Overdose
In case of overdose of the drug when applied topically, wash the excess drug from the eye(s) with warm water.
Given the characteristics of this drug, serious toxic reactions are not expected to occur in the event of overdose after application to the eye(s) or accidental ingestion of the contents of the tube.
Clinical manifestations of overdose resemble side effects observed in some patients: mottled keratitis, erythema, increased lacrimation, swelling and itching of the eyelids.
When is Next shown?
The combination drug copes with severe pain symptoms much better than other NSAIDs. Including:
- with migraine;
- neuralgia;
- muscle pain that develops as a result of injuries, infectious pathologies, inflammatory processes;
- with pain syndrome due to damage, inflammation of ligaments and joints: with sprains, fractures, exacerbations of arthritis, with degenerative processes in the hard tissues of the joints;
- with toothache;
- with lumbago;
- with painful menstruation and PMS pain.
Next improves the condition of patients during the postoperative recovery period. It is recommended for use in acute respiratory and other types of infections accompanied by fever, physical malaise, chills, headaches and other signs of fever.
Note!
Description of the drug Tobrotsim-Next eye ointment. 3mg/g tube 5g on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
How Next works
The pharmacological activity of the drug is determined by the medicinal substances it contains. The combined use of paracetamol and ibuprofen gives a more effective and long-lasting result than either alone.
- Paracetamol is a non-steroidal analgesic with pronounced antipyretic properties. In the body, it suppresses the activity of specific receptors in the central nervous system, affecting the functioning of thermoregulation centers and susceptibility to pain.
- Ibuprofen also has an analgesic effect and is more effective as an anti-inflammatory agent.
The complex therapeutic activity of Next ensures the elimination of pain and fever within 15–30 minutes after taking the capsules. The drug shell quickly dissolves in the gastrointestinal tract, analgesics are adsorbed into the bloodstream within a few minutes. The analgesic and antipyretic effect of the drug lasts up to 5–8 hours. Metabolites of the drug are bound by bile acids and are completely excreted from the body by the kidneys within 10–12 hours.
Side effects
When using the product, undesirable reactions of the body are possible:
- dry mouth, nausea, heartburn, heaviness in the epigastrium, intestinal upset;
- tachycardia;
- changes in laboratory blood parameters, increase in leukocytes, liver tests;
- dizziness, insomnia, muscle weakness, tinnitus;
- decreased amount of urine;
- blurred vision.
Possible signs of an intolerance reaction: itching, redness, rash, conjunctivitis, swelling of the mucous membranes.
How to use Next: instructions
Capsules of the drug can be taken occasionally: when sudden pain develops. If the unpleasant symptom goes away quickly, there is no need to continue drinking Next. In other cases, it is recommended to take 1 capsule 2-3 times a day:
- The pills must be swallowed whole with plain water;
- Desirable time: 1 hour after eating;
- maximum course of daily use: no more than 5 days.
For adults, the maximum daily dose of the drug is 3 capsules. Adolescents 12–17 years old whose body weight does not exceed 50 kg are allowed to take no more than 2 capsules per day. During the treatment period, people with chronic health problems should monitor their physical condition and take a biochemical blood test.
Next cannot be combined with other NSAIDs, including drugs that contain ibuprofen or paracetamol. Simultaneous therapy with anticoagulants, glucocorticoids, and barbiturates is also undesirable. The product should not be taken while intoxicated or hangover; ethanol greatly increases the risk of intoxication.
After taking Next, you should stop driving and using other equipment, since the speed of motor reactions under the influence of NSAIDs may decrease.
Next activegel
International nonproprietary or generic name:
Ibuprofen + Levomenthol
Dosage form:
gel for external use
Composition per 1 g of gel:
Active ingredients: ibuprofen – 50.0 mg, levomenthol – 30.0 mg Excipients: propylene glycol – 100.0 mg, ethanol 95%, 300.0 mg, carbomer – 20.0 mg, diisopropanolamine – 55.0 mg, water purified – up to 1000.0 mg.
Description:
Transparent, colorless or yellowish gel with a menthol odor.
The presence of opalescence and air bubbles is acceptable. Pharmacotherapeutic group:
non-steroidal anti-inflammatory drug (NSAID).
ATX code:
M02AA13
Pharmacological properties: Pharmacodynamics:
Next Activegel is a combination of two active substances - ibuprofen and levomenthol. Ibuprofen is a non-steroidal anti-inflammatory drug, a propionic acid derivative, that indiscriminately blocks the enzymes cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2), as a result of which it suppresses the synthesis of prostaglandins - mediators of pain, inflammation and hyperthermic reaction. When applied topically, ibuprofen has an analgesic and anti-inflammatory effect. Levomenthol has a local irritant effect, which causes the rapid development of the analgesic effect of the drug. The combination of ibuprofen and levomenthol reduces pain and inflammation, is effective for joint pain during movement and at rest, and reduces morning stiffness of the joints.
Pharmacokinetics:
After application to the skin, ibuprofen is detected in the epidermis and dermis after 24 hours. Reaches high therapeutic concentrations in the underlying soft tissues, joints and synovial fluid. Clinically significant systemic absorption practically does not occur. The maximum plasma concentration of ibuprofen when administered topically is 5% of the maximum concentration level when ibuprofen is administered orally. Ibuprofen is metabolized in the liver. It is excreted by the kidneys (no more than 1% unchanged) and, to a lesser extent, with bile through the intestines.
Indications for use:
As a local analgesic and anti-inflammatory agent for conditions such as muscle pain, back pain, arthritis, pain from ligament injuries and sprains, sports injuries and neuralgia.
Contraindications
- hypersensitivity to ibuprofen or other components of the drug;
- hypersensitivity to acetylsalicylic acid and other NSAIDs;
- complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including a history);
- violation of the integrity of the skin at the site of application of the drug (including infected wounds and abrasions, weeping dermatitis, eczema);
- children under 14 years of age;
- pregnancy, lactation period.
Carefully:
Before using the drug, you should consult a doctor if you have concomitant diseases of the liver and kidneys, gastrointestinal tract, exacerbation of hepatic porphyria, bronchial asthma, urticaria, rhinitis, polyps of the nasal mucosa, chronic heart failure, as well as elderly patients.
Use during pregnancy and breastfeeding:
The use of the drug during pregnancy and breastfeeding is contraindicated. If it is necessary to use the drug during lactation, breastfeeding should be stopped.
Directions for use and dosage:
The drug is intended for external use. For adults and children over 14 years of age, a small amount of gel (a strip 3-5 cm long) is applied in a thin layer to the skin above the lesion and rubbed in with light movements. Immediately after using the drug, you must wash your hands if they are not being treated. Repeated use of the drug is possible no earlier than after 4 hours. The drug can be applied up to 4 times within 24 hours. The duration of use of the drug without consulting a doctor is no more than 10 days. If longer use is necessary, consult your doctor.
Side effect:
The incidence of adverse reactions was assessed based on the following criteria: very often (≥1/10), often (from ≥1/100 to <1/10), infrequently (from ≥1/1000 to <1/100), rarely ( from ≥1/10,000 to <1/1000), very rare (>1/10,000), frequency unknown (frequency cannot be determined based on available data).
- Immune system disorders Frequency unknown: hypersensitivity reactions (nonspecific allergic reactions and anaphylactic reactions), respiratory tract reactions (bronchial asthma, including its exacerbation, bronchospasm, shortness of breath, dyspnea), skin reactions (itching, urticaria, purpura, exfoliative and bullous dermatoses, including toxic epidermal necrolysis (Lyell's syndrome), Stevens-Johnson syndrome, erythema multiforme, eczema, photosensitivity), Quincke's edema.
- Gastrointestinal disorders Frequency unknown: abdominal pain, dyspepsia.
- Renal and urinary tract disorders Frequency unknown: renal dysfunction.
With long-term use, systemic side effects of NSAIDs may develop.
If side effects occur, you should stop using the drug and consult a doctor.
Overdose:
Overdose phenomena with external use of the drug have not been described. If the drug is taken orally, headache, vomiting, drowsiness, and decreased blood pressure may occur. Gastric lavage (only within an hour after administration), intake of activated charcoal, alkaline drinking, forced diuresis, and symptomatic therapy are recommended.
Interaction with other drugs:
The drug may enhance the effect of drugs that cause photosensitivity. Clinically significant interactions with other drugs have not been described. Due to the fact that even with topical use of ibuprofen the possibility of a systemic effect of the drug cannot be completely excluded, caution should be exercised when used simultaneously with the following drugs: anticoagulants and thrombolytic drugs, antihypertensive drugs, acetylsalicylic acid, other NSAIDs. Theoretically, when used simultaneously with other NSAIDs, side effects may increase.
Special instructions:
It is necessary to avoid getting the drug into the eyes, lips and other mucous membranes, damaged areas of the skin. After application, do not apply an occlusive (sealed) bandage to the skin. Avoid exposure to sunlight on the area where the drug is applied. With long-term use of large amounts of the drug, there is a risk of developing systemic side effects. Before using the drug, you should consult your doctor if you have kidney disease.
Impact on the ability to drive vehicles and machinery:
The drug does not affect the ability to drive vehicles or operate machinery.
Release form:
Gel for external use, 5.0% + 3.0%. Gel 50 g in aluminum tubes with polymer bushes or in tubes made of a combined material with polymer bushes. The tube, along with instructions for medical use, is placed in a cardboard pack.
Storage conditions:
At a temperature not higher than 25 °C. Keep out of the reach of children.
Best before date:
2 years. Do not use after the expiration date stated on the package.
Vacation conditions:
Available without a prescription.
Name and address of the enterprise - Russia, 601125, Vladimir region, Petushinsky district, pos. Volginsky, tel./fax: (49 243) 71 5 52
Marketing authorization holder/organization receiving consumer complaints:
OTCPharm JSC, Russia 123112, Moscow, st. Testovskaya, 10, fl. 12, room II, room 29 Tel. Fax www.otcpharm.ru
