of the organ of vision: visual disturbances, decreased tear production (must be taken into account when wearing contact lenses), conjunctivitis.
From the cardiovascular system: in some cases - orthostatic hypotension, bradycardia, AV conduction disturbances, decompensation of heart failure with the development of peripheral edema, at the beginning of treatment - deterioration of the condition of patients with intermittent claudication or Raynaud's syndrome.
From the respiratory system: in isolated cases - shortness of breath (in patients prone to bronchospasm).
From the gastrointestinal tract: in some cases - diarrhea, constipation, nausea, abdominal pain, increased activity of liver enzymes in the blood serum (AST, ALT), hepatitis.
From the musculoskeletal system: in some cases - muscle weakness, cramps, arthropathy affecting one or more joints (mono- or polyarthritis).
From the endocrine system: decreased glucose tolerance (with latent diabetes mellitus) and masking of signs of hypoglycemia, in some cases - increased TG levels in the blood, potency disorders.
On the skin: sometimes - itching, skin hyperemia, increased sweating, rash. When treated with beta-adrenergic receptor blockers, hair loss, hearing impairment or tinnitus, weight gain, mood changes, short-term memory loss, allergic rhinitis, and priapism are observed in some cases.

Corinfar

From the cardiovascular system: tachycardia, arrhythmias, peripheral edema (ankles, feet, legs), manifestations of excessive vasodilation (asymptomatic decrease in blood pressure, “flushes” of blood to the facial skin, flushing of the facial skin, feeling of heat), excessive decrease in blood pressure (rarely), fainting , development or worsening of heart failure (usually worsening of an existing one). In some patients (especially with severe obstructive lesions of the coronary arteries), at the beginning of treatment or when the dose is increased, attacks of angina pectoris may occur, including the development of myocardial infarction (requires discontinuation of the drug).

From the nervous system: headache, dizziness, increased fatigue, asthenia, drowsiness. With long-term ingestion in high doses - paresthesia of the limbs, tremor, extrapyramidal (parkinsonian) disorders (ataxia, mask-like face, shuffling gait, stiffness of the arms or legs, tremor of the hands and fingers, difficulty swallowing), depression.

From the digestive system: dry mouth, increased appetite, dyspepsia (nausea, diarrhea or constipation); rarely - gum hyperplasia (bleeding, pain, swelling), with long-term use - liver dysfunction (intrahepatic cholestasis, increased activity of liver transaminases).

From the musculoskeletal system: rarely - arthralgia, swelling of the joints, myalgia.

From the hematopoietic organs: anemia, leukopenia, thrombocytopenia, thrombocytopenic purpura, asymptomatic agranulocytosis.

From the urinary system: increased daily diuresis, deterioration of renal function (in patients with renal failure).

Allergic reactions to the components of the drug: rarely - itching, urticaria, exanthema, autoimmune hepatitis.

Local reactions: burning at the site of intravenous administration.

Other: rarely - visual impairment (including transient loss of vision against the background of Cmax in plasma), gynecomastia (in elderly patients, completely disappearing after withdrawal), galactorrhea, hyperglycemia, pulmonary edema (difficulty breathing, cough, wheezing), weight gain. Overdose. Symptoms: headache, flushing of the facial skin, prolonged pronounced decrease in blood pressure, suppression of sinus node function, bradycardia, bradyarrhythmia.

Treatment: in case of severe poisoning (collapse, depression of the sinus node), gastric lavage is performed and activated charcoal is prescribed. The antidote is Ca2+ preparations: slow intravenous administration of 10% CaCl2 or calcium gluconate is indicated, followed by switching to a long-term infusion.

With a pronounced decrease in blood pressure, dopamine or dobutamine is administered intravenously. For conduction disorders - atropine, isoprenaline or an artificial pacemaker. With the development of heart failure - intravenous administration of strophanthin. Catecholamines should be used only when there is a threat to life (due to their reduced effectiveness, a high dosage is required, which increases the risk of developing arrhythmia). It is recommended to monitor blood concentrations of glucose (insulin release may decrease) and electrolytes (K+, Ca2+).

Hemodialysis is ineffective.