Compound
- 1 gram of Triderm ointment contains 10 mg of clotrimazole , 1 mg of gentamicin , 0.5 mg of betamethasone . Additional components: liquid paraffin, soft paraffin.
- 1 gram of Triderm cream also contains 10 mg of clotrimazole , 1 mg of gentamicin , 0.5 mg of betamethasone . Additional components: propylene glycol, petrolatum, liquid paraffin, cetostearyl alcohol, benzyl alcohol, macrogol cetostearate, phosphoric acid, sodium dihydrogen phosphate dihydrate, water, phosphoric acid.
Main active ingredients, description
Triderm is a drug for local use with a complex effect. Available in the form of ointment and cream. 1 g of ointment includes:
- antifungal agent clotrimazole – 10 mg;
- antibiotic gentamicin – 1 mg;
- hormonal anti-inflammatory component betamethasone – 0.5 mg.
Additionally, liquid and soft paraffin are present to give the mass its shape. The substance has a uniform structure, translucent white or yellowish color, no pungent odor. Packaged in tubes of 15 or 30 g, each is sold in a box with instructions.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Multicomponent product for external use. Combines the antipruritic, anti-inflammatory, antiallergic and antiexudative effect of betamethasone with the antifungal effect of clotrimazole and the antibacterial activity of gentamicin .
Clotrimazole has an antifungal effect due to its ability to inhibit the biosynthesis of ergosterol , which is an important structural unit of the fungal cell membrane. Effective on Epidermophyton floccosum, Trichophyton rubrum and mentagrophytes, Candida albicans, Microsporum canis, Malassezia furtur.
Gentamicin has a wide spectrum of effects. Exhibits a bactericidal effect and provides local treatment of bacterial skin lesions. Effective on:
- gram-negative bacteria – Proteus vulgaris, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes;
- gram-positive bacteria – Staphylococcus aureus.
Pharmacokinetics
There is no data on the pharmacokinetics of this drug.
Pharmacodynamics
Combined preparation for external use.
Triderm® ointment and cream combine the anti-inflammatory, antipruritic, antiallergic and antiexudative effect of the GCS betamethasone dipropionate with the antifungal activity of clotrimazole and the broad antibacterial effect of gentamicin sulfate.
Clotrimazole has an antifungal effect by disrupting the synthesis of ergosterol, which is an integral part of the cell membrane of fungi. Active against Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, Candida albicans, Malassezia furfur (Pityrosporum orbiculare).
Gentamicin sulfate, a broad-spectrum antibiotic from the aminoglycoside group, is bactericidal and provides highly effective local treatment of primary and secondary bacterial skin infections. Active against gram-negative microorganisms: Pseudomonas aeruginosa, Enterobacter aerogenes, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae; gram-positive microorganisms: Staphylococcus aureus (coagulase-positive, coagulase-negative and some strains producing penicillinase).
Indications for use
What does Triderm ointment and Triderm cream treat and for what? Indications for use of Triderm ointment:
- infections associated with microorganisms sensitive to the drug and frolicking against the background of dermatoses , or suspicion of them, including atopic , allergic and simple dermatitis , diffuse and limited neurodermatitis , dermatomycosis ( candidiasis , dermatophytosis , pityriasis versicolor ), eczema ;
- lichen simplex of a chronic nature.
Indications for Triderm®
Dermatoses complicated by infections caused by pathogens sensitive to the drug, or when such infections are suspected, including:
simple and allergic dermatitis;
atopic dermatitis (including diffuse neurodermatitis);
limited neurodermatitis;
eczema;
dermatomycosis (dermatophytosis, candidiasis, lichen versicolor), especially when localized in the groin area and large folds of the skin;
simple chronic lichen (limited neurodermatitis).
Contraindications
- skin symptoms of syphilis ;
- chicken pox;
- lupus ;
- post-vaccination skin reactions;
- herpes simplex;
- hypersensitivity to the components of the drug;
- age less than 2 years.
It is recommended to use the drug with caution for long-term therapy, in children over 2 years of age, during pregnancy, on large areas of skin or in the presence of wounds, when applying occlusive dressings.
Side effects
- Local phenomena: erythema , burning sensation, pigmentation disorder, exudation , itching.
- Side effects after using local glucocorticosteroids : itching, burning sensation, folliculitis , dry skin, hypertrichosis, hypopigmentation, acne, allergic contact dermatitis , skin maceration, perioral dermatitis , atrophy , secondary infection, prickly heat , stretch marks .
- Side effects after using clotrimazole : urticaria , tingling sensation, erythema , peeling, blistering, itching, local swelling, irritation.
- Side effects after using gentamicin : temporary erythema and itching, which does not require discontinuation of therapy.
Instructions for use of Triderm (Method and dosage)
Triderm ointment, instructions for use
The ointment is for external use only.
The use of Triderm ointment is carried out in the following way: a thin layer is applied to the affected and surrounding skin twice a day (morning and evening). To ensure a therapeutic effect, the product must be applied regularly. The duration of treatment depends on the size and location of the lesion, as well as the response to therapy.
If improvement is registered after 4 weeks of treatment, you should consult a doctor and clarify the diagnosis.
Triderm cream, instructions for use
The cream is for external use only. The method of application and dosage when using the cream are completely consistent with those when using the ointment.
Triderm cream in the complex treatment of pustular psoriasis
The significant prevalence and insufficient effectiveness of existing treatment methods have necessitated the further development of methods for treating psoriasis [5]. Great difficulties arise when choosing methods for treating the pustular form of the disease [1, 3]. In external therapy, glucocorticosteroids and antibacterial agents are often used [6]. Meanwhile, taking into account the characteristics of the microbial flora of the skin and local immune changes [4, 7–10], it is advisable to act not only on bacteria, but also on fungal microorganisms.
The purpose of our study was to study the effectiveness and tolerability of Triderm cream (Schering Plough) in patients with pustular psoriasis. 1 g of cream contains 0.64 mg betamethasone dipropionate, equivalent to 0.5 mg (0.05%) betamethasone, gentamicin sulfate, equivalent to 1 mg (0.1%) gentamicin base, and 10 mg clotrimazole (1%). Previously, the effectiveness of the drug was shown for seborrheic dermatitis, yeast balanoposthitis, and allergic dermatoses.
We observed 21 patients with pustular psoriasis aged from 42 to 54 years, including 14 women and 7 men. In 20 patients, the lesions were located on the palms and soles (psoriasis pustuposa palmaris et plantaris Barber). On the hyperemic areas of the skin, intraepidermal pustules the size of a pinhead were located, partially merging. The pustules gradually shriveled into brownish-brown crusts without opening. The predominant localization of lesions is the area of the thenar and the inner surface of the metatarsus. All patients were diagnosed with psoriasis vulgaris 2–4 years before the present observation.
In one patient, we observed widespread foci of erytherma with pustulization on the skin of the trunk and extremities (psoriasis suppurativa Zumbusch). Psoriasis was diagnosed 18 years before the present examination (previously there were manifestations of seborrheic psoriasis and psoriatic onychodystrophy).
All patients were prescribed oral calcium supplements, antihistamines, and sedatives. Triderm cream was applied in a thin layer to the lesions twice a day. The duration of treatment ranged from 14 to 21 days, with an average of 19 days.
The results obtained were compared with data from a group of patients who received external cream “Belogent” containing 0.05% betamethasone dipropionate and 0.1% gentamicin sulfate. This group included 20 patients aged 43 to 53 years, including 14 women and 6 men. 19 patients were diagnosed with Barber pustular psoriasis of the palms and soles, and one patient was diagnosed with the common form of Zumbusch disease. All patients were previously (for 2–5 years) observed for vulgar psoriasis. Like the patients of the main group, they received calcium supplements, antihistamines, and sedatives orally. Externally, Belogent cream was applied in a thin layer to the lesions twice a day. The duration of treatment ranged from 14 to 21 days, with an average of 19 days.
After treatment among patients receiving Triderm (21 people), significant improvement was noted in 12 patients, improvement in 8, no effect in 1 patient with widespread pustular psoriasis Zumbusch.
After therapy among patients receiving Belogent (20 people), significant improvement was noted in 5 patients, improvement in 5, no effect in 10 patients.
Treatment was well tolerated in both groups; no adverse reactions were recorded in any case.
The results obtained indicate the preferable use of Triderm cream in the complex treatment of pustular psoriasis of the palms and soles compared to Belogent cream. For a final assessment of the feasibility of using Triderm cream for a common form of the disease, it is necessary to increase the number of observations.
- In conclusion, we can say the following:
- In the complex therapy of pustular psoriasis of the palms and soles, it is advisable to include Triderm cream, the therapeutic effectiveness of which is higher than that of Belogent cream.
- Triderm cream is well tolerated and does not cause adverse reactions.
Literature 1. Treatment of skin diseases: A guide for doctors // Ed. A. L. Mashkilleyson. M.: Medicine. 1990, p. 560. 2. Mashkilleyson A.L., Golousenko I.Yu. // Bulletin of Dermatology and Venereology. 1995. No. 1. p. 48-49. 3. Mashkilleyson L.N. Private dermatology. M., 1965, p. 174-179. 4. Noble W. K. Microbiology of human skin. Per. from English M.: Medicine. 1986, p. 496 Per. ed.: England, 1981. 5. Skripkin Yu. K., Samsonov V. A., Selissky G. D., Gomberg M. A. // Bulletin of Dermatology and Venereology. 1997. No. 6. p. 4-8. 6. Shakhtmeister I. Ya., Shimanovsky N. L. // Ibid. 1998. No. 2. p. 27-30. 7. Aly R., Maibach HI // Applied & Environmental Microbiology. 1976, vol. 31. r. 931-937. 8. Noble WC, Willie JA // J. of Medical Microbiology. 1980, vol. 13. r. 329-333. 9. Price PB // J. of Infectious Diseases. 1938, vol. 63. rub. 302-307. 10. Schmid MH, Korting HC // Dermatology. 1995, vol. 191, No. 4. r. 276-280.
Overdose
Signs of overdose with local glucocorticosteroids : with long-term use in large doses, suppression of adrenal function with the appearance of adrenal insufficiency and hypercortisolism .
An overdose of clotrimazole when applied locally does not lead to the development of any symptoms.
In case of an overdose of gentamicin, no symptoms are detected either. Long-term treatment with gentamicin in large doses may cause the appearance of insensitive flora.
Overdose therapy: symptomatic. Acute hypercortisolism is usually reversible. If necessary, correct electrolyte imbalance. In case of chronic overdose of local glucocorticosteroids, slow withdrawal is recommended.
Triderm drug overdose, symptoms and treatment
With prolonged or excessive use of local corticosteroids, suppression of the pituitary-adrenal system is possible with the development of secondary adrenal insufficiency and the appearance of symptoms of hypercortisolism, including Cushing's syndrome. The use of clotrimazole under an occlusive dressing for 6 hours did not lead to the development of overdose symptoms. An overdose of gentamicin when applied topically is practically impossible. Treatment. Prescribe appropriate symptomatic therapy. Acute symptoms of hypercortisolism are usually reversible. If necessary, electrolyte balance should be corrected. In case of chronic toxic effects, gradual withdrawal of GCS is recommended. If excessive growth of microorganisms occurs, the use of Triderm should be discontinued and adequate therapy should be prescribed.
special instructions
Triderm ointment and cream are not intended for use in ophthalmic practice.
Prolonged use of local antibiotics in some cases can lead to the emergence of resistant microflora. In such a case, as well as in case of sensitization , irritation or superinfection , Triderm therapy should be stopped and symptomatic treatment should be started. Cross allergic phenomena with aminoglycoside antibiotics cannot be excluded .
All side effects that occur when taking systemic glucocorticosteroids , including suppression of the adrenal cortex, can also develop when using local glucocorticosteroids , especially in children.
The absorption of active substances into the systemic circulation when applied topically is enhanced if treatment is carried out with the application of occlusive dressings or over large areas of the skin, especially during prolonged treatment or when the skin is wounded. It is strongly recommended to avoid contact of gentamicin with open wounds or broken skin, as this may cause adverse reactions characteristic of systemic use of gentamicin .
With long-term use of the drug, its withdrawal should be carried out slowly.
There was no effect of the drug on the ability to drive vehicles.
Triderm ointment 15g No. 1
Name
Triderm.
Release forms
Ointment.
Compound
1 g of ointment contains: active ingredients: betamethasone dipropionate equivalent to betamethasone 0.5 mg, clotrimazole 10 mg and gentamicin sulfate equivalent to gentamicin 1 mg; excipients: liquid paraffin, white petroleum jelly.
Description
Soft consistency, white to light yellow, homogeneous ointment, without foreign inclusions.
Pharmacotherapeutic group
Corticosteroids for use in dermatology. Corticosteroids are highly active in combination with other drugs. ATC code: D07XC01.
Pharmacological properties
The mechanism of action of Triderm combines the following mechanisms of action: the anti-inflammatory effect of betamethasone dipropionate, the antibacterial effect of gentamicin and the antifungal effect of clotrimazole.
Pharmacodynamics
Betamethasone in the form of dipropionate is a potent corticosteroid (class III) with anti-inflammatory, antiallergic and antipruritic effects. Gentamicin is an aminoglycoside antibiotic with antibacterial activity. Its action is based on suppressing the synthesis of proteins of sensitive microorganisms. Gentamicin affects many aerobic gram-negative and some gram-positive bacteria. In vitro, gentamicin at concentrations of 1-8 μg/ml inhibits the growth of most sensitive strains of Escherichia coli (Escherichia coli), Haemophilus influenzae (Haemophilus influenzae), Moraxella lacunata (Morax-Axenfeld sticks), Neisseria (Neisseria), indole-positive and indole-negative Proteus, Pseudomonas (pseudomonas), including most strains of Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis and Serratia. Different species and different strains of the same species may exhibit large differences in susceptibility under in vitro conditions. In addition, in vitro sensitivity does not always correlate with in vivo sensitivity. Gentamicin is not effective against most anaerobic bacteria, fungi and viruses. Gentamicin has only minimal effect on streptococci. Resistance to gentamicin can develop in both gram-negative and gram-positive bacteria. Clotrimazole is a synthetic antifungal agent - an imidazole derivative. The spectrum of action covers a number of fungi that are pathogenic for humans and animals. Clotrimazole is effective against dermatophytes, yeasts and molds. In in vitro assays, clotrimazole was effective against the fungi Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis and fungi of the genus Candida, including Candida albicans. According to current knowledge, the antifungal effect of clotrimazole is explained by the inhibition of ergosterol synthesis. Ergosterol is a vital component of the cell membrane of fungi.
Pharmacokinetics
There are no data on the pharmacokinetics of Triderm. Betamethasone Under normal conditions, when applied topically, only a portion of betamethasone enters the systemic circulation. The percentage of penetration and absorption depends on the body area, skin condition, dosage form, age and method of application. Gentamicin When gentamicin is applied to intact skin, absorption is unlikely to be expected. If the keratin layer is damaged, inflamed, used under an occlusive dressing, or applied to a large area, increased percutaneous absorption should be expected. Clotrimazole Most of the applied clotrimazole remains in the stratum corneum, and absorption into the systemic circulation is negligible. 6 hours after applying 1% radioactive clotrimazole to healthy skin, as well as to skin with acute inflammation, the following concentrations could be determined: stratum corneum - 100 μg/cm3, reticular layer - 0.5-1 μg/cm3, subcutaneous tissue - 0.1 µg/cm3.
Indications for use
Triderm is indicated for the treatment of corticosteroid-sensitive dermatoses in which bacterial and/or fungal infection either already exists or is to be feared.
Contraindications
Skin infections (viral, bacterial
incl. tuberculosis
, as well as fungal origin), reactions to vaccines, skin ulcers and acne are contraindications for the use of topical corticosteroids. If you have rosacea or perioral dermatitis, you should avoid applying the ointment to your face. Hypersensitivity to one of the active or excipient substances of the drug, to other aminoglycoside antibiotics (cross-allergy with gentamicin) or imidazole derivatives (cross-allergy with clotrimazole). Triderm is not intended for use under an occlusive dressing. Triderm should not be applied to mucous membranes, skin around the eyes or near the eyes.
Directions for use and dosage
Adolescents and adults 2 times a day (morning and evening), apply a thin layer to the affected areas of the skin and rub in lightly, covering both the entire affected area and the healthy surface of the skin surrounding it. The duration of treatment depends on the results of both clinical examination and microbiological examination, as well as on the response to treatment. For athlete's foot, the need for longer treatment (2-4 weeks) may be considered. Children from 2 to 12 years Apply a small amount only to affected areas of skin and rub in gently. Use no more than twice a day, taking a break of at least 6-12 hours between applications of the ointment. Apply the ointment to the face, neck, scalp, genital area, rectal area and areas with diaper rash under the supervision of a physician. The duration of treatment is limited to 5-7 days. See sections "Precautions" and "Use in pediatric patients".
Adverse reactions
At the beginning of treatment Skin Rarely: irritation, burning, itching, dryness, hypersensitivity reactions to any of the ingredients of the drug and changes in skin color. When used over large areas, under an occlusive dressing and/or with longer use. When used over large areas, under an occlusive dressing and/or with longer use, local skin changes are possible. When applying the ointment to large areas, there is a possibility of systemic effects (suppression of adrenal cortex function). It should be taken into account that due to reduced local resistance to infections, there is an increased risk of secondary infections. Skin Local skin changes such as atrophy (especially on the face), telangiectasias, striae, stripe-like skin atrophy, skin hemorrhages, purpura, steroid acne, rosacea-like or perioral dermatitis, hypertrichosis, and changes in skin color. It is not known whether skin color changes are reversible. Sometimes: contact hypersensitivity to gentamicin. In some patients, possible photosensitivity was observed, which, however, did not resume with repeated application of gentamicin followed by exposure to ultraviolet radiation. Endocrine system Suppression of the synthesis of endogenous corticosteroids, hypercortisolism with edema. Metabolism Diabetes mellitus (manifestation of a previously hidden form). Ear, inner ear/kidney Cumulative ototoxicity/nephrotoxicity should be expected during treatment with large areas of ointment or use on broken skin with concomitant systemic use of aminoglycoside antibiotics. Musculoskeletal system Osteoporosis, growth retardation (in children). Systemic adverse reactions, such as blurred vision, have also been reported with the use of topical corticosteroids. If the listed adverse reactions occur, as well as reactions not listed in the instructions for use, you should consult a doctor.
Overdose
Symptoms: with prolonged or excessive use of local glucocorticosteroids, suppression of pituitary-adrenal function with the development of secondary adrenal insufficiency and the appearance of symptoms of hypercortisolism, including Cushing's syndrome, are possible. A single overdose of gentamicin is not expected to cause any symptoms. The use of clotrimazole under an occlusive dressing for 6 hours did not lead to the development of overdose symptoms. Excessive or prolonged use of gentamicin may lead to overgrowth of microorganisms that are not sensitive to the antibiotic. Treatment: appropriate symptomatic therapy is prescribed. Symptoms of acute hypercortisolism are usually reversible. If necessary, electrolyte balance is corrected. In case of chronic toxicity, gradual withdrawal of corticosteroids is recommended. If there is excessive growth of resistant microorganisms, it is recommended to stop treatment with Triderm and prescribe the necessary therapy.
Precautionary measures
If irritation or sensitization occurs due to the use of Triderm, treatment should be discontinued and appropriate therapy should be initiated. The absorption of active substances intended for topical use into the systemic circulation may be enhanced if Triderm is applied over a large area, in particular with long-term use or use on damaged skin. Under these conditions, undesirable effects may occur in the form in which they appear after systemic use of active substances. When used in children in such cases, extreme caution is recommended. In case of simultaneous systemic use of aminoglycoside antibiotics, with increased percutaneous absorption, cumulative toxic effects (ototoxicity, nephrotoxicity) should be expected. The possibility of possible cross-allergy to other aminoglycoside antibiotics should be taken into account. With long-term treatment with drugs containing antibiotics, insensitive microorganisms may appear. In this case or if superinfection occurs, appropriate therapy should be started. High-dose, large-scale or occlusive application of a potent or very potent corticosteroid should only be done under regular medical supervision, especially given the suppression of endogenous corticosteroid production and possible metabolic effects. Avoid use on open wounds and damaged areas of skin. The period of continuous use, if possible, should not exceed 2-3 weeks. Very strong, strong and moderate-acting corticosteroids should be used on the face and genital area with extreme caution and for no longer than 1 week. In principle, only weak corticosteroids are used near the eyes (due to the risk of developing glaucoma). Corticosteroids may mask the symptoms of an allergic skin reaction to the drug's ingredients. The patient should be instructed to use the drug only for the treatment of his current skin condition and not to give the drug to others. When using systemic and local corticosteroids (including intranasal, inhaled and intraocular administration), visual disturbances may occur. If symptoms such as blurred vision or other visual disturbances occur, the patient should be evaluated by an ophthalmologist to evaluate possible causes of the visual disturbance, which may include cataracts, glaucoma, or rare diseases such as central serous chorioretinopathy, which has been reported following the use of corticosteroids systemic and local action. Use in pediatric patients This medicinal product is not recommended for use in children under 2 years of age. Pediatric patients may be more sensitive than adult patients to hypothalamic-pituitary-adrenal axis suppression and exogenous corticosteroid activity caused by topical corticosteroids because the greater ratio of skin surface area to body weight results in greater absorption. Suppression of the hypothalamic-pituitary-adrenal axis, Cushing's syndrome, decreased linear growth, decreased weight gain, and increased intracranial pressure have been reported with the use of topical corticosteroids in children. Symptoms of adrenal suppression in children include, among other things, low plasma cortisol levels and lack of response after adrenocorticotropic hormone (ACTH) stimulation. Symptoms of increased intracranial pressure include bulging fontanel, headaches, and bilateral papilledema, among others.
Use during pregnancy or breastfeeding
Pregnancy: In animal testing, topical corticosteroids were teratogenic. There are no data on use in pregnant women. Aminoglycosides cross the placental barrier and may cause fetal harm if taken by pregnant women. There have been reports of complete irreversible bilateral congenital deafness in children whose mothers took aminoglycosides, including gentamicin, during pregnancy. There are no sufficient data on the topical use of gentamicin in pregnant women. There are no sufficient data on the use of clotrimazole in pregnant women. Results from animal studies did not reveal any risks to the fetus. Triderm should only be used in cases where it is absolutely necessary. Triderm should not be used over a large area, in large quantities or for a long time. Breastfeeding There is no data on the excretion of gentamicin, clotrimazole and topical corticosteroids into breast milk, but corticosteroids that enter the systemic circulation also pass into breast milk. When applying Triderm to the mammary glands, breastfeeding is contraindicated.
The ability to influence the reaction rate when driving a vehicle or working with other mechanisms
As a rule, the drug does not affect the speed of reaction when driving vehicles or operating other mechanisms.
Interaction with other drugs and other types of interactions
Due to the content of white soft paraffin and liquid paraffin, the tensile strength and, therefore, the safety of using latex condoms may be reduced; this should be taken into account when using the ointment in the genital or anal area. When applied topically, clotrimazole may have an antagonistic effect on amphotericin and other polyene antibiotics.
Best before date
3 years. It is not recommended to use the drug after the expiration date indicated on the package.
Storage conditions
Store out of the reach of children at a temperature not exceeding 25°C.
Package
15 g in aluminum tubes. One tube each along with instructions for use in a cardboard box.
Vacation category
On prescription.
Buy Triderm ointment 15g No. 1 in the pharmacy
Price for Triderm ointment 15g No. 1
Instructions for use for Triderm ointment 15g No. 1
Triderm's analogs
Level 4 ATX code matches:
Rederm
Losterine
Akriderm SK
Akriderm
Akriderm GK
Akriderm Genta
Elokom S
Diprosalik
Belosalik
Kanizon Plus
Betasalik
Triacutan
Momat-S
Analogues of Triderm cream and ointment: Akriderm (Russian substitute), Kanizon , Triakutan, Betazon Ultra, Lokoid, Diprosalik, Betasalik.
The price of analogues of Triderm ointment, which are listed above, is an order of magnitude lower than the price of the product itself.
For children
The medicine is prescribed only to children over 2 years of age, according to strict indications and under the supervision of a doctor, since it is possible that systemic side effects associated with betamethasone appear in this category of patients more often than in adults. Such side effects include: Cushing's syndrome , inhibition of the pituitary-hypothalamic-adrenal system , growth retardation, increased intracranial pressure (as a consequence, headache, swelling of the optic nerve and bulging of the fontanelles), slower growth of body weight.
Reviews about Triderm
Reviews of the cream, as well as reviews of Triderm ointment, report rare cases of ineffectiveness and even more rarely undesirable effects (mainly itching). Otherwise, 90% of reports give an excellent rating to the drug. Due to the complex composition and the possibility of severe side effects, it is not recommended to use this medicine independently and unsupervised.
Is Triderm ointment hormonal or not?
The ointment and cream of the same name contain the hormonal component betamethasone , so they can be called hormonal.
Triderm and balanoposthitis
Despite the good results of treating balanoposthitis with this remedy, many doctors do not recommend its use for this pathology, due to the high probability of damage to the skin of the genitals under the influence of hormones.
Cream or ointment: which is better?
Reviews do not reveal any significant correlation between the effectiveness of these forms of release of the drug.
Triderm price, where to buy
The price of Triderm ointment 15 g in Russia is 570-680 rubles, and cream 15 g costs 580-640 rubles. Buying a cream in Moscow (like ointment) will cost a large amount; here its cost reaches 820 rubles.
Ointment 15 g costs 230-300 hryvnia in Ukraine. The price of Triderm cream 15 g is on average 230-290 hryvnia.
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