The effectiveness of the use of a combined preparation of butyric acid in patients with irritable bowel syndrome

Compound

Indications and contraindications

The product is indicated for use as an additional source of inulin and butyric acid. It is used for digestive disorders, insufficient fiber content in incoming food.

“Zakofalk” is especially useful for the treatment of dysbiosis associated, for example, with hormonal disorders, taking antibiotics, chronic poor nutrition, age-related changes, the consequences of treatment, food poisoning and other reasons.

Against the background of such diseases and disorders, patients note the appearance of the following symptoms:

• diarrhea, often alternating with constipation;
• frequent belching;
• feeling of an unpleasant taste in the mouth;
• bloating, flatulence;
• pain in the abdomen;
• heartburn.

There are no strict contraindications for use, with the exception of:

• pregnancy period;
• breastfeeding period;
• individual intolerance to individual components - one or more.

In some cases, allergic reactions may develop. Then the reception is stopped. It is also recommended to consult a doctor for a possible change in therapy.

It is also worth considering that the product should not be used by children under the age of 11 inclusive. Children's age is an absolute contraindication, even if the components of the drug are normally tolerated by the body. It is important to note that even healthy patients should consult a doctor. After this, you can begin treatment.

Component Properties

Butyric acid is normally formed in the colon as a result of the breakdown of indigestible carbohydrates supplied with food by normal intestinal microflora. The main function of butyric acid is to supply energy to the cells of the colon mucosa and maintain them in a healthy functional state.

Inulin is a soluble dietary fiber that creates a nutrient environment for the intestinal microflora, thereby stimulating the growth of beneficial bacteria (prebiotic effect). Also, as a result of the metabolism of inulin by intestinal bacteria, endogenous butyric acid is formed.

Release of active substances in the colon. In order to fully realize its basic biological functions, butyric acid, when taken orally, must enter the large intestine without being subjected to premature absorption in the overlying sections of the gastrointestinal tract. This becomes possible thanks to the use of special technology based on a polymer multi-matrix structure, which allows the tablets to pass unchanged through the stomach and small intestine and reach the colon. Throughout the colon there is a gradual release of active substances.

Zakofalk NMX

Biologically active food supplement in tablets based on a polymer multi-matrix structure with the release of butyric acid and inulin directly in the colon.

Release form:

tablets weighing 1.36 g. One tablet contains 307 mg of calcium butyrate (which corresponds to 250 mg of butyric acid) and 250 mg of inulin. 30 tablets per package.

Compound:

calcium butyrate, inulin, maltodextrin, carriers: sorbitol, hydroxypropyl methylcellulose and microcrystalline cellulose, corn starch, tablet coating (anti-caking agent talc, glazing agent shellac, titanium dioxide dye, stabilizer hydroxypropylcellulose, carriers: triethyl citrate and hydroxypropyl methylcellulose, vanillin flavoring ), acidity regulator citric acid, anti-caking agent magnesium stearate, stabilizer stearic acid, antioxidant lecithin.

Does not contain lactose, casein and gluten.

Contains sweetener. If consumed in excess, it may have a laxative effect.

Application area:

an additional source of inulin containing butyric acid.

Butyric acid

Normally, it is formed in the large intestine as a result of the breakdown of indigestible carbohydrates supplied with food by the normal microflora of the intestine. The main function of butyric acid is to supply energy to the cells of the colon mucosa (colonocytes) and maintain them in a healthy functional state. Butyric acid, as a waste product of beneficial intestinal bacteria, is the main regulator of water and electrolyte balance in the colon, promotes the absorption of excess water in the colon, preventing loose stools (diarrhea). Acting as an energy and regulatory substrate for colonocytes, butyric acid regulates the processes of development and renewal of cells of the colon mucosa, strengthens the protective barrier of the mucous membrane, reduces the visceral sensitivity of the colon to irritating stimuli, primarily to colon stretching. intestines in a number of conditions.

Rice. Metabolism of butyric acid in the colonocyte (cell of the colon mucosa).

Inulin

is a soluble dietary fiber that creates a nutrient medium for intestinal microflora, thereby stimulating the growth of beneficial bacteria (prebiotic effect). As a result of the metabolism of inulin by intestinal bacteria, endogenous butyric acid is also formed. Inulin is one of the widely used classical prebiotics. Inulin is not digested by human digestive enzymes and easily enters the large intestine, where it stimulates the growth of beneficial intestinal bifidobacteria. Accordingly, due to the growth of beneficial bacteria, colon peristalsis improves and the formation of bacterial metabolites beneficial to the body occurs. Inulin and metabolites of beneficial microflora of the colon have a positive effect not only on metabolic processes in the cells of the colon, but also on metabolism in general, and have an antioxidant effect, which is especially important for older people.

Rice. Metabolism of inulin in the colon, including the formation of endogenous butyric acid

Release of active substances in the colon.

In order to fully realize its basic biological functions, butyric acid, when taken orally, must enter the large intestine, avoiding premature absorption in the overlying parts of the gastrointestinal tract. This becomes possible thanks to the use of special technology based on a polymer multi-matrix structure, which allows the tablets to pass unchanged through the stomach and small intestine and reach the colon. Throughout the colon there is a gradual release of active substances. The polymer multimatrix system (NMX) provides the action of butyric acid and inulin throughout the colon for 24 hours.

Recommendations for use:

adults: 3-4 tablets per day before meals. Do not chew the tablets. Duration of treatment is at least 30 days. Depending on the initial level of butyric acid and inulin deficiency, it is possible to reduce the number of tablets taken to 1–2 per day.

Contraindications:

individual intolerance to product components, pregnancy, breastfeeding.

It is recommended to consult a doctor before use.

Storage conditions:

store in a dry place, at a temperature not exceeding 15°C.

Best before date:

2 years.

A dietary supplement to food, it is not a medicine.

Certificate of state registration:

No. RU.77.99.32.003.E.000508.01.15 dated January 20, 2015

Manufacturer:

COSMO SpA, Via Cristoforo Colombo, 1, 20020 Lainate, Milano.

Importing organization accepting complaints from consumers:

Representative office (Germany)

127055, Moscow, Butyrsky Val 68/70, building 4, 5; Tel. (495) 933-99-04. www.drfalkpharma.ru

www.zacofalk.ru – Zacofalk and intestinal health

Analogs

There are many drugs that, if necessary, can replace Zakofalk, but their general description will be different. All of these analogues normalize the intestinal microflora and have a beneficial effect on the mucous membranes of the digestive organs, but each of them has its own application characteristics and an expanded list of indications.

When replacing Zakofalk with other drugs, it is important to pay attention to possible differences in contraindications.

The following drugs have similar properties.

Storage conditions and periods

The shelf life of the drug is two years from the date of its manufacture. The release date is always indicated on the packaging and is duplicated on blisters or tubes. Storage temperature should not exceed 25 degrees. Children's access to tablets should be limited. Do not expose the product to direct sunlight or exposure to other heat sources. The place where tablets are stored should be dark and cool enough.

Video on the topic: Zakofalk NMX

Instructions for use "Zakofalk"

The tablets are taken orally and washed down with water. They should not be sucked or chewed. It is best to take 3-4 pieces half an hour before meals at equal intervals, for example, 3-4 hours. In this mode, treatment is carried out for the first 30 days in a row. Subsequently, the dosage is reduced to 1-2 tablets per day. The interval between doses increases to 6-8 hours.

There are also recommendations about taking the drug “Zakofalk” directly during breakfast, lunch or dinner. Thus, if the main time of administration (before meals) is missed, it is allowed to take it during meals.

Side effects

Zakofalk is safe for the body and does not cause side effects. The exception is when taking the drug if there are contraindications. As a result of such violation of recommendations, an allergic reaction may occur on the skin.

If Zakofalk is not suitable for use due to the individual characteristics of the body, then as a result of its use, symptoms of gastrointestinal dysfunction may intensify.

Overdose

In medical practice, no cases of overdose with Zakofalk have been recorded . The drug contains herbal components, which, even at high concentrations, are not capable of creating a threat to human life or causing serious disruptions to the performance of internal systems. An overdose in the presence of contraindications will provoke side effects.

Contraindications

During pregnancy, the components of the drug can harm the condition of the fetus. Contraindications for taking the drug include individual intolerance to its components. Before taking Zakofalk, it is recommended to undergo a comprehensive examination. Patients prone to allergic reactions should take the supplement with caution and only after consultation with a specialist.

If hypersensitivity to substances contained in the tablets is detected, the drug should be replaced with a safer option.

The following conditions are contraindications for taking the drug:

• children under 12 years of age;
• pregnancy at any stage and lactation period;
• hypersensitivity to individual components of the tablets.

During pregnancy

At any stage of pregnancy and during lactation, taking the drug is contraindicated. The components included in its composition can harm the condition of the fetus and cause problems with its gestation. During pregnancy, it is better to replenish the supply of vitamins and useful elements with specialized and harmless biologically active food additives for this period.

See the article about a drug that copes well with diarrhea. The product is absolutely safe both during pregnancy and during breastfeeding. https://gastrocure.net/preparaty/protivodiarejnye-i-protivovospalitelnye/enterosgel-sokhranyaet-balans-mikroflory-kishechnika.html

Price

The cost of Zakofalka in different regions may vary slightly. When ordering a dietary supplement online, the price includes delivery costs. Due to this nuance, the cost increases and differs from the pharmacy option. When purchasing a drug, it is important to pay attention to the integrity of its packaging and the information in the instructions.

Cost of the drug:

• the average price in Russia is from 900 rubles;
• in Ukraine, the cost of the drug is approximately 500 hryvnia.