Ichthyol


Pharmacodynamics and pharmacokinetics

What is ichthyol ?

The pharmacopoeia states that this substance is ammonium bituminous sulfonate salt , obtained from resins (derivatives of oil shale). In medicine, drugs based on this component began to be used back in the 80s of the 19th century for the treatment of gout, rheumatism , etc. Pure ichthyol is not used; ointments and suppositories are made on its basis for use in medical practice.

Medicines containing this component have local anesthetic, anti-inflammatory, antiseptic, and keratoplasty effects . Also, ointment and suppositories can improve blood circulation in the skin. The substance moderately irritates nerve endings, thereby reducing their sensitivity, leads to denaturation of protein molecules, and regulates normal vascular tone.

The drug is not absorbed into the systemic circulation and has only a local effect on the skin or mucous membrane.

Indications for use

What is Ichthyol ointment for?

The ointment has a fairly wide range of applications; it is prescribed for burns, neuralgia, arthritis, eczema, erysipelas, rheumatism, and for the treatment of acne.

The dosage form of the “suppository” is used for hemorrhoids and other inflammatory diseases of the pelvic organs.

Instructions for use (method and dosage)

Ichthyol suppositories, instructions for use

For parametritis, prostatitis and metritis, suppositories are carefully inserted into the rectum. According to the instructions for use, ichthyol suppositories are prescribed in the amount of 1-2 pieces per day.

Ichthyol suppositories for hemorrhoids are recommended to be used after an enema.

The course of treatment is determined by the doctor.

Ichthyol ointment, instructions for use

Externally. The drug is applied in a thin layer to the affected areas 3 times a day.

You can put a bandage over the ointment or leave it in the fresh air.

The duration of therapy is determined by the attending physician.

Ichthyol

Dosage form:

rectal suppositories.

Composition per suppository:

Active substance

: Ichthyol (ichthammol) – 0.2 g.

Excipients

: Purified water – 0.038 g, emulsifier “Solid-2” (T-2) – 0.05 g.

Suppository base:

Solid fat (Vitepsol (brands N 15, W 35), Supposir (brands NA 15, NAS 50)) - until a suppository weighing 1.23 g is obtained.

Description

Suppositories are dark brown in color with a characteristic odor, torpedo-shaped, with a maximum diameter of 1.2 cm

Pharmacotherapeutic group

Anti-inflammatory agent for topical use

ATX code

: D10BX01

Pharmacological properties

Anti-inflammatory agent, has local analgesic and antiseptic effect. The anti-inflammatory effect is associated with inhibition of the release of inflammatory mediators. When administered rectally, the drug has an irritating effect on the mucous membrane of the rectum, as a result of which blood circulation in the pelvic organs reflexively increases, metabolism improves, which helps eliminate inflammation in the prostate gland in men, ovaries, fallopian tubes, and uterus in women.

Indications for use

Salpingoophoritis, endometritis, prostatitis as part of complex therapy.

Contraindications

Hypersensitivity to the components of the drug, children under 18 years of age.

Use during pregnancy and breastfeeding

During pregnancy and lactation, the drug is used with caution; you should consult your doctor.

Directions for use and doses

Rectally: 1 suppository 1-2 times a day after a cleansing enema or spontaneous bowel cleansing. The duration of treatment is determined by the attending physician.

Side effect

Allergic reactions, burning sensation in the anus.

If any of the side effects indicated in the instructions worsen, or any other side effects not specified in the instructions are noted, you should immediately inform your doctor.

Overdose

No cases of overdose have been reported.

Interaction with other drugs

Not compatible in solutions with iodine salts, alkaloids, or salts of heavy metals.

Information about the possible effect of a medicinal product for medical use on the ability to drive vehicles and machinery

Not studied.

Release form

Rectal suppositories 200 mg.

4, 5, 6 suppositories in a blister pack made of a two-layer film or a film made of polymer materials or a white PVC/PE combined film or a polyvinyl chloride film.

1, 2 blister packs together with instructions for medical use of the drug are placed in a cardboard pack.

Storage conditions

In a place protected from light at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Best before date

2 years. Do not use after the expiration date stated on the package.

Vacation conditions

Available without a prescription.

Analogs

Level 4 ATC code matches:
Ichthyol ointment

Antiseptol, Biosept, Vishnevsky Ointment, Bioantisept, Diamond Green, Potassium Permanganate, Manisoft, Tea Tree Oil, Methylene Blue, Fukortsin, Chlorophyllipt, Elekasol.

Reviews

Due to its wide range of applications and low cost, reviews of Ichthyol are extremely positive. The ointment is often used in the fight against acne, inflammation and abscesses . Some people are embarrassed by the unpleasant smell of the product and dry skin after use.

Reviews of Ichthyol suppositories in gynecology are also very good:

“A natural remedy at a cheap price. It was prescribed to me by a gynecologist. After using 2 packs rectally at night, the symptoms of ovarian inflammation disappeared. An ultrasound showed that the dimensions were within normal limits”;

“I have been suffering from inflammation of the appendages for several years. They treated me with everything, but after a few months I had to go to the gynecologist again to prescribe me a new medicine. The most effective drug for me was the one containing Ichthyol. These candles are not expensive, without harmful additives, I use them often.”

The remedy also helps against prostatitis:

“I have prostatitis, I’m 23 years old. When my right side starts to hurt, I put on ichthyol suppositories every other day. I started to feel better. There is an itching in the anus from the suppositories, which then goes away.”

Treatment of other diseases

Among the indications for the active substance in Russia, neuralgia and arthritis are mentioned, but not in all instructions for the drug. Scientific laboratories in the West have studied the ability of ichthammol to treat osteoarthritis, bruises and sprains.

For neuralgia and arthritis, apply 10-20% ichthyol in an even layer to the affected area and rub into the skin. Then apply a bandage, which is changed after 1-3 days.

The external product Ichthammol 50% is produced abroad and is prescribed for joint sprains, bursitis and other orthopedic indications.

Ichthyol is used for exacerbation of hemorrhoids, eczema and dermatitis in the anus. The use of the product helps reduce pain and inflammation.

Treat painful nodes with Ichthyol ointment for hemorrhoids or apply it on a cotton swab into the rectum twice a day after hygiene procedures. You can alternate with the use of rectal suppositories with the same active ingredient.

The use of Ichthyol ointment for sinusitis is possible only outside periods of exacerbation of the disease. The medicine is applied to a cotton swab and injected into the cleansed nasal passage for 10-15 minutes. Use a drug containing 10% ichthammol.

Ichthyol ointment in gynecology is prescribed for bacterial infections of the female genital organs in the form of a mixture with glycerin (1:1).

Used for salpingitis, inflammatory processes in the ovaries and uterine tissue (parametritis). Moisten a cotton swab with the prepared mixture and administer as directed.

Ichthyol price, where to buy

The approximate cost of 20% ointment with a capacity of 25 grams is 10 rubles.

The price of ichthyol suppositories depends on the pharmacy chain. So the price of Ichthyol suppositories can range from 40 to 60 rubles, 10 pieces per pack.

  • Online pharmacies in RussiaRussia
  • Online pharmacies in UkraineUkraine
  • Online pharmacies in KazakhstanKazakhstan

ZdravCity

  • Ichthyol ointment d/nar.
    approx. 20% tube 25g No. 1 Ozon LLC 122 rub. order
  • Ichthyol ointment d/nar. approx. 10% tube 25g No. 1Ozon LLC

    99 RUR order

  • Ichthyol ointment for external use. approx. 20% of bank 25gZAO Yaroslavl f.f.

    51 RUR order

  • Ichthyol suppositories rectal. 200 mg 10 pcsAO "Nizhpharm"

    93 RUR order

  • Ichthyol ointment d/nar. approx. 20% 25 JSC Usolye-Sibirsky Chemical Pharmaceutical Plant

    52 RUR order

Pharmacy Dialogue

  • Ichthyol ointment 20% 25g Tverskaya FF

    56 RUR order

  • Ichthyol ointment 10% 25g Tverskaya FF

    35 rub. order

  • Ichthyol ointment (tube 20% 25g)BZMP

    82 RUR order

  • Ichthyol candles (sup. No. 10) DHF JSC

    70 rub. order

  • Ichthyol ointment (can 10% 25g) Tula FF

    38 rub. order

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Pharmacy24

  • Ichthyol 20% 25 g ointment for external use PAT "Lubnipharm", Ukraine
    14 UAH. order
  • Ichthyol 10% 30 g ointment PAT "Khimpharmzavod" Chervona Zirka", Kharkov, Ukraine

    18 UAH order

  • Ichthyol Ointment 10% 30 g PRAT "Fitofarm", Ukraine

    17 UAH order

  • Ichthyol No. 10 candles PAT Monfarm, Ukraine

    32 UAH order

  • Ichthyol ointment 10% 30 g PrAT FF "Viola", Ukraine

    17 UAH order

PaniPharmacy

  • Ichthyol ointment Ichthyol ointment 10% 25g Ukraine, Ternopharm LLC

    18 UAH order

  • Ichthyol suppository Supp. with ichthyol 0.2g No. 10 Ukraine, Monfarm JSC

    38 UAH order

  • Ichthyol ointment Ichthyol ointment 10% 30g Ukraine, Fitofarm ChAO

    21 UAH order

  • Ichthyol ointment Ichthyol ointment 10% 30g Ukraine, Red Star OJSC

    20 UAH order

  • Ichthyol ointment Ichthyol ointment 20% 25g Ukraine, Lubnyfarm PJSC

    16 UAH order

show more

ICHTHYOL. Ichthyolum.

Synonyms: bitaminol, ichthammol, ichthyol-ammonium, ichthyosulfol.

Properties.

A black, thin layer of brown syrup-like liquid with a peculiar pungent odor and taste. Soluble in water, glycerin, partially in alcohol and ether. Aqueous solutions foam when shaken.

Ichthyol contains at least 10.5% organically bound sulfur. It is a product of dry distillation of bituminous shale containing the remains of fossil marine animals and fish. Incompatible in solutions with alkaloids, salts of heavy metals, iodide salts, ammonia solutions, glycosides.

Store in glass jars.

Action and application.

It has an antiseptic, antiparasitic, anti-inflammatory, keratoplastic and local anesthetic effect. The antimicrobial and antiparasitic effect of ichthyol is explained by the content of sulfur and aromatic substances. After application to wounds and mucous membranes, in addition to the antiseptic effect, it constricts blood vessels, reduces secretion and exudation, moderates pain and accelerates the regeneration of affected tissue.

After intravenous administration, it acts as a nonspecific therapy - irritation, due to which a number of reflex reactions develop, accompanied by an increase in the body's defenses, an increase in the release of adrenaline, serotonin and vasopressin, and a constriction of blood vessels and capillaries.

Prescribed externally for various diseases of the skin (wounds, eczema, burns, dermatitis, furunculosis, pyoderma), subcutaneous tissue and muscles, for arthritis, neuralgia, tendonitis, tendovaginitis, bursitis, mastitis in the form of ointment (10-30%) or aqueous-alcoholic solutions (10-30%). Alcohol-ichthyol solutions (1:25) are widely used in the form of lotions for phlegmon and myositis. For skin diseases of parasitic origin, including scabies, scab, ringworm, it is used in the form of an ointment (10-20%), liniment and paste (5-10%). By adding tar, sulfur and creolin, the therapeutic effect for scabies and dermatomycosis increases.

As an antiseptic and anti-fermentation agent, it is used orally for acute rumen tympany, flatulence, functional intestinal disorder, inflammation of the stomach and intestines, and acute dilatation of the intestines in horses (colic). In case of acute dilatation of the stomach in horses, it is recommended to rinse the stomach with a 1-2% aqueous solution and give an alcohol-ichthyol-valerian mixture orally. Aqueous solutions of ichthyol (1-2%) are prescribed for prolapse and inflammation of the rectum (irrigation in the form of enemas), for lobar inflammation of the larynx, and inflammation of the esophagus. In obstetric practice, it is used for metritis, vaginitis, salpingitis in the form of douching with a 3-5% solution or suppositories (for small animals 0.1-0.3 g). For endometritis and subinvolution of the uterus in cows, ichthyol is used intramuscularly in the form of a 7% solution in a 40% glucose solution in a dose of 10 ml. The use of ichthyol 2-3 times a week helps to heal and restore the reproductive functions of the genital organs. An aqueous solution of ichthyol is used orally for coccidiosis in lambs once a day for 3 days in a row, then a three-day break, and again prescribed for three days.

Ichthyol is included in the composition of finished medicines: a) ichthyol-naphthalan paste (4 parts ichthyol, 10 parts zinc oxide, 16 parts naphthalan ointment and 10 parts starch), used for dermatomycosis and eczema; b) zinc-ichthyol paste (zinc oxide 10 parts, ichthyol 1, petroleum jelly 19 parts), prescribed for eczema, seborrheic skin lesions; c) ichthyol in glycerin (10%); d) ichthyol ointment (10% and 20%) and other drugs used for skin diseases. Intravenous sterile solutions of ichthyol (2%) are recommended to be administered as a hemostatic agent for colic (sand), acute dilatation of the stomach in horses, intestinal atony (horses 50-150 ml, small ruminants 10-20 ml). There are reports of the positive effect of ichthyol (0.25-0.5% solution) when lambs and sheep eat wool; lambs are injected with 30-90 ml of this solution, sheep 100-300 ml per day for 7 days in a row, then after 10 days the solution is given again for seven days.

A 3-5% solution of ichthyol is used to treat thelaziosis in cattle by washing the eyes. After removing the horns, the wound surface is tamponed with a paste consisting of 2 g of ichthyol, 10 g of wax or paraffin and 2 g of vaseline oil. Ichthyol is prescribed orally in the form of solutions (1-2%), boluses, mixtures, porridges.

doses :

horses 10-30 g; cattle 10-20 g; small cattle and pigs 1-5 g; dogs 0.2-1 g; foxes 0.2-0.5 g.

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