Hyalgan 20 mg/2 ml No. 1 solution for intra-articular administration in a syringe


Composition and release form

Solution for intra-articular administration2 ml
sodium hyaluronate20 mg
excipients:
sodium chloride; disodium hydrogen phosphate dodecahydrate; sodium dihydrogen phosphate dihydrate; water for injections

bottles: 2 ml in bottles of colorless borosilicate glass type I, sealed with rubber stoppers, varnished aluminum caps and removable plastic seals; 1 or 5 bottles with instructions for use are placed in a cardboard box.

syringes: 2 ml in sterile syringes of colorless borosilicate glass type I, with rubber stoppers on which polypropylene pistons are fixed; syringes are equipped with luer locks to protect the needle; 1 or 5 syringes, each of which is placed in a blister pack made of PVC and paper, placed in a cardboard box with instructions for use.

Pharmacodynamics

Hyalgan Fidia is a sterile, pyrogen-free, viscous buffered aqueous solution of a highly purified sodium salt fraction of hyaluronic acid with a molecular weight of 500 to 730 kDa. Hyaluronic acid is an essential component of the extracellular matrix and is present in high concentrations in articular cartilage and synovial fluid. Endogenous hyaluronic acid provides viscosity and elasticity to synovial fluid, and is also necessary for the formation of proteoglycans in articular cartilage. With osteoarthritis, there is a deficiency and qualitative changes in hyaluronic acid in the composition of synovial fluid and cartilage. Intra-articular administration of hyaluronic acid against the background of degenerative changes in the surface of synovial cartilage and pathology of synovial fluid leads to an improvement in the functional state of the joint. When using Gialgan Fidia, there is an improvement in the clinical course of osteoarthritis within six months from the date of treatment, and an anti-inflammatory and analgesic effect is observed.

Gialgan Fidia (solution for intra-articular injection 20 mg/2 ml 2 ml syringe)

A country

Italy
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Compound

Syringe 2 ml
Sodium hyaluronate 20 mg. Excipients: sodium chloride - 17 mg, disodium hydrogen phosphate dodecahydrate - 1.2 mg, sodium dihydrogen phosphate dihydrate - 0.1 mg, water for injection - up to 2 ml. The solution for intra-articular administration is colorless, transparent, viscous.

pharmachologic effect

Stimulator of reparative processes. Hyalgan Fidia is a sterile, pyrogen-free, viscous buffered aqueous solution of a highly purified sodium salt fraction of hyaluronic acid with a molecular weight of 500 to 730 kDalton. Hyaluronic acid is an essential component of the extracellular matrix and is present in high concentrations in articular cartilage and synovial fluid. Endogenous hyaluronic acid provides viscosity and elasticity to synovial fluid, and is also necessary for the formation of proteoglycans in articular cartilage. With osteoarthritis, there is a deficiency and qualitative changes in hyaluronic acid in the composition of synovial fluid and cartilage. Intra-articular administration of hyaluronic acid against the background of degenerative changes in the surface of synovial cartilage and pathology of synovial fluid leads to an improvement in the functional state of the joint. When using Gialgan Fidia, there is an improvement in the clinical course of osteoarthritis within 6 months from the date of treatment, and an anti-inflammatory and analgesic effect is observed.

Indications for use

— for relieving pain and improving the mobility of synovial joints, with osteoarthritis and post-traumatic changes; - as an aid in orthopedic surgery.

Mode of application

The drug is intended for intra-articular administration. The drug is administered into the knee and hip joints in a dose of 20 mg once a week (contents of 1 bottle 20 mg/2 ml or filled syringe). The course consists of 3-5 injections. Rules for administering the drug The rules of asepsis and antisepsis should be observed when performing the procedure. Before administering Gialgan Fidia, effusion from the joint capsule should be removed. The drug should be administered precisely into the joint cavity using standard methods, taking into account the anatomical features. To remove the effusion and administer the drug, you can use the same needle, inserted once before aspiration. In this case, the syringe with the drug should be attached to the needle, freed from the syringe with the aspirated liquid. To confirm that the needle is in the joint cavity, an available amount of synovial fluid should be aspirated before slowly injecting the drug. Injection of the drug into the joint cavity should be stopped if pain occurs during injection. Avoid getting air into the syringe with the drug. The drug remaining in the syringe cannot be stored.

Interaction

Gialgan Fidia should not be prescribed concomitantly with other drugs for intra-articular administration due to the lack of sufficient clinical experience. Disinfectants containing quaternary ammonium salts should not be used, since hyaluronic acid precipitates in the presence of these substances.

Side effect

Local reactions: possible - moderate transient pain, swelling, increased exudate in the joint cavity, increased temperature and redness in the injection area. These reactions are transient and usually disappear after 24 hours (if these symptoms occur, it is recommended to unload the affected joint and apply ice). Allergic reactions: in isolated cases - itching, rash, urticaria, anaphylactic reactions.

Contraindications

- severe liver diseases;
- infections or damage to the skin in the injection area; - hypersensitivity to the components of the drug; - increased sensitivity to avian proteins. Use during pregnancy and breastfeeding The drug should not be prescribed during pregnancy and lactation (breastfeeding) due to the lack of clinical data on use in this category of patients.

Use in children Due to the lack of clinical data on use in pediatrics, the drug should not be prescribed to children.

special instructions

During the first 2 days after the procedure, it is recommended not to overload the joint, especially prolonged activity should be avoided. When obtaining aspiration fluid, appropriate studies should be carried out before administering the drug to exclude a bacterial etiology of arthritis. Use in pediatrics Due to the lack of clinical data on use in pediatrics, the drug should not be prescribed to children. Effect on the ability to drive vehicles and operate machinery Gialgan Fidia does not affect the ability to drive vehicles and other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Dispensing conditions in pharmacies

On prescription

Pharmacokinetics

When administered intra-articularly, the sodium salt of hyaluronic acid is eliminated from the synovial fluid within 2–3 days. Pharmacokinetic studies have shown rapid distribution of the substance in the synovial membrane. The highest concentrations of labeled hyaluronic acid were found in the synovial fluid and joint capsule, lower concentrations in the synovial membrane, ligaments and adjacent muscles.

Hyaluronic acid in synovial fluid does not undergo significant metabolic changes. In experimental models, the main metabolism occurs in the periarticular tissues and liver, excretion is mainly carried out by the kidneys.

Hyalgan fidia

Release form, composition and packaging

The solution for intra-articular administration is colorless, transparent, viscous.

1 ml 1 fl. sodium hyaluronate 10 mg 20 mg.

Excipients: sodium chloride, disodium hydrogen phosphate dodecahydrate, sodium dihydrogen phosphate dihydrate, water for injection.

The solution for intra-articular administration is colorless, transparent, viscous.

1 ml 1 syringe sodium hyaluronate 10 mg 20 mg.

Excipients: sodium chloride, disodium hydrogen phosphate dodecahydrate, sodium dihydrogen phosphate dihydrate, water for injection.

Clinical and pharmacological group

Synovial fluid substitute.

pharmachologic effect

Stimulator of reparative processes. Hyalgan Fidia is a sterile, pyrogen-free, viscous buffered aqueous solution of a highly purified sodium salt fraction of hyaluronic acid with a molecular weight of 500 to 730 kDalton. Hyaluronic acid is an essential component of the extracellular matrix and is present in high concentrations in articular cartilage and synovial fluid. Endogenous hyaluronic acid provides viscosity and elasticity to synovial fluid, and is also necessary for the formation of proteoglycans in articular cartilage.

With osteoarthritis, there is a deficiency and qualitative changes in hyaluronic acid in the composition of synovial fluid and cartilage. Intra-articular administration of hyaluronic acid against the background of degenerative changes in the surface of synovial cartilage and pathology of synovial fluid leads to an improvement in the functional state of the joint.

When using Gialgan Fidia, there is an improvement in the clinical course of osteoarthritis within 6 months from the moment of treatment, and an anti-inflammatory and analgesic effect develops.

Pharmacokinetics

Suction and distribution

When administered intra-articularly, the sodium salt of hyaluronic acid is eliminated from the synovial fluid within 2-3 days. Pharmacokinetic studies have shown rapid distribution of the substance in the synovial membrane. Cmax of labeled hyaluronic acid was found in synovial fluid and the joint capsule, lower concentrations were found in the synovial membrane, ligaments and adjacent muscles.

Metabolism and excretion

Hyaluronic acid in synovial fluid does not undergo significant metabolic changes. In experimental models, the main metabolism occurs in the periarticular tissues and liver, excretion is mainly carried out by the kidneys.

Indications for use of the drug

  • for relieving pain and improving the mobility of synovial joints, with osteoarthritis and post-traumatic changes;
  • as an aid in orthopedic surgery.

Dosage regimen

The drug is intended for intra-articular administration.

The drug is administered into the knee and hip joints in a dose of 20 mg once a week (contents of 1 bottle 20 mg/2 ml or filled syringe). The course consists of 3-5 injections.

Rules for administering the drug

The rules of asepsis and antisepsis should be observed when performing the procedure.

Before administering Gialgan Fidia, effusion from the joint capsule should be removed. The drug should be administered precisely into the joint cavity using standard methods, taking into account the anatomical features. To remove the effusion and administer the drug, you can use the same needle, inserted once before aspiration. In this case, the syringe with the drug should be attached to the needle, freed from the syringe with the aspirated liquid. To confirm that the needle is in the joint cavity, an available amount of synovial fluid should be aspirated before slowly injecting the drug. Injection of the drug into the joint cavity should be stopped if pain occurs during injection.

Avoid getting air into the syringe with the drug.

The drug remaining in the syringe cannot be stored.

Side effect

Local reactions: rarely - moderate pain, swelling, increased exudate in the joint cavity, increased temperature and redness in the injection area. These reactions are transient and usually disappear after 24 hours (if these symptoms occur, it is recommended to unload the affected joint and apply ice).

Allergic reactions: in isolated cases - itching, rash, urticaria, anaphylactic reactions.

Contraindications to the use of the drug

  • severe liver disease;
  • infections or damage to the skin in the injection area;
  • hypersensitivity to the components of the drug;
  • hypersensitivity to poultry proteins.

Pregnancy and lactation

The drug should not be prescribed during pregnancy and lactation (breastfeeding) due to the lack of clinical data on its use in this category of patients.

Use for liver dysfunction

The drug is contraindicated in severe liver diseases.

special instructions

During the first 2 days after the procedure, it is recommended not to overload the joint, especially prolonged activity should be avoided.

When obtaining aspiration fluid, appropriate studies should be carried out before administering the drug to exclude a bacterial etiology of arthritis.

Use in pediatrics

Due to the lack of clinical data on use in pediatrics, the drug should not be prescribed to children.

Impact on the ability to drive vehicles and operate machinery

Gialgan Fidia does not affect the ability to drive vehicles or perform other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Overdose

Currently, there are no cases of overdose.

Drug interactions

Gialgan Fidia should not be prescribed concomitantly with other drugs for intra-articular administration due to the lack of sufficient clinical experience.

Disinfectants containing quaternary ammonium salts should not be used, since hyaluronic acid precipitates in the presence of these substances.

Conditions for dispensing from pharmacies

The drug is available with a prescription.

Storage conditions and periods

The drug should be stored out of the reach of children, protected from light at a temperature not exceeding 25°C; do not freeze. Shelf life: 3 years when stored in original packaging.

Do not use Gialgan Fidia with damaged or opened packaging.

Directions for use and doses

Intra-articular.

The contents of one bottle (20 mg/2 ml) or a filled syringe (20 mg/2 ml) should be administered into the knee and hip joints once a week, in a course of 5 injections according to the standard method.

Method of administration

Before administering Gialgan Fidia, effusion from the joint capsule should be removed. The drug should be administered precisely into the joint cavity using standard methods, taking into account the anatomical features. The same needle can be used to remove the effusion and administer the drug, inserted once before aspiration. In this case, the syringe with the drug is attached to the needle freed from the syringe with aspirated liquid. To confirm that the needle is in the joint cavity, an available amount of synovial fluid should be aspirated before slowly injecting the drug. The rules of asepsis and antisepsis should be observed when performing the procedure. Administration of the drug into the joint cavity should be stopped if pain occurs during injection. Avoid getting air into the syringe with the drug. The drug, which has not been completely used, cannot be stored.

Hyalgan 20 mg/2 ml No. 1 solution for intra-articular administration in a syringe

Instructions for medical use of the drug Gialgan® Trade name Gialgan® International nonproprietary name No Dosage form Solution for intra-articular administration, 20 mg/2 ml 2.0 ml Composition active substance - sodium hyaluronate 20.00 mg, excipients: sodium chloride, sodium dihydrogen phosphate dihydrate, disodium hydrogen phosphate dodecahydrate , water for injections. Description Colorless, transparent viscous solution. Pharmacotherapeutic group Drugs for the treatment of diseases of the musculoskeletal system. Other drugs for the treatment of diseases of the musculoskeletal system. Hyaluronic acid. ATC code M09AX01 Pharmacological properties Pharmacokinetics The sodium salt of hyaluronic acid, when administered intra-articularly, is eliminated from the synovial fluid within 2-3 days. Pharmacokinetic studies have shown rapid distribution of the substance in the synovial membrane. The highest concentrations of labeled hyaluronic acid were found in the synovial fluid and joint capsule, lower concentrations in the synovial membrane, ligaments and adjacent muscles. Hyaluronic acid in synovial fluid does not undergo significant metabolic changes. Experimental models have established that metabolism occurs mainly in the periarticular tissues and liver, excretion is mainly carried out by the kidneys. Pharmacodynamics Hyalgan® is a sterile, pyrogen-free, viscous buffered aqueous solution of a highly purified sodium salt fraction of hyaluronic acid with a molecular weight of 500 to 730 kDa. Hyaluronic acid is an essential component of the extracellular matrix and is present in high concentrations in articular cartilage and synovial fluid. Endogenous hyaluronic acid provides viscosity and elasticity to synovial fluid, and is also necessary for the formation of proteoglycans in articular cartilage. With osteoarthritis, there is a deficiency and qualitative changes in hyaluronic acid in the composition of synovial fluid and cartilage. Intra-articular administration of hyaluronic acid against the background of degenerative changes in the surface of synovial cartilage and pathology of synovial fluid leads to an improvement in the functional state of the joint. When using Gialgan®, there is an improvement in the clinical course of osteoarthritis within six months from the date of treatment, and an anti-inflammatory and analgesic effect is observed. Indications for use - osteoarthritis and post-traumatic changes in joints - pain relief and improvement of joint mobility - as an adjuvant in orthopedic surgery. Method of administration and dosage: Intra-articular. The contents of one filled syringe (20 mg/2 ml) should be injected into the knee and hip joints once a week, in a course of 5 injections according to the standard method. Method of administration Before administering Gialgan®, the effusion from the joint capsule should be removed. The drug should be administered precisely into the joint cavity using standard methods, taking into account the anatomical features. The same needle can be used to remove the effusion and administer the drug, inserted once before aspiration. In this case, the syringe with the drug is attached to the needle freed from the syringe with aspirated liquid. To confirm that the needle is in the joint cavity, an available amount of synovial fluid should be aspirated before slowly injecting the drug. The rules of asepsis and antisepsis should be observed when performing the procedure. Administration of the drug into the joint cavity should be stopped if pain occurs during injection. Avoid getting air into the syringe with the drug. The drug, which has not been completely used, cannot be stored. Side effects Rarely - moderate pain, joint swelling, increased exudate in the joint cavity, increased temperature and redness in the injection area. The above symptoms are transient and usually disappear after 24 hours. If these symptoms occur, it is recommended to unload the affected joint and apply ice. In isolated cases - allergic (itching, skin rash, urticaria) and anaphylactic reactions Contraindications - hypersensitivity to the components of the drug or bird proteins - severe liver pathology - infection or damage to the skin in the injection area Drug interactions Gialgan® should not be prescribed simultaneously with other intra-articular injections, due to the lack of significant experience. Disinfectants containing quaternary ammonium salts should not be used, since hyaluronic acid precipitates in the presence of these substances. Special instructions During the first 2 days after the procedure, it is recommended not to overload the joint, especially prolonged loading should be avoided. When obtaining aspiration fluid, appropriate studies should be carried out before administering the drug to exclude a bacterial etiology of arthritis. Do not use Hyalgan® with damaged or opened packaging. Pregnancy and lactation should not be used during pregnancy or breastfeeding. Pediatric Use: Should not be used in children due to lack of clinical data. Peculiarities of influence on the ability to drive a vehicle or potentially dangerous mechanisms Gialgan® does not affect a person’s ability to engage in potentially hazardous activities that require increased concentration and speed of psychomotor reactions. However, given the effect of the drug on the functions of the joints of the lower extremities, you should refrain from driving for the first 2 days after the injection. Overdose There have been no cases of overdose. RELEASE FORM AND PACKAGING SOLUTION FOR INTRA-ARTICULAR ADMINISTRATION. 2.0 ML IN CLEAR GLASS SYRINGES TYPE I, SEALED WITH A RUBBER CAP. 1 SYRINGE TOGETHER WITH INSTRUCTIONS FOR USE IN THE STATE AND RUSSIAN LANGUAGES IS PLACED IN A PACK OF CARDBOARD. STORAGE CONDITIONS AT TEMPERATURES NOT HIGHER THAN 25 °C. DO NOT FREEZE. KEEP OUT OF THE REACH OF CHILDREN! SHELF LIFE IS 3 YEARS IN ORIGINAL PACKAGING DO NOT USE AFTER THE EXPIRATION DATE STATED ON THE PACKAGING. CONDITIONS FOR DISCHARGING FROM PHARMACIES ACCORDING TO A PRESCRIPTION MANUFACTURER/PACKAGER FIDIA PHARMACEUTIS S.P.A. 35031, ABANO TERME, VIA PONTE DELLA FABBRICA, Z/A, ITALY REGISTRATION AUTHORITY HOLDER FIDIA PHARMACEUTISI S.P.A. 35031, ABANO TERME, VIA PONTE DELLA FABBRICCA, Z/A, ITALY ADDRESS OF THE ORGANIZATION RECEIVING CLAIMS FROM CONSUMERS ON THE QUALITY OF PRODUCTS (GOOD) LLP IN THE TERRITORY OF THE REPUBLIC OF KAZAKHSTAN FIDIA PHARMA KAZAKHSTAN REPUBLIC KAZAKHSTAN, ALMATY, Ave. AL-FARABI 7, NURLY-TAU ADMINISTRATIVE RESIDENTIAL COMPLEX, BLOCK 4A, OFF. 6 TEL/FAX, 311 02 53 EMAIL ADDRESS

special instructions

During the first 2 days after the procedure, it is recommended not to overload the joint, especially prolonged loading should be avoided. When obtaining aspiration fluid, appropriate studies should be carried out before administering the drug to exclude a bacterial etiology of arthritis.

Gialgan Fidia does not affect a person’s ability to drive vehicles or engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Do not use Gialgan Fidia with damaged or opened packaging.

Synonyms of nosological groups

Category ICD-10 Synonyms of diseases according to ICD-10

M19.1 Post-traumatic arthrosis of other jointsPost-traumatic changes in joints
M19.9 Arthrosis, unspecifiedArthrosis
Arthrosis deforming
Arthrosis of large joints
Pain syndrome in osteoarthritis
Pain syndrome in osteoarthritis
Pain syndrome in acute inflammatory diseases of the musculoskeletal system
Pain syndrome in chronic inflammatory diseases of the musculoskeletal system
Deforming arthrosis
Deforming osteoarthritis
Deforming osteoarthritis of joints
Changes in the hand with osteoarthritis
Osteoarthritis
Osteoarthritis in the acute stage
Osteoarthritis of large joints
Acute pain syndrome in osteoarthritis
Post-traumatic osteoarthritis
Rheumatic osteoarthritis
Spondylarthrosis
Chronic osteoarthritis
M25.5 Joint painArthralgia
Pain syndrome in muscular and joint diseases
Pain syndrome in osteoarthritis
Pain syndrome in osteoarthritis
Pain syndrome in acute inflammatory diseases of the musculoskeletal system
Pain syndrome in chronic inflammatory diseases of the musculoskeletal system
Pain in the joints
Joint pain
Joint pain during heavy physical activity
Painful inflammatory joint lesions
Painful conditions of the musculoskeletal system
Painful joint conditions
Painful traumatic joint lesions
Pain in the musculoskeletal system
Shoulder pain
Joint pain
Joint pain
Joint pain due to injury
Musculoskeletal pain
Osteoarthritis pain
Pain due to joint pathology
Rheumatoid arthritis pain
Pain in chronic degenerative bone diseases
Pain in chronic degenerative joint diseases
Osteoarticular pain
Rheumatic pain
Rheumatic pains
Joint pain
Joint pain of rheumatic origin
Joint pain syndrome
Joint pain
M25.6 Joint stiffness, not elsewhere classifiedJoint stiffness
Joint stiffness
Z100* CLASS XXII Surgical practiceAbdominal surgery
Adenomectomy
Amputation
Angioplasty of coronary arteries
Carotid angioplasty
Antiseptic treatment of skin for wounds
Antiseptic hand treatment
Appendectomy
Atherectomy
Balloon coronary angioplasty
Vaginal hysterectomy
Corona bypass
Interventions on the vagina and cervix
Bladder interventions
Intervention in the oral cavity
Restorative and reconstructive operations
Hand hygiene of medical personnel
Gynecological surgery
Gynecological interventions
Gynecological surgeries
Hypovolemic shock during surgery
Disinfection of purulent wounds
Disinfection of wound edges
Diagnostic interventions
Diagnostic procedures
Diathermocoagulation of the cervix
Long surgical operations
Replacing fistula catheters
Infection during orthopedic surgery
Artificial heart valve
Cystectomy
Short-term outpatient surgery
Short-term operations
Short-term surgical procedures
Cricothyroidotomy
Blood loss during surgery
Bleeding during surgery and in the postoperative period
Culdocentesis
Laser coagulation
Laser coagulation
Laser coagulation of the retina
Laparoscopy
Laparoscopy in gynecology
CSF fistula
Minor gynecological operations
Minor surgical interventions
Mastectomy and subsequent plastic surgery
Mediastinotomy
Microsurgical operations on the ear
Mucogingival surgeries
Stitching
Minor surgeries
Neurosurgical operation
Immobilization of the eyeball in ophthalmic surgery
Orchiectomy
Complications after tooth extraction
Pancreatectomy
Pericardectomy
Rehabilitation period after surgery
The period of convalescence after surgical interventions
Percutaneous transluminal coronary angioplasty
Pleural thoracentesis
Pneumonia postoperative and post-traumatic
Preparing for surgical procedures
Preparing for surgery
Preparing the surgeon's hands before surgery
Preparing the colon for surgery
Postoperative aspiration pneumonia during neurosurgical and thoracic operations
Postoperative nausea
Postoperative bleeding
Postoperative granuloma
Postoperative shock
Early postoperative period
Myocardial revascularization
Resection of the apex of the tooth root
Gastric resection
Bowel resection
Resection of the uterus
Liver resection
Small bowel resection
Resection of part of the stomach
Reocclusion of the operated vessel
Bonding tissue during surgery
Removing stitches
Condition after eye surgery
Condition after surgery
Condition after surgical interventions in the nasal cavity
Condition after gastrectomy
Condition after resection of the small intestine
Condition after tonsillectomy
Condition after removal of the duodenum
Condition after phlebectomy
Vascular surgery
Splenectomy
Sterilization of surgical instruments
Sterilization of surgical instruments
Sternotomy
Dental operations
Dental intervention on periodontal tissues
Strumectomy
Tonsillectomy
Thoracic surgery
Thoracic operations
Total gastrectomy
Transdermal intravascular coronary angioplasty
Transurethral resection
Turbinectomy
Removal of a tooth
Cataract removal
Cyst removal
Tonsil removal
Removal of fibroids
Removal of mobile baby teeth
Removal of polyps
Removing a broken tooth
Removal of the uterine body
Removing stitches
Urethrotomy
CSF duct fistula
Frontoethmoidohaymorotomy
Surgical infection
Surgical treatment of chronic limb ulcers
Surgery
Surgery in the anal area
Colon surgery
Surgical practice
Surgical procedure
Surgical interventions
Surgical interventions on the gastrointestinal tract
Surgical interventions on the urinary tract
Surgical interventions on the urinary system
Surgical interventions on the genitourinary system
Heart surgery
Surgical procedures
Surgical operations
Vein surgery
Surgical intervention
Vascular surgery
Surgical treatment of thrombosis
Surgery
Cholecystectomy
Partial gastrectomy
Transperitoneal hysterectomy
Percutaneous transluminal coronary angioplasty
Percutaneous transluminal angioplasty
Coronary artery bypass surgery
Tooth extirpation
Extirpation of baby teeth
Pulp extirpation
Extracorporeal circulation
Tooth extraction
Tooth extraction
Cataract extraction
Electrocoagulation
Endourological interventions
Episiotomy
Ethmoidotomy
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