LONGIDAZE lyophilized powder for the preparation of solution for infusion 3000me No. 5

Longidaza suppositories are a drug unique in properties and composition, which is used in urology, gynecology, surgery, dermatovenereology, pulmonology and phthisiology. It helps with the proliferation of connective tissue that occurs as a result of inflammation, surgical interventions and various diseases. Longidaza has also been proven to increase the bioavailability of other drugs, making treatment more effective.

As analogues of Longidase, it is possible to use drugs with similar composition or properties. There are not many of the former offered in pharmacies now, but you can pick up enough of the latter, but their purpose is usually narrower. When compiling the rating of Longidaz analogues, we took into account both the features of the drugs and reviews about them left by doctors and ordinary people on the sites Yandex.Market, Otzovik, Doctors.rf, Otabletkah, Protabletky.

pharmachologic effect

The drug is highly active and is a macromolecular complex of the proteolytic enzyme hyaluronidase. When taken, it has the following effects:

• relieves inflammation;
• eliminates swelling;
• promotes activation of humoral immunity;
• antifibrotic.

Longidaza improves tissue nutrition, eliminates adhesions, contractures, accelerates the resorption of bruises and hematomas, and also increases joint mobility.

The drug works best in the initial stages of the disease, preventing its progression and the development of complications.

Longidaza also enhances the effect of local anesthetics, increasing their bioavailability.

The medication is characterized by incredibly low toxicity and the absence of negative effects on the body.

Top 4. Galavit

Rating (2021): 4.14

Multidisciplinary use Galavit is a universal drug, the use of which is recommended for a fairly extensive list of various diseases.

• Characteristics

  Average price: 1250 rub. (10 supp. 100 mg)

• Manufacturer: Selvit (Russia)
• Active ingredient: sodium aminodihydrophthalazindione

Galavit is a drug with immunomodulatory and anti-inflammatory effects, which is actively used as part of the complex therapy of urological and gynecological diseases, in the postoperative period and for many other indications. This makes it in many ways similar to Longidaza candles. Galavit is produced in the form of suppositories, tablets and powder for the preparation of a solution for injection. Doctors have different opinions about this drug; a number of reviews contain statements about lack of effectiveness and lack of evidence base. However, you can find many positive recommendations that talk about quickly obtaining positive results from using the product. The price, according to many, could have been cheaper.

Advantages and disadvantages

• Three release forms
• Safety and effectiveness
• Many indications for use

• High price
• Partially similar action

Pharmacodynamics and pharmacokinetics

When the drug is administered by injection, it immediately enters the bloodstream, due to which the maximum concentration of the active substance is achieved in less than half an hour. The bioavailability of Longidase is about 90 percent, and it penetrates into any tissue of the human body. The half-life in this case is one day, and the drug is completely eliminated only after 5 days. It is excreted mainly by the kidneys, partly by the intestines.

When using suppositories, the maximum concentration is achieved only after 60 minutes. This dosage form has 70% bioavailability, and its half-life is extended to 2-3 days.

Comparison of rating participants by main indicators

There are contraindications! Consult your doctor!

Indications and contraindications for taking Longidaza

This drug is prescribed not only for the treatment, but also for the prevention of many diseases with connective tissue hyperplasia syndrome. It is used in the following medical fields:

• Gynecology: for inflammatory diseases of the genital organs, as well as for adhesions in the pelvic area.
• Pulmonology: fibrosing and sclerosing diseases of the lungs and respiratory tract, tuberculosis.
• Urology: chronic prostatitis and complicated cystitis.
• Surgery: prevention of adhesions after extensive abdominal surgery.
• Dermatovenereology: scleroderma, rough, keloid, disfiguring scars after various skin pathological processes.

There are also contraindications to the use of Longidase and, despite the low toxicity of the drug, there are quite a few of them:

• Individual intolerance to hyaluronidase.
• Oncological diseases.
• CKD.
• Bleeding and hemorrhage.
• Age under 18 years.
• Infections during the acute period of the disease.

Top 5. Chymotrypsin

Rating (2021): 4.11

Prevents scars Chymotrypsin is not able to fight scars that have already formed, but it helps prevent their appearance.

• Characteristics

  Average price: 960 rub. (10 ampoules 10 mg)

• Manufacturer: Samson Honey (Russia)
• Active ingredient: chymotrypsin

Chymotrypsin belongs to the category of enzyme preparations. It has a proteolytic and anti-inflammatory effect, and is capable of breaking down necrotic tissue and fibrinous formations. The drug can be classified as an analogue of Longidase only partially, since it is not able to influence already formed scars, but is used mainly for purulent wounds and inflammation, including to prevent adhesions. Chymotrypsin is available only in lyophilisate format. There are few reviews about it, but the existing ones sound contradictory. The drug is a prescription drug and, when used correctly under the supervision of a doctor, can show good results.

Advantages and disadvantages

• Enzyme preparation
• Complex action
• Effective for purulent wounds and lesions

• Available only in lyophilisate format
• Not considered inexpensive

Longidaza: how to take

• Injection form. The course of therapy ranges from 5 to 25 injections, each of which is given once every few days, the frequency depends on the prescription of the treating doctor. When using Longidase for prophylactic purposes, the interval between injections is 2 weeks.

Before administration, the powder is dissolved in 1-2 milliliters of procaine or in saline if the anesthetic is intolerant. The drug is administered slowly and immediately after preparation; it cannot be stored.

• Suppositories. They are administered vaginally before bedtime and in a lying position, rectally only after cleansing the intestines. The course of treatment ranges from 10 to 20 suppositories, depending on the pathology. The interval between administrations is from 48 to 72 hours.

Top 2. Adenoprosin

Rating (2021): 4.47

The best analogue of Longidase for prostatitis Adenoprosin is used only for prostate diseases, but is able to act more effectively than Longidase, which is confirmed by high ratings in reviews.

• Characteristics

  Average price: 920 rub. (10 supp. 29 mg)

• Manufacturer: Farmaprim (Moldova)
• Active ingredient: adenoprosin

Adenoprosin can be called an analogue of Longidase only if this drug is used to treat prostatitis. The active substance of the same name, which has anti-inflammatory and antioxidant properties, is isolated from gypsy moth larvae. The use of these suppositories allows you to alleviate the condition, normalize urination and reduce tissue swelling from the first day of use. While Longidaza for prostatitis is usually used as part of complex therapy, Adenoprosin can be used as an independent drug. The medicine cannot be called cheap, but its properties are truly unique and it receives only good reviews.

Advantages and disadvantages

• Active ingredient based on natural raw materials
• Pronounced therapeutic effect
• Complex action
• Quick relief

• Used only for prostatitis
• Price

See also:

• 10 best suppositories for prostatitis

Top Pharmaceutical Companies

When choosing an analogue of a medicine, you need to pay attention to the manufacturer. There are a large number of pharmaceutical companies both in our country and abroad. The best of them are presented below.

1. AbbVie;
2. Amgen;
3. Bristol-Myers Squibb;
4. GlaxoSmithKline;
5. Hoffmann-La Roche;
6. Johnson & Johnson;
7. Merck & Co.
8. Novartis;
9. Pfizer;
10. Sanofi.

These enterprises are leaders in terms of income received. Their products are in demand and are trusted by a huge number of people.

Among the Russian pharmaceutical companies, based on the Forbes magazine rating, the following companies can be distinguished:

1. R-Pharm;
2. Biocad;
3. Generium;
4. Valenta Farm;
5. Pharmasynthesis;
6. Kanonpharma Production;
7. Pharmstandard-Ufavita;
8. Ozone;
9. Vertex;
10. Pharm.

The manufacturer of Longidaza, NPO Petrovax Pharm, is in 16th place in this ranking in terms of revenue and net profit received for the year.

Longidaza or Afalaza

Manufacturer: Materia Medica NPF, Russia
Release form: lozenges

Active ingredient: antibodies to NO synthase, antibodies to prostate-specific antigen

Synonyms: Afala

Afalase is a combined homeopathic analogue with a pronounced effect on the functions and condition of the prostate gland in men. The drug contains active antibodies that are specific to prostate tissue. Such active substances in the analog composition allow Longidase to safely and effectively eliminate prostate swelling, reduce inflammation and impaired urine outflow. The product improves blood flow in affected tissues and external genitalia in men.

Afalase is used only internally in the form of lozenges. This analogue is intended for long-term use in male patients over 18 years of age.

What are generics?

It is not always possible to purchase an expensive original medicine in pharmacies. Sometimes you have to settle for an inexpensive substitute. What is their main difference? Let's try to figure it out using a comparison table:

Which product is better to buy? It is advisable to give preference to proven global brands, whose products fully comply with all standards and have the necessary certificates. A review of reviews shows that Chinese and Indian products (even originals) are made from poorly purified raw materials, so their effectiveness is questionable.

This is not to say that all generics are inexpensive. If the price for a package is less than 30 rubles, then it is a counterfeit. A counterfeit is revealed by sloppy packaging, blurry letters, unusual shape of tablets and their color. Experts do not advise purchasing products at a “ridiculous” price.

The advantages of generics include:

• the opportunity to make an independent choice;
• effectiveness in selecting the correct dosage;
• reasonable cost;
• Possibility to purchase at any pharmacy.

There are also negative characteristics, and they are worth mentioning:

• changing the formulation may negatively affect the treatment: the effect decreases or becomes excessively strong;
• when producing a generic drug, the raw materials may be of insufficient quality or not completely purified;
• the presence of additional components other than the original may lead to allergies or side effects.

Longidase analogs

Regardless of which generic or analogue is to be found, it must, first of all, have a similar list of components and matching active ingredients, as well as indications for use. The identity of the active substance indicates that the product is pharmaceutically equivalent or pharmaceutically alternative to the original. Do not overlook the inactive ingredients in analogues, which affect safety and effectiveness.

There is no need to self-medicate and self-prescribe. Therefore, before you start taking a medication, even if it is over-the-counter, you must consult your doctor.

There are a huge number of Longidase analogues. There are generics of Russian and foreign origin. Your doctor will tell you how to choose and which company is better to give preference to. Cost should not be the main selection criterion. It is necessary to carefully study the instructions and determine its identity with the original.

The question of where to buy medication is not difficult. Longidaz analogues are sold in any pharmacy. You can order goods online in the online store. However, this is not the best option. This applies not only to this medicine, but to all medicines whose main task is to improve human health.

Longidaza or Prostamol Uno

Manufacturer: RP SCHERER GmbH, Germany
Release form: capsules

Active ingredient: creeping palm extract

Synonyms: Prostaplan, Prostacker, Prostatoff, Permixon

Prostamol Uno is a herbal preparation that is used only for the complex treatment of prostatitis in men. The product more effectively eliminates swelling and inflammation in the prostate gland, improves urine flow, slows down the proliferation of prostate tissue, and improves blood flow in it. Such an analogue can be prescribed with Longidase to increase the effectiveness of therapy for prostatitis or benign prostate adenoma. When changing drugs, their characteristics should be taken into account to ensure maximum effectiveness and safety for patients.

Prostamol Uno is used only orally in capsule form once a day after meals. The drug is prescribed for a long time to male patients over 18 years of age.

Why do we need analogs?

Analogues, or generics (from the English Generic drug) are drugs that are based on the same amount of active substance of the same quality as the original medicine. Analogs occupy about 60% of the pharmaceutical market.

The process of creating generics is less expensive and faster in comparison with the original, which determines their low price. The original drug and the generic have the same international nonproprietary name (INN) and the same dosage form (tablets, suppositories, etc.), but different trade names, different packaging and different manufacturers.

The excipients used to create the drug and the quality of the raw materials from which they are made will also differ. As a rule, generics have both of these indicators lower than the original. Magnesium stearate, corn starch, lactose monohydrate are often used as excipients, dyes and flavors are added.

Analogs do not undergo a full course of clinical trials and do not have patent protection, unlike the original prototype. This has a positive effect on the price, but the effectiveness of such a medicine may be lower.

How to choose an analogue

The best way to choose a pharmaceutical drug is to consult a specialist. But if for some reason it is not possible to get an appointment with a doctor, there is an alternative option.

In order not to get confused in the huge number of pharmaceuticals, you can use the development of American specialists. Especially for doctors, they created the “Orange Book”, which is based on the reference book “List of Approved Drug Products with Therapeutic Equivalence Evaluations”. There is both an online version of this book and a web application that is available for free download for iOS and Android.

This application will make it possible to independently find analogues for certain drugs. If they are listed in List A on the green pages, then the medicine can be trusted. If they are on the red pages, their effectiveness has not yet been sufficiently studied.

A competent approach to choosing medications and careful attention to your body will allow you to preserve youth and beauty for a long time, and excellent health will be the best addition to every day you live.