Ospamox is intended to treat the following infections:
- acute bacterial sinusitis;
- acute otitis media;
- acute streptococcal tonsillitis and pharyngitis;
- exacerbation of chronic bronchitis;
- community-acquired pneumonia
- acute cystitis,
- asymptomatic bacteriuria during pregnancy;
- acute pyelonephritis;
- typhoid and paratyphoid fever
- dental abscesses with widespread cellulite;
- prosthetic joint infections
- eradication of Helicobacter pylori (as part of combination therapy);
- Lyme disease.
The drug is used for the treatment and prevention of endocarditis.
Compound
active ingredient: amoxicillin;
5 ml of suspension contain amoxicillin 125 mg or 250 mg, or 500 mg in the form of amoxicillin trihydrate;
Excipients: citric acid, sodium benzoate (E 211), aspartame (E 951), talc, trisodium citrate anhydrous, guar gum, precipitated silicon dioxide, powdered lemon flavor, powdered peach-apricot flavor, powdered orange flavor.
Amoxicillin is a broad-spectrum bactericidal antibiotic from the group of semisynthetic penicillins. Suppresses the synthesis of bacterial cell walls. Amoxicillin is inactive against microorganisms that produce beta-lactamases. The level of resistance of susceptible microorganisms may vary depending on region.
pharmachologic effect
The drug is an antibiotic that belongs to the group of penicillins , beta-lactam antimicrobial agents. Provides a wide range of antimicrobial effects.
The active ingredient amoxicillin is part of the aminopenicillin subgroup. Produces a pronounced bactericidal effect, acts on a number of microorganisms, both gram-positive and gram-negative. Its mechanism of action is associated with the ability of the active substance to inhibit the synthesis of peptidoglycan, which forms the basis of the bacterial cell membrane. peptidoglycan formation at the final stage is disrupted under the influence of amoxicillin due to inhibition of the enzymatic activity of penicillin-binding proteins. Since the structure of the cell membrane is disrupted during their reproduction and growth, the integrity of the cell membranes is disrupted and bacterial lysis is observed.
Amoxicillin does not have a toxic effect on the body, since mammals do not have peptidoglycan and penicillin-binding proteins, which are affected by the drug.
Amoxicillin is an unprotected penicillin; it is destroyed by beta-lactamases. Therefore, those bacteria that produce penicillinase demonstrate resistance to Ospamox.
The drug is effective in the treatment of infectious diseases that were caused by microorganisms that are sensitive to the effects of amoxicillin.
Citrobacter, Klebsiella, Proteus vulgaris, Bacteroides fragilis, Enterobacter, Serracia, Acinetobacter, Moraxella catarrhalis, Riketsia, Providencia, Chlamidia, Mycoplasma, Proteus, Pseudomonas do not demonstrate sensitivity to the influence of the active substance.
Features of application
Amoxicillin penetrates the placental barrier; its concentration in the fetal blood plasma is approximately 25-30% of the concentration in the pregnant woman's blood plasma. Limited data on the use of amoxicillin during pregnancy indicate no negative effects on the fetus/newborn. Animal studies have shown the absence of teratogenic effects of amoxicillin. If it is necessary to prescribe amoxicillin during pregnancy, a careful assessment of the relationship between the potential risk to the fetus and the expected benefit to the woman should be carried out.
Amoxicillin is excreted in small amounts into breast milk, so the risk of hypersensitivity in a child during breastfeeding cannot be excluded. The use of the drug during this period is possible only when the expected benefit to the mother outweighs the potential risk to the child. Breastfeeding should be discontinued if the newborn develops gastrointestinal distress (diarrhea), candidiasis, or skin rashes.
Fertility. There are no data on the effects of amoxicillin on fertility in humans. Reproductive toxicity studies in animals have shown no effect on fertility.
Children
The drug is prescribed to children from birth. Children over 12 years old can use other dosage forms of the drug - tablets; tablets are dispersed.
The ability to influence the reaction rate when driving vehicles or other mechanisms
No studies have been conducted on the effect on the ability to drive a car or use other machinery. However, some adverse reactions (for example, allergic reactions, dizziness, convulsions) may affect the ability to drive a car or use other machines.
special instructions
Before starting treatment, a high sensitivity reaction test to penicillins and cephalosporins .
People with a history of severe allergies may develop severe reactions. The possible need to eliminate an anaphylactic reaction should be taken into account.
People suffering from severe gastrointestinal disorders accompanied by vomiting and diarrhea should not take Ospamox orally, as the risk of absorption is reduced.
It should be borne in mind that in people suffering from kidney disease, the elimination of amoxicillin is slowed down. In this case, you need to stop therapy or reduce the dose of the medication.
With long-term treatment, excessive proliferation of yeast or resistant microorganisms may occur. There is a possibility of developing superinfection.
When treating with large doses of Ospamox, you need to drink a lot of fluid to prevent crystalluria. If there are large concentrations of amoxicillin in the urine, sediment may form in the urinary catheter. It is important to check the catheter periodically.
When taking large doses, it is important to constantly monitor laboratory blood values. In people with epilepsy or kidney failure, large doses of the medicine may cause seizures.
Ospamox suspension contains sodium citrate and , this is important to take into account for patients who follow a sodium-restricted diet.
Care must be taken when driving vehicles and working with dangerous devices until the individual reaction to the drug is established.
Directions for use and doses
The dose of amoxicillin is determined by the doctor depending on the age, body weight and kidney condition of the patient, as well as the sensitivity of microorganisms and the localization of the infectious process.
Preparation of the suspension.
Shake the bottle so that the powder separates from the walls and bottom. Add drinking water in two portions (first 2/3, and then to the circular mark on the bottle in the form of a recess in the glass), shaking the bottle each time. Shake well before each use.
To measure the suspension, a dosing syringe with an adapter or a 5 ml measuring spoon with 1.25 ml and 2.5 ml marks is included.
Mode of application.
Eating does not affect the absorption of amoxicillin. The prepared suspension should be taken undiluted with water.
Ospamox price, where to buy
The price of Ospamox in Ukraine is from 70 UAH. (tablets) and from 80 UAH. (granules).
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
Pharmacy24
- Ospamox 500 mg/5 ml 12 g 60 ml powder Sandoz GmbH, Austria
155 UAH.order - Ospamox DT 1000 mg No. 12 tablets Sandoz GmbH-TechOps, Austria
100 UAH order
- Ospamox 500 mg N12 tablets Sandoz GmbH, Austria
88 UAH order
- Ospamox DT 500 mg No. 12 tablets Sandoz GmbH, Austria
64 UAH order
- Ospamox 1000 mg No. 12 tablets Sandoz GmbH-TechOps, Austria
117 UAH. order
PaniPharmacy
- Ospamox liquid Ospamox powder for the preparation of 60 ml suspension 500 mg/5 ml in bottle No. 1 Austria, Sandoz
163 UAH order
- Ospamox DT tablets Ospamox DT tablets. 1000 mg No. 12 Austria, Sandoz
117 UAH. order
- Ospamox tablets Ospamox tablets 1000 mg No. 12 Austria, Sandoz
132 UAH order
- Ospamox tablets Ospamox tablets 500 mg No. 12 Austria, Sandoz
89 UAH order
- Ospamox DT tablets Ospamox DT tablets. 500 mg No. 12 Austria, Sandoz
77 UAH order
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Overdose
Symptoms: dysfunction of the digestive tract - nausea, vomiting, diarrhea, which may result in an imbalance of water and electrolyte balance.
Cases of crystalluria have been reported, sometimes leading to renal failure.
Patients with impaired renal function or those who have received high doses of amoxicillin may experience seizures.
Treatment: induce vomiting or rinse the stomach, then take activated charcoal and an osmotic laxative. Water and electrolyte balance should be maintained. Amoxicillin is removed from the blood using hemodialysis. A specific antidote is unknown.
Side effects
Ospamox 250 suspension, 500 mg tablets and Ospamox 1000 mg are generally well tolerated by patients. But sometimes during the treatment the development of such negative effects was noted:
- Gastrointestinal tract: nausea, anorexia , vomiting, abdominal pain, flatulence , stool disorders, feeling of dry mouth; change in taste, temporary discoloration of the tongue in a black tint, change in the color of teeth - in isolated cases.
- Central nervous system, peripheral nervous system : dizziness , hyperkinesia , fainting; People with kidney disease may experience seizures.
- Liver and kidneys: temporary changes in the activity of liver transaminases, interstitial nephritis .
- Allergies: itching, rash, urticaria , exanthema , erythema multiforme , dermatitis ; Stevens-Johnson syndrome , anaphylactic shock , Quincke's edema , toxic epidermal necrolysis may develop .
- Hematopoiesis: agranulocytosis , thrombocytopenia .
- Other manifestations: superinfection, fever , fungal infections of the mucous membranes, in particular candidiasis .
If side effects develop, you need to stop treatment and consult a specialist.
Interaction with other drugs and other types of interactions
Probenecid, phenylbutazone, oxyphenbutazone, and to a lesser extent, acetylsalicylic acid and sulfinpyrazone reduce the renal tubular secretion of amoxicillin, which can lead to an increase in its level in the blood plasma and prolongation of action. Concomitant use with amoxicillin is not recommended.
Allopurinol. Concomitant use with amoxicillin may increase the likelihood of allergic skin reactions.
Tetracycline. Tetracycline and other drugs that have a bacteriostatic effect (macrolides, chloramphenicol) can neutralize the bactericidal effect of amoxicillin.
Indications
Amoxicillin is intended to treat the following infections:
- acute bacterial sinusitis;
- acute otitis media;
- acute streptococcal tonsillitis and pharyngitis;
- exacerbation of chronic bronchitis;
- community-acquired pneumonia;
- acute cystitis;
- asymptomatic bacteriuria during pregnancy;
- acute pyelonephritis;
- typhoid and paratyphoid fever;
- dental abscesses with widespread cellulite;
- infections of prosthetic joints;
- eradication of Helicobacter pylori (as part of combination therapy);
- Lyme disease.
The drug is used for the treatment and prevention of endocarditis.
Storage conditions
Store at a temperature not exceeding 25°C in the original packaging.
Keep out of the reach of children.
Use the finished suspension within 14 days;
Store the prepared suspension in the refrigerator (2-8°C).
Shelf life: 3 years.
Product description certified by the manufacturer Sandoz
.
Verified by
Likar Turumkulova Irina
Note!
Description of the drug Ospamox por. d/oral. susp. 125 mg/5 ml, 5.1 g d/p 60 ml suspension. on this page is a simplified author's version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
Analogs
Level 4 ATC code matches:
Hiconcil
Ampioks
Ampicillin Trihydrate
Ampicillin
Amoxicar
Penicillin
Flemoxin Solutab
Amoxicillin
Amosin
Amoxil
Ecoball
Analogues of this drug, containing a similar component as an active substance, are the following drugs: Amoxicillin , Amosin , Gonoform , Grunamox , Flemoxin Solutab , Danemox , Ecobol , etc.
Any of the analogues can be taken instead of Ospamox only after a doctor’s prescription.
