Pharmacodynamics and pharmacokinetics
The basis of the drug is phenibut , which determines its use as an antihypoxant and anti-anamnestic agent . It is characterized by the properties of an anticonvulsant and tranquilizer : reducing the severity of cognitive disorders, anxiety, fear, normalizing sleep, improving physical and mental performance .
For patients suffering from asthenia , taking the drug helps improve performance without side effects, for example: agitation or irritability . Also, effectiveness is manifested in the treatment of patients who are bothered by vasovegetative symptoms : headache, sudden changes in mood, sleep disturbances, dizziness. At the same time, while providing a positive effect, therapy does not contribute to the deterioration of attention, memory or speed of mental reactions.
The drug potentiates the effect of hypnotics, tranquilizers, anticonvulsants and neuroleptics , without having a negative effect on the activity of adrenergic and cholinergic receptors. Noofen is well tolerated and completely absorbed from the gastrointestinal tract, penetrating the BBB. Excretion of the active substance occurs gradually through the kidneys. Repeated administration does not cause accumulation.
Pharmacological properties
The drug belongs to the group of nootropic drugs. The capsules have some calming effects, improve memory and increase concentration. After taking the drug orally, patients note increased ability to work, elimination of anxiety and anxiety, and normalization of night sleep.
Unlike sedative drugs, Noofen capsules do not cause drowsiness and lethargy, and after cessation of therapy, patients do not develop withdrawal syndrome.
Under the influence of the drug, panic attacks associated with neurocirculatory dysfunction are significantly reduced.
The dominant antihypoxic and antiamnestic effect of Noofen is. Has tranquilizing properties, stimulates memory and learning, increases physical performance; eliminates psycho-emotional tension, anxiety, fear and improves sleep; prolongs and enhances the effect of sleeping pills, narcotics, neuroleptics and anticonvulsants. Does not affect cholinergic and adrenergic receptors. The drug lengthens the latent period and shortens the duration and severity of nystagmus, and has an antiepileptic effect. Noticeably reduces the manifestations of asthenia and vasovegetative symptoms, including headache, a feeling of heaviness in the head, sleep disturbance, irritability, emotional lability, and increases mental performance.
Indicators of higher nervous activity (attention, memory, speed and accuracy of sensory-motor reactions) improve under the influence of Noofen. In patients with asthenia and in emotionally labile patients, from the first days of therapy with the drug, their well-being improves, their interest and initiative, and motivation for vigorous activity without sedation or agitation increase. When used after a traumatic brain injury, Noofen increases the number of mitochondria in the cells of perifocal tissues and improves the bioenergetics of the brain.
The drug lengthens the latent period and shortens the duration and severity of nystagmus. Significantly reduces the manifestations of asthenia and vasovegetative symptoms, incl. headache, feeling of heaviness in the head, sleep disturbance, irritability, emotional lability, increases mental performance, improves well-being, increases interest and initiative, motivation for vigorous activity without sedation or agitation.
Unlike tranquilizers, under the influence of Noofen, psychological indicators (attention, memory, speed and accuracy of sensory-motor reactions) improve. There was no development of addiction or dependence on the drug or withdrawal syndrome.
Pharmacokinetics
Suction and distribution
After oral administration, the drug is well absorbed and penetrates into all tissues of the body. About 0.1% of γ-amino-β-phenylbutyric acid hydrochloride penetrates into brain tissue from the dose of the drug taken; in young and elderly patients, increased penetration through the BBB is possible. After 3 hours, γ-amino-β-phenylbutyric acid hydrochloride is detected in the urine, at the same time the concentration in brain tissue does not decrease; it is detected in the brain after another 6 hours.
With repeated use, the drug does not accumulate in the body.
The greatest binding of γ-amino-β-phenylbutyric acid hydrochloride occurs in the liver (80%), it is not specific.
Metabolism and excretion
80-95% of the drug is metabolized in the liver to pharmacologically inactive metabolites. 5% is excreted unchanged from the body by the kidneys. The day after taking the drug, γ-amino-β-phenylbutyric acid hydrochloride can only be detected in the urine; it is determined in urine 2 days after administration, but the detectable amount is 5% of the administered dose.
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The drug has a positive effect on the metabolism of brain cells. Patients who take Noofen for a long time notice a psychostimulating, tranquilizing, nootropic effect of the drug. Vasovegetative symptoms and asthenia become less pronounced under the influence of aminophenylbutyric acid hydrochloride.
Taking the medication helps lengthen the latent period and reduce the severity of nystagmus. Aminophenylbutyric acid hydrochloride helps cope with mild attacks of epilepsy, but does not affect adrenergic and cholinergic receptors. Patients with asthenia and emotional lability from the first days of the course note an improvement in their overall well-being, the emergence of motivation for vigorous activity without sedation.
In case of traumatic brain injury, the use of aminophenylbutyric acid hydrochloride helps to increase the number of mitochondria in the cells of perifocal tissues. As a result, the speed of bioenergetic processes in the brain increases, which contributes to the patient’s accelerated recovery after injury. In patients with a sick stomach and heart, the process of lipid peroxidation is normalized during the course.
Instructions for Noofen (Method and dosage)
As the instructions for use of Noofen indicate, adult patients are usually prescribed a daily dosage of 0.25-0.5 g. Take tablets 3 times a day and, if necessary, the dose is increased to 2.5 g. In this case, a single dose of the drug should not exceed 0 .75 g. For patients over 60 years of age, no more than 0.5 g is prescribed.
When the drug is prescribed during the treatment of alcoholism or withdrawal syndrome , a certain regimen is established: 0.25-0.5 g 3 times during the day and 0.75 g before bedtime. This regimen is followed for several days, after which the patient is transferred to standard dosages.
Thus, if mild symptoms of the disorder occur, an average or reduced dosage is prescribed. If an increase in symptoms is noted, the dosage is increased.
Interaction with other drugs
For the purpose of mutual potentiation, Noofen can be combined with other nootropic drugs, reducing the doses of Noofen and the combined medications.
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Extends and enhances the effect of hypnotic, neuroleptic and antiparkinsonian drugs.
Sometimes Noofen is prescribed in combination therapy with other drugs, including psychotropic drugs. Simultaneous use with tranquilizers, hypnotics and antipsychotics leads to a mutual enhancement of the effect.
Noofen can be used with other drugs, including psychotropic drugs (tranquilizers and antipsychotics), since their effects can be mutually reinforcing.
It is prohibited to drink alcohol while using Noofen.
Noofen tablets can be used with other psychotropic drugs. The dosage of the product is reduced several times. When using a nootropic simultaneously with sleeping pills, antipsychotics, and tranquilizers, the effects mutually enhance. When managing complex mechanisms, it is not recommended to use neurometabolic stimulants with antipsychotics. This combination of drugs leads to inhibition of mental reactions.
Noofen for children
For the treatment of children, Noofen powder is mainly used, which is prescribed according to age groups. As the instructions indicate, children 3-4 years old are given the medicine 0.1 g 2 times a day, from 5 to 6 years old - 2-3 times 0.1 g daily, 7-10 years old - 3-4 times 0.1- 0.2 g, 11-14 years – 2-3 times 0.2-0.3 g. Patients over 14 years old can be prescribed an adult dosage.
In general, powder for children is actively used in pediatric practice. It is often used to treat babies under one year old. In most cases, Noofen has a beneficial effect - sleep improves, motor activity normalizes, and so on. The main thing is not to take the drug yourself, since prescribing it requires consultation with a specialist and a thorough examination.
Special conditions
In a dry place, protected from light, at a temperature of 15–25 °C.
Shelf life: 2 years.
With long-term use of Noofen, liver function indicators and blood cellular composition should be monitored.
Reviews of Noofen report its effect on the ability to drive a car and operate machinery (dizziness, drowsiness). Therefore, during treatment, special care should be taken when driving a car and performing potentially dangerous activities that are associated with increased concentration and speed of reactions.
Price in Russian pharmacies: Noofen capsules 250 mg 20 pcs. – from 984 to 1180 rubles. The drug can be bought at a pharmacy without a doctor's prescription.
Instructions for use recommend storing Noofen capsules away from children, in a dark, dry, cool place. The expiration date is indicated on the packaging and is 3 years from the date of manufacture. After the expiration date, the drug is disposed of.
Store in a dry place, protected from light, at a temperature of 15–25°C.
Overdose
As clinical practice shows, cases of overdose are caused only by significantly exceeding the prescribed dosage over a long period of time, which leads to a hepatotoxic effect.
The main symptoms of overdose are:
- nausea;
- liver failure;
- drowsiness;
- hypotension.
In this case, gastric lavage, sorbents and further treatment are prescribed depending on the symptoms.
Pregnancy
It is not recommended to take Noofen during pregnancy and breastfeeding, since there are not enough clinical observations.
Experimental studies on animals did not establish mutagenic, teratogenic or embryotoxic effects of the drug.
Use of Noofen during pregnancy and breastfeeding is not recommended, because there are not enough clinical observations.
In experimental studies on animals, the mutagenic, teratogenic and embryotoxic effects of the drug were not established.
Noofen's analogs
Level 4 ATX code matches:
Bravinton
Acefen
Carnicetine
Pyracesin
Nooclerin
Semax
Piracetam
Olatropil
Fezam
Vinpocetine
Cerebrocurin
Cavinton Forte
Calcium hopantenate
Glutamic acid
Cephabol
Olanzapine
Cerebrolysate
Pramistar
Sidnocarb
Vinpotropil
It is believed that analogues of Noofen are all drugs created on the basis of the substance - Phenibut . At the same time, the following have a similar effect: Phenopropyl, Calcium hopanthenate, Entrop, Picamilon, Semax, Kindinorm and so on.
Additionally
With long-term use of Noofen, it is necessary to monitor the cellular composition of the blood and liver function indicators.
Impact on the ability to drive vehicles and operate machinery
During the treatment period, patients must be careful when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions, since some patients may experience central nervous system disorders, such as drowsiness and dizziness.
Reviews of Noofen
Numerous reviews on forums show that this drug affects adult patients differently. For some patients, treatment with Noofen turned out to be very effective, as they got rid of almost all unwanted symptoms. However, you can also find reviews where patients did not receive any results. This remedy is especially useless in the treatment of vegetative-vascular dystonia . There are also many reviews that describe cases of developing addiction to this drug or fear of it.
In addition, this remedy is often prescribed to children. Therefore, the most common discussions on the Internet are discussions about the features of reception for children. Reviews about Noofen contain information that in most cases such therapy is highly effective.
As doctors' reviews show, many patients begin to take Noofen on their own when they need to relieve stress, tension, or improve memory. In fact, doing this is strictly contraindicated, since only the attending physician can prescribe competent treatment.
Indications for use
The drug is not prescribed for acute renal failure, phenylketonuria, during pregnancy, lactation, or in case of hypersensitivity to the drug.
Noofen is prescribed with caution for gastrointestinal pathologies - the drug has an irritating effect.
Indications for the use of the drug Noofen are: asthenic and anxiety-neurotic conditions; stuttering, tics and enuresis in children; insomnia and night anxiety in the elderly; Meniere's disease, dizziness associated with dysfunction of the vestibular analyzer of various origins; prevention of motion sickness during kinetosis; as part of complex therapy for alcohol withdrawal syndrome to relieve psychopathological and somatovegetative disorders.
Contraindications to the use of the drug Noofen are: acute renal failure; pregnancy; lactation period; children under 8 years of age (for this dosage form); rare congenital galactose intolerance, lactase deficiency or glucose-galactose malabsorption (since the drug contains lactose); hypersensitivity to the components of the drug.
The drug should be prescribed with caution to patients with erosive and ulcerative diseases of the gastrointestinal tract (due to the irritating effect of the drug, it is recommended to prescribe the drug in smaller doses).
Noofen is indicated for decreased intellectual and emotional activity, memory impairment, and decreased concentration.
Also indicated for asthenic and anxious-neurotic conditions, restlessness, fear, anxiety, neuro-obsessive conditions, psychopathy; in children - with stuttering, enuresis, tics; in elderly people - with insomnia, night restlessness. Prescribed for the prevention of stress, before operations or painful diagnostic tests.
Noofen is used as an adjuvant in the treatment of alcoholism to relieve psychopathological and somatovegetative disorders during withdrawal syndrome.
The drug can be used in combination with generally accepted detoxification agents for the treatment of alcoholic predilection and delirium. It is also prescribed for Meniere's disease, dizziness associated with dysfunction of the vestibular apparatus, and for the prevention of motion sickness.
It is used in the complex treatment of women with osteochondrosis of the cervicothoracic spine and menopausal disorders.
Contraindications to the use of the drug Noofen are: hypersensitivity to the drug, pregnancy, lactation.
Noofen should not be given to children on their own. A prescription for the use of the drug can only be prescribed by the attending physician. Under no circumstances should you rely on the opinions of other parents about this drug. Each child is individual and unique. What is not suitable for one person according to indications and contraindications may be suitable for another. In addition, the medicine can play a critical role in your child's recovery, even if it causes mild side effects.
Noofen price, where to buy
This drug in any form can be bought in Moscow at a cost of 550 rubles.
The average price of Noofen in Ukraine is 137 UAH for the drug in powder, 230 UAH for tablets. At the same time, for example, Donetsk has a lower cost than Kharkov, where tablets cost from 267 UAH.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
LuxPharma* special offer
- Noofen powder 100 mg/dose 1g N15
RUB 2,970 order
ZdravCity
- Noofen capsules 250 mg 20 pcs. Olainfarm JSC
RUB 1,043 order
Pharmacy Dialogue
- Noofen (caps. 250 mg No. 20) Olainfarm OA
1030 rub. order
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Pharmacy24
- Noofen 500 mg N30 capsules AT "Olainfarm", Latvia
952 UAH.order - Noofen 250 mg N20 capsules AT "Olainfarm", Latvia
499 UAH. order
- Noofen 500 mg/dose 2.5 g No. 5 powder AT "Olainfarm", Latvia
385 UAH. order
- Noofen 100 mg/dose 1 g N15 powder AT "Olainfarm", Latvia
301 UAH order
- Noofen 250 mg N20 tablets AT "Olainfarm", Latvia
499 UAH. order
PaniPharmacy
- Noofen capsule Noofen (phenibut) capsules 250 mg No. 20 Latvia, Olainfarm JSC
570 UAH. order
- Noofen Noofen 500 por. doses 500mg/dose pack. 2.5g No. 5 Latvia, Olainfarm JSC
465 UAH. order
- Noofen capsule Noofen capsules 500 mg No. 30 Latvia, Olainfarm JSC
990 UAH. order
- Noofen Noofen 100 por. doses 100mg/dose pack. 1g No. 15 Latvia, Olainfarm JSC
323 UAH. order
- Noofen tablets Noofen (phenibut) tablets. 250 mg No. 20 Latvia, Olainfarm JSC
546 UAH order
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Release form
I produce the sedative Noofen in dosages of 100, 250 and 500 mg. Dosage 100 is a children's version of this antipsychotic. Noofen for children is:
- In capsules;
- In powder;
- In tablets.
The use of a particular form of release of the drug is dictated to a greater extent by the age of the child. After all, it is easier and more convenient for young children to give powder dissolved in warm water rather than a bitter tablet or capsule that will stick to the tongue and throat.
Noofen capsules; per pack 20 pcs.
You can purchase the drug Noofen in the form of tablets and powder for preparing a solution. The standard concentration of the active substance in capsules is 250 mg. The powder may contain 100 or 500 mg of aminophenylbutyric acid hydrochloride. The medicine is classified as a weak tranquilizer, so you cannot buy it in an online store without a doctor’s prescription. Any form of the drug should be stored at a temperature of no more than 25 ° C.
Noofen – tablets 250 mg.
Action
Aminophenylbutyric acid, which is part of Noofen, has the following effects on the human body:
- calming – removes irritability, neutralizes anxiety and fear, relieves emotional stress;
- nootropic – increases mental abilities, improves memory, enhances physical capabilities;
- psychomotor – increases the speed of reactions, enhances attention;
- physical – eliminates headache severity;
- has a positive effect on the quality and duration of sleep.
An important quality of the drug is the absence of drowsiness during its use, and after stopping use, the absence of withdrawal syndrome.
