To treat psoriasis, neurodermatitis, eczema and other skin diseases, various ointments are used, including those based on hydrocortisone. Such drugs include Lokoid cream. It has a quick effect and is safe for health. Suitable for both adults and children aged 6 months and older. You can buy the product at an affordable price and without a prescription.
Lokoid cream: description
The drug is a thick, translucent ointment for external use only. The composition includes the active ingredient hydrocortisone in the form of butyrate - a concentration of 1 mg per 1 g or 0.1%. Auxiliary components are a base with petroleum jelly and polyethylene.
The ointment is packaged in aluminum tubes weighing 30 g. It can be stored under normal room conditions at temperatures up to 25 degrees Celsius. It is necessary to exclude access to direct sunlight and also keep it away from children. The ointment can be used within the general shelf life of 5 years from the date of production.
Which ointment to choose
Only a professional dermatologist should decide which ointment to treat psoriasis. His task is to choose the safest and at the same time effective drug. For more than 25 years, the PsorMak clinic has been practicing treatment with ointment against psoriasis, made according to the original recipe. There are no hormonal components in the composition, which provides the product with the following advantages:
- Possibility of use by children and pregnant women;
- absence of withdrawal and addiction syndrome;
- mild impact without provoking relapses;
- no contraindications.
But our specialists understand that even the most effective ointment for the treatment of psoriasis must be suitable for the patient. Therefore, before prescribing, we make sure to conduct a complete diagnosis.
In addition, an integrated approach is important in the treatment of psoriasis.
In this regard, our dermatologists develop an individual diet for the patient, and, if necessary, provide a referral for acupuncture and psychotherapy. If you want to achieve a long-term relapse and stop struggling with unpleasant symptoms every day, sign up for a consultation at PsorMac and we will select an individual treatment regimen for you. April 27, 2020
Author of the article: dermatologist Mak Vladimir Fedorovich
Pharmacodynamics
The components of the drug esterify the hydrocortisone molecule, combining with butyric acid. This leads to a significant increase in chemical activity compared to native compounds. The product inhibits inflammatory processes, reduces itching and swelling.
If the dosage is observed, the drug acts safely for health and does not suppress the hypothalamic, pituitary and adrenal systems. Moreover, if used in large doses for a long period, the content of cortisol in the bloodstream may increase. But as a rule, this does not lead to a deterioration in the functioning of the pituitary gland and adrenal glands. In addition, stopping treatment almost immediately normalizes cortisol synthesis.
After use, the active substance quickly accumulates in the superficial tissues of the skin, mainly in the granular layers of the epidermis. Penetration into the bloodstream is negligible. The substance is processed mainly in the tissues of the skin, and is partially excreted in the urine and through the intestines in the same form.
Lokoid ointment 0.1% 30g No. 1
Name
Lokoid.
Release form
Ointment for external use.
Dosage
0.1% 30 g. Quantity per package: 1 pc.
Manufacturer
Astellas Pharma Inc.
INN
Hydrocortisone.
FTG
Glucocorticosteroid for local use.
Compound
1 g of ointment contains: Active substance: hydrocortisone 17-butyrate -1.0 mg, Excipients: polyethylene ointment base (vaseline oil 95%, polyethylene 5%) - up to 1.0 g.
Description
Translucent, from light gray to almost white, homogeneous, soft, greasy ointment.
Pharmacotherapeutic group
Corticosteroids for use in dermatology. ATX code: D07AB02.
Pharmacological properties
Pharmacodynamics Hydrocortisone butyrate is an active synthetic non-halogenated glucocorticosteroid for topical use. It has a fast-onset anti-inflammatory, anti-edematous, anti-allergic effect. The anti-inflammatory effect of hydrocortisone butyrate is more powerful than hydrocortisone acetate, its effectiveness is comparable to halogenated steroids. Pharmacokinetics Absorption After application, the active substance accumulates in the epidermis, mainly in the granular layer; systemic absorption is negligible. A small amount of hydrocortisone 17-butyrate is absorbed into the systemic circulation unchanged. Metabolism Most hydrocortisone 17-butyrate is metabolized to hydrocortisone and other metabolites directly in the epidermis and subsequently in the liver. Excretion Metabolites and a small part of unchanged hydrocortisone 17-butyrate are excreted by the kidneys and intestines.
Indications for use
Superficial, non-infected skin diseases sensitive to local glucocorticosteroids: dermatitis, including atopic, contact, seborrheic; eczema; psoriasis. Topical corticosteroids are not usually indicated for psoriasis, but they may occasionally be used, except in the advanced plaque form, in which they are not recommended.
Contraindications
hypersensitivity to hydrocortisone or auxiliary components of the drug. bacterial skin infections (strepto- and staphyloderma, gram-negative folliculitis, etc.); viral skin infections (herpes simplex, chicken pox, shingles, etc.) fungal skin infections; tuberculous and syphilitic skin lesions; parasitic skin infections; neoplastic skin changes (benign and malignant tumors); acne, rosacea, perioral dermatitis; post-vaccination period; violation of the integrity of the skin (wounds, ulcers); With caution: pregnancy, lactation period.
Pregnancy and lactation
The safety of corticosteroids during pregnancy has not been proven. Topical application of corticosteroids to animals during pregnancy can cause fetal developmental disorders, including patent palate and intrauterine growth restriction. There is a small risk of such consequences when using the drug in humans. Theoretically, there is a possibility of dysfunction of the child's adrenal glands due to systemic absorption of corticosteroids in the mother's body. There is no data on the amount of hydrocortisone excreted in breast milk. Prescribing the drug to women during lactation is possible only in cases where the potential benefit of use outweighs the possible risk to the child. It is recommended to take special care when prescribing the drug to women during lactation. Women who are breastfeeding should not apply the cream to the mammary gland.
Directions for use and doses
For topical use. Lokoid in the form of an ointment is used for subacute and chronic processes, especially in the presence of lichenification, infiltration, and dryness. A small amount of the drug is evenly applied with massaging movements to the affected skin no more than twice a day. The frequency of application of the drug and the duration of therapy are determined by the doctor. If the dynamics are positive, the frequency of use of the drug can be reduced to 2-3 times a week. Under occlusive dressings, the drug can be applied only to small areas in case of a resistant course of the disease, for example, when dense psoriatic plaques are localized on the elbows and knees. The dose of the drug used during the week should not exceed 30-60 g. No dose adjustment or dosage regimen is required in the elderly. Children. In children, the drug should be prescribed for the shortest possible time. In young children, the total duration of treatment should not exceed 7 days.
Side effect
Side effects are listed by frequency of occurrence: rare (> 1: 10,000,
Overdose
When applied to large areas of skin and/or prolonged use, as well as use under occlusive dressings, symptoms of hypercortisolism and suppression of adrenal cortex function may develop. If symptoms of overdose appear, you should stop using the drug.
Interaction with other drugs
There are no data on drug interactions with Lokoid. During the treatment period, vaccination is not recommended.
Precautionary measures
Locoid® should not be applied to the periorbital area due to the risk of developing glaucoma. In case of systematic contact with the conjunctiva, there is a risk of increasing intraocular pressure. It is not advisable to use any glucocorticosteroids for external use in the form of an ointment on the scalp, as well as in acute inflammation (especially exudative). For the treatment of steroid-sensitive skin lesions localized in the face, folds, genitals, as well as on areas of skin with abundant hair, it is preferable to use other dosage forms of Lokoid (cream, crelo). It is not advisable to use the drug in the presence of atrophic skin changes. The risk of local and systemic side effects increases when applied to large areas, long-term use, use of occlusion and in childhood. If there is no effect within 7 days of continuous treatment or the condition worsens, it is recommended to consult a doctor. As with the use of any glucocorticosteroid drug, it is advisable to limit the duration of use and the course dose to the minimum sufficient to stop the skin process. As a result of topical use of hydrocortisone butyrate, the release of adrenocorticotropic hormone (ACTH) by the pituitary gland may decrease due to inhibition of the pituitary-adrenal axis, the level of cortisol in the blood will decrease and iatrogenic Cushing's syndrome may occur, which disappears after discontinuation of the drug. It is recommended to periodically monitor the function of the adrenal cortex by determining cortisol in the blood and urine after stimulation of the adrenal glands with ACTH. If an infection occurs at the site of application of the drug, antibacterial or antifungal treatment should be used. If symptoms do not go away, you should stop using the drug until the infection is cured. Use the drug on the skin of the face, as well as on the skin of the axillary and groin areas only in extremely necessary cases due to increased absorption and the high possibility of side effects (telangiectasia, perioral dermatitis), even after short-term use. Topical corticosteroids may be harmful in psoriasis for a number of reasons, including relapse after tolerance has developed, risk of generalized pustular psoriasis, and local systemic toxicity due to decreased skin barrier function. Steroids may be used for scalp psoriasis and chronic vulgar plaque psoriasis of the arms and legs with close medical supervision.
Use in pediatrics
The drug is used in children from 6 months of age. Do not use in children under 10 years of age without consulting a doctor. When used in children, the area of the treated skin area should not exceed 20% of the body surface area. In children, the drug should be prescribed for the shortest possible time. In young children, the total duration of treatment should not exceed 7 days. Avoid measures that lead to increased absorption of corticosteroids (warming, fixing and occlusive dressings). In childhood, suppression of adrenal function may develop more quickly with the use of topical corticosteroids. In addition, there may be a decrease in growth hormone production. When using the drug for a long time, it is necessary to monitor body weight, height, and plasma cortisol levels.
Impact on the ability to drive vehicles and operate machinery
There is no data on the effect of Lokoid on the ability to drive vehicles and operate machinery.
Release form
Ointment for external use 0.1%. 30 g of ointment is placed in an aluminum tube with an aluminum membrane and a screw cap made of high-density polyethylene. 1 tube along with instructions for use in a cardboard box.
Storage conditions
At a temperature not exceeding 25°C. Keep out of the reach of children.
Best before date
5 years. Do not use after expiration date.
Conditions for dispensing from pharmacies
By doctor's prescription.
Buy Lokoid ointment 0.1% 30g No. 1 in the pharmacy
Price for Lokoid ointment 0.1% 30g No. 1
Instructions for use for Lokoid ointment 0.1% 30g No. 1
Indications
Lokoid is a hormone belonging to the group of glucocorticoids. Use only under close medical supervision. The main indications for use are:
- psoriasis (as an additional therapeutic measure);
- neurodermatitis;
- barley;
- eczema;
- allergic reactions;
- conjunctivitis;
- reaction to insect bites;
- itching of the skin of various nature;
- shock - treatment and preventive measures.
Contraindications and side effects
In some cases the drug cannot be used:
- bacterial skin infections;
- viral infectious skin lesions;
- fungal infections;
- syphilis;
- tuberculosis;
- infections associated with parasites;
- skin tumors of various natures, including cancer;
- period after vaccination;
- wounds, ulcers;
- individual intolerance to components;
- all stages of pregnancy;
- feeding period.
The drug is safe for health, but in some cases it can cause allergic reactions, including itching and irritation. They do not require treatment and go away on their own after you stop taking them.
Also, during long-term treatment, systemic side effects are possible. The risks of their occurrence are not as high compared to the use of fluorinated steroids.
Signs of hypercortisolism may occur, including:
- the skin becomes very sensitive;
- wounds and bruises take a long time to heal, poorly;
- menstrual irregularities;
- skin rash;
- increased hair growth;
- general weakness;
- rapid weight gain;
- increase in pressure;
- anxiety, mood disorders;
- depressive states;
- sleep disorders.
Such symptoms appear rarely and only after prolonged use. If at least one of the described effects is detected, you should stop therapy and immediately consult a doctor to prescribe a course of treatment.
Contraindications to the use of the drug Lokoid
- dermatitis complicated by bacterial (pyoderma, syphilis and tuberculosis), viral (herpes, chickenpox, herpes zoster, genital warts, warts, molluscum contagiosum), fungal and parasitic infections;
- wounds and ulcerative skin lesions;
- perioral dermatitis; atrophic skin lesions;
- rosacea localized in the facial area; acne, ichthyosis, teenage plantar dermatosis, fragility of skin vessels;
- hypersensitivity to the components of the drug or to other corticosteroids;
- age up to 6 months.
special instructions
The product should not be applied to the area near the eyes (eyelids), as this may lead to the development of glaucoma. If the drug constantly gets on the conjunctiva, this can cause an increase in intraocular pressure.
If dry eyes are severe, hyperkeratosis is observed, the drug is used only in the form of an ointment, lipocrem is also available. The ointment should not be used if atrophic changes in the skin are diagnosed.
It should be remembered that the risk of side effects increases when applied to large areas of the body, as well as during prolonged use.
If the therapeutic effect does not occur within 2 weeks (reception is carried out in a row), therapy should be discontinued and consult a doctor to clarify the diagnosis.
Use in pediatrics
The ointment can be prescribed to children from 6 months, but only under the supervision of a doctor. If the product is applied using occlusive dressings or on the skin of the face, the course of therapy should be reduced to a minimum. In this case, the maximum area of the treated cover should be less than 20% of the entire surface.
It should be noted that in children, adrenal suppression may manifest itself more quickly. A decrease in the synthesis of growth hormone is also often observed. If you use the ointment for a long time, it is important to monitor the child’s weight and monitor the concentration of cortisol in the blood, which is only possible with the participation of a doctor.
There is research data according to which children who received 7-8 g of ointment daily for a month did not experience side effects. The adrenal cortex worked normally in all those observed.
Use of the drug Lokoid
For adults and children (over 6 months of age), a small amount of the drug is applied to the affected area of the skin 1-3 times a day. When positive dynamics appear, the drug is used 1 to 3 times a week. To improve penetration, the drug is applied with massaging movements. In cases of resistant disease, for example, when dense psoriatic plaques are localized in the elbows, knees, Lokoid ointment or cream must be applied under occlusive dressings. In case of weeping skin lesions, it is advisable to use Locoid Crelo cutaneous emulsion under an occlusive dressing. The dose of the drug used during the week should not exceed 30–60 g. The duration of the course of treatment is determined individually and depends on the dynamics of the disease.
