Indications and contraindications
The drug afalase, the instructions warn about this, is approved for use from the age of 18 years. Most often it is prescribed for the treatment of stage I and II prostate adenoma. It also helps in the following cases:
- For vegetative disorders during menopause. It helps relieve fatigue, prevent a decrease in physical activity and maintain libido.
- For disorders characterized by frequent urge and difficulty urinating, as well as pain and discomfort in the perineal area.
- When erectile dysfunction occurs due to various reasons.
Afalase is a popular remedy in the complex therapy of prostatitis in acute and chronic form. The product has an anti-inflammatory and analgesic effect, which speeds up the process of treating the disease. Afalase is also prescribed in combination with other medications before and after prostate surgery.
A contraindication for using the product is individual intolerance. This is manifested by the occurrence of negative reactions of the body. In this case, you should immediately stop taking the drug and consult a doctor to select an effective analogue. Lactose is used in the production of afalase tablets. Therefore, there are contraindications for patients with intolerance to this substance.
Effect of the drug
After taking a dissolving tablet, the active substances in its composition are exposed to saliva
They break down in the mouth. They are absorbed through the hypoglossal artery and are carried through the bloodstream, producing a systemic effect. In particular, getting into the tissue of the prostate gland, they accelerate metabolic processes and normalize blood circulation in the tissues. Against this background, the likelihood of vascular spasms decreases.
When treated with the drug at the initial stage of development of prostate adenoma, it is possible to:
- Restore damaged organ cells.
- Gradually reduce the size of the prostate gland.
- Remove blood stagnation in the pelvic area.
In addition, the active substances in the drug have the ability to liquefy the ejaculate. This increases sperm activity and eliminates the problem of infertility. In addition, afolase tablets, reviews indicate that they improve urination and relieve pain.
Features of the product
A common drug prescribed to prevent the development of prostate adenoma is afolase. The effectiveness of the drug has been confirmed in practice. This medicine has an affordable price. It can be bought at a pharmacy without a prescription.
The main components of the product are two types of antibodies. The instructions for use of the product describe in detail its pharmacological effects. When taken, a targeted medicine increases blood flow in the tissues of the prostate gland and penis. The active ingredients have a positive effect on endothelium, ensuring an improvement in the general condition of blood vessels. During treatment, functional and metabolic processes are normalized, inflammation and swelling are relieved.
The active substances included in the drug are affinity purified. That is, they undergo special processing to remove other proteins and components of the donor's DNA. This guarantees the absolute safety of the drug. When taking it, the risks of negative side reactions of the body are minimized.
Afalase 100 pcs. lozenges
pharmachologic effect
Antidysuric, anti-inflammatory.
Composition and release form Afalase 100 pcs. lozenges
Lozenges - 1 tablet:
- active ingredients: antibodies to endothelial NO synthase, affinity purified* - 0.006 g; affinity purified antibodies to prostate-specific antigen* - 0.006 g;
- excipients: lactose monohydrate; MCC; magnesium stearate.
* applied to lactose in the form of a mixture of three active aqueous-alcoholic dilutions of the substance, diluted 10012, 10030, 100200 times, respectively.
Lozenges. 20 tablets each in blister packs made of PVC film or aluminum foil. 1, 2 or 5 blister packs are placed in a cardboard pack.
Description of the dosage form
Tablets are flat-cylindrical, scored and chamfered, from white to almost white. On the side with the mark there is the inscription “MATERIA MEDICA”, on the other - “AFALAZA”.
Directions for use and doses
Inside, not during meals. For one appointment - 2 tablets. (keep in mouth until completely dissolved). Take the drug twice a day, in the evening and in the morning.
The recommended duration of taking the drug is 16 weeks. In case of severe pain and dysuric disorders in the first 2–3 weeks of therapy, taking the drug up to 4 times a day is recommended.
If necessary, on the recommendation of a doctor, it is possible to conduct a second course of treatment after 1–4 months.
Pharmacodynamics
Affinity-purified antibodies to PSA modify the functional activity of endogenous PSA, altered in benign prostatic hyperplasia, which is accompanied by an increase in the regulatory effect of this antigen on functional and metabolic processes in prostate tissue. Antibodies to PSA have a preventive and therapeutic effect in prostate adenoma.
Affinity purified antibodies to endothelial NO synthase help to increase the speed of blood flow in the vessels of the penis and prostate gland; have a protective effect on the endothelium (help reduce vascular reactivity, reduce vascular spasm and improve peripheral microcirculation).
The combined use of components in the complex drug Afalase is accompanied by a synergistic effect: antibodies to endothelial NO synthase, due to their endothelial protective effect and improved vascularization, enhance the antiproliferative and anti-inflammatory activity of antibodies to PSA. The synergistic effect is probably also due to nonspecific mechanisms of enhancing intracellular signal transduction by antibodies to endothelial NO synthase.
The complex use of the drug components helps improve the quality of life of patients with BPH and prostatitis, reducing dysuria and erectile dysfunction; has a vegetative stabilizing effect. The drug has been experimentally shown to have a pronounced anti-inflammatory and anti-edematous effect.
The drug helps to normalize the functional state of the prostate and lower urinary tract, improve urodynamics (decrease in residual urine volume, increase the maximum rate of urine excretion), normalize PSA levels. The drug also helps to reduce dysuric disorders, and in some cases, a moderate reduction in the volume of the prostate gland. The combined use of the components improves spermatological parameters (increasing the concentration of sex hormones, the number of sperm and their motility, reducing the viscosity of seminal fluid, normalizing prostate secretions); activates regenerative and repair processes in patients who have undergone surgery for BPH, reduces the likelihood of developing complications after surgery.
Pharmacokinetics
The sensitivity of modern physicochemical methods of analysis (gas-liquid chromatography, high-performance liquid chromatography, gas chromatography-mass spectrometry) does not allow assessing the content of ultra-low doses of antibodies in biological fluids, organs and tissues, which makes it technically impossible to study the pharmacokinetics of the drug Afalase.
Indications for use Afalase 100 pcs. lozenges
- benign prostatic hyperplasia stages I and II;
- as part of complex therapy of acute and chronic prostatitis (as an anti-inflammatory and analgesic agent);
- dysuric disorders (frequent urge to urinate, difficulty urinating, pain and discomfort in the perineum);
- erectile dysfunction (erectile dysfunction) of various origins;
- vegetative disorders of menopause in men (including weakness, fatigue, decreased physical activity, decreased libido);
- complex therapy before and after surgical interventions on the prostate gland.
Contraindications
Increased individual sensitivity to the components of the drug.
special instructions
The drug contains lactose, and therefore is not recommended for use in patients with congenital galactosemia, glucose or galactose malabsorption syndrome, or congenital lactase deficiency.
Impact on the ability to drive vehicles and other potentially dangerous mechanisms. Does not affect.
Overdose
In case of accidental overdose, dyspeptic symptoms are possible due to the fillers included in the drug.
Side effects of Afalase 100 pcs. lozenges
When using the drug for the indicated indications and in the indicated dosages, no side effects were identified.
Drug interactions
No cases of incompatibility with other drugs have been registered to date.
