September 9, 2022 The unpleasant symptoms of sore throat and the complications for which this disease is widely known force us to look for new and increasingly improved means for its treatment. One of the directions in eliminating the manifestations of the disease and combating its causes is the use of local remedies in the form of sprays. Used in conjunction with systemic drugs, they can achieve significant relief of well-being by acting directly on the inflamed areas. In addition, they are able to cope with the infectious component of the disease. Today, one of the most popular forms of release of such drugs has become sprays against sore throat.
Features of treating sore throat with sprays
The choice of drugs for topical use should be based on the effect they have on the inflamed and infected mucous membrane of the throat. The main directions in the treatment of angina are:
- Relief of symptoms;
- Anti-inflammatory effect;
- Antimicrobial action;
- Elimination of mucosal edema
Symptom relief
Pain and burning in the throat caused by the inflammatory process seriously reduce the patient’s quality of life, disrupting appetite, sleep, and general condition. But it is during illness that the body most of all needs proper rest and nutrition. The analgesic effect of sprays occurs when the active substances come into direct contact with the inflamed areas;
Anti-inflammatory effect
The cause of sore throat with sore throat is inflammation of the mucous membrane. A spray for the treatment of sore throat helps to cope with this aspect of the disease and prevent inflammation from spreading to healthy areas;
Antimicrobial action
Sore throat is the result of the penetration of pathogenic microorganisms into the mucous membrane and their active growth and reproduction. Therefore, a spray for purulent or herpes sore throat should have an antimicrobial effect. In addition, the constituent substances of the product must be active against a wide range of bacteria and fungi, since sore throat can be caused by a combination of several types of microbes or complicated by a secondary infection;
Elimination of mucosal edema
Enlarged tonsils and swelling of the mucous membrane of the throat are one of the most unpleasant symptoms of tonsillitis.
It greatly worsens a person’s general well-being, disrupts swallowing function and, accordingly, interferes with the treatment process, since even fluid intake (which is extremely necessary for sore throat) is difficult. Anti-swelling sprays relieve this symptom, which overall promotes recovery. In addition to the listed requirements for sore throat sprays, the convenience of the bottle and dispenser deserves special attention. Since a sore throat can be taken by surprise on a business trip or on vacation, it is important that the drug is convenient for use in any circumstances.
Tanflex 0.15% 30 ml spray
Instructions for medical use of the drug TANFLEX Trade name Tanflex International nonproprietary name Benzidamine Dosage form Oral spray 0.15% Composition 30 ml of spray contain the active substance - benzydamine hydrochloride 0.045 g, excipients: glycerin, sodium saccharin, sodium bicarbonate, ethyl alcohol 96% , methylparaben, mint essence, polysorbate 20, purified water. Description Transparent, colorless liquid with the smell of mint Pharmacotherapeutic group Other drugs for the treatment of diseases of the oral cavity Code ATC A01AD02 Pharmacological properties Pharmacokinetics When applied topically, the drug is easily absorbed into the oral mucosa and quickly penetrates into inflammatory tissues Benzidamine hydrochloride is metabolized in the body in the form of metabolites and excreted kidneys through the intestines. Pharmacodynamics Non-steroidal anti-inflammatory drug. It has anti-inflammatory, anti-edematous and analgesic effects. The mechanism of action is associated with the stabilization of cell membranes and inhibition of prostaglandin synthesis. Indications for use Inflammatory diseases of the oral cavity: - gingivitis, glossitis, stomatitis (including after radiation chemotherapy) periodontal disease, periodontosis - condition after tooth extraction Inflammatory diseases of the ENT organs: - pharyngitis, laryngitis, tonsillitis, tonsillectomy - jaw fractures - calculous inflammation salivary glands. Method of administration and dosage Spray for irrigation of the mouth and throat. Adults and elderly people 4 or 8 times a day with intervals between doses of 1.5-3 hours. Children (aged 6 to 12 years) no more than 4 times a day with intervals of 1.5-3 hours between doses. The treatment period is 4-5 days. If a positive result is not achieved, consult your doctor. Side effects - allergic reactions, drowsiness Local reactions (numbness of tissues or burning sensation in the mouth, dryness of the oral mucosa). Contraindications - hypersensitivity to the active substance or to one of the ingredients - children under 6 years of age Drug interactions Not established Special instructions For infectious and inflammatory diseases, use as part of complex therapy is possible. Avoid contact of the drug with the eyes. Pregnancy and lactation Use with caution during pregnancy and lactation. Features of the effect of the drug on the ability to drive vehicles and work with potentially dangerous mechanisms Not identified Overdose No cases of overdose were noted. Release form and packaging 30 ml of the drug is poured into dark glass bottles equipped with a mechanical sprayer. 1 bottle, along with instructions for medical use in the state and Russian languages, is placed in a cardboard box. Storage conditions Store in a dry place, protected from light, at a temperature not exceeding 30° C. Keep out of the reach of children! Shelf life: 3 years Do not use after the expiration date indicated on the package! Dispensing conditions Without a prescription, Turkey Owner of the registration certificate "ABDI IBRAHIM", Turkey Address of the organization that accepts claims from consumers on the quality of products in the territory of the Republic of Kazakhstan "Abdi Ibrahim Global Pharm" LLP Republic of Kazakhstan, Almaty, st. Dzhandosova 184 “g”, tel., fax +7 (727) 309-74-14 e-mail
The importance of the complex action of the spray for sore throat
A common misconception is that if a sore throat is accompanied by a severe sore throat, an anesthetic rinse or spray is sufficient and an antibiotic aerosol for sore throat is not needed. But the complex effect of the drug, which combines several different effects, is very important. And that's why:
The need for broad antimicrobial action. The inflamed mucous membrane of the throat and tonsils are areas favorable for the growth and development of pathogens. Therefore, no matter what type of pathogens a sore throat is caused by, if left untreated, it can quickly become complicated by secondary infections. So, with a sore throat provoked by viruses, the addition of bacteria can be observed, and with a bacterial infection, the addition of a fungal infection can be observed. Since pathogens may already be present on the mucous membrane of the throat and tonsils and wait until the local immunity is sufficiently weakened, a throat spray for sore throat should have a wide spectrum of action in order not only to cope with an existing infection, but also to prevent secondary infection.
Reducing medication load. Sore throat has a negative effect on the entire body - waste products of pathogenic microorganisms cause general intoxication. Taking a large number of medications can cause additional stress on various systems and organs. The complex action spray allows you to avoid taking local painkillers, anti-inflammatory drugs and antibiotics separately.
Tanflex Plus 0.15% spray for topical use 30ml
Trade name Tanflex Plus International nonproprietary name No Dosage form Spray for topical use Composition 1 bottle (30 ml) contains active substance: benzydamine hydrochloride - 45 mg, chlorhexidine digluconate solution * - 180 mg excipients: glycerin, sodium saccharin, ethanol 96%, peppermint oil, polysorbate 20, sodium bicarbonate or hydrochloric acid, purified water. *- 0.036 g of chlorhexidine gluconate is equivalent to 180.00 mg of chlorhexidine digluconate solution. Description Colorless, transparent liquid with a mint odor. Pharmacological group Digestive tract and metabolism. Dental preparations. Other drugs for the treatment of diseases of the oral cavity Code ATC A01AD Pharmacological properties Pharmacokinetics Absorption After topical application of benzydamine hydrochloride, benzydamine is absorbed from the inflamed mucosa and has an anti-inflammatory and local anesthetic effect at the treatment site. Distribution Tanflex Plus is a topical medicine. Therefore, it should not be swallowed when used as described. Therefore, systemic absorption and distribution are not expected. In addition, the absorption of both components from the gastrointestinal mucosa is low. Approximately 30% of the administered chlorhexidine gluconate remains in the mouth and is excreted in saliva within 24 hours. Biotransformation Due to the minimal absorption of chlorhexidine, it cannot be measured in plasma. In general, benzydamine is metabolized by oxidation and conjugation in the liver. Elimination Chlorhexidine does not accumulate in the body and only a small amount is metabolized. Approximately 10% of ingested chlorhexidine is excreted by the kidneys after absorption and the remaining unabsorbed 90% of the drug is excreted in the feces. Benzidamine and metabolites that enter the systemic circulation are mainly excreted in the urine. Pharmacodynamics Benzydamine is an anti-inflammatory analgesic agent that is not structurally related to steroids. Benzidamine differs from other non-steroidal anti-inflammatory agents due to its basic structure. At concentrations used for topical treatment, benzydamine has a local anesthetic effect. The analgesic effect of benzydamine was more often recorded in experimental models of inflammation compared to non-inflammatory pain. The anti-inflammatory mechanism of action of benzydamine is not associated with the adrenal secretion channels. Like other nonsteroidal anti-inflammatory agents, benzydamine inhibits prostaglandin biosynthesis under certain conditions. This property, however, has not been precisely studied. It may depend on a stabilizing mechanism of action on cell membranes. Chlorhexidine is a biguanide antiseptic that helps reduce the development of plaque and gingivitis while interrupting general oral hygiene. It has an affinity for hydroxyapatite enamel, tooth surfaces, and oral tissues containing bacteria and salivary proteins. Chlorhexidine reduces plaque deposition and associated gum inflammation, which is characterized by redness, swelling and bleeding from the gums. It reduces the incidence of aphthous ulcer formation and increases the rate of healing after periodontal surgery. After routine topical use of the drug, chlorhexidine has a bactericidal effect after a long-term bacteriostatic effect. Chlorhexidine is effective against most microorganisms, such as gram (+) and gram (-) bacteria, mold and some fungi and viruses. Due to its delayed effect on the surface, chlorhexidine slows down the growth of bacteria. It is absorbed from the microbial cell wall and causes the membrane to leak. Indications for use - treatment of gingivitis, stomatitis, pharyngitis, tonsillitis and aphthous wounds - inflammation and pain of the mucous membranes of the mouth and throat - disinfection of the oral cavity and throat, to make it easier for the patient to swallow and symptoms of gum disease - before and after periodontal interventions - treatment of mucositis caused by radiotherapy, chemotherapy or other origin - prevention of dental plaque Method of administration and dosage Tanflex Plus is used without dilution. Tanflex Plus should not be swallowed or spat out after use. Adults The usual dose of Tanflex Plus spray for direct treatment of the throat/inflamed area is 4-8 applications every 1.5 - 3 hours during the day. Chlorhexidine in Tanflex Plus promotes the formation of plaque in the treatment of gingivitis. Before use, you should first brush your teeth with a toothbrush. If Tanflex Plus spray is used as an alternative to oral hygiene procedures, the mouth should be rinsed for at least 1 minute. In order to reduce the formation of stains caused by chlorhexidine in Tanflex Plus spray, you should first brush your teeth with a toothbrush. Children Not recommended for use by children under 12 years of age. The usual dose of Tanflex Plus spray for children over 12 years of age for direct treatment of the throat/inflamed area is 4 applications every 1.5 - 3 hours during the day. Elderly patients. For elderly patients, the same doses are used as for adults. Patients with renal and hepatic impairment Use with caution in patients with severe renal dysfunction or severe hepatic dysfunction. If your sore throat is caused by or associated with a bacterial infection, additional treatment may be considered besides Tanflex Plus. Side Effects Reported side effects are listed below according to the following frequency of occurrence. Very common (≥1/10); often (>1/100, <1/10); uncommon (>1/1,000, <1/100); rare (>1/10,000, <1/1,000); very rare (<1/10,000), unknown (cannot be determined from available data). Immune system disorders Very rare: Allergic reactions, hypersensitivity and anaphylaxis Endocrine system disorders Very rare: Temporary swelling of the parotid gland Nervous system disorders Very common: Temporary loss of taste Common: Tingling and burning in the mouth Not known: Dizziness, headache, drowsiness Respiratory diseases tract, chest and mediastinum: Very rare: Laryngospasm, bronchospasm Not known: Cough, pharyngeal irritation Gastrointestinal disorders Common: Nausea, vomiting, retching, gastrointestinal disorders Skin and subcutaneous tissue disorders Very rare: Skin reactions due to irritation, itching, rash, urticaria, photodermatosis, oral desquamation General disorders and conditions at the site of application: Common: Changes in taste and discoloration of teeth, increased formation of tartar Rare: Burning and tingling sensations Very rare: Local dryness, dryness, tingling, coolness in the mouth Contraindications - hypersensitivity to benzydamine, chlorhexidine or any other ingredients of the composition - children under 12 years of age - during pregnancy and breastfeeding Drug interactions Chlorhexidine is incompatible with anionic additives in conventional toothpastes. Therefore, you should use Tanflex Plus before brushing your teeth with toothpaste. Chlorhexidine salts are incompatible with soap and other anionic compounds. Although chlorhexidine salts are compatible with cationic and nonionic surfactants, when used in high concentrations, the activity of chlorhexidine may be reduced due to micelle binding. The solubility of chlorhexidine salts can be increased by surfactants such as cetrimide and lissapol NX. Chlorhexidine salts are incompatible with anionic polyelectrolytes such as gum arabic, sodium alginate, sodium carboxymethylcellulose, starch and tragacanth; their effectiveness decreases when used simultaneously. They are also incompatible with brilliant green, chloramphenicol, copper sulfate, sodium fluorescein, formaldehyde, silver nitrate and zinc sulfate. When diluting the drug with hard water, it may precipitate in the form of invisible salts because it interacts with Ca2 + and Mg2 + cations. If the concentration of solutions of chlorhexidine salts with benzoate, bicarbonate, carbonate, borate, nitrate, phosphate and sulfates exceeds 0.05%, precipitation may occur due to the formation of less soluble salts. Chlorhexidine gluconate is compatible with cetrimide and benzalkonium chloride. They increase the bactericidal effect of chlorhexidine synergistically. Cetrimide prevents chlorhexidine from settling in hard water. Compared to chlorhexidine gluconate, chlorhexidine and other salts are more soluble in alcohol than in water. The presence of 7% alcohol in the composition makes the solution more effective against gram-negative microorganisms. They can be absorbed when filtered through cellulose filters. No interaction of the drug with benzydamine has been recorded. Special instructions Avoid getting the spray in your eyes. Women of reproductive potential / Contraception Tanflex Plus should be used with caution by women of reproductive potential due to the fact that it contains alcohol. Pregnancy and lactation The use of Tanflex Plus during pregnancy and nursing mothers is contraindicated. Features of the effect of the drug on the ability to drive vehicles and work with potentially dangerous mechanisms The drug does not affect the ability to drive vehicles and other activities that require increased attention. Overdose In case of alcohol consumption, symptomatic and supportive therapy must be carried out. There is no specific antidote. Release form and packaging 30 ml of the drug is poured into dark glass bottles equipped with a spray bottle. A self-adhesive label is placed on the bottle. 1 bottle, along with instructions for medical use in the state and Russian languages, is placed in a cardboard box. Storage conditions Store in a place protected from light, at a temperature not exceeding 25° C. life: 2 years Do not use after the expiration date indicated on the package!
Features of the spray angle
The quality of spraying the drug is no less important, as it allows you to evenly apply the product to the mucous membrane of the throat and tonsils. With this method, it becomes possible to cover all foci of inflammation, which, otherwise, can increase in area and cover healthy areas. The optimal requirements for spray quality are the following:
- drip type,
- uniformity of irrigation,
- wide spray angle.
Taken together, these characteristics make it possible to apply the drug evenly over the maximum area and avoid a situation where some areas of the mucous membrane are treated with the drug and others are not.
Tantum® Verde spray for the treatment of sore throat
Tantum® Verde is widely used in the treatment of various forms of sore throat, as it has the following advantages:
Wide spray angle. One click on the dispenser allows you to evenly cover the entire area of the oral mucosa1,2. This is especially convenient for children, in whom local treatment often becomes difficult.
Ease of use. Any procedure on a sore throat looks unpleasant. But Tantum®Verde spray, sprayed onto the mucous membrane, does not cause discomfort and does not require frequent use. To relieve symptoms and fight inflammation, it is enough to use the product 2-6 times a day according to the instructions3.
Relief of symptoms. Already a minute4 after spraying Tantum® Verde on the mucous membrane of the throat, a local anesthetic effect occurs, and within the first day from the start of treatment, inflammation is reduced and swelling is eliminated.
Complex action. Tantum® Verde has anti-inflammatory3, antibacterial3, analgesic4 effects, and, thanks to this, when using the spray, there is no need to use several separate drugs.
