Pharmacodynamics and pharmacokinetics
Pharmacodynamics
The main active ingredient of the drug, lactulose, is a synthetic derivative of lactose. It is practically not absorbed in the stomach and small intestine due to the lack of necessary enzymes. In the large intestine, its breakdown into low molecular weight organic acids occurs under the influence of intestinal microflora, as a result of which the pH and the osmotic pressure increases, which stimulates intestinal motility. As a result of this, the consistency of stool is normalized and its volume increases, which normalizes the process of defecation and intestinal function in general.
The drug stimulates the growth of bifidobacteria , while the process of development of pathological microflora in the large intestine is inhibited and intoxication by their waste products is reduced, since the bacteria of the large intestine in the presence of lactulose do not decompose amino acids , which reduces the accumulation of toxic products of protein decomposition. Normolact inhibits the growth and development of salmonella in the colon.
The drug is not addictive and does not reduce the absorption of vitamins . The effect of the drug occurs 1-2 days after taking it, which is due to the duration of the process of lactulose through the gastrointestinal tract .
Pharmacokinetics
Lactulose, when ingested, passes into the large intestine, where bacteria that break down sugar metabolize it mainly to lactic acid and, to a lesser extent, to formic and acetic acids. The components of lactulose are practically not absorbed into the blood and are excreted in small quantities through the kidneys.
Normobact - L powder sachet 3g No. 10 for children from 1 month
Compound
For 1 sachet (3 g): maltodextrin, lyophilized lactic acid bacteria Lactobacillus rhamnosus GG - 4×109 CFU, fructooligosaccharides, mono- and diglycerides of fatty acids (E471) - a substance that prevents caking.
| 1 sachet | |
| Lactobacillus rhamnosus GG (LGG®) | 4×109 CFU |
Indications for use
As a biologically active food supplement - a source of probiotic microorganisms and fructooligosaccharides that contribute to:
- improving bowel function;
- restoring the balance of intestinal microflora;
- strengthening the immune system and accelerating the body’s adaptation processes.
Possible applications:
- taking antibiotics;
- intestinal infections and poisoning;
- stool disorders (diarrhea, constipation);
- food allergies, atopic dermatitis;
- change of diet and diet (travel);
- decrease in the body's defenses;
- imbalance of microflora.
Contraindications
Individual intolerance to dietary supplement components
Directions for use and doses
Take orally during meals, immediately after dissolution in liquid.
Infants over 1 month and children under 3 years of age are prescribed 1 sachet/day. For children under 3 years of age, the contents of the sachet should be dissolved in a sufficient amount of liquid before use; For breastfed children, the contents of the sachet should be dissolved in expressed breast milk before use.
Children over 3 years of age and adults are prescribed 1-2 sachets/day. The contents of the sachet should be dissolved in water, yogurt or milk before use.
Do not exceed the recommended daily dose.
The average duration of use is 10-14 days. During and after the end of antibiotic treatment, the duration of use of Normobact L can be 2-3 weeks.
Storage conditions
Store in a dry place, protected from light, at a temperature not exceeding 25°C. Keep out of the reach of children.
Best before date
2 years. Do not use after the expiration date stated on the packaging.
special instructions
A dietary supplement to food, it is not a medicine.
Before use, you should consult your doctor.
Normobact L is not intended for parenteral use.
Normobact L has not been treated with ionizing radiation.
In the dietary supplement Normobakt L, the Lactobacillus rhamnosus GG (LGG®) strain is of natural origin and is not subject to any genetic changes.
Normobakt L does not contain cow's milk proteins, lactose, gluten and sucrose, so it can be used in people who are intolerant to these substances.
Normobact L should not be used as the main source of nutrition.
Description
Dietary supplement - synbiotic (probiotic + prebiotic).
Action
Normobact L is a biologically active food supplement that combines probiotics (live lactic acid bacteria Lactobacillus rhamnosus GG) and prebiotics (fructooligosaccharides). This combination prolongs the life of “good” bacteria and significantly increases their number in the intestines; restores the body's immune resistance.
Fructooligosaccharides (prebiotics) are dietary fibers that belong to the class of low-calorie indigestible carbohydrates. Necessary for normal intestinal function and are a source of nutrition for intestinal microflora.
Maltodextrin is a product of incomplete hydrolysis of starch and is non-toxic. It is an auxiliary component of the dietary supplement Normobakt L, neutral for the baby’s digestion.
Mono- and diglycerides of fatty acids (E471) are a food additive of natural origin, classified as harmless. Widely used as a stabilizer and emulsifier in the production of baby food, confectionery and baking.
LGG® - Lactobacillus rhamnosus, isolated by Professors Gorbach and Goldin.
1. LGG® Safety:
- LGG® belongs to the normal microbiota of the gastrointestinal tract and is a natural part of the intestinal barrier;
- LGG® is the most studied strain of probiotic microorganisms;
- LGG® has been in use since 1990;
- LGG® has been described in more than 1000 scientific publications;
- More than 300 clinical studies have been conducted with LGG® in all age groups (from newborns to adults, including pregnant women) on all continents (Asia, Australia, Africa, Europe, North and South America);
- LGG® has been awarded GRAS status “Generally Recognized as Safe” by the FDA (US Food and Drug Administration (2007);
- LGG® has been awarded QPS status “Qualified Presumption of Safety” by the European Food Safety Authority (EFSA).
2. LGG® properties:
- resistance to the effects of hydrochloric acid of gastric juice and bile, therefore, when passing through the gastrointestinal tract, LGG® remains viable;
- maximum adhesive ability - LGG® effectively attach to the epithelium of the intestinal mucosa, colonize it and displace pathogenic flora.
3. LGG® contributes to:
- synthesis of compounds that inhibit the growth of pathogenic microorganisms;
- synthesis of lactic acid, beneficially affecting the development of bifidobacteria;
- reducing the risk of developing microflora imbalance;
- increasing nonspecific resistance of the body;
- increasing the activity of phagocytes;
- increasing the level of immunoglobulins (IgA), anti-inflammatory cytokines, 1L-6,1L-10 (interleukins 6 and 10).
4. Studied effects of LGG® on the human body:
| Application area | LGG® effect |
| Acute diarrhea/acute gastroenteritis/intestinal infections | - LGG® is included in the recommendations of the National Center for Women's and Children's Health (UK), the World Organization of Gastroenterology, the European Society of Pediatric Gastroenterology, Hepatology and Nutrition (ESPHGAN) for the management of patients with acute gastroenteritis - Reduced duration of diarrhea - Reduced length of hospitalization - Reduced incidence of " traveler's diarrhea" - Reducing the incidence of bacterial intestinal infections |
| Antibiotic-associated diarrhea (AAD) | — LGG® is the only strain of lacto- and bifidobacteria recommended by the European Society of Pediatric Gastroenterologists, Hepatologists and Nutritionists (ESPHGAN) to reduce the risk of AAD in children — Reduced the incidence of diarrhea by ~71% — Reduced the number of bowel movements — Normalized stool consistency |
| Functional gastrointestinal disorders and irritable bowel syndrome (IBS) | — Reducing the intensity of pain in children with IBS and functional disorders — Reducing the frequency of pain in children with IBS — Reducing flatulence, incl. when taking plant fiber |
| Allergic diseases | — Positive effect on the course of atopic dermatosis (against the background of traditional treatment) — Preventive effect against the development of atopy in children when prescribed to pregnant women and nursing mothers |
| Respiratory infections | — Reduced incidence of respiratory viral infections in children's groups — Reduced the risk of developing upper respiratory tract infections by 34% — Reduced the number of illnesses lasting more than 3 days — Reduced the number of sick days by 43% |
| Rotavirus infection | — Reducing the duration of rotavirus diarrhea (in combination with rehydration therapy — Accelerating the elimination of rotavirus from the body |
| Caries | — Reduced risk of developing caries by 44% — Positive effect on the composition of oral microflora |
| Strengthening the immune response | — Activation of post-vaccination immunity |
Normolakt, instructions for use (Method and dosage)
Normolakt syrup is taken orally. The dosage of the drug is selected individually. Treatment begins with a higher dose, which is reduced 2-3 times after achieving the effect. When treating hepatic encephalopathy, the dose is from 30 to 50 ml two to three times a day.
For constipation , in the first days of treatment, take 15-45 ml of the drug, and then reduce the dose to 10 to 25 ml. If there is no effect after 2-3 days of use, the initial dose should be increased. It is recommended to take the daily dose of the drug during breakfast in one dose. Normolact can be mixed with food mixtures, vegetable and fruit juices.
Normolact for children under one year of age is measured using a scale on the dosing device provided with the drug. For older children and adults, the drug can be dosed with spoons (teaspoon - 5 ml), (dessert spoon - 10 ml or table spoon - 5 ml. The effect of the drug occurs in 1-2 days.
Indications for use of the drug Normolakt
- constipation (including chronic);
- intestinal dysbiosis;
- intoxication of various origins;
- hypercholesterolemia;
- hepatic encephalopathy;
- liver failure;
- hepatic precoma and coma;
- liver cirrhosis with a tendency to hyperammonemia.
It is also prescribed for putrefactive dyspepsia syndrome in young children, pain syndrome after removal of hemorrhoids; for softening stool in case of hemorrhoids, if surgical intervention on the colon/anus is necessary.
Normolakt's analogs
Level 4 ATC code matches:
Romphalac
Transipeg
Medulak
Fortrans
Exportal
Fleet Phospho-Soda
Good luck
Lactulose
Sorbitol
Duphalac
Normaze
Forlax
Lactulose , Bioflorax , Dufulak , Medulak , Lactuvit , Depurax , Portalak , Normaze and others.
Reviews about Normolakt
Reviews about the drug are overwhelmingly favorable. Patients note its high effectiveness.
- “... Due to a sedentary lifestyle, my grandmother began to experience regular constipation, and it is very difficult to persuade her to take a pill. The use of Normolakt practically solved this problem. Add it to compote or juice.”
- “... Our six-month-old son began to have constipation, we gave enemas, it helped for a while, and then it started again. The doctor recommended Normolact syrup, a day later stool appeared and then everything returned to normal.”
Special instructions for the use of the drug Normolact
Do not use the drug for abdominal pain, nausea and vomiting. With the appearance of diarrhea, treatment is stopped. Should be used with caution in patients with diabetes mellitus. For gastrocardial syndrome, the dose should be increased gradually to avoid flatulence. During long-term treatment (more than 6 months), the level of electrolytes in the blood plasma should be regularly monitored, especially in elderly and debilitated patients. Patients with lactase deficiency should monitor their sugar intake when using the drug. Use during pregnancy and lactation . It is possible to use Normolact during pregnancy or breastfeeding. Children. Normolakt is used in children. The ability to influence the reaction rate when driving vehicles or other mechanisms. Taking Normolact does not affect the ability to drive vehicles or engage in other potentially hazardous activities that require increased concentration and visual acuity.
Normolakt price, where to buy
The price of Normolakt syrup in a 100 ml bottle varies from 126 to 177 rubles per package; in a 200 ml bottle - from 228 to 344 rubles. You can purchase the drug without problems in most pharmacies in Moscow.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
LuxPharma* special offer
- Normolact syrup bottle 200ml
1490 rub. order
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